Health and Me

Supriya Ramesh

It Might Not Be Diabetes; It Could Be This Common Pill Causing Heart Disease: Study

Credits: Canva

When it comes to managing <span>type 2 diabetes</span>, most of us worry about <span>blood sugar levels</span>, not our heart. But a recent study is shaking things up by pointing fingers not at the disease itself but at a commonly prescribed <span>diabetes medication</span> that might be causing some unwanted side effects. If you thought it was just the sugar playing tricks on your heart, you might be wrong.

What is this sugar pill reportedly causing heart disease?

Researchers from Mass General Brigham have stirred the medical pot with a new study published in JAMA Network Open. Their findings suggest that <span>glipizide</span>, a drug widely prescribed for type 2 diabetes, may be increasing the risk of <span><a href="https://www.healthandme.com/health/heart-failure">heart failure</a></span>, hospitalisation due to heart issues, and even death.

To arrive at these conclusions, they sifted through the health data of nearly 50,000 Americans living with type 2 diabetes. Every participant was already on <span>metformin</span>, the gold standard in diabetes treatment, but had been prescribed an additional medication. The researchers then tracked what happened over the next five years.

Glipizide belongs to a class of drugs called <span>sulfonylureas</span>, which have long been popular thanks to their affordability and ability to lower blood sugar quickly. However, the study shows that glipizide users had a 13 per cent higher risk of serious cardiovascular events when compared to those on a newer class of drugs known as DPP-4 inhibitors. These newer medications, while more expensive, tend to be kinder to the heart.

Other sulfonylureas like glimepiride also showed a slightly raised risk, though less than glipizide. As for glyburide, the results were more inconclusive.

Dr Alexander Turchin, senior author of the study and physician at Brigham and Women’s Hospital, pointed out something crucial: “Each drug needs to be evaluated individually.” Just because drugs share a class does not mean they all behave the same way in the body, especially when the heart is involved.

A 13 per cent increase in heart risk may sound small in isolation, but in the context of millions of people living with diabetes, it becomes a number that matters.

Importantly, the study does not outright claim that glipizide causes heart problems. It points out an association, a trend that should make healthcare providers think twice before reflexively prescribing it, particularly to patients who already have underlying <span>cardiovascular risk</span>.

When the heart is already under pressure due to diabetes, adding even a slight extra load might not be the wisest move.

The harsh truth is that one reason glipizide remains a go-to drug is cost. It is far more affordable than DPP-4 inhibitors, making it the default in many healthcare settings. But should your treatment be based on price or on safety? Ask yourself. 

In reality, cost often plays a role in treatment decisions. But this study nudges the conversation towards a more nuanced, patient-centred approach, one that weighs not just the immediate numbers on a glucose monitor but also the long-term impact on <span>heart health</span> and quality of life.

Know that glipizide is still a legal, approved, and effective medication. This study is not suggesting patients throw away their pills. What it is doing is encouraging conversations. With doctors. With pharmacists. Within families managing diabetes together.

It is a reminder that medicines are not one-size-fits-all and that newer does not just mean more expensive; it might also mean safer, especially when it comes to the silent dangers of cardiovascular strain.

What is refreshing about this study is that it does not stoke fear. Instead, it empowers patients and healthcare providers to look deeper. To examine older medications through a modern lens. To question what has been “good enough” so far and whether it still holds true today.

Glipizide might still have a place in diabetes treatment, but with this new information, it becomes clearer that its role should be more carefully defined. After all, in managing diabetes, it is not just about sugar anymore. It is about protecting the heart that works overtime behind the scenes and making sure the very pills meant to help are not doing quiet harm in the background.

Health Conditions A-Z

health

glipizide

type 2 diabetes

heart failure

sulfonylureas

cardiovascular risk

metformin

diabetes medication

heart health

blood sugar levels

With Over 3,100 Infected, Deadly Mosquito-Borne Virus Spreads Rapidly In China—Is It Climate, Travel, Or Both?

Ivermectin Proven To Cut Malaria Cases By 26%, Study Finds—Here’s How It Works

Skipping This Basic Yet Vital Oral Hygiene Step Could Put You In Trouble

Health News

10 Healthy Pasta Salad Dressing For Weight Loss

Breathing Exercise You Should Do To Relieve Stress

Headache vs. Migraine: Difference Explained In 60 Seconds

High Carb Foods That Are Actually Healthy

How Many Times Do You Need To Wash Your Face?

