While the world is still trying to catch its breath from the aftermath of COVID-19, a new virus is quietly gaining prominence in the headlines—H5N1 avian flu, or bird flu. The recent upsurge of this highly pathogenic virus among the dairy cattle of the United States, and the increasing number of human cases, has raised alarm among global health experts. Is H5N1 taking silent steps toward becoming the next pandemic? The key is to carefully look at the numbers, the science, and the public health response.

In a frightening trend, Idaho has become the hotbed of the ongoing H5N1 outbreak in U.S. livestock, with the US Department of Agriculture's (USDA) Animal and Plant Health Inspection Service (APHIS) verifying 86 cases in dairy cows—the second-largest in the nation following California. The outbreak, which took a massive turn in March 2024, has now reached 17 states, with more than 1,047 cases detected in dairy herds.

This is a troubling change in the behavior of the virus, previously recognized to infect wild birds and poultry. The spread of the virus into mammalian livestock and now into humans suggests a chilling evolutionary trend that health authorities are scrambling to contain.

Why the H5N1 Human Infections Is Growing?

As reported by the Global Virus Network (GVN), more than 70 human infections have been confirmed in the U.S. since the outbreak began, with one reported fatality. Although human-to-human transmission has not yet been reported, scientists caution that virus mutations—particularly in mammalian hosts—may enhance the potential for person-to-person spread, potentially leading to a pandemic.

Dr. Sten H. Vermund, GVN Chief Medical Officer, explains, "In its capacity to infect animals and humans, as well as in recent genetic evolution, the threat of H5N1 disease highlights the need for active surveillance and immediate response."

Why Is H5N1 a Serious Threat?

Avian influenza A(H5N1) is an extremely contagious virus that, while initially infecting birds, can also cross-species, including to mammals and humans. When contracted by humans—most commonly through close contact with infected animals or contaminated surroundings—the disease tends to be severe and potentially deadly.

The World Health Organization (WHO) has cautioned that if this virus develops to transmit effectively among humans, it has the potential to create a world health emergency equal to previous pandemics. Already, 168 million birds have been slaughtered in the U.S. since 2022 because of avian flu outbreaks, and the threat to food supply chains, animal well-being, and human health is staggering.

The GVN, in partnership with the Centers for Disease Control and Prevention (CDC), has called on governments around the world to implement a multi-pronged preparedness strategy to prevent the virus from spreading before it mutates into a pandemic-strain. The strategy entails:

• Increased surveillance on farms, milk chains, and wastewater, as well as systematic testing of those who have been exposed to infected animals.
• Accelerated genomic data sharing to monitor the mutation and spread of the virus.
• Improved farm biosecurity, such as compulsory PPE use and sanitization practices.
• Rapid diagnostic testing of farm workers, especially self-testing with rapid healthcare access.
• Development and deployment of human and animal vaccines at high risk.
• Readiness for clinical research, such as pre-approved vaccine and antiviral trial protocols in the event that the virus continues to spread.
• Collaboration at the international level to exchange real-time information, coordinate response strategies, and support vulnerable areas.

What Is the Risk to the General Public?

Even as the outbreak was large, the CDC insists that the risk to the general public is still low. The agency has, however, suggested added caution for those who are in close contact with animals, particularly dairy and poultry workers. Hygiene, wearing of PPE, and prevention of exposure to ill animals continue to be paramount.

The CDC also insists on vigilance and says:

"We are following people with exposures to animals very closely, and continue to closely monitor the situation."

Could H5N1 Be the Next Pandemic?

The short answer is: not yet—but we shouldn't wait for it to do so. The virus has yet to reach sustained human-to-human transmission, the key element which converts an outbreak into a pandemic. But the spread of the virus in cows, coupled with the number of human infections and a confirmed death, are troubling indications that urgently need global notice.

Learning from COVID-19, experts call on policymakers to act now and not respond later. Research on vaccination, quick diagnostics, public health preparedness, and international collaboration need to be prioritized in order to remain ahead of the next move of the virus.

