Fertility is a complex combination of various elements; however, age is perhaps the most significant factor. Women - and to a slightly lesser degree, men - experience their reproductive well-being and the probability of conception change as they age.

It would be reassuring for individuals who plan to start or are starting families later in life if they knew more about these effects and how age affects fertility and in vitro fertilization (IVF) success rates.

The Effect of Age on Female Fertility

Female fertility takes a dive in the late 20s and early 30s, and then it dramatically drops after the age of 35. The reason for this decline in female fertility is largely attributed to the reduced amount and quality of eggs. Women are born with only an approximate number of eggs in their lifetime, which continues to decrease with age. In fact, at age 40, there is very little chance of becoming pregnant without advanced reproductive technology, and the risk of eggs having significant chromosomal abnormalities in the egg increases dramatically, hence increased miscarriage and birth defects.

It's not just the female side that declines with age; male fertility declines as well. Although the decline is probably less dramatic, the quality of sperm decreases, mainly in the areas of motility and morphology, which adversely affects male fertility as well, unfortunately.

IVF and Age

IVF has emerged as a potent of choice for couples that have been facing fertility issues most especially those related to age. Age, however, still a decisive success factor in IVF treatment. According to different studies, it has been indicated that the great success rate achieved from IVF is when the females are below 35 years with the overall live birth rate per cycle close to 40-50%. The percentage rate stands at around 40-50% for women aged 32-34, followed by about 30-40% for women aged 35-37, and approximately 20-30% for women aged 38-40. Success rates hit a mere 5-10% per cycle for women older than 40. Such is why age becomes a critical issue for those attempting ART.

Why Are Success Rates Dropping?

The reduced success rate of IVF with increasing age has been mostly attributed to the conditions such as egg quality, hormonal imbalances, and a higher risk of existing medical conditions. With time, the risk of having medical conditions such as endometriosis or uterine fibroids to make the pregnancy complicated also increases. Older eggs are also more likely to have chromosomal defects, which may lead to failures at the implantation or miscarriages.

In men, though the quality of sperms is affected by the age, the decline is not that steep as it is in the case of women. The opposite, however has proved true with advanced paternal age also leading to several risks such as genetic mutations and various developmental disorders in their offspring.

Overcoming Age-Related Fertility Issues

For those who would wish to avoid age-related fertility issues, it's not too early to take some proactive measures. Early consultation with a fertility specialist can help in assessing one's individual circumstances and then take expert advice on the best course of action. Then, there is egg freezing that helps women preserve their eggs at a relatively younger age for potential use or the use of donor eggs that can greatly increase chances for older women.

Lifestyle choices contribute significantly to fertility. Proper weight maintenance, nonsmoking, no dependence on heavy alcohol intake, and less stress are some of the indicators of maintaining a healthy reproductive system that can enhance the chances and possibility of successful IVF treatments.

Weight-loss jabs, or GLP-1 receptor agonists, have provided many people with results that diets alone could not achieve. For those struggling with constant cravings, these medications have quieted the persