Ozzy Osbourne, the legendary heavy metal artist passed away at 76 just a few weeks after his farewell show. Known for his contributions as the lead vocalist in the band Black Sabbath, Ozzy Osbourne was also dealing with the difficult diagnosis of Parkinson's. In 2020, during an interview with Good Morning America (GMA) the Grammy winner revealed that he had been diagnosed with Parkinson’s disease.

Assuring fans of his well-being, his wife Sharon Osbourne told the GMA audience that the diagnosis was not a “death sentence” but that he also had his good and bad days. Addressing his fans once again, the Osbourne family gave a joint statement conveying love to Ozzy and telling fans he passed among family members, surrounded with love.

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His death has put a spotlight on the disease, here is what you need to know.

What Is Parkinson’s: Signs, Cause, Risk Factors And Treatment

According to the National Health Service UK (NHS) Parkinson's disease is a brain condition that gets worse over many years. It slowly damages parts of your brain. The most common signs of Parkinson's disease are:

Shaking that you can't control (tremor)

This means parts of your body, like your hand, might shake without you wanting them to. It's often one of the first things people notice.

Slow movements

Everyday actions, like walking or getting dressed, start to take much longer. It's like your body is moving in slow motion.

Stiff muscles

Your muscles can feel rigid and hard to bend. This can make it difficult to move freely and can even cause pain.

Besides these main signs, people with Parkinson's can also have other problems. These might include feeling down or worried (depression and anxiety), having trouble with balance (which means you might fall more easily), losing your sense of smell, finding it hard to sleep, and even having some memory issues.

Causes

If you're worried you might have symptoms of Parkinson's disease, it's a good idea to see your family doctor (GP). Parkinson's disease happens because certain nerve cells in a part of your brain called the substantia nigra die off. These cells usually make a chemical called dopamine. Dopamine is really important for controlling your body's movements. When there's less dopamine, that's why you get the shaking, slowness, and stiffness.

Risk

Most people start to notice symptoms of Parkinson's disease when they are over 50 years old. However, some people can get it earlier, even before they turn 40. Also, men are a bit more likely to get Parkinson's disease than women.

Parkinson’s Treatment

Right now, there's no cure for Parkinson's disease. But there are treatments that can help manage the symptoms and keep you living as well as possible for as long as possible. These treatments include:

Supportive care: This means things like physiotherapy, which helps with movement, and occupational therapy, which helps with daily tasks.

Medication: There are medicines that can help control the symptoms.

Brain surgery: In some specific cases, surgery on the brain might be an option.

In the very early stages, your symptoms might be mild, and you might not need treatment right away. But your specialist will want to see you regularly to keep an eye on your condition.

What to Expect Over Time

As Parkinson's disease gets worse, the symptoms can become more severe, making it harder to do everyday things without help. Many people respond well to treatments and can live with only mild to moderate difficulties. However, a smaller number of people might not respond as well and could become more severely affected over time.

Parkinson's disease itself doesn't directly cause death. But it can put a lot of strain on your body and make you more likely to get serious infections. Good news is, with all the new treatments, most people with Parkinson's disease can now expect to live a normal or close-to-normal lifespan.n

In a disturbing case from the US state of Florida, a pregnant woman in active labor was forced to attend a virtual court hearing via Zoom from her hospital bed for refusing a Cesarean delivery, also known as C-section — a common method of childbirth.

ProPublica reported that Cherise Doyley was in her 12th hour of contractions at the University of Florida Health facility, when she was, without her consent, made to sit in front of a host of people — a judge in a black robe and several lawyers, doctors, and hospital staff — for the Zoom proceeding.

While in active labor, a nurse came in with a bedsheet and told her to cover up, and a supervisor followed with a tablet.

“It’s a real judge in there?” Doyley asked the nurse at the beginning of what would be a three-hour hearing.

What Was The Case?

The mother of three, and a professional birthing doula, Doyley had arrived at the facility after her water broke.

While her doctors expressed concerns about the risk of uterine rupture —a potentially deadly complication for her and her baby — Doyley wanted to try for a vaginal delivery, as the risk was less than 2 percent, unless there was an emergency.

She told doctors she wouldn’t consent to a cesarean without trying to have a vaginal delivery first.

While the doctors initially relented, after several hours, she had to face a virtual court hearing, where the hospital and state attorney’s office forced Doyley to undergo a cesarean section.