Hypothyroidism Diet – What To Eat And What You Should Avoid

Stretches To Relieve Leg Pain And Numbness After Sitting For Too Long

No-Cook Healthy Meals For Lazy Days At Home

Easy Breakfast Options To Try During Calorie Deficit

How To Stop Muscle Cramps Immediately

Why You Should Go For An Anti-Inflammatory Diet

Foods To Lower Cortisol Levels In Your Body

High-Fiber Dips You Can Make At Home For The Week

Weekend Warrior Exercises To Makeup For Stressful Week

Experiencing Headaches At Word? Natural Remedies To Try

Yoga Poses That Enhance Digestion

Health Benefits of Walking Backwards

No Eggs? Egg-Alternatives You Can Add To Your Diet

Savory And Smart Ways To Add Broccoli To Your Diet

Calorie Burning Habits That Can Help You Shed Extra Pounds

Yoga Poses That Can Help With Bloating

Fiber-Rich Oatmeal Dishes You Can Have For Breakfast

Signs You Must Visit A Doctor For Your Back Pain

Avocado Meal Prep Ideas To Increase Healthy Fat In Your Diet

Arm Exercises You Can Do At Home

Quick-Office Lunches That Can Keep You Full-Longer

How Increased Screen Time Affects Children's Health

Homemade Recipe To Make Protein-Rich Pancakes With Healthy Alternatives

Push-Up Variations You Can Do At Home

Common Mistakes Running Mistakes People Make

Low-Calorie Foods That Keep You Full For Long

Yoga Poses That Help You Get Rid Of Back Pain

Natural Ways To Increase Protein In Your Diet

Managing Excessive Daytime Sleepiness – Tips To Try

How Much Protein Is Too Much?

High Fiber Indian Foods You Should Try

10 Easy Ways To Boost Daily Fiber Intake

Adding Walnut Oil To Your Diet? Benefits You Should Know

Drinks That Soothe Headaches And Migraines

Waist Exercises For More Toned Belly

When it comes to managing type 2 diabetes, most of us worry about blood sugar levels, not our heart. But a recent study is shaking things up by pointing fingers not at the disease itself but at a commonly prescribed diabetes medication that might be causing some unwanted side effects. If you thought it was just the sugar playing tricks on your heart, you might be wrong.What is this sugar pill reportedly causing heart disease?Researchers from Mass General Brigham have stirred the medical pot with a new study published in JAMA Network Open. Their findings suggest that glipizide, a drug widely prescribed for type 2 diabetes, may be increasing the risk of heart failure, hospitalisation due to heart issues, and even death.To arrive at these conclusions, they sifted through the health data of nearly 50,000 Americans living with type 2 diabetes. Every participant was already on metformin, the gold standard in diabetes treatment, but had been prescribed an additional medication. The researchers then tracked what happened over the next five years.Here is where things got a bit worrying:Not All Drugs Are Created EqualGlipizide belongs to a class of drugs called sulfonylureas, which have long been popular thanks to their affordability and ability to lower blood sugar quickly. However, the study shows that glipizide users had a 13 per cent higher risk of serious cardiovascular events when compared to those on a newer class of drugs known as DPP-4 inhibitors. These newer medications, while more expensive, tend to be kinder to the heart.Other sulfonylureas like glimepiride also showed a slightly raised risk, though less than glipizide. As for glyburide, the results were more inconclusive.Dr Alexander Turchin, senior author of the study and physician at Brigham and Women’s Hospital, pointed out something crucial: “Each drug needs to be evaluated individually.” Just because drugs share a class does not mean they all behave the same way in the body, especially when the heart is involved.It is Not Just About NumbersA 13 per cent increase in heart risk may sound small in isolation, but in the context of millions of people living with diabetes, it becomes a number that matters.Importantly, the study does not outright claim that glipizide causes heart problems. It points out an association, a trend that should make healthcare providers think twice before reflexively prescribing it, particularly to patients who already have underlying cardiovascular risk.When the heart is already under pressure due to diabetes, adding even a slight extra load might not be the wisest move.Cheap Is Not Always GoodThe harsh truth is that one reason glipizide remains a go-to drug is cost. It is far more affordable than DPP-4 inhibitors, making it the default in many healthcare settings. But should your treatment be based on price or on safety? Ask yourself. In reality, cost often plays a role in treatment decisions. But this study nudges the conversation towards a more nuanced, patient-centred approach, one that weighs not just the immediate numbers on a glucose monitor but also the long-term impact on heart health and quality of life.Time to Revisit the Medicine Cabinet?Know that glipizide is still a legal, approved, and effective medication. This study is not suggesting patients throw away their pills. What it is doing is encouraging conversations. With doctors. With pharmacists. Within families managing diabetes together.It is a reminder that medicines are not one-size-fits-all and that newer does not just mean more expensive; it might also mean safer, especially when it comes to the silent dangers of cardiovascular strain.Awareness Over AlarmWhat is refreshing about this study is that it does not stoke fear. Instead, it empowers patients and healthcare providers to look deeper. To examine older medications through a modern lens. To question what has been “good enough” so far and whether it still holds true today.Glipizide might still have a place in diabetes treatment, but with this new information, it becomes clearer that its role should be more carefully defined. After all, in managing diabetes, it is not just about sugar anymore. It is about protecting the heart that works overtime behind the scenes and making sure the very pills meant to help are not doing quiet harm in the background.

it might not be diabetes; it could be this common pill causing heart disease: study

Tanya Dutt

ivermectin proven to cut malaria cases by 26%, study finds—here’s how it works

Possible Hepatitis A Exposure At Popular Toronto Restaurant, Health Officials Warn Of Serious Threat

possible hepatitis a exposure at popular toronto restaurant, health officials warn of serious threat

Health & Wellness

More Men In Their 30s Are Getting Diagnosed With Diabetes And Hypertension But Is Only Lifestyle To Be Blamed?

more men in their 30s are getting diagnosed with diabetes and hypertension but is only lifestyle to be blamed?

