For decades, aspirin has worn the crown as the go-to pill for keeping heart disease at bay. A tiny tablet, a household name, and hailed as a lifesaver. But a new study says another drug called clopidogrel might be ready to snatch the spotlight. The study, published in The Lancet and showcased at the European Society of Cardiology (ESC) Congress in Madrid, analysed seven clinical trials. That is nearly 29,000 patients with coronary artery disease (CAD) under the microscope.

CAD is what happens when fatty gunk (plaque) clogs up your coronary arteries, putting you on the fast track to heart attacks and strokes.

Half the patients were put on aspirin, the age-old defender of arteries. The other half were handed clopidogrel, a lesser-known antiplatelet drug that prevents blood cells from clumping together into dangerous clots. And the clopidogrel group had a 14 per cent lower risk of scary outcomes like strokes, heart attacks, or even death.

And rates of major bleeding — one of the biggest worries with blood thinners — were no worse than with aspirin.

What Did the Experts Say?

Researchers did not mince their words. They concluded that clopidogrel “offers superior protection against major cardiovascular and cerebrovascular events compared with aspirin, without an excess risk of bleeding.”

Even stronger, they said: “These results support a preference for clopidogrel over aspirin for chronic antiplatelet monotherapy for patients with stable CAD.”

And for those worried about costs, availability, or whether clopidogrel will mean taking out a small loan at the pharmacy, researchers reassured: “The widespread availability, generic formulation, and affordability of clopidogrel further supports its potential for extensive adoption in clinical practice.”

Why Does This Matter?

Aspirin is practically medical royalty. For years, patients with CAD were told to take it indefinitely, usually in low doses. The logic was simple: aspirin makes blood less sticky, so the chances of clots clogging up those already narrowed arteries drop.

But aspirin is not without its flaws. Long-term use can irritate the stomach and, more worryingly, increase the risk of major bleeding. Doctors have tolerated this risk because the heart benefits outweighed the downsides. Until now, perhaps.

If clopidogrel can give patients better protection without adding extra bleeding danger, it could flip decades of medical wisdom on its head.

The British Heart Foundation Weighs In

Reacting to the findings, Professor Bryan Williams, chief scientific and medical officer at the British Heart Foundation, acknowledged the potential shake-up.

“Aspirin is a commonly prescribed drug to help prevent repeat heart attacks and strokes,” he said. “This research suggests that clopidogrel, an alternative to aspirin, might be more effective at preventing recurrent heart attacks or strokes. Importantly, these benefits come without a greater risk of major bleeding.

“These findings are likely to impact the medications doctors prescribe to their patients to reduce their risk of future heart problems.”

What Patients Should Know

If you are one of the millions of people popping an aspirin a day, do not chuck your tablets in the bin just yet. Experts are not advising patients to swap medications on their own. But the findings will almost certainly fuel conversations between cardiologists and their patients.

Doctors may start leaning more towards clopidogrel, particularly for people with stable CAD who are expected to stay on antiplatelet therapy for the long haul. With its generic version already widely available, the shift could be smoother and faster than most medical revolutions.

Aspirin is cheap, it is trusted, and it has saved countless lives. But medicine does not stand still. Clopidogrel might just be the upgrade the cardiology world did not know it needed. The real test will be whether global health guidelines change in the wake of this research.

Tamil Nadu health authorities have ramped up surveillance efforts and implemented preventive and control measures to curb rising chickenpox cases in the state.

The Directorate of Public Health (DPH) and Preventive Medicine has instructed all health officers to intensify active and passive surveillance in all government and private health facilities, schools, colleges and hostels.

They were also directed to ensure that all suspected and confirmed cases are entered into the Integrated Disease Surveillance Programme (IDSP) line list with complete demographic and clinical details.

All medical officers across the state have further been asked to be alert to differentiate chickenpox from other rash illnesses such as measles, rubella, and hand, foot and mouth disease.

This comes weeks after doctors across Pune also warned against the exponential rise in chickenpox cases this winter.