The H5N1 epidemic sweeping the United States is an awakening call. Short of a pandemic, it is a definite indication that the edge between animal and human viruses is rapidly growing thin. Whether or not H5N1 becomes an actual worldwide menace hinges on how quickly and efficiently we act now.

Liliana “Lili” Castaneda thought she was experiencing her first period at the age of 14, right in the middle of the COVID-19 pandemic. Initially, she was excited, but her monthly bleeding soon turned into daily bleeding. The flow became so heavy that she would soak through pads in just 15 minutes and feel dizzy when standing up. When she first visited her doctor, she was told it was likely stress related to the pandemic.

Teen’s Heavy Bleeding Dismissed As Pandemic Stress

Dario Roque, MD, a gynecologic oncologist at the Lurie Cancer Center at Northwestern Medicine, said in a statement that in his 15 years of practice, Liliana was the youngest patient he had ever seen with clear cell carcinoma, a disease he typically treats in women in their sixties.

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Her radiation oncologist, Jonathan Strauss, MD, explained that the tumour was roughly the size of a golf ball when it was found. “It was too large to remove surgically at the time of diagnosis, so we relied on both external and internal radiation to shrink it. Eliminating the tumour required extensive radiation along with chemotherapy,” he said.

What Is Clear Cell Carcinoma?

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Symptoms may include pain, blood in the urine, unexplained weight loss, or a lump in the affected area, though sometimes the cancer is discovered incidentally during imaging for unrelated issues. Diagnosis is typically confirmed with imaging scans and a biopsy. The National Cancer Institute describes it as “a rare type of cancer in which the cells look clear when viewed under a microscope.”

Clear Cell Carcinoma Symptoms

• Blood in the urine (hematuria)
• Persistent fatigue
• Fever
• A lump on the affected kidney
• Pain in the side or flank
• Unexplained weight loss

What Causes Clear Cell Renal Cell Carcinoma?Most kidney cancers, including ccRCC, develop without a clear cause. Certain factors, however, may increase risk, such as:

• Tobacco use, including smoking and vaping
• Being overweight or having a BMI over 25
• High blood pressure
• Chronic kidney disease requiring dialysis
• Exposure to workplace toxins like trichloroethylene
• Long-term use of pain relievers such as acetaminophen.

With obesity now affecting 41.9% of adults in the United States, according to the Centers for Disease Control and Prevention (CDC), medications like semaglutide have gained enormous attention. Semaglutide belongs to a class of drugs called GLP-1 receptor agonists, which help the body release more insulin, lower blood sugar levels, and send signals to the brain to reduce appetite.

The U.S. Food and Drug Administration (FDA) has approved several versions of semaglutide for diabetes and weight management. Wegovy and Ozempic are available as injections, while Rybelsus comes in tablet form. A new study now suggests that a daily pill containing semaglutide could be even more effective for weight loss than the injectable versions.

Ozempic Pills For Weight Loss More Effective Than Injections?

Currently, semaglutide injections such as Ozempic and Wegovy are taken weekly, with doses of up to 2.4 milligrams administered under the skin of the stomach, thigh, or arm. While effective, many patients avoid them because of the discomfort of injections. The trial results, part of the OASIS-4 phase 3 study, highlight that a pill form could be a needle-free, more convenient alternative if approved by regulators.

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Researchers also noted other advantages. Pills don’t require refrigeration, unlike injections, which could make treatment more accessible in places where storage and transport of injectable drugs are difficult.

How Ozempic Works

Ozempic vs. WegovyWhile both Ozempic and Wegovy contain semaglutide, there are key differences:

• Dosage and delivery: Wegovy is usually prescribed at a slightly higher dose than Ozempic. Both are available as injection pens, but Ozempic pens contain multiple doses, while Wegovy pens are single-use.
• Conditions treated: Wegovy is FDA-approved specifically for long-term weight management, whether or not a person has diabetes. Ozempic, on the other hand, is officially approved for type 2 diabetes, though doctors often prescribe it “off-label” for weight loss.