Doyley has her own reasons to avoid a C-sec. She already had three prior C-sections, and one that resulted in a hemorrhage. She feared that a C-sec would lead to another serious complication and a lengthy recovery, and her kids would suffer.

However, the hospital was worried that her medical decisions may cause harm to the fetus, and that the courts may help decide which one mattered more, the report said.

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After three hours of testimony — all while Doyley lay in her hospital bed — the judge ruled that she could keep laboring unless there was an emergency. If that happened, the hospital could operate, whether she wanted it or not.

Overnight, doctors said the baby’s heart rate dropped for seven minutes. Doyley woke to her hospital bed being wheeled into surgery. The baby girl was delivered by C-section, the report said.

What Happens In A C-section?

It is a surgical procedure that is used to deliver a baby through an incision made in the abdomen and uterus.

The method is preferred, especially in cases with complications during labor or breech presentation, or multiple births.

Unlike the popular conception, it hurts. In a vaginal delivery, the pain is experienced during labor and pushing, especially if done without an epidural.

Whereas, in a C-section, a surgery is performed that numbs the body from the chest down. However, the recovery could be painful and prolonged. It is also because in a C-section, it involves healing from a major abdominal surgery, while vaginal birth recovery may be quicker, more complicated, or traumatic.

Also read: 'Husband Stitch': A Medical Necessity Or Just A Tool To Objectify Women's Bodies?

Does A C-sec Affect The Baby?

Usually, it does not harm the baby, but there could be potential risks to the baby, including:

• Surgical injury, which is very rare; however, the baby may be accidentally nicked during the incision.

• Respiratory issues: Babies born via C-section may have a higher risk of breathing, since they miss the natural compression during the vaginal birth that helps expel the amniotic fluid from their lungs

• Delayed bonding: Immediate skin-to-skin contact may take longer due to the surgical process.
• Feeding challenges: Some newborns may initially struggle with breastfeeding.

Risks Of A C-section Birth?

• Excessive blood loss
• Infection
• Blood clots in the legs, lungs, or pelvis
• Damage to nearby organs
• Adverse reactions to anesthesia

The American College of Obstetricians and Gynecologists (ACOG) advises against elective C-sections due to these potential complications.

American drugmaker Eli Lilly’s first oral pill for weight loss, Orforglipron, marketed as Foundayo, has been given the green signal by the US Food and Drug Administration (FDA).

Lilly is also known for injectable drugs like Zepbound for obesity and Mounjaro and Trulicity for diabetes.

Foundayo’s approval comes after the US FDA in December last year approved Novo Nordisk’s Wegovy pill — the first-ever GLP-1 pill for weight loss. The Danish drugmaker rolled out the pill in January this year.

Novo Nordisk was also the first to launch oral GLP 1 Rybelsus to treat type 2 diabetes. It was approved by the US FDA in September 2019.

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In a statement, the US FDA said that "Foundayo has been approved for use in combination with a reduced-calorie diet and increased physical activity. The pill is targeted to reduce excess body weight and maintain weight reduction for the long term in adults with obesity or overweight".

Lilly said that the drug will be available from April 6 through its its direct-to-consumer platform LillyDirect at a cost of $149 per month for the lowest dose for self-pay customers — on par with Novo's pill. "Shortly after” it will be available through retail pharmacies and telehealth providers in the US.

"Today, fewer than 1 in 10 people who could benefit from a GLP-1 are taking one, held back by access, stigma, perceived complexity, or the belief that their condition isn't serious enough for treatment. We believe Foundayo can help level the playing field for those living with obesity or who are overweight and living with weight-related complications," said David A. Ricks, chair and CEO of Eli Lilly and Company.

"As a convenient, once-daily oral pill that delivers meaningful weight loss, this is obesity care designed for the real world," he added.

Foundayo: A Meaningful Reduction In Body Weight

Also Read: Foundayo: US FDA Approves Eli Lilly’s GLP-1 Weight Loss Pill

In these trials, 72 weeks of treatment with Foundayo, in combination with a reduced-calorie diet and increased physical activity, resulted in a statistically significant and clinically meaningful reduction in body weight.

Deborah Horn, Director of the Center for Obesity Medicine at McGovern Medical School at UTHealth Houston, stated that Foundayo “delivered an average of 12.4 percent weight loss at the highest dose in clinical trials – addressing both the clinical realities of obesity and the practical challenges patients face every day."

