Heart diseases are one of the most common issues people face in the world. Despite being the leading cause of death globally, according to the world health organization, many people miss critical signs of it. The best way to ensure a person gets treatment, is that the disease must be diagnosed in its early stages. A new study suggests diagnosing the risk of heart disease early is also possible, with the help of eye scans. Researchers at McMaster University and the Population Health Research Institute (PHRI) have made an incredible discovery. They found that the tiny blood vessels in your eyes could be a powerful way to guess how likely you are to develop heart disease and how fast your body is truly aging on the inside. This is a big deal because right now, checking for these risks involves many complicated tests. The study, which was published in the journal Science Advances, suggests that soon, doctors might be able to use a simple scan of your retina, which is the back of your eye, as a quick and non-invasive tool. This scan could show them the overall health of your blood circulation and reveal your body’s real biological age. This new method could open up amazing possibilities for catching serious health issues much earlier. Can You Diagnose Heart Diseases From Eye Scan? The study was massive, involving over 74,000 people from large international research groups. The scientists analyzed their retinal images, genetic makeup, and blood data. Their key discovery was striking, people whose blood vessels in the retina were simpler and looked less branched (not as tree-like) were found to be at a higher risk for heart problems. These same people also showed clear signs of faster biological aging, meaning they had more inflammation in their bodies and a potentially shorter life expectancy. Dr. Marie Pigeyre, one of the main researchers on the study, explains that the eye is unique. It gives doctors a special, clear, and easy way to look at your entire circulatory system—all the veins and arteries that carry blood throughout your body. Mirroring the Body Think of the eye's small blood vessels like a mirror. Changes happening in these vessels reflect the same changes happening in the small blood vessels everywhere else in your body. If the vessels in your eye look unhealthy, chances are, the vessels around your heart and brain are also struggling. Molecular Clues The team didn't just look at pictures. By combining the retinal scans with genetic information and blood test results, they were able to uncover specific "molecular pathways." These are basically the biological rules or processes that explain exactly how aging causes problems in your blood vessel system. Can You Cure Genetic Heart Diseases? The researchers went beyond just finding a link; they used the blood and genetic data to hunt for the root causes of these eye vessel changes. This led them to pinpoint specific proteins that appear to be the main drivers of both aging and disease. They identified two major proteins: MMP12 and IgG–Fc receptor IIb. Both of these are strongly linked to inflammation and the deterioration of blood vessels as we age. Dr. Pigeyre is excited because these specific proteins could become targets for new drugs. Medicines designed to control or slow down these proteins could help reduce the impact of vascular aging, lower the risk of heart disease, and ultimately help people live longer and healthier lives. Right now, to check for serious age-related diseases like heart disease, stroke, and memory problems (dementia), doctors have to perform many different tests. The big hope is that a quick, simple retinal scan could one day become an easy-to-access tool to immediately check a person's risk for heart problems and determine their biological age.
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