Jack Georgakis was in his mid-thirties when he was diagnosed with gastroesophageal junction (GEJ) cancer. Troubles for the hardy New Yorker, who had an active lifestyle that included hobbies such as car racing, riding motorcycles, and working out in the gym, began when he had difficulty swallowing and was initially misdiagnosed. However, he was correctly diagnosed later, and his doctors chose a newer treatment regimen, setting him on the path to recovery.

Gastric and oesophageal cancers are among the most aggressive cancers, representing the fifth most common cancer worldwide, with 1.7 million new patients diagnosed in 2022.

They are also the fifth highest leading cause of cancer mortality, with approximately 1.2 million deaths expected globally in 2025Traditionally, they are treated with chemotherapy before and after surgery. However, they frequently recur, leaving patients and their families in despair. A trial, whose findings were published in 2025, found that adding immunotherapy to the standard treatment regimen significantly improved survival. Jack is one patient who has undergone this innovative treatment and is a living example of its effectiveness. This new approach can fundamentally alter how these cancers are treated and potentially save millions of lives.

What are gastric and oesophageal cancers?

Gastric cancer, or stomach cancer, occurs when the cells in the lining of the stomach grow abnormally. These cells form a tumour which may spread to other organs, including the lungs and liver. What makes this cancer challenging is that the symptoms only appear in advanced stages, reduces chances of survival.

Oesophageal cancer begins on the lining of the oesophagus, which is a tube that transports food and liquids from the mouth to the stomach. Tumours usually begin on the innermost layer of this tube and can spread to the lymph nodes or other organs. Just like gastric cancer, early-stage oesophageal cancer has no warning signs, and it is diagnosed only after it has spread.

New study yields promising results

The groundbreaking clinical trial was led by Dr. Yelena Janjigian, Chief of Gastrointestinal Medical Oncology at Memorial Sloan Kettering Cancer Center (MSK).

The trial was conducted at 147 study centers across 20 countries worldwide, demonstrating the global commitment to advancing treatment for these aggressive cancers.

As per studies, the recurrence rate of stomach cancer is between 14% and 60%.

For oesophageal cancer, this rate is between 36% and 52% post-surgery.iv The new study found that the risk of recurrence was drastically reduced when immunotherapy was included as a part of standard therapy.

Immunotherapy trains the body’s immune system to recognise and destroy cancer cells. This trial used an immunotherapy drug called durvalumab, which is a checkpoint inhibitor. It works by exposing cancer cells, making it easier for the immune system to detect them. Out of the 948 patients in the trial, half received the usual regimen along with immunotherapy, and the rest received standard therapy alone.

After two years, 67.4% of the first group did not see a recurrence as compared to 58.5% of the second group. group. Furthermore, the risk of serious side effects from chemotherapy and immunotherapy was relatively low, and no new safety concerns were identified. This treatment did not compromise the patients’ chances for surgery either.

Aggressive cancers are daunting for patients, their families, and healthcare professionals. However, this newer method of treatment for gastric and oesophageal cancer is a clear sign that the tide is turning. The integration of immunotherapy into standard treatment has opened a world of possibilities. As more findings emerge, newer approaches like this can become the new standards for treatment, paving the way for more effective and personalised care.

We often associate stress with dramatic breakdowns, overwhelming work, or emotional turmoil. But what if the real danger lies in the tiny, everyday pressures we don’t even notice building up?

What Is Microstress and Why It Matters

“Stress is the most notorious yet underplayed disease,” says Alma Chopra, motivational speaker, disability rights activist and life coach. “It’s often thought of as an emotional onslaught that makes it difficult to function. But stress isn't just limited to our emotions; we can also become physically stressed from a chronic illness or an injury.”

Alma explains that microstresses are small, fleeting moments of stress that sneak into our daily routines. “Sometimes it creeps up through daily pressures until we hit our melting point. These are called microstresses,” she shares. These could include running late for a meeting or scrolling social media right after waking up. They may feel harmless in the moment but layer up to become chronic stress over time.