In addition, Foundayo also led to reductions in many markers of cardiovascular risk, including waist circumference, non-HDL cholesterol, triglycerides, and systolic blood pressure across all doses, Eli Lilly said.

How Foundayo Works

Lilly licensed Orforglipron, the main ingredient in Foundayo, from a Japanese pharmaceutical company in 2018.

As with the injectable forms of GLP-1s, Foundayo is available in six doses, ranging from 0.8mg to 17.2mg.

In consultation with their doctors, patients start with the lowest dose and gradually work up to higher doses; not everyone may need to reach the highest dose.

Also read: Eli Lilly's Experimental GLP-1 Pill Shows Promising Weight Loss

Unlike the Wegovy pill, people taking orforglipron do not need to restrict food or drink after taking the pill. Orforglipron is a small molecule that the body can absorb quickly and get into the blood, where it reaches the necessary tissues.

Foundayo: Side Effects

Foundayo is not safe for use in children and has an increased list of side effects, such as tumors in the thyroid, including thyroid cancer.

The drugmaker urged watching for possible symptoms, such as

• a lump or swelling in the neck,
• hoarseness,
• trouble swallowing
• shortness of breath.

• nausea,
• constipation,
• diarrhea,
• vomiting,
• indigestion,
• stomach (abdominal) pain,
• headache,
• swollen belly,
• feeling tired,
• belching,
• heartburn,
• gas,
• hair loss.

New Zealand has stepped up surveillance after the first detection of a dengue and Zika-carrying mosquito larvae in the country.

The larval species was confirmed as 'Aedes aegypti' — known to carry diseases including dengue fever, yellow fever, Zika, and chikungunya, across the globe.

As New Zealand does not normally have the mosquito species, the larvae detected were counted as "exotic".

The mosquito species did not cause any outbreak, but were spotted during a routine surveillance program in Auckland.

"The National Public Health Service has commenced a heightened surveillance and interception programme following mosquito larvae being collected from a routine surveillance trap at Queens Wharf, Auckland, on Monday 30 March," Health New Zealand said in a statement.

Health New Zealand reported that exotic species were occasionally found at ports and airports.

Not A Public Threat Yet

The health body noted that the larvae were not considered a public health or biosecurity threat yet because there was no indication they had become established.

But the agency aimed to continue "intensive monitoring for at least three weeks".

"The monitoring would take place within a 400m radius of the site where the larvae were identified. Health Protection Officers would place mosquito traps in the survey area," the statement said.

"These have been hidden away from plain sight so they are not disturbed, for example, in old tyres, bushes, or pools of water. We ask members of the public to avoid touching or disturbing these traps if they find them, as it may disrupt our monitoring and trapping efforts," medical officer of health Dr David Sinclair said.

Sinclair said New Zealanders were most at risk from diseases transmitted by mosquitoes when travelling overseas, including to Pacific Island countries and territories where dengue fever was known to be present.

Dengue Surging In 17 Countries

The US Centers for Disease Control and Prevention recently issued a travel alert of dengue outbreaks across 17 countries.

The CDC alert issued on March 23 identified 17 countries reporting an increased number of cases of dengue. These include: Afghanistan, Bangladesh, Bolivia, Colombia, Cook Islands, Cuba, Guyana, Maldives, Mali, Mauritania, New Caledonia, Pakistan, Samoa, Sudan, Timor-Leste, Vietnam, and the United States territories of American Samoa, Puerto Rico, and the US Virgin Islands, where local transmission is already common.

Also read: Long-term Exposure To Air Pollution Increases Fatality Rates In Dengue: Study

What Is Dengue?

Dengue is a disease caused by a virus spread through mosquito bites. It is transmitted through infected mosquitoes, primarily the species Aedes aegypti.

The breakbone fever is caused by an infection with any of four different dengue viruses. These include:

• Dengue virus type 1 (DENV-1 or DEN-1)

• Dengue virus type 2 (DENV-2 or DEN-2)

• Dengue virus type 3 (DENV-3 or DEN-3)

• Dengue virus type 4 (DENV-4 or DEN-4)

Also read: New dengue vaccine over 80% effective, prevents severe disease for up to 5 years

Common Symptoms of dengue include:

• Sudden onset of high-grade fever.

• Intense headache

• Severe muscle, joint, or bone pain.

• Skin Rash that often appears 2–5 days after the fever starts

• Nausea and Vomiting

• Minor bleeding

• Fatigue.