Brain-Eating Amoeba: What To Know About The Microscopic Killer That Took A 12-Year-Old Boy’s Life In Days

brain-eating amoeba: what to know about the microscopic killer that took a 12-year-old boy’s life in days

Foshan city in Guangdong Province is experiencing the country’s largest outbreak of chikungunya, a mosquito-borne viral disease that causes debilitating joint pain, fever, and fatigue. As of July 24, 2025, 3,645 cases have been confirmed—most of them mild, but alarming due to the rapid spread and potential for further outbreaks in surrounding regions.

This surge represents the most significant chikungunya transmission on the Chinese mainland since the virus was first detected there nearly two decades ago.

The epidemic began with an imported case of chikungunya in early July in Shunde District of Foshan, which is roughly 119 kilometers north of Hong Kong. Within weeks, cases ballooned to more than 3,300 in Shunde alone. Chinese officials have not officially attributed the cause, but experts cite favorable climatic conditions—hot and humid that facilitate mosquito breeding—and increased global travel as main drivers.

Chikungunya is transmitted by the Aedes mosquito, most specifically Aedes aegypti and Aedes albopictus. Both insects are famous for their daytime aggression of biting and love for tropical and subtropical regions.

<h2>Why Chikungunya Is No Minor Illness Even After All These Years?</h2>

The World Health Organization (WHO) defines chikungunya as a disease that is marked by severe joint pain, high fever, and signs and symptoms of headache, muscle pain, rash, vomiting, and fatigue. Though the majority of Foshan cases have been reported as mild, the disabling joint pain of the disease may persist for weeks or even months and can affect daily activities and productivity.

While not usually lethal, chikungunya has the potential to create large-scale public health disturbances, particularly in highly congested urban areas with inadequate mosquito control. To date, no serious or deadly cases have been reported in this outbreak, as indicated by China's Centre for Health Protection (CHP), but public health specialists caution against taking the situation lightly.

<h2>How Climate and Travel Are Driving This Outbreak?</h2>

Specialized tropical medicine doctors attribute the peak to favorable climatic conditions that promote quick growth of Aedes populations. These are aggressive, day-biting mosquitoes that thrive in warm, wet conditions, noting how climate change plays a major role in expanding habitats for mosquitoes.

Combine this international travel—imported and first case—and lack of immunity in the general population in China, and the stage was set for an outbreak. Chikungunya is not indigenous to China, so there is no herd immunity in the general population, and it was easier for the virus to establish itself and spread rapidly.

<h2>Link Between Chikungunya Cases on the Rise Globally</h2>

This outbreak is not unique. The European Centre for Disease Prevention and Control (ECDC) has reported 220,000 cases of chikungunya and 80 deaths in 2025 thus far worldwide. The WHO has made a global call to action citing the spread of chikungunya into new regions such as France and Italy, which have each reported locally-acquired infections in 2025.

Over five billion individuals in 119 countries reside in regions exposed to chikungunya infection and thus is considered a global health issue. The tropical diseases of chikungunya, dengue, and Zika are no longer limited to the equatorial belt-they are now reported from temperate regions as well.

To date, Hong Kong—a highly populated international center—has not seen any chikungunya cases after 2020. The territory is not home to Aedes aegypti, the main vector mosquito, but Aedes albopictus, a secondary vector known to spread the disease, is found there. The CHP cautions that imported cases still have the potential to result in local transmission if infected persons are bitten by mosquitoes within their communicable period.

Macao, just south of Guangdong, has registered its first two cases of chikungunya this year, both of them imported from Foshan and nearby Nanhai. Local authorities have stepped up mosquito control as a precaution against possible spread.

<h2>How Is China Managing The Outbreak?</h2>

With not much else in its bag of tricks, Guangdong Province has increased mosquito control operations, encouraging residents to clear standing water, unblock choked drains, and observe simple household sanitation. This is essential in interrupting the mosquito life cycle because still water provides a breeding ground for Aedes mosquitoes.

The CHP also recommends applying insect repellents, especially containing DEET or other WHO-recommended active compounds, and wearing long-sleeved clothing, especially in the early morning and late afternoon when mosquitoes are most prevalent.

The United States has only two licensed chikungunya vaccines, recommended mainly for visitors going to outbreak areas. However, China also doesn't have these vaccines available, which makes its citizens susceptible to successive waves unless mass vaccination is implemented or localized vaccines are created.

This leaves health authorities with few options: mosquito control, public awareness, and early diagnosis remain the main line of defense for the time being.

This epidemic is a clear message. Diseases such as chikungunya no longer remain isolated in small enclaves of tropical countries. With the climate still rising and international travel recovering after the pandemic, infectious disease is set to travel quicker and more far-reaching than ever before.

