Most of us just grab ibuprofen for a headache or paracetamol for a fever without giving it a second thought. Painkillers like these are pantry staples, safe enough to purchase over the counter and reliable for generations but emerging research indicates they could be unwittingly driving one of the world's most urgent health challenges: antibiotic resistance.

A ground-breaking University of South Australia study has discovered that paracetamol and ibuprofen not only lead to bacterial resistance by themselves but can enhance it when combined especially when taken with antibiotics. That discovery overturns long-established beliefs about resistance formation and provokes question marks over how commonly used medicines are rewriting the rules for how bacteria adapt.

The World Health Organization (WHO) has designated antimicrobial resistance as one of the greatest threats to health, food security, and development worldwide. In 2019, bacterial resistance was a direct cause of 1.27 million deaths across the globe. These "superbugs" occur when bacteria evolve in such manners that antibiotics are no longer useful, transforming once-treatable infections into potentially lethal ones.

The finger of blame has long been pointed at the overuse and misuse of antibiotics prescribing them when they are not necessary, not finishing a course, or using them as pesticides. But now this new study puts a sinister spin on things, even non-antibiotic drugs could be contributing to helping bacteria get one over on advanced medicine.

The South Australia researchers studied how ubiquitous non-antibiotic drugs interact with ciprofloxacin, an antibiotic used to treat infections of the gut, urinary tract, and skin. The researchers emphasized Escherichia coli (E. coli), a bacterium that often results in these infections.

When E. coli was given ciprofloxacin alone, mutations happened as anticipated. But when ciprofloxacin was given in combination with ibuprofen and paracetamol, mutations went through the roof. The bacteria not only developed resistance against ciprofloxacin but also demonstrated resistance against several other antibiotics belonging to various categories.

Both paracetamol and ibuprofen seemed to trigger bacterial defense mechanisms that flush out antibiotics, rendering them much less potent. In effect, the medications were preparing bacteria to be resistant to treatment.

Polypharmacy and the Aged Care Connection

One of the most disturbing implications of the results is for vulnerable populations, particularly for older adults in long-term care. Residents in aged care homes are often prescribed several medications painkillers, blood pressure medications, sleep medication, cholesterol-lowering drugs, and others. This "polypharmacy" presents the ideal condition for gut bacteria to be exposed to drug combinations that fuel resistance.

As lead researcher for the study, Associate Professor Rietie Venter said, "Antibiotics have been used for decades to treat infectious illnesses, yet overuse and misuse across the globe have fueled a worldwide increase in antibiotic-resistant bacteria. This research indicates that the issue is greater and more profound than antibiotics alone."

What Are The Other Medications Under Scrutiny?

The research did not end at paracetamol and ibuprofen. Scientists also experimented on nine widely prescribed drugs, such as diclofenac for arthritis, furosemide for blood pressure, metformin for diabetes, atorvastatin for cholesterol, tramadol for pain after surgery, temazepam for insomnia, and pseudoephedrine for nasal congestion.

While not every drug caused the same degree of alarm, the findings added to a larger message: antibiotic resistance is no longer just an issue of antibiotics alone. Common medications the ones you have in bathroom cabinets and bedside tables around the globe could be part of the solution to resistance.

It's easy to think of antibiotic resistance as an intangible problem something that happens in hospitals or somewhere far away in the world. But it's already impacting lives around the world. Resistant bacteria complicate simple infections, increase healthcare costs, and pose a risk of complications and death.

If over-the-counter medications such as ibuprofen and paracetamol are fueling resistance, then millions of individuals unknowingly might be part of the issue simply by controlling a fever or arthritis. This is not to say these drugs are bad or should be stopped they work and are vital for many sicknesses. But it does indicate that we require a better understanding of how they work with antibiotics and bacteria.

The University of South Australia group is appealing for further research on how various combinations of drugs affect resistance, especially in long-term drug regimen populations. Such information could assist prescribing clinicians in making better-informed choices regarding prescribing and managing medications.

A Pennsylvania nursing home caught on fire due to an apparent gas explosion. The Silver Lake Nursing home in Pennsylvania's Bristol Township caught on fire, and videos show flames erupting from the building, and debris scattered around the area. The Pennsylvania Governor Josh Shapiro confirmed the that there are so far two deaths, with 21 people found injured. Many have been rescued, yet rescuers believe that five people are unaccounted for.

What Happened At The Silver Lake Nursing Home?

At 2.15pm is when the flames could be seen from the gas-related explosion. PECO confirmed that crew had started to respond around 2pm itself after they received reports of a gas odor. The explosion had occurred when the crew were on the scene.