Dr Shirish Kankariya, head of paediatrics at Apollo Hospital Swargate, said he had seen around 15 chickenpox patients in Jan alone, and the current season has brought a visible uptick in cases.

"Chickenpox cases have risen. We are also seeing infections in older children and adult family members, who never had the disease earlier," he told Times of India.

Dr Prateek Kataria, consultant pediatrician and neonatologist at Sahyadri Hospital also noted that out-patient departments (OPDs) have recently seen a large increase confirmed chickenpox cases this year.

He also told the publication: "We are seeing many children with chickenpox in the OPD even among those who have taken both doses of the vaccine. This is expected because the vaccine does not guarantee 100% protection, but vaccinated children usually develop milder illness and do not need hospitalization."

What Is Chickenpox And How Does It Spread?

Chickenpox, caused by the varicella-zoster virus, is extremely contagious and spreads through respiratory droplets or direct contact with someone who is infected. In children, it often starts as a mild rash accompanied by fever, but it can spread quickly in crowded areas.

The virus can also be transmitted through coughing or sneezing, and it is most infectious a day or two before the rash appears and in the early days of the rash. In individuals with weak immunity, the dormant virus may reactivate later in life, causing shingles (herpes zoster).

How To Detect Chickenpox Symptoms Early?

Spotting chickenpox early means looking for general warning signs like fever, fatigue, headache, and loss of appetite, which usually appear one to two days before the rash.

The rash itself starts as tiny red spots that later form fluid-filled blisters and eventually scab over. Paying attention to these early symptoms, especially after known exposure, can help identify the infection sooner.

How To Spot A Chickenpox Rash

The first rash usually shows up as small red bumps on the face, chest, or back. These bumps quickly turn into blisters filled with fluid, which are contagious. Over a few days, the blisters break and crust over, forming scabs. It’s common to see spots, blisters, and scabs all at the same time, according to the CDC.

Stages Of Chickenpox

The Mayo Clinic explains that chickenpox progresses in three main stages:

• Incubation Stage (10–21 days): After exposure, the virus remains inactive. Infected individuals typically show no symptoms during this period.
• Prodromal Stage (1–2 days): Early signs include fever, tiredness, headache, loss of appetite, and body aches. This is also when the virus can start spreading to others.
• Rash Stage (5–10 days): Red, itchy spots appear first on the face and chest, spreading across the body. These spots develop into fluid-filled blisters that scab over within a few days. Mild fever, itching, and discomfort are common during this stage.

A new study published in The Lancet Oncology journal today revealed that breast cancer continues to be the most common cancer among women worldwide, and predicted that the number of new cases of the deadly disease will reach more than 3.5 million globally in 2050 -- rising by a third from 2.3 million in 2023.

The Global Burden of Disease analysis with data from 204 countries revealed that despite advancements in breast cancer treatments, yearly deaths from the disease will rise by 44 percent -- from around 764,000 to 1.4 million.

While breast cancer disproportionately impacts countries with limited resources, maintaining a healthy lifestyle, including not smoking, getting sufficient physical activity, lowering red meat consumption, and having a healthy weight were found to prevent over a quarter of healthy years lost to illness and premature death.

“Breast cancer continues to take a profound toll on women’s lives and communities,” said lead author Kayleigh Bhangdia from the Institute for Health Metrics and Evaluation (IHME), University of Washington, US.

“While those in high-income countries typically benefit from screening and more timely diagnosis and comprehensive treatment strategies, the mounting burden of breast cancer is shifting to low- and lower middle-income countries where individuals often face later-stage diagnosis, more limited access to quality care, and higher death rates that are threatening to eclipse progress in women’s health,” Bhangdia added.

Inequalities In Breast Cancer Burden

The study revealed that the rates of new cases remain highest in high-income countries (HICs), but are growing fastest in low-income countries (LICs).