Dr. Tsui, a Guangdong public health official, explained in a press statement that chikungunya has the potential to quickly blow into large-scale outbreaks, particularly in highly populated regions with low mosquito densities and little immunity. The burden on healthcare systems, particularly in fast-growing urban areas of Asia, is a legitimate and increasing concern.

china chikungunya outbreak

mosquito borne virus china

guangdong disease cases 2025

aedes mosquito spread

tropical disease china

chikungunya symptoms

chikungunya global rise

Foshan city in Guangdong Province is experiencing the country’s largest outbreak of chikungunya, a mosquito-borne viral disease that causes debilitating joint pain, fever, and fatigue. As of July 24, 2025, 3,645 cases have been confirmed—most of them mild, but alarming due to the rapid spread and potential for further outbreaks in surrounding regions.This surge represents the most significant chikungunya transmission on the Chinese mainland since the virus was first detected there nearly two decades ago.The epidemic began with an imported case of chikungunya in early July in Shunde District of Foshan, which is roughly 119 kilometers north of Hong Kong. Within weeks, cases ballooned to more than 3,300 in Shunde alone. Chinese officials have not officially attributed the cause, but experts cite favorable climatic conditions—hot and humid that facilitate mosquito breeding—and increased global travel as main drivers.Chikungunya is transmitted by the Aedes mosquito, most specifically Aedes aegypti and Aedes albopictus. Both insects are famous for their daytime aggression of biting and love for tropical and subtropical regions.Why Chikungunya Is No Minor Illness Even After All These Years?The World Health Organization (WHO) defines chikungunya as a disease that is marked by severe joint pain, high fever, and signs and symptoms of headache, muscle pain, rash, vomiting, and fatigue. Though the majority of Foshan cases have been reported as mild, the disabling joint pain of the disease may persist for weeks or even months and can affect daily activities and productivity.While not usually lethal, chikungunya has the potential to create large-scale public health disturbances, particularly in highly congested urban areas with inadequate mosquito control. To date, no serious or deadly cases have been reported in this outbreak, as indicated by China's Centre for Health Protection (CHP), but public health specialists caution against taking the situation lightly.How Climate and Travel Are Driving This Outbreak?Specialized tropical medicine doctors attribute the peak to favorable climatic conditions that promote quick growth of Aedes populations. These are aggressive, day-biting mosquitoes that thrive in warm, wet conditions, noting how climate change plays a major role in expanding habitats for mosquitoes.Combine this international travel—imported and first case—and lack of immunity in the general population in China, and the stage was set for an outbreak. Chikungunya is not indigenous to China, so there is no herd immunity in the general population, and it was easier for the virus to establish itself and spread rapidly.Link Between Chikungunya Cases on the Rise GloballyThis outbreak is not unique. The European Centre for Disease Prevention and Control (ECDC) has reported 220,000 cases of chikungunya and 80 deaths in 2025 thus far worldwide. The WHO has made a global call to action citing the spread of chikungunya into new regions such as France and Italy, which have each reported locally-acquired infections in 2025.Over five billion individuals in 119 countries reside in regions exposed to chikungunya infection and thus is considered a global health issue. The tropical diseases of chikungunya, dengue, and Zika are no longer limited to the equatorial belt-they are now reported from temperate regions as well.To date, Hong Kong—a highly populated international center—has not seen any chikungunya cases after 2020. The territory is not home to Aedes aegypti, the main vector mosquito, but Aedes albopictus, a secondary vector known to spread the disease, is found there. The CHP cautions that imported cases still have the potential to result in local transmission if infected persons are bitten by mosquitoes within their communicable period.Macao, just south of Guangdong, has registered its first two cases of chikungunya this year, both of them imported from Foshan and nearby Nanhai. Local authorities have stepped up mosquito control as a precaution against possible spread.How Is China Managing The Outbreak?With not much else in its bag of tricks, Guangdong Province has increased mosquito control operations, encouraging residents to clear standing water, unblock choked drains, and observe simple household sanitation. This is essential in interrupting the mosquito life cycle because still water provides a breeding ground for Aedes mosquitoes.The CHP also recommends applying insect repellents, especially containing DEET or other WHO-recommended active compounds, and wearing long-sleeved clothing, especially in the early morning and late afternoon when mosquitoes are most prevalent.The United States has only two licensed chikungunya vaccines, recommended mainly for visitors going to outbreak areas. However, China also doesn't have these vaccines available, which makes its citizens susceptible to successive waves unless mass vaccination is implemented or localized vaccines are created.This leaves health authorities with few options: mosquito control, public awareness, and early diagnosis remain the main line of defense for the time being.This epidemic is a clear message. Diseases such as chikungunya no longer remain isolated in small enclaves of tropical countries. With the climate still rising and international travel recovering after the pandemic, infectious disease is set to travel quicker and more far-reaching than ever before.Dr. Tsui, a Guangdong public health official, explained in a press statement that chikungunya has the potential to quickly blow into large-scale outbreaks, particularly in highly populated regions with low mosquito densities and little immunity. The burden on healthcare systems, particularly in fast-growing urban areas of Asia, is a legitimate and increasing concern.

with over 3,100 infected, deadly mosquito-borne virus spreads rapidly in china—is it climate, travel, or both?

Male Birth Control Pill Passes Early Safety Trials, Scientists Test New Contraceptive Without Side Effects

male birth control pill clears early safety trials, scientists test new contraceptive without side effects

Fat Loss Jabs No Longer Just About Weight Loss; They Could Also Help Asthma Symptoms in Obese People, Study Finds

fat loss jabs no longer just about weight loss; they could also help asthma symptoms in obese people, study finds

Fitness

Daily Yoga Could Cut Diabetes By 40%, Says New Study

daily yoga could cut diabetes by 40%, says new study

A new study published in the New England Journal of Medicine has delivered a striking insight into the global fight against <span>malaria</span>. Ivermectin—a widely used antiparasitic drug—has been shown to reduce malaria incidence by 26% in a large-scale trial conducted in Kenya. While ivermectin’s role in treating diseases like river blindness and elephantiasis is well-known, its impact on malaria prevention opens the door to a new, complementary strategy in high-risk regions. The finding is especially significant as malaria control efforts face stagnation due to growing resistance to traditional tools like insecticide-treated nets.