“While crews were on site, an explosion occurred at the facility. PECO crews shut off natural gas and electric service to the facility to ensure the safety of first responders and local residents,” the utility said in a the statement.

State Rep. Tina Davis told the Associated Press. "I saw smoke and I saw car after car after car was a fire truck or ambulance from all over the city, from all over."

Davis says that there were talks of using a nearby school as a temporary evacuation area.

Also Read: Birthday Celebrations Gone Wrong When A Hydrogen Balloon Exploded, Leaving The 33-year-Old Birthday Girl With First And Second Degree Burns

How Are Burn Injuries Treated?

Burn injuries are first classified before the treatment. Their classification decides the treatment the burn will require. There are for classifications of burns:

First-degree or superficial burns: They only affect the outer layer of the skin or the epidermis. In these injuries, the burn site is red, painful, dry, and has no blisters.

Second-degree or partial thickness burns: They are only the burns of epidermis and part of the lower layer of the skin, the dermis. The burn site looks red and blistered and may be swollen and painful.

Third-degree or full thickness burns: Third-degree burns destroy the epidermis and dermis. They could also go to the innermost later of the skin, the subcutaneous tissue. The burn site could look white or blackened and charred.

Fourth-degree burns: They burn through both layers of the skin and underlying tissue as well as deeper tissue, and could possibly reach muscle and bone. There is no feeling in the area since the nerve endings are destroyed.

The right way to treat a burn depends on its depth and how much of the body it covers. While minor, superficial burns can be managed at home, deeper or larger burns may need medical attention. Keep these essential guidelines in mind:

Do's:

• Remove the source of the burn immediately – For example, take off clothing soaked in hot liquid to prevent further damage.
• Run cool water over the burn – This helps soothe the skin, except in cases of certain chemical burns.
• Keep the burn clean and protected – Cover it with a clean, non-stick bandage when possible.
• Seek medical help – If the burn is deeper than a superficial layer, larger than your hand, or full-thickness, see a doctor.

Don’ts:

• Use home remedies like bleach or butter – These can make the burn worse.
• Apply ointments or creams on deep burns – They can trap heat and worsen the injury.
• Put ice on the burn – It can cause more damage to the skin.
• Pop blisters – This increases the risk of infection.

Former Senator Ben Sasse shared on Tuesday that he has been diagnosed with Stage 4 pancreatic cancer. The former two-term senator, now 53, revealed in a long social media message that he learned about the illness last week. “This is a hard note to write, but since many of you have already sensed something, I’ll get straight to it: Last week I was diagnosed with metastasized, stage-four pancreatic cancer, and I am going to die,” Sasse wrote. He went on to describe advanced pancreatic cancer as “brutal” and called it a death sentence, adding that mortality is something everyone carries.

“I’m fortunate to have incredible siblings and half a dozen friends who are truly like brothers to me. As one of them said, ‘Yes, you’re on the clock, but all of us are.’ Death is a cruel thief, and none of us escape it,” he added.

The Nebraska Republican also wrote, “I’ll have more to share. I’m not giving up without a fight.”

Ben Sasse Diagnosed With Stage 4 Cancer

Former senator and former University of Florida president Ben Sasse announced on Tuesday, Dec. 23, that he has been diagnosed with terminal stage 4 cancer, as per CNN News.

In the deeply personal message, the former Republican lawmaker from Nebraska described the diagnosis as a “death sentence,” while expressing appreciation for the steady support of his family and close friends.

Ben Sasse: What Happens In Stage 4 Pancreatic Cancer?

Stage 4 pancreatic cancer, also known as metastatic pancreatic cancer, means the disease has spread beyond the pancreas to distant organs such as the liver, lungs, or the lining of the abdomen. At this advanced stage, the cancer is generally considered incurable, and care focuses on prolonging life and easing symptoms like pain, weight loss, and jaundice through palliative treatment, with the goal of preserving quality of life, as per Cleveland Clinic.

Stage 4 Pancreatic Cancer: How Do Pancreatic And Prostate Cancer Survival Rates Compare?

Pancreatic cancer has a far poorer survival outlook than prostate cancer, largely because it is usually detected late and has fewer effective treatment options. Most men diagnosed with prostate cancer that has not spread survive at least five years, while pancreatic cancer is often found at an advanced stage, where long-term survival is uncommon.

