As the global temperatures continue to rise and extreme heatwaves become the new normal, the attention turns to a unexpected but critical health factor: how your prescription medications might be making the summer heat even more intolerable. While everyone knows to drink plenty of water and steer clear of the outdoors during the hottest part of the day, few recognize that prescriptions might be combating their body's cooling mechanisms.For millions, dealing with the heat is more than a comfort issue—it's a health emergency, particularly for those on certain prescription medications. While dehydration, shade, and sunscreen are important, a lesser-known risk is from the medicine cabinet. Many medications regularly prescribed to millions of Americans can disrupt the body's natural cooling system, making it more difficult to cool down and heighten the risk of heat illnessMillions of Americans, especially those experiencing scorching heat domes in the eastern U.S., are more susceptible to heat illnesses. For those on medications that disrupt thermoregulation, the risks are even greater.How the Body Regulates Heat?The human body depends on a number of sensitive mechanisms to keep its internal temperature within a safe range. Sweating, blood flow to the skin, and sensitive fluid balance all dissipate heat. But certain drugs interfere with these mechanisms by changing the production of sweat, the way the blood circulates, or thirst and fluid retention. The consequence: a higher risk of overheating, dehydration, and potentially life-threatening heatstroke.How Medication Undermines Body's Ability to Withstand Heat?Below are five popular types of medications that disrupt your heat tolerance, and how you can get around them.1. AntidepressantsAntidepressants, especially selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs), are the most widely used medicines globally. Antidepressants act by modulating neurotransmitter levels in the brain, primarily serotonin and noradrenaline. They do affect other systems that regulate body temperature as well.TCAs, for instance, can block acetylcholine, a neurotransmitter essential to sweating. This can result in diminished sweat, and the body is less able to cool itself on warm days. Ironically, both SSRIs and TCAs have the opposite effect on some users as well—up to 14% report this side effect—and stimulate sweat glands through excessive noradrenaline. This excessive sweating can contribute to dehydration if fluids aren't replenished.In addition, SSRIs can interfere with the hypothalamus, the thermostat of the brain, and cause the signal to initiate sweating to be interrupted. Any disruption in sweating—either too much or too little—will make the body less able to deal with heat, increasing the danger of heat exhaustion or heatstroke.2. AntipsychoticsAntipsychotic medication, prescribed to patients with schizophrenia and bipolar disorder, can also increase the danger of summer heat. They block dopamine, which has a side effect of impacting serotonin and interfering with the hypothalamus's function of detecting and responding to changes in temperature.Individuals on antipsychotics can be as non-heated and non-thirsty as possible when their bodies are under pressure. This can cause plummeting blood pressure and impaired cardiac function. The body adapts by vasoconstricting and holding onto heat, further diminishing the sweat and cooling capacity. Most antipsychotics are also anticholinergic, inhibiting acetylcholine and making sweating even more difficult.3. Heart DrugsCardiovascular medications are another important category that can disrupt heat tolerance. Beta blockers, used in heart failure and arrhythmias, slow the heartbeat and decrease the strength of heart contractions. Although effective for heart disease, these actions can restrict blood flow to the skin, lessening the body's ability to dissipate heat.Diuretics, which are often prescribed to manage high blood pressure and heart failure, boost urine production and lead to dehydration and electrolyte imbalances—both of which make it more difficult to sweat effectively. Other medications for high blood pressure, including ramipril and losartan, can suppress the body's natural thirst drive by interfering with the body's fluid balance mechanism, increasing the risk for dehydration in hot weather.4. StimulantsStimulant drugs like amphetamines used for ADHD can raise body temperature, enhance metabolism, and distort patterns of sweat. These medications target dopamine and noradrenaline, which can make cooling down more difficult, particularly after physical exertion or in hot weather. Stimulants can also suppress feelings of fatigue, leading people to overwork without perceiving the risk.Interestingly, some studies indicate that individuals with ADHD who use stimulants can have a reduced risk for heat-related illness, perhaps as a function of reduced body weight or improved hydration practices. More research is necessary to verify this effect.5. Insulin and Diabetes MedicationsFor individuals with diabetes, control of blood sugar during heat is tough. High temperatures dilate blood vessels, enhancing blood flow and accelerating the absorption of insulin. This may result in hypoglycemia (low blood sugar), with signs such as dizziness, perspiration, irritability, and even loss of consciousness or seizures.Heat can also destroy insulin, reducing its effectiveness or rendering it dangerous. Insulin must be refrigerated until the time of use, and any alteration in color or cloudiness means it must be thrown away. Other diabetes medications, including sulfonylureas, may also predispose patients to sun sensitivity and dehydration.How Are Medications and Sun Sensitivity Linked?Aside from thermoregulation, various drugs heighten sensitivity to the sun. Antibiotics, antihistamines, oral contraceptives, and diabetes medications such as insulin may all augment the risk of heat reaction and sunburn. Always look for warnings regarding exposure to the sun on drug labels and take special precautions such as sunscreen and shade.Outside of these five major categories, a number of other medications can make it more difficult to deal with the heat. Antibiotics, antihistamines, antifungals, and certain cholesterol-lowering statins all can raise sun sensitivity, increasing risk of sunburn or rash. Oral contraceptives and hormone therapies might also be expected to do the same. Tip to Cope and Stay Cool This SummerIf you are on one of these medications, you do not have to endure summer. Begin by talking to your healthcare professional to learn your individual risk factors. Do not stop any prescribed drug without discussing with a doctor. Some major coping mechanisms include:Stay well hydrated unless otherwise instructed by your physician.Keep medications such as insulin and inhalers in a proper condition to continue being effective.Wear loose, light garments and broad-spectrum sunscreens.Avoid leaving your home during the 10 a.m. to 4 p.m. peak heat times.Watch for dizziness, confusion, nausea, or profuse sweating.Does Heat Affect Mental Health?Heat also affects mental health, whereas winter seasonal affective disorder (SAD) is more well-known, summer SAD may result from inadequate sleep and protracted heat exposure, aggravating depression and anxiety symptoms. Heat doesn't only impact the body—some individuals have summer-pattern seasonal affective disorder (SAD), with deteriorating depression or anxiety during extended, hot days. Inadequate sleep resulting from heat can also heighten these symptoms. Hydration, cooling down, and stress management practices such as deep breathing or meditation can assist with maintaining mental health during heat waves.The Anxiety & Depression Association of America suggests staying hydrated, practicing mindfulness techniques for stress management, and getting proper rest. For individuals who are experiencing mental fatigue in the summer months, contacting a mental health professional is highly recommended.As we endure increasingly hotter, longer summers, it is more important than ever to know how drugs interact with heat. From antidepressants to insulin, every drug has special risks related to thermoregulation, dehydration, and sun sensitivity.For people on antidepressants, antipsychotics, cardiac medications, stimulants, or insulin, summer poses special challenges—but also the potential for proactive self-protection, see your physician or health care provider for further assistance.Disclaimer: This article is for informational purposes only and does not substitute professional medical advice. Always consult your doctor before making changes to your medication or health routine.