People using injectable weight loss drugs may need long-term medical and lifestyle support, researchers have warned, after a large study found that weight is regained far more quickly than with traditional diet and exercise plans. Scientists at the University of Oxford found that people taking medications such as semaglutide (Wegovy) and tirzepatide (Mounjaro) lose weight while on treatment, but typically regain it within around 20 months after stopping the injections.

The study also showed that improvements in blood sugar control, cholesterol levels, and blood pressure fade once the drugs are discontinued, leaving patients back at their original health markers. By comparison, people who lose weight through structured diet and exercise programmes tend to maintain the loss for longer, close to four years on average, although most eventually regain weight as well.

Health Gains Reverse After Treatment Ends

The findings come alongside separate research from University College London and the University of Cambridge, which suggests that people prescribed newer weight loss drugs could face risks such as nutrient deficiencies and loss of muscle mass. Under current NHS rules, Wegovy can only be prescribed for up to two years, while Mounjaro has no set time limit.

Most people using these medications pay for them privately, due to strict NHS eligibility criteria. Research indicates that around half stop treatment, often because of cost, side effects, or because they feel they have reached their target weight.

The Oxford analysis, published in the British Medical Journal, reviewed 37 studies involving more than 9,000 participants. On average, people stayed on medication for 10 months and were followed up for eight months after treatment ended.

Across all weight loss drugs, participants lost an average of 8.3 kg during treatment, but regained 4.8 kg within a year, returning to their starting weight within about 1.7 years. Those taking Wegovy or Mounjaro lost nearly 15 kg, but regained around 10 kg in the first year after stopping. Based on projections from one year of data, full weight regain occurred within roughly 1.5 years. Measures linked to heart and metabolic health, including blood glucose and cholesterol, also returned to baseline within about 1.4 years.

Experts Say Obesity Requires Ongoing Care

Professor Susan Jebb, professor of diet and population health at the University of Oxford and an adviser to ministers and the NHS on obesity, said the findings were clear. “What we’ve shown is that weight regain after medication is common and happens quickly. The benefits for blood sugar and cholesterol closely track weight changes, so when weight comes back, those benefits disappear too.”

She noted that weight regained after medication happens almost four times faster than after behaviour-based programmes, regardless of how much weight was initially lost. Professor Jebb said long-term solutions may be necessary, whether through ongoing medication, behavioural support, or a combination of both.

“Obesity is a chronic, relapsing condition,” she said. “It’s reasonable to expect that treatment may need to continue for life, much like medicines for high blood pressure. We should think of this as long-term treatment for a long-term condition.”

She added that combining diet and exercise programmes with drug treatment helps people lose more weight initially. However, once medication stops and appetite returns, those strategies alone often fail to prevent regain. In contrast, people in behavioural programmes without drugs may practice these habits more consistently, which could explain why weight regain is slower.

Professor Jebb said it is clear that some form of ongoing intervention is needed if the benefits of weight loss drugs are to last. Some patients try tapering doses or using medication intermittently, while others rely on lifestyle support alone, but she said evidence on what works best remains limited.

Sam West, a postdoctoral researcher at the University of Oxford and co-author of the study, said: “People on medication lose more weight than those in behavioural programmes, but they regain it about four times faster.”

The researchers also questioned whether long-term drug treatment is cost-effective for the NHS. They concluded that since obesity is a long-term, relapsing condition, extended use of weight management medications may be needed to maintain health benefits.

Concerns Over Nutrition and Muscle Loss

Separate findings published in Obesity Reviews highlighted gaps in nutritional guidance for people taking semaglutide and tirzepatide. Dr Marie Spreckley from the University of Cambridge said many patients receive little structured advice on diet quality, protein intake, or micronutrient needs, despite significant appetite suppression.

“If nutritional care isn’t built into treatment,” she said, “there’s a real risk of trading one health problem for another, through avoidable nutrient deficiencies and unnecessary muscle loss.”

An NHS spokesperson said that while these drugs are a valuable addition to weight loss treatment, they are not a quick fix. “They must be combined with lifestyle and behavioural support, including advice on healthy eating and physical activity, to help people maintain weight loss over time,” the spokesperson said.