Malaria remains one of the deadliest diseases globally, with nearly 600,000 deaths and over 260 million cases reported in 2023 alone. Africa accounts for the vast majority of these cases, where bed nets and indoor spraying have long been the frontline defense. But here’s the problem: mosquitoes are adapting. Insecticide resistance is on the rise, and some species have shifted behavior, biting outdoors or at times when nets offer no protection.

The need for an alternative, preferably one that can work alongside existing tools, is urgent. Enter ivermectin.

<h2>How Ivermectin Works Against Malaria?</h2>

Ivermectin doesn’t target the malaria parasite itself. Instead, it turns humans into mosquito killers.

Here’s how: when a person takes ivermectin, the drug circulates in their bloodstream for several days. If a mosquito bites that person during that window, the drug is toxic to the mosquito. This reduces the mosquito population and, by extension, cuts malaria transmission.

This “endectocide” approach—targeting parasites both inside and outside the body—adds an entirely different layer to malaria control.

The BOHEMIA (Broad One Health Endectocide-based Malaria Intervention in Africa) trial is the largest study to date exploring ivermectin’s impact on malaria. Led by the Barcelona Institute for Global Health (ISGlobal), the study took place in Kwale County, a malaria-endemic region of coastal Kenya where the use of insecticide-treated bed nets is already high. Here’s what the researchers did:

84 clusters of households were randomly assigned to receive either ivermectin or a control drug (albendazole).

Participants (nearly 29,000 people in total) were given their respective drugs once a month for three months during the region’s rainy season, when malaria transmission spikes.

Researchers then tracked malaria infection rates specifically in children aged 5 to 15, testing them monthly for six months.

Children in the ivermectin group had 2.20 malaria infections per child-year, compared to 2.66 in the control group—a 26% relative reduction.

What stood out in the findings was the gradient effect—the farther a child lived from the border of the study clusters, the stronger the protection. This points to a community-wide benefit, not just an individual one. In simpler terms, the more people around you who take ivermectin, the less likely you are to get malaria.

The protective effect also met and surpassed the World Health Organization’s minimum efficacy threshold, which recommends at least a 20% reduction in infection lasting one month after treatment.

Dr. Carlos Chaccour, co-principal investigator of the study, called the results “thrilling,” adding that ivermectin “could complement existing control measures.” His colleague, Dr. Regina Rabinovich, emphasized the drug’s potential in areas where traditional tools are beginning to fail.

Safety is always a sticking point with mass drug administration. But in this trial, ivermectin had a favorable safety profile, consistent with its use in other public health campaigns against neglected tropical diseases.

No serious drug-related adverse events were reported. The few side effects that did appear—such as dizziness or nausea—were mild and short-lived.

This is crucial because any tool proposed for broad-scale use, especially in children, must not only be effective but also safe.

<h2>Where Does This Leave Us With Malaria Treatment?</h2>

In an accompanying editorial, US-based malaria experts have praised the study as “well-conducted” and “not unexpected.” Noting that ivermectin has long shown potential but hadn’t been tested at this scale until now. He also raised a practical point—future studies may explore longer-acting formulations or more frequent dosing, although delivering such strategies at scale could be challenging.

But he also sounded a sobering note: funding for malaria control programs is being slashed across the globe, including Africa, Asia, and the Americas. Without renewed investment, progress could stall—or worse, reverse.

The study results have already been reviewed by the World Health Organization’s Vector Control Advisory Group, which acknowledged the impact and called for additional studies. National health authorities in Kenya and elsewhere are now considering whether to include ivermectin in their malaria control toolkits.

The BOHEMIA team also hopes this will trigger more large-scale research to evaluate the most effective dosing schedules, combination strategies, and delivery methods.

Ivermectin is not a replacement for bed nets or other established tools but it adds a much-needed weapon to the malaria arsenal, especially in regions where mosquitoes are outsmarting traditional methods.

This trial shows us that with the right strategy, an old drug can offer a new solution to one of the world’s deadliest diseases. As malaria continues to evolve, so must our response. Ivermectin might just be the unexpected ally the global health community needs to push the fight forward.

