Leading pharmaceutical companies are preparing to increase the prices of hundreds of prescription medicines in the United States, even as the Trump administration continues to push for lower drug costs.Hundreds of Medicines AffectedPrices for at least 350 branded drugs are expected to rise, including vaccines for Covid-19 and shingles, as well as the cancer medication Ibrance. Some of these increases will take effect from January 1, according to figures shared with Reuters by healthcare research firm 3 Axis Advisors.Price Hikes Climb Compared to Last YearThe data indicates that planned price increases for 2026 have climbed compared to the same period last year, when drugmakers had disclosed hikes for more than 250 medicines. This year, the typical price rise is about 4 percent, roughly in line with increases seen in 2025.US Patients Pay the Highest CostsPatients in the U.S. continue to pay significantly more for prescription medicines than those in other developed countries, often close to three times as much, Reuters reported. Reducing these costs is something Donald Trump has repeatedly promised to address.White House Announces New AgreementsEarlier this month, the White House said it had reached fresh agreements with nine major pharmaceutical companies to bring down prescription drug prices for Americans. The companies named were Amgen, Bristol Myers Squibb, Boehringer Ingelheim, Genentech, Gilead Sciences, GlaxoSmithKline, Merck, Novartis, and Sanofi.Companies Still Raising PricesThe administration said these agreements were designed to support Medicaid, which serves low-income Americans, as well as people who pay for medicines in cash. However, data from 3 Axis Advisors shows that several of the same companies, including Pfizer, Sanofi, Boehringer Ingelheim, Novartis, and GSK, are also planning to raise prices on certain medicines from January 1.Expert Criticism“These deals are being presented as game-changing, but in reality they barely touch the deeper issues that keep prescription drug prices so high in the U.S.,” said Dr. Benjamin Rome, a health policy researcher at Brigham and Women’s Hospital in Boston, in comments to Reuters.Pfizer Leads in Number of HikesPfizer is set to introduce the highest number of list price increases, covering around 80 medicines. These include the cancer drug Ibrance, migraine treatment Nurtec, and Covid-19 therapy Paxlovid, along with hospital-used drugs such as morphine and hydromorphone. Most of Pfizer’s planned increases are under 10 percent. An exception is its Covid-19 vaccine Comirnaty, which will see a price jump of about 15 percent. The company said the average list price rise for its innovative medicines and vaccines in 2026 would remain below overall inflation, describing the increases as modest.GSK Price HikesGSK, based in Europe, said it plans to raise prices on roughly 20 drugs and vaccines, with increases ranging from 2 percent to 8.9 percent. The company said it remains committed to fair pricing and added that the hikes are necessary to continue funding scientific research and innovation.The Independent has reached out to the White House and the pharmaceutical companies named by Reuters for comment on the reported price increases.