New health data has prompted the NHS to once again encourage certain groups to get their flu vaccination. Recent figures from NHS England show that cases of winter viruses are climbing again.

For example, as per Mirror, hospital admissions due to flu have risen by 9% over the past two weeks, after the previous fortnight had suggested a decline in cases. At the same time, daily numbers of patients admitted with norovirus and Covid have increased compared with the previous week.

Despite these rising cases, the NHS confirmed that it has administered over 18.6 million flu vaccines this winter, an increase of more than half a million compared with the same period last year. With the surge in winter viruses putting extra strain on hospitals and ambulance services, the NHS emphasised that thousands of flu vaccination appointments are still available.

NHS Issues New Flu Jab Alert

Posting on X, the NHS said: "Flu can be serious, especially for older people and those at higher risk. Millions have already been vaccinated this season, and there are still thousands of appointments available.

"If you're eligible, it’s not too late to get yours." Many people, particularly those in vulnerable groups, may qualify for a free flu vaccine.

Who Is Eligible For The Free Flu Jab?

According to NHS guidance, there are six main categories of people eligible for a free flu jab. You might qualify if you need additional protection or if someone in your household does.

This includes people who:

• Are pregnant
• Have certain long-term health conditions
• Live in a care home
• Are aged 65 or over, or will turn 65 by March 31, 2026
• Are the main carer for an older or disabled person, or receive a carer's allowance
• Live with someone with a weakened immune system (for example, someone undergoing chemotherapy)

NHS national medical director Professor Meghana Pandit said: "It’s clear that the worst is far from over for the NHS this winter. Hospitals have seen another rise in admissions from flu and other respiratory viruses last week. The cold weather is also contributing to an increase in vulnerable patients visiting A&E with respiratory issues and more injuries from slips and falls due to icy conditions, so it remains an extremely busy period."

How To Get The Flu Vaccine For Free?

If you qualify for a free flu jab, there are several ways to access it. As per Mirror, you can call your GP surgery directly to book an appointment, or arrange one at a pharmacy either online or through the NHS app, as long as you are 18 or older.

Some pharmacies also offer the NHS vaccine at no cost and accept walk-ins without prior booking. This service isn’t available at every pharmacy, but you can locate the nearest pharmacy offering the complimentary vaccine here.

Itchy skin is something most of us deal with occasionally, and in many cases, it is harmless. Everyday triggers such as rough clothing, insect bites, or dry winter air can all leave the skin irritated. Itching is also commonly linked to skin conditions like eczema or psoriasis.

That said, an oncologist has pointed out that persistent itching can, in some cases, be linked to certain cancers. In a TikTok video, Dr Amit Garg, a cancer specialist based in California, explained that itching can appear as a symptom in four specific types of cancer. While itching alone is not usually a cause for concern, it may become more meaningful when it occurs alongside other symptoms that should be checked by a GP.

1. Hodgkin Lymphoma

Hodgkin lymphoma is a relatively rare cancer that affects lymphocytes, the white blood cells that help the body fight infection. Dr Garg explained that this cancer can cause “severe, widespread itching,” which often becomes worse at night. The NHS also lists itchy skin as a possible symptom, along with:

• A painless lump or swelling, usually in the neck, armpit, or groin, which is the most common sign
• Pain in the glands of the neck, armpit, or groin after drinking alcohol
• A high temperature
• Night sweats
• Shortness of breath
• Sudden, unexplained weight loss

The NHS advises seeing a GP if you notice any of these symptoms. Although they are common and do not always point to Hodgkin lymphoma, it is important to rule it out. Early diagnosis improves the chances of successful treatment, so symptoms should not be ignored.

2. Polycythemia Vera

Polycythemia vera is a rare, slow-developing blood cancer. According to the NHS, it is most often caused by a change in the JAK2 gene, which leads the bone marrow to produce too many red blood cells. An increased concentration of red blood cells is known as erythrocytosis, although having this condition does not automatically mean cancer.