malaria

ivermectin malaria study

malaria prevention 2025

bohemia trial kenya

mosquito control drug

child malaria protection

ivermectin safety profile

malaria control strategies

A new study published in the New England Journal of Medicine has delivered a striking insight into the global fight against malaria. Ivermectin—a widely used antiparasitic drug—has been shown to reduce malaria incidence by 26% in a large-scale trial conducted in Kenya. While ivermectin’s role in treating diseases like river blindness and elephantiasis is well-known, its impact on malaria prevention opens the door to a new, complementary strategy in high-risk regions. The finding is especially significant as malaria control efforts face stagnation due to growing resistance to traditional tools like insecticide-treated nets.Malaria remains one of the deadliest diseases globally, with nearly 600,000 deaths and over 260 million cases reported in 2023 alone. Africa accounts for the vast majority of these cases, where bed nets and indoor spraying have long been the frontline defense. But here’s the problem: mosquitoes are adapting. Insecticide resistance is on the rise, and some species have shifted behavior, biting outdoors or at times when nets offer no protection.The need for an alternative, preferably one that can work alongside existing tools, is urgent. Enter ivermectin.How Ivermectin Works Against Malaria?Ivermectin doesn’t target the malaria parasite itself. Instead, it turns humans into mosquito killers.Here’s how: when a person takes ivermectin, the drug circulates in their bloodstream for several days. If a mosquito bites that person during that window, the drug is toxic to the mosquito. This reduces the mosquito population and, by extension, cuts malaria transmission.This “endectocide” approach—targeting parasites both inside and outside the body—adds an entirely different layer to malaria control.The BOHEMIA (Broad One Health Endectocide-based Malaria Intervention in Africa) trial is the largest study to date exploring ivermectin’s impact on malaria. Led by the Barcelona Institute for Global Health (ISGlobal), the study took place in Kwale County, a malaria-endemic region of coastal Kenya where the use of insecticide-treated bed nets is already high. Here’s what the researchers did:84 clusters of households were randomly assigned to receive either ivermectin or a control drug (albendazole).Participants (nearly 29,000 people in total) were given their respective drugs once a month for three months during the region’s rainy season, when malaria transmission spikes.Researchers then tracked malaria infection rates specifically in children aged 5 to 15, testing them monthly for six months.Children in the ivermectin group had 2.20 malaria infections per child-year, compared to 2.66 in the control group—a 26% relative reduction.What stood out in the findings was the gradient effect—the farther a child lived from the border of the study clusters, the stronger the protection. This points to a community-wide benefit, not just an individual one. In simpler terms, the more people around you who take ivermectin, the less likely you are to get malaria.The protective effect also met and surpassed the World Health Organization’s minimum efficacy threshold, which recommends at least a 20% reduction in infection lasting one month after treatment.Dr. Carlos Chaccour, co-principal investigator of the study, called the results “thrilling,” adding that ivermectin “could complement existing control measures.” His colleague, Dr. Regina Rabinovich, emphasized the drug’s potential in areas where traditional tools are beginning to fail.Safety is always a sticking point with mass drug administration. But in this trial, ivermectin had a favorable safety profile, consistent with its use in other public health campaigns against neglected tropical diseases.No serious drug-related adverse events were reported. The few side effects that did appear—such as dizziness or nausea—were mild and short-lived.This is crucial because any tool proposed for broad-scale use, especially in children, must not only be effective but also safe.Where Does This Leave Us With Malaria Treatment?In an accompanying editorial, US-based malaria experts have praised the study as “well-conducted” and “not unexpected.” Noting that ivermectin has long shown potential but hadn’t been tested at this scale until now. He also raised a practical point—future studies may explore longer-acting formulations or more frequent dosing, although delivering such strategies at scale could be challenging.But he also sounded a sobering note: funding for malaria control programs is being slashed across the globe, including Africa, Asia, and the Americas. Without renewed investment, progress could stall—or worse, reverse.The study results have already been reviewed by the World Health Organization’s Vector Control Advisory Group, which acknowledged the impact and called for additional studies. National health authorities in Kenya and elsewhere are now considering whether to include ivermectin in their malaria control toolkits.The BOHEMIA team also hopes this will trigger more large-scale research to evaluate the most effective dosing schedules, combination strategies, and delivery methods.Ivermectin is not a replacement for bed nets or other established tools but it adds a much-needed weapon to the malaria arsenal, especially in regions where mosquitoes are outsmarting traditional methods.This trial shows us that with the right strategy, an old drug can offer a new solution to one of the world’s deadliest diseases. As malaria continues to evolve, so must our response. Ivermectin might just be the unexpected ally the global health community needs to push the fight forward.

Male Birth Control Pill Clears Early Safety Trails, Scientists Test New Contraceptive Without Side Effects

Parenting

Not All Infertility Needs IVF; Sometimes, It’s The Bravest Choice You’ll Make

not all infertility needs ivf; sometimes, it’s the bravest choice you’ll make

IVF Day 2025: What Happens To The Unused Embryo After An Unsuccessful IVF?

ivf day 2025: what happens to the unused embryo after an unsuccessful ivf?

World IVF Day 2025: History, Theme, And Significance

world ivf day 2025: history, theme, and significance

<span>Male birth control pill</span> might finally be here- the burden of birth control has disproportionately fallen on women. That may soon change. A groundbreaking experimental male birth control pill, YCT-529, has successfully passed its first human safety trial — without any significant side effects. The result marks a pivotal step toward giving men more contraceptive options beyond condoms or vasectomy.

Developed through a collaboration between the University of Minnesota, Columbia University, and biotech company YourChoice Therapeutics, YCT-529 is distinct from previous male contraceptive attempts because it is non-hormonal. That means it sidesteps the hormonal manipulation that often causes side effects in traditional contraceptives, making it a potentially safer and more acceptable option for widespread use.

Unlike female birth control pills that regulate estrogen and progesterone, YCT-529 works by targeting a specific protein known as retinoic acid receptor alpha. This protein, activated by vitamin A derivatives, plays a critical role in sperm production and maturation. The drug effectively blocks the receptor, halting sperm production without impacting other bodily systems.

“The innovation here lies in how precisely this pill works,” explained Dr. Gunda Georg, professor at the University of Minnesota’s College of Pharmacy. “We’re not interfering with the body’s hormonal balance, which is a huge step forward in terms of safety and user experience.”

