Novo Nordisk on Saturday announced that its diabetes pill, Rybelsus, demonstrated cardiovascular benefits in a late-stage trial. The findings pave the way for the medication to become a new treatment option for people living with both diabetes and heart disease.In the trial, Rybelsus reduced the risk of cardiovascular-related death, heart attack, and stroke by 14% compared to a placebo over an average follow-up period of four years. The study involved patients with Type 2 diabetes and established heart disease, some of whom also had chronic kidney disease. The Danish drugmaker presented these results at the American College of Cardiology’s Annual Scientific Session in Chicago.Rybelsus, already approved for Type 2 diabetes, is the once-daily oral formulation of Novo Nordisk’s blockbuster weekly injection, Ozempic. Both drugs, along with the company’s weekly weight-loss injection Wegovy, contain semaglutide as their active ingredient.According to Stephen Gough, Novo Nordisk’s global chief medical officer, the company has submitted applications in the U.S. and EU to expand Rybelsus’ approval to include reducing the risk of serious cardiovascular events. “We know not everybody wants an injection, whether it is painful or not, they want the option of an oral medication,” Gough told CNBC. “We provide that option, that you can have one or the other, depending on what the patients and the healthcare professional think is right in that joint discussion.”In March 2024, Wegovy received U.S. approval for lowering the risk of major cardiovascular events in adults who are overweight or obese and have heart disease. The new data on Rybelsus suggests an additional option for patients hesitant about injections, offering a more convenient pill-based treatment.The phase three trial included over 9,600 participants aged 50 and older, who received either Rybelsus or a placebo, in addition to standard therapies. Nearly half of the participants also received SGLT2 inhibitors—commonly used to lower blood sugar—at some point during the trial. By the end, 12% of those on Rybelsus and 13.8% of those on placebo experienced cardiovascular-related death, heart attack, or stroke, amounting to a 14% overall reduction in risk for the Rybelsus group.The most significant reduction was seen in non-fatal heart attacks, which were reduced by 26%, followed by a 12% drop in non-fatal strokes and a 7% reduction in cardiovascular-related deaths. These findings align with previous trials of injectable GLP-1s like semaglutide, which mimic gut hormones to regulate blood sugar, reduce appetite, and curb inflammation.While the study showed no major differences in kidney-related outcomes, Gough clarified that the trial primarily focused on heart health. Ozempic, however, is already approved for treating chronic kidney disease in diabetic patients.Common side effects of Rybelsus were gastrointestinal issues such as nausea, diarrhea, and constipation—similar to those experienced with injectable semaglutide. These symptoms rarely led to patients discontinuing the drug.Dr. Darren McGuire, the study’s lead author from UT Southwestern Medical Center, noted that despite needing to be taken on an empty stomach at least 30 minutes before eating, patients successfully adhered to Rybelsus and experienced cardiovascular benefits across all age, sex, and health condition subgroups.