How Microstresses Mess With You

“These reactions feel minor and temporary, so they're quickly replaced by the next task or eased by a smiling face or a piece of cake,” says Alma. But the danger lies in how these minor stressors build up over time. “We tend to ignore these micro-stresses, but over time, they build low-level tension that will affect your sleep, focus, mood and health.”

Alma lists common microstressors and their effects:

• Alarm: “Jerks the body into a sudden state of alertness, disrupting natural rest.”
• Checking work email: “Doing this first thing in the morning puts us into a state of panic and anxiety.”
• Scrolling social media: “Overstimulates the brain and drains mental focus.”
• Confrontations: “Force us to deal with discomfort we’re not emotionally prepared for.”
• Unfinished tasks: “Juggling a long list without breaks builds pressure and leads to burnout.”
• Bruising your knee: “Even minor damage to the bone or soft tissue creates physical stress in the body.”

Alma advises recognising patterns and creating little routines to manage stress before it spirals. “Begin by recognising patterns, checking what drains you and creating little routines to relieve stress,” she says. “Start taking short breaks, creating boundaries and incorporating rejuvenating practices into your day.”

When Lifestyle Fuels Microstress

Sukirti Midha, spiritual wellness coach and founder of Sukh Yog, points out that microstress is a lifestyle issue. “Micro stress, as the name suggests, is small things we face as a working person or a householder. No gender age or designation we are discussing here; it’s the same for all,” she says.

According to Sukirti, “It’s in our lifestyle now; still, we are not aware of it.” She adds that people often don’t even feel it building up. “Do you think it happens overnight? No, nothing happens overnight except the sun comes out,” she jokes, adding a serious note that many people today don’t even see the sunrise, contributing to deficiencies like vitamin D.

Sukirti points out how society’s pressure to look good and maintain appearances feeds microstress. “When one gets conscious about looks, which include not only clothes but also touch-ups, make-up and hair. It’s not social pressure but created by us only.” She questions why people rely on external validation to feel good. “Why is it always important to look good to feel good?”

She also flags social media’s impact. “Many social media applications have filters to make you feel more beautiful and younger, which gives you plenty of stress when we look back in a basic mirror.” Comparing ourselves to others’ curated lives triggers a subtle but ongoing sense of inadequacy.

“Maintaining a status is a pressure these days,” she says. “Always remember as we shift from past to present or future to present, we learn happiness is about you & not the things or society status.”

The Simple Way Out

Both experts agree that while microstress can’t always be avoided, we can manage it better by slowing down, drawing boundaries and valuing simplicity. As Sukirti says, “Staying away from microstress isn’t easy, but preferring solace is an easy way out.”

If you have ever colour-coded your wardrobe, wiped the kitchen slabs repeatedly just because a speck of dust exists, or straightened a slightly off-centre painting on the wall, someone has probably laughed and said, I am so OCD too. But the thing is that you are probably not. And neither are they.

Somewhere along the way, we all misunderstood Obsessive Compulsive Disorder (OCD), a serious mental health condition, and casually said it. OCD has become shorthand for being neat, organised, or a lover of clean aesthetics. But as mental health professionals and those who actually live with OCD will tell you, that stereotype could not be further from the truth.

OCD is a clinically diagnosed anxiety disorder. It is not just about being extra clean or a control freak. It involves a cycle of obsessions, which are intrusive, unwanted thoughts and compulsions, which are repetitive behaviours or mental acts done to try to neutralise those thoughts.

Imagine being haunted by a constant fear that your loved one will die unless you tap the light switch exactly five times. Or being plagued by the thought that you have hit someone with your car, even though there is no evidence of it happening, and then going back to the same stretch of road again and again to check. That is the lived reality of OCD. It is not cute, it is not fun, and it definitely does not feel satisfying or neat.

