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Itisha Arya

Oral Cholera Vaccine Shanchol Gets WHO Prequalification; What You Should Know

cholera oral vaccine

The <span>oral cholera vaccine</span> <span>Shanchol</span>, made in Hyderabad and first developed by Shantha Biotechnics, has received World Health Organization (WHO) prequalification after its production was recently revived under new management. The clearance allows global procurement agencies such as UNICEF, Gavi, and PAHO to source the vaccine for countries where <span>cholera</span> continues to have a serious public health threat, according to GCBC Vaccines. With the approval in place, here’s a closer look at the vaccine, how it works, and why it matters.

Dr. K.I. Varaprasad Reddy, founder of Shantha Biotechnics, said, “Shanchol was designed to be an affordable and accessible answer for countries that struggle with repeated cholera outbreaks. The WHO’s prequalification continues that mission.”

Shanchol is an oral, inactivated, bivalent <span>cholera vaccine</span> that protects against Vibrio cholerae, the bacteria responsible for the disease. The name itself is a brand term rather than an abbreviation.

<h2>How Does The <span rel="noindex">Shanchol Vaccine</span> Work?</h2>

Type of vaccine: Shanchol is a killed whole-cell vaccine, which means it contains dead cholera bacteria. These are used to train the immune system without causing infection. Being bivalent, it offers protection against the two major cholera strains, O1 and O139.

<ul><li>Administration: The vaccine is taken by mouth and usually given in two doses for full protection.</li><li>Mechanism: Once ingested, the vaccine activates the immune system in the gut, prompting it to produce antibodies that stop Vibrio cholerae from attaching to the intestinal lining. This prevents the infection from taking hold and causing illness.</li></ul>

<h2>Shanchol Vaccine: Why It Matters?</h2>

<ul><li>WHO prequalification: The WHO’s approval confirms that Shanchol meets global standards for safety and effectiveness, making it eligible for international procurement.</li><li>Part of global stockpile: It plays a key role in the world’s oral cholera vaccine stockpile, which supports emergency response efforts in regions hit by cholera outbreaks.</li><li>Current use: Shanchol is widely used in mass immunization drives across cholera-prone and outbreak-affected regions.</li></ul>

Originally created by Shantha Biotechnics, the vaccine later came under Sanofi’s ownership, which eventually halted its production. Manufacturing has now resumed under GCBC Vaccines, part of the Gland Family Office. With WHO prequalification restored, Shanchol will once again be distributed globally to support vaccination programs.

<h2>The Role of Oral Cholera Vaccines</h2>

Oral cholera vaccines (OCVs) such as Shanchol and Dukoral are tools in preventing the spread of cholera, a severe diarrheal disease caused by Vibrio cholerae. Taken orally, they help trigger an immune response in the intestine that limits bacterial infection. These vaccines are especially valuable in areas with poor sanitation and limited access to clean water.

Vishy Chebrol, Executive Director of GCBC Vaccines, said the company’s priority is to ensure that vaccines reach the countries that need them most, affordably and consistently. “We are also working to bring more affordable and innovative vaccines to global markets, continuing Shantha’s legacy of improving access to life-saving immunization,” he added.

With WHO’s renewed approval, Shanchol, a bivalent, killed whole-cell oral cholera vaccine effective against Vibrio cholerae O1 and O139, will continue to be supplied worldwide to meet growing demand and support national immunization programmes.

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The oral cholera vaccine Shanchol, made in Hyderabad and first developed by Shantha Biotechnics, has received World Health Organization (WHO) prequalification after its production was recently revived under new management. The clearance allows global procurement agencies such as UNICEF, Gavi, and PAHO to source the vaccine for countries where cholera continues to have a serious public health threat, according to GCBC Vaccines. With the approval in place, here’s a closer look at the vaccine, how it works, and why it matters.Shanchol: What Is the Vaccine?Dr. K.I. Varaprasad Reddy, founder of Shantha Biotechnics, said, “Shanchol was designed to be an affordable and accessible answer for countries that struggle with repeated cholera outbreaks. The WHO’s prequalification continues that mission.”Shanchol is an oral, inactivated, bivalent cholera vaccine that protects against Vibrio cholerae, the bacteria responsible for the disease. The name itself is a brand term rather than an abbreviation.How Does The Shanchol Vaccine Work?Type of vaccine: Shanchol is a killed whole-cell vaccine, which means it contains dead cholera bacteria. These are used to train the immune system without causing infection. Being bivalent, it offers protection against the two major cholera strains, O1 and O139.Administration: The vaccine is taken by mouth and usually given in two doses for full protection.Mechanism: Once ingested, the vaccine activates the immune system in the gut, prompting it to produce antibodies that stop Vibrio cholerae from attaching to the intestinal lining. This prevents the infection from taking hold and causing illness.Shanchol Vaccine: Why It Matters?WHO prequalification: The WHO’s approval confirms that Shanchol meets global standards for safety and effectiveness, making it eligible for international procurement.Part of global stockpile: It plays a key role in the world’s oral cholera vaccine stockpile, which supports emergency response efforts in regions hit by cholera outbreaks.Current use: Shanchol is widely used in mass immunization drives across cholera-prone and outbreak-affected regions.Production RevivalOriginally created by Shantha Biotechnics, the vaccine later came under Sanofi’s ownership, which eventually halted its production. Manufacturing has now resumed under GCBC Vaccines, part of the Gland Family Office. With WHO prequalification restored, Shanchol will once again be distributed globally to support vaccination programs.The Role of Oral Cholera VaccinesOral cholera vaccines (OCVs) such as Shanchol and Dukoral are tools in preventing the spread of cholera, a severe diarrheal disease caused by Vibrio cholerae. Taken orally, they help trigger an immune response in the intestine that limits bacterial infection. These vaccines are especially valuable in areas with poor sanitation and limited access to clean water.Vishy Chebrol, Executive Director of GCBC Vaccines, said the company’s priority is to ensure that vaccines reach the countries that need them most, affordably and consistently. “We are also working to bring more affordable and innovative vaccines to global markets, continuing Shantha’s legacy of improving access to life-saving immunization,” he added.With WHO’s renewed approval, Shanchol, a bivalent, killed whole-cell oral cholera vaccine effective against Vibrio cholerae O1 and O139, will continue to be supplied worldwide to meet growing demand and support national immunization programmes.

oral cholera vaccine shanchol gets who prequalification; what you should know

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Oral Cholera Vaccine Shanchol Gets WHO Prequalification; What You Should Know

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