<h2>How the <span rel="noindex">Male Contraceptive Pill</span> Works?</h2>

The experimental male birth control pill, known as YCT-529, targets a specific protein called retinoic acid receptor alpha (RAR-α)—a key player in sperm production. Normally, this receptor gets activated by a vitamin A derivative, which acts like a key turning on the body’s sperm-making machinery. YCT-529 blocks that key from fitting into the receptor, effectively shutting down the process.

By stopping this molecular interaction in the testes, the pill halts the formation and maturation of sperm. Scientists identified this mechanism by studying the receptor's structure and testing dozens of compounds to find one that could selectively block it.

In lab tests on male mice, the pill worked remarkably well. It brought sperm production to a halt within four weeks, was 99% effective at preventing pregnancy, and had no significant side effects. Importantly, the effects were reversible—mice regained fertility within four to six weeks after stopping the pill.

Unlike hormonal methods that can disrupt testosterone and cause mood or libido changes, this non-hormonal approach targets a specific biological pathway, making it a promising, low-risk alternative in male contraception research.

The initial preclinical testing in lab mice was promising: male mice treated with YCT-529 became temporarily infertile within four weeks. The drug had a 99% effectiveness rate in preventing pregnancy, and fertility rebounded four to six weeks after stopping treatment. Similar results were seen in nonhuman primates, where sperm counts dropped significantly but later recovered completely.

This encouraging data paved the way for a Phase 1 clinical trial involving 16 human volunteers aged 32 to 59 — all of whom had previously undergone vasectomies. This added layer of safety ensured that even in the event of unexpected long-term side effects, fertility would not be a concern.

Participants were divided into groups that received either a placebo, a low dose, or a high dose of the drug. Some took the pill on an empty stomach, while others took it after a meal to assess absorption differences.

No significant side effects were reported across any dose or condition. Heart rate, hormone levels, mood, inflammation, and sexual function all remained stable, a rare feat for early-stage contraceptive development.

While 16 people make for a strong safety signal, larger trials are needed to confirm YCT-529’s safety and, more importantly, its efficacy in real-world scenarios. Researchers are now moving ahead with longer studies involving daily use over 28 to 90 days. These new trials will monitor not just side effects, but changes in sperm count and motility, setting the stage for potential FDA approval.

Dr. Nadja Mannowetz, co-founder and chief science officer of YourChoice Therapeutics, emphasized that while the early data is encouraging, they're moving forward cautiously. “Our next trials will give us a much clearer picture of how this drug works in daily life — and whether it can become a reliable option for men everywhere.”

Currently, male contraception is stuck in the past. Only condoms and vasectomies are FDA-approved options for men, while women navigate a far more complex landscape of pills, patches, injections, implants, and IUDs — many of which come with long lists of side effects.

This imbalance has consequences. Nearly 75% of women say they believe both partners should be equally responsible for contraception, but the tools to support that belief simply don’t exist.

"A safe and effective male pill will provide more options to couples for birth control,” Dr. Georg noted. “It will allow a more equitable sharing of responsibility for family planning and provide reproductive autonomy for men.”

The journey to develop male contraception has been long and winding. Past attempts, particularly hormone-based options, stumbled due to low effectiveness or unpleasant side effects like mood swings, acne, or reduced libido. YCT-529 represents a dramatic departure from those efforts. By targeting the molecular machinery of sperm production, it gets the job done without compromising other bodily functions.

Still, hurdles remain. Even if the next stages of trials confirm its effectiveness, it could be years before YCT-529 is available to the public. Manufacturing, regulatory approval, public education, and access issues will all need to be addressed.

That said, the early buzz is unmistakable. Scientists are cautiously optimistic. Reproductive health advocates are hopeful. And couples around the world are watching closely.

This isn’t just about birth control. It’s about giving men agency over their reproductive choices, and relieving women of the disproportionate burden they’ve carried for decades. It’s about science catching up with society’s expectations.

As we enter a new era in contraceptive innovation, YCT-529 could become the first of many tools that give men a real seat at the table when it comes to family planning. The next phase of trials will tell us more. But for now, the signal is clear: male birth control is no longer science fiction. It’s becoming science fact and it’s arriving not a moment too soon.