According to the American Cancer Society, pancreatic cancer makes up about 3 percent of all cancers in the United States but accounts for roughly 8 percent of cancer-related deaths. Most patients are diagnosed at Stage 4, and the disease is widely regarded as largely incurable. Prostate cancer, by contrast, is the second most common cancer among men, and the majority of those diagnosed do not die from it. The five-year relative survival rate for non-metastasized prostate cancer is 97.9 percent, dropping to about 38 percent once it spreads. These figures highlight how early detection and effective treatment options make prostate cancer far more survivable than pancreatic cancer.

Recent news has included diagnoses such as Ben Sasse’s terminal pancreatic cancer, as well as public figures like John Eimen, who died from prostate cancer. These cases draw attention to the difficulty of detecting pancreatic cancer early, since there are few reliable screening tools before symptoms appear. Prostate cancer, in contrast, often progresses slowly, and with regular screening and multiple treatment options, many men live for decades after diagnosis.

Ben Sasse: What Treatment Options Is Ben Sasse Pursuing For Stage-Four Pancreatic Cancer?

While treatments including chemotherapy, radiation, and in rare situations surgery are available, stage-four pancreatic cancer is still considered largely incurable. The absence of effective early screening contributes to delayed diagnosis, and although a small number of patients, such as Ruth Bader Ginsburg, have lived longer following surgery, these cases are rare. Well-known individuals including Alex Trebek and Aretha Franklin also battled the disease, which remains one of the deadliest cancers in the United States.

Union Minister of State (Independent Charge) for Science and Technology and Earth Sciences, along with responsibilities in the PMO, Personnel, Public Grievances, Pensions, Atomic Energy, and Space, Dr Jitendra Singh on Tuesday called for careful and evidence-led use of anti-obesity and weight-reduction medicines. He stressed that these drugs should be prescribed thoughtfully and not treated as routine or easy solutions.

Addressing the inaugural session of the Asia Oceania Conference on Obesity (AOCO), the minister said obesity is a complex, long-term condition that tends to recur and cannot be managed through isolated medical treatment alone. Instead, he said, it needs a wider response involving society at large.

At the same event, Dr Singh also launched the National Obesity Registry, describing it as an important step towards strengthening India’s obesity research framework. The initiative aims to support structured data collection, generate reliable evidence, and guide long-term policymaking in the area.

What Is National Obesity Registry?

During the conference, Dr Jitendra Singh formally unveiled the AIAARO Obesity Registry, calling it a major move to strengthen India’s research ecosystem. The registry will focus on systematic data collection, long-term follow-up, and evidence-based policymaking. It is expected to help improve clinical understanding of obesity and support the development of national strategies for its management.

India’s National Obesity Registry (NOR), launched in December 2025, is designed to create a strong and reliable data base on obesity trends across the country. This data will support public health policies, research efforts, and targeted interventions to address the growing obesity burden. The initiative is particularly significant for India, given its unique challenges related to metabolic obesity and its strong links with non-communicable diseases.

While launching the registry, Dr Singh also highlighted the strong focus placed by Prime Minister Narendra Modi on tackling lifestyle-related illnesses. He noted that the Prime Minister has repeatedly spoken about obesity on national platforms, reflecting a clear shift towards preventive healthcare. This approach, he said, is supported by initiatives such as FIT India, Khelo India, and programmes that encourage small but lasting behavioural changes.

Obesity Cannot Be Treated with Shortcuts: Dr Jitendra Singh

The minister warned against the increasing commercialisation of obesity treatment and the spread of misinformation in this space. Referring to a PIB release, he said unscientific claims and so-called quick solutions often mislead people and divert attention from treatments backed by medical evidence.

India has seen a growing use of injectable obesity treatments such as Wegovy and Poviztra, both based on semaglutide, and Yurpeak, which uses tirzepatide. These once-weekly injections work by mimicking gut hormones that help regulate appetite and are marketed by companies like Novo Nordisk and Eli Lilly. However, doctors caution that these drugs are not miracle solutions and must be combined with proper diet and physical activity. There are also concerns about their overuse at a time when obesity rates continue to rise.

India And Obesity

According to the World Health Organisation, obesity was linked to 3.7 million deaths globally in 2024. If strong action is not taken, the number of people living with obesity is expected to double by 2030. Recently, the WHO released its first-ever guideline on the use of Glucagon-Like Peptide-1, or GLP-1, therapies for managing obesity as a chronic and relapsing condition.

“Obesity is a major global health challenge that WHO is committed to addressing by supporting countries and people worldwide to control it effectively and equitably. Our new guidance recognises that obesity is a chronic disease that can be treated with comprehensive and lifelong care,” said WHO Director-General Dr Tedros Adhanom Ghebreyesus.