One symptom of erythrocytosis can be itchy skin, particularly after bathing or showering. You should speak to a GP if symptoms persist. Other signs may include:

• Headaches
• Blurred vision
• Reddened skin, especially on the face, hands, and feet
• Tiredness
• High blood pressure
• Dizziness
• Discomfort in the abdomen
• Confusion
• Bleeding issues such as nosebleeds or bruising
• Gout, which can cause joint pain, stiffness, and swelling

3. Gallbladder And Pancreatic Cancer

Gallbladder cancer and pancreatic cancer often share similar symptoms. These can include a reduced appetite, unintentional weight loss, fever, nausea, and changes in bowel habits such as diarrhoea or constipation.

Dr Garg explained that both cancers can cause “intense itching,” which happens when bile salts build up under the skin. The NHS also lists itching as a symptom for both conditions, noting it may occur alongside darker urine, paler stools, and jaundice, which can cause yellowing of the skin or the whites of the eyes.

One key difference between the two cancers is the type of pain experienced. Gallbladder cancer may cause a dull ache on the right side of the abdomen, while pancreatic cancer more commonly causes pain in the upper abdomen and back, which can worsen after eating or when lying down.

In both cases, you should see a GP if symptoms last longer than two weeks or if you have lost weight without trying. You should call 111 if vomiting lasts more than two days, diarrhoea continues for more than seven days, or if your skin turns yellow.

4. Cutaneous T-cell Lymphoma

Cutaneous T-cell lymphoma is a form of skin lymphoma and a rare type of non-Hodgkin lymphoma. It begins in the T cells of the skin and often appears as flat, red patches that may be itchy.

In its early stages, these patches can resemble common skin conditions such as eczema or psoriasis. Seeing a GP is important if symptoms develop, as they can assess whether it is a common skin issue or something more serious.

Cancer Research UK states that around 150 people in the UK are diagnosed with cutaneous T-cell lymphoma each year, making it a rare cancer. As with many cancers, early diagnosis can play a key role in improving treatment outcomes.

A GP has advised women to make three simple health checks part of their monthly routine, saying the start of the month can act as a helpful prompt to stay consistent. The advice comes from Dr Carys Sonnenberg, an NHS women’s health GP and the founder of the Rowena Health Menopause Clinic. Speaking to her large audience on TikTok through her account @Rowenahealth_menopause, the doctor, author, and public speaker suggested setting aside the first day of every month for these routine checks.

Even if the date has already passed this month, she noted it can still serve as a timely nudge for those who have not yet done them, and a useful habit to follow going forward.

Three Health Checks Doctor Recommends

In her video, Dr Carys explained to viewers: “It’s the first of the month, so it’s a really good day to do your chest check, to do your vulva check, and also to examine any moles that you have on your body, not forgetting your head.” She added that becoming familiar with your own body is key. “When you’re checking yourself, it really helps to understand what’s normal for you. I’m Dr Carys Sonnenberg.

“I’m a GP and a menopause specialist. There is some excellent guidance online that shows you how to check your chest properly, what changes to be mindful of, and which symptoms should be discussed with your GP.

How To Do Health Checks Properly

“For the rest of your body, you’ll need a mirror. You might also want someone to help check areas you cannot easily see, such as your back, in case there are skin moles that look different or have changed. Don’t forget to part your hair and look at your scalp as well, in case there’s anything unusual that needs attention. I hope that’s helpful.”

Breast Changes To Watch For

Health experts stress the importance of staying alert to changes in your breasts or chest that could signal a problem. Making monthly checks a habit is a simple way to stay aware, while also remembering that some changes can occur naturally, such as during different phases of your menstrual cycle.

Possible signs of breast cancer can include:

• Skin changes like puckering or dimpling
• An unusual lump or swelling in the armpit or near the collarbone
• New lumps or areas of thickened tissue
• Fluid leaking from the nipple
• Crusting or a rash on or around the nipple
• A nipple that turns inward or changes direction
• A sudden change in breast size or shape
• Ongoing, unexplained pain in the breast, chest, or armpit

Secondary symptoms may include trouble sleeping, feeling generally unwell or sick, a loss of appetite, unexpected weight loss, and ongoing tiredness or low energy. While these signs do not always point to breast cancer, doctors advise contacting your GP if you notice anything unusual. Always speak to your GP if you have concerns about your health.