male birth control pill

male contraceptive trials

non hormonal male birth control

male contraceptive pill

male birth control safety

men contraception options

new male birth control

Male birth control pill might finally be here- the burden of birth control has disproportionately fallen on women. That may soon change. A groundbreaking experimental male birth control pill, YCT-529, has successfully passed its first human safety trial — without any significant side effects. The result marks a pivotal step toward giving men more contraceptive options beyond condoms or vasectomy.Developed through a collaboration between the University of Minnesota, Columbia University, and biotech company YourChoice Therapeutics, YCT-529 is distinct from previous male contraceptive attempts because it is non-hormonal. That means it sidesteps the hormonal manipulation that often causes side effects in traditional contraceptives, making it a potentially safer and more acceptable option for widespread use.Unlike female birth control pills that regulate estrogen and progesterone, YCT-529 works by targeting a specific protein known as retinoic acid receptor alpha. This protein, activated by vitamin A derivatives, plays a critical role in sperm production and maturation. The drug effectively blocks the receptor, halting sperm production without impacting other bodily systems.“The innovation here lies in how precisely this pill works,” explained Dr. Gunda Georg, professor at the University of Minnesota’s College of Pharmacy. “We’re not interfering with the body’s hormonal balance, which is a huge step forward in terms of safety and user experience.”How the Male Contraceptive Pill Works?The experimental male birth control pill, known as YCT-529, targets a specific protein called retinoic acid receptor alpha (RAR-α)—a key player in sperm production. Normally, this receptor gets activated by a vitamin A derivative, which acts like a key turning on the body’s sperm-making machinery. YCT-529 blocks that key from fitting into the receptor, effectively shutting down the process.By stopping this molecular interaction in the testes, the pill halts the formation and maturation of sperm. Scientists identified this mechanism by studying the receptor's structure and testing dozens of compounds to find one that could selectively block it.In lab tests on male mice, the pill worked remarkably well. It brought sperm production to a halt within four weeks, was 99% effective at preventing pregnancy, and had no significant side effects. Importantly, the effects were reversible—mice regained fertility within four to six weeks after stopping the pill.Unlike hormonal methods that can disrupt testosterone and cause mood or libido changes, this non-hormonal approach targets a specific biological pathway, making it a promising, low-risk alternative in male contraception research.The initial preclinical testing in lab mice was promising: male mice treated with YCT-529 became temporarily infertile within four weeks. The drug had a 99% effectiveness rate in preventing pregnancy, and fertility rebounded four to six weeks after stopping treatment. Similar results were seen in nonhuman primates, where sperm counts dropped significantly but later recovered completely.This encouraging data paved the way for a Phase 1 clinical trial involving 16 human volunteers aged 32 to 59 — all of whom had previously undergone vasectomies. This added layer of safety ensured that even in the event of unexpected long-term side effects, fertility would not be a concern.Participants were divided into groups that received either a placebo, a low dose, or a high dose of the drug. Some took the pill on an empty stomach, while others took it after a meal to assess absorption differences.No significant side effects were reported across any dose or condition. Heart rate, hormone levels, mood, inflammation, and sexual function all remained stable, a rare feat for early-stage contraceptive development.While 16 people make for a strong safety signal, larger trials are needed to confirm YCT-529’s safety and, more importantly, its efficacy in real-world scenarios. Researchers are now moving ahead with longer studies involving daily use over 28 to 90 days. These new trials will monitor not just side effects, but changes in sperm count and motility, setting the stage for potential FDA approval.Dr. Nadja Mannowetz, co-founder and chief science officer of YourChoice Therapeutics, emphasized that while the early data is encouraging, they're moving forward cautiously. “Our next trials will give us a much clearer picture of how this drug works in daily life — and whether it can become a reliable option for men everywhere.”Currently, male contraception is stuck in the past. Only condoms and vasectomies are FDA-approved options for men, while women navigate a far more complex landscape of pills, patches, injections, implants, and IUDs — many of which come with long lists of side effects.This imbalance has consequences. Nearly 75% of women say they believe both partners should be equally responsible for contraception, but the tools to support that belief simply don’t exist."A safe and effective male pill will provide more options to couples for birth control,” Dr. Georg noted. “It will allow a more equitable sharing of responsibility for family planning and provide reproductive autonomy for men.”The journey to develop male contraception has been long and winding. Past attempts, particularly hormone-based options, stumbled due to low effectiveness or unpleasant side effects like mood swings, acne, or reduced libido. YCT-529 represents a dramatic departure from those efforts. By targeting the molecular machinery of sperm production, it gets the job done without compromising other bodily functions.Still, hurdles remain. Even if the next stages of trials confirm its effectiveness, it could be years before YCT-529 is available to the public. Manufacturing, regulatory approval, public education, and access issues will all need to be addressed.That said, the early buzz is unmistakable. Scientists are cautiously optimistic. Reproductive health advocates are hopeful. And couples around the world are watching closely.This isn’t just about birth control. It’s about giving men agency over their reproductive choices, and relieving women of the disproportionate burden they’ve carried for decades. It’s about science catching up with society’s expectations.As we enter a new era in contraceptive innovation, YCT-529 could become the first of many tools that give men a real seat at the table when it comes to family planning. The next phase of trials will tell us more. But for now, the signal is clear: male birth control is no longer science fiction. It’s becoming science fact and it’s arriving not a moment too soon.

About Us

Contact Us

Terms & Conditions

Privacy Policy

Company

Health and Me is a premium website with content written and curated to function as a handbook for all Health concerns.

It Might Not Be Diabetes; It Could Be This Common Pill Causing Heart Disease: Study

Quick Stories

With Over 3,100 Infected, Deadly Mosquito-Borne Virus Spreads Rapidly In China—Is It Climate, Travel, Or Both?

Ivermectin Proven To Cut Malaria Cases By 26%, Study Finds—Here’s How It Works

Male Birth Control Pill Passes Early Safety Trials, Scientists Test New Contraceptive Without Side Effects

Health Conditions A-Z

With Over 3,100 Infected, Deadly Mosquito-Borne Virus Spreads Rapidly In China—Is It Climate, Travel, Or Both?

Ivermectin Proven To Cut Malaria Cases By 26%, Study Finds—Here’s How It Works

Skipping This Basic Yet Vital Oral Hygiene Step Could Put You In Trouble