Health and Me

Ishita Srivastava

Spanish Scientists Find Breakthrough Cure For Pancreatic Cancer

In a breakthrough study, a group of Spanish researchers have created a drug-based cure that can kill pancreatic <a href="https://www.healthandme.com/health/cancer">cancer</a> tumors in the body and eliminate the disease completely.

A study from the Spanish National Cancer Research Centre (CNIO) found that a combination of three drugs, known as CNIO therapy, can shut down multiple tumor survival mechanisms at the same time, preventing the cells from the rewiring themselves and defeating the treatment

Led by renowned cancer biologist Dr Mariano Barbacid, the authors wrote of the results: 'These studies open a way to design new combination therapies that can improve the survival of patients with pancreatic ductal adenocarcinoma. These results set the direction for the development of new clinical trials."

To overcome cancer's ability to block the effects of singular therapy drugs, Dr Barbacid’s team attempted attacking the cancerous tumors from three directions together.

The first drug, daraxonrasib, blocked the main KRAS signal that drives tumor growth while the second drug, afatinib, shut down EGFR and HER2, both pathways that cancer cells often use to escape KRAS-targeted treatment.

The third drug, SD36, stopped the functioning of bSTAT3, a backup system that helps cancer cells survive stress and resist therapy.

In the mice study, when scientists combined and used all three drugs together in the rodents, they saw the pancreatic tumours shrank completely and did not return, even more than 200 days after treatment stopped.

The same effect was seen in genetically engineered mouse models and in tumors taken from human patients that were grown in a laboratory. The animals who underwent CNIO therapy did not show serious side effects, suggesting the combination could be safe enough to test in humans.

Despite promising results, the authors advised caution and noted: ""We are not yet in a position to carry out clinical trials with triple therapy. The authors themselves warn that optimising this combination for patients will be a complex process, although they are confident that the finding will set the course for future trials."

<h2>Pancreatic Cancer: All You Need To Know</h2>Pancreatic cancer typically begins in the ducts of the organ and can rapidly spread from there to the rest of the organ. Early-stage pancreatic tumors do not show up on imaging tests, making this version of the disease difficult to diagnose until it infects other organs.

While there are no clear signs of early pancreatic cancer, symptoms begin to show once the disease reaches the digestive system. Some of these include: 

<ul><li>Jaundice (yellowing of your skin).</li><li>Dark urine</li><li>Light-colored stool</li><li>Upper abdominal pain</li><li>Middle back pain</li><li>Fatigue</li><li>Itchy skin</li><li>Nausea and vomiting</li><li>Gas or bloating</li><li>Lack of appetite</li><li>Blood clots</li><li>Weight loss</li><li>New-onset diabetes</li></ul>Many people report that their first pancreatic cancer symptoms were back pain or stomach pain. These symptoms can come and go at first, but may get worsen after meals or when you lie down.

Certain prominent risk factors include smoking cigarettes, cigars and using other forms of tobacco; obesity; Type 2 diabetes and genetic factors. 

Pancreatic cancer is also resistant to many common cancer drugs and it notoriously difficult to treat, making this discovery exceptionally important in the search for a permanent cure. 

About 22,000 new cases of pancreatic cancer are estimated to occur annually in India out of which nearly 13,000 die from the cause, making it the 24th most common cancer in India.

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In a breakthrough study, a group of Spanish researchers have created a drug-based cure that can kill pancreatic cancer tumors in the body and eliminate the disease completely. A study from the Spanish National Cancer Research Centre (CNIO) found that a combination of three drugs, known as CNIO therapy, can shut down multiple tumor survival mechanisms at the same time, preventing the cells from the rewiring themselves and defeating the treatmentLed by renowned cancer biologist Dr Mariano Barbacid, the authors wrote of the results: 'These studies open a way to design new combination therapies that can improve the survival of patients with pancreatic ductal adenocarcinoma. These results set the direction for the development of new clinical trials."How Does The Drug Work?To overcome cancer's ability to block the effects of singular therapy drugs, Dr Barbacid’s team attempted attacking the cancerous tumors from three directions together.The first drug, daraxonrasib, blocked the main KRAS signal that drives tumor growth while the second drug, afatinib, shut down EGFR and HER2, both pathways that cancer cells often use to escape KRAS-targeted treatment. The third drug, SD36, stopped the functioning of bSTAT3, a backup system that helps cancer cells survive stress and resist therapy.In the mice study, when scientists combined and used all three drugs together in the rodents, they saw the pancreatic tumours shrank completely and did not return, even more than 200 days after treatment stopped.The same effect was seen in genetically engineered mouse models and in tumors taken from human patients that were grown in a laboratory. The animals who underwent CNIO therapy did not show serious side effects, suggesting the combination could be safe enough to test in humans. Despite promising results, the authors advised caution and noted: ""We are not yet in a position to carry out clinical trials with triple therapy. The authors themselves warn that optimising this combination for patients will be a complex process, although they are confident that the finding will set the course for future trials."Pancreatic Cancer: All You Need To KnowPancreatic cancer typically begins in the ducts of the organ and can rapidly spread from there to the rest of the organ. Early-stage pancreatic tumors do not show up on imaging tests, making this version of the disease difficult to diagnose until it infects other organs. While there are no clear signs of early pancreatic cancer, symptoms begin to show once the disease reaches the digestive system. Some of these include: Jaundice (yellowing of your skin).Dark urineLight-colored stoolUpper abdominal painMiddle back painFatigueItchy skinNausea and vomitingGas or bloatingLack of appetiteBlood clotsWeight lossNew-onset diabetesMany people report that their first pancreatic cancer symptoms were back pain or stomach pain. These symptoms can come and go at first, but may get worsen after meals or when you lie down.Certain prominent risk factors include smoking cigarettes, cigars and using other forms of tobacco; obesity; Type 2 diabetes and genetic factors. Pancreatic cancer is also resistant to many common cancer drugs and it notoriously difficult to treat, making this discovery exceptionally important in the search for a permanent cure.  About 22,000 new cases of pancreatic cancer are estimated to occur annually in India out of which nearly 13,000 die from the cause, making it the 24th most common cancer in India.