The Cleanliness Myth

Yes, some people with OCD have cleanliness-related compulsions. But not everyone with OCD is a neat freak, and not all neat freaks have OCD. The need to wash your hands repeatedly until they are raw is not about loving cleanliness; it is about desperately trying to get rid of a feeling that something is terribly wrong. Often, the compulsion is not even rationally linked to the obsession. It is about trying to regain control over overwhelming anxiety, even if only temporarily.

In fact, OCD themes can be disturbingly varied, from fears of harming others to taboo thoughts to symmetry to morality. The common thing is that the thoughts are distressing, the anxiety is debilitating, and the rituals are exhausting.

Why It is Harmful To Mislabel Yourself As “OCD”

Calling yourself “OCD” because you like your stuff arranged by colour might seem harmless. But this kind of throwaway comment does a real disservice to people living with the actual condition. It trivialises their experiences and contributes to misinformation.

It also prevents those who might truly be struggling with OCD from recognising their symptoms and seeking help. Because if society keeps painting OCD as a personality problem, why would anyone think it is a serious problem?

What OCD Actually Feels Like

Ask anyone with OCD, and they will tell you it is not fun. It is not satisfying to double-check the lock for the 17th time. It is not enjoyable to feel like you are going to vomit because of a thought you did not ask for and cannot get rid of. It is a relentless loop of “what ifs” and “just in cases” that can take over your entire life.

OCD can interfere with relationships, work, sleep, and basic daily functioning. It is often accompanied by shame and secrecy because people worry others would not understand, or worse, will think they are dangerous or irrational.

Time To Rethink The Label

You might just be tidy. Or meticulous. Or even perfectionistic. And that is fine. But OCD? That is a diagnosis. A tough, often debilitating one that deserves respect. If you think you might actually have OCD, then help is available. Cognitive Behavioural Therapy (CBT), particularly Exposure and Response Prevention (ERP), has been proven to be effective. But it starts with understanding what OCD really is.

In vitro fertilisation (IVF) is not just about science, syringes and success rates. What lies behind the walls of fertility clinics is a deeply personal journey filled with hope, heartbreak and resilience, making it more than just a medical procedure. Beyond the social taboos, infertility brings huge stress to the patients. And while IVF offers hope, it does not come easy. It is a rollercoaster ride that patients experience as they take on the road to this procedure; highs and lows can take a severe mental toll on them.

However, for those unversed, infertility has been classified by the World Health Organisation as a disease like diabetes or hypertension; the social taboo around it still persists. Over the years, advancements in reproductive science have made IVF treatments more patient-friendly and significantly improved outcomes. Yet, the focus often leans heavily on science, expertise and clinic proficiency, while the mental and emotional toll on the couple is overlooked.

For many, the psychological impact of IVF can match that of the death of a family member or going through a divorce. Although many people find IVF very stressful, every patient experiences it differently. Personalities and life experiences play a big role in determining how one handles the process and what part of IVF they find most difficult.

Why Is IVF So Emotionally Draining?

We ask an expert to break down several key factors that contribute to the immense stress IVF brings:

• Uncertainty of Outcomes

• Physical Strain

• Societal Pressure

• Guilt and Shame

• Depression After Failed Attempts

• Relationship Strain

Learning to Cope with Support Systems That Help

There is light at the end of the tunnel, and as Dr Saple says, there are several strategies that can help couples better cope with the IVF process.

• Psychological Counselling

• Support Groups

• Mind–Body Practices

Setting Realistic Expectations

“IVF may take more than one cycle to succeed,” she explains. Being mentally prepared for the outcome, while knowing you have done your best, helps couples accept results with resilience.

It is Okay to Ask for Help

As Dr Saple reminds us, mental and emotional health are as important as physical health during IVF. Prioritising emotional wellbeing not only makes the journey more bearable but can also improve the overall outcome. “Seeking help is a sign of strength, not weakness,” she says.