Ozempic Pill vs. Injection for Weight Loss: Which Is Better?

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Still, there are important points to note. The FDA has approved Wegovy for weight loss in both diabetic and non-diabetic patients, but neither Ozempic nor Rybelsus (the current oral version of semaglutide) has official FDA clearance for this purpose. These drugs are only approved for type 2 diabetes, though doctors can prescribe them off-label for weight management if they see fit.

A recent report revealed that the number of infections from drug-resistant "nightmare bacteria" has jumped significantly in the US. The numbers of cases increased by almost 70% from 2019 to 2023. This information comes from a new report by scientists at the Centers for Disease Control and Prevention (CDC), US. These bacteria are becoming a major concern because they are harder to treat, making common infections potentially dangerous.

What Is Nightmare Bacteria?

According to the Association for Professionals in Infection Control and Epidemiology (APIC), "nightmare bacteria" are extremely dangerous germs because they have become resistant to almost all antibiotics, making them nearly impossible to treat. Some examples include VRSA (Vancomycin-resistant Staphylococcus aureus), Candida auris, and CRE (Carbapenem-resistant Enterobacterales). The CDC also estimates that more than 23,000 Americans die each year from infections that are resistant to antibiotics.

What Makes This Bacteria Immune To Drugs?

A big reason for this increase is a specific type of bacteria that has the NDM (New Delhi metallo beta lactamase) gene. This gene makes the bacteria resistant to most antibiotics. According to the CDC researchers, only two antibiotics can fight these infections, and they are expensive and have to be given through an IV (intravenous drip).

These bacteria with the NDM gene were once very rare in the U.S., usually found only in people who had received medical care in other countries. However, the number of U.S. cases has increased more than five times in recent years. Experts called this rise a "grave danger" and "very worrisome."

The CDC scientists also warned that many people might be carrying these drug-resistant bacteria without even knowing it, which could lead to them spreading easily in communities. This means that infections that have always been simple to treat, like a urinary tract infection (UTI), could become a long-term problem.

How Many Cases of Nightmare Bacteria Have Been Reported?

The researchers gathered data from 29 states that have the necessary systems to test for and report these drug-resistant bacteria. In 2023, they counted 4,341 cases of carbapenem-resistant infections in those states. Out of these, 1,831 were caused by the NDM-type bacteria. The report didn't mention how many people died from these infections.

The rate of carbapenem-resistant infections went from just under 2 per 100,000 people in 2019 to more than 3 per 100,000 in 2023, which is a 69% increase. Even more alarming, the rate of NDM cases shot up from about 0.25 to 1.35 per 100,000, an incredible 460% increase.

Experts believe this rapid increase is likely connected to the COVID-19 pandemic. They noted that there was a huge spike in antibiotic use during the pandemic, which probably led to the rise in drug resistance.

How Do You Contract Nightmare Bacteria?

APIC explains that you can only get sick from nightmare bacteria if you are exposed to them. They are most common in healthcare settings like hospitals and nursing homes. Patients who have devices like catheters, tubes, or drains may be at the highest risk.

Symptoms of these infections can vary.

• You might have a wound that won't heal or a serious bloodstream infection that leads to sepsis.
• It's also possible to carry these bacteria without showing any symptoms at all.

How Do You Prevent Getting Infected With Nightmare Bacteria?

Since these infections are so difficult to treat, prevention is key. Since these infections are so difficult to treat, prevention is key.

• Wash your hands often with soap and water or use an alcohol-based hand sanitizer.
• Ask others to clean their hands before they touch you or your surroundings.
• Tell your doctor if you have recently been cared for in another country or medical facility.
• Talk to your healthcare provider about how you can reduce your risk of infection, especially if you have a chronic health condition.
• Learn about antibiotics so you know when it's appropriate to take them, which helps prevent the spread of resistant germs.