Women in low- and lower-middle-income countries accounted for 27 percent (around 628,000) of new cases globally, exposing likely disparities in timely diagnosis and shortages of quality treatment, including radiotherapy machines, chemotherapy drugs, and pathology labs, and standard treatments.

In 2023, an estimated 2.3 million new breast cancers were diagnosed worldwide in women (with 73 percent or 1.67 million cases occurring in high- and upper-middle-income countries). Of these, 764,000 ended in deaths (with 39 percent or 300,000 deaths occurring in low- and lower-middle-income countries).

Further, the number of years of healthy life lost due to poor health and early death more than doubled from 11.7 million years in 1990 to 24 million years in 2023.

Women in low- and lower-middle-income countries also contribute to more than 45 percent of all the ill-health and early deaths from breast cancer globally (nearly 11 million years of healthy life lost).

Three-fold Rise In Pre-menopausal Breast Cancer

The study reported a three-fold rise in pre-menopausal breast cancer in women aged 55 or older in 2023 -- compared to women aged 20-54 years.

However, rates of new cases have risen in women aged 20-54 years (up 29 percent) since 1990, with rates in older women remaining relatively unchanged.

Major Lifestyle Risk Factors

In 2023, 28 percent of the global breast cancer burden (6.8 million years of healthy life lost to disability, illness, and early death) was linked to six potentially modifiable risk factors. These include:

• High red meat consumption -- linked to nearly 11 percent of all healthy life lost
• tobacco use (including second-hand smoke; 8 percent),
• high blood sugar (6 percent),
• high body mass index (4 percent),
• high alcohol use and low physical activity (both 2 percent)

Substantial progress has been made in reducing the global breast cancer burden linked to high alcohol use and tobacco between 1990 and 2023, which declined by 47 percent and 28 percent, respectively.

Donald Trump is again in the news, this time not for his cognitive conditions and speculations around it, but for a skin rash and redness around his neck. During a Medal of Honor ceremony in the East Room of the White House, many pointed out the redness around his neck and asked if there was any underlying medical reason to it. The close-up photos shows clear red marks around the 79-year-old president's neck.

Why Does President Trump Have Red Rashes Around His Neck?

As per the White House, this redness around his neck is due to a skin cream he has been using. However, the White House has not given any specific reason behind the treatment for which the skin cream has been prescribed. "President Trump is using a very common cream on the right side of his neck, which is a preventative skin treatment, prescribed by the White House Doctor,” Sean Barbabella, the president's doctor, said in a statement. “The President is using this treatment for one week, and the redness is expected to last for a few weeks.”

No follow-up questions on the treatment were given, neither any clarity was given on the condition. However, zoomed in photos from as far back as the Board of Peace meeting at the US Institute of Peace on February 19 too show the redness on President's neck.

Topical treatments can sometimes lead to temporary skin irritation, flushing, or redness - especially if they contain active ingredients like retinoids, benzoyl peroxide, alpha hydroxy acids, or prescription-strength dermatological compounds.

Trump’s medical report from his April 2025 physical exams has noted he was on mometasone cream “as needed” for an unspecified skin condition.

Why Do Skin Cream Cause Redness And Rashes?

While this is not true for all creams, some skin cream could make your skin red by increasing the turnover of cells that stimulate collagen production or reduce inflammation.

In this process, the skin may appear red, slightly inflamed, or sensitive – especially in areas like the neck, which tends to have thinner skin than the face.

Common reasons for redness caused by skin cream include:

• Irritant contact dermatitis
• Allergic reaction to ingredients
• Increased blood flow from active compounds
• Over-application of product
• Sun sensitivity after use
• Skin around your neck may especially react more visibly than other areas due to its delicate texture.

When should redness be a concern?

Even though temporary redness from skincare products is usually harmless, doctors say you must always use creams after a prescription and reach out to them in case of:

• Severe burning or itching
• Blistering or peeling
• Swelling of the face or throat
• Symptoms lasting more than a few days
• Signs of infection
• In most cases, discontinuing the product allows the skin to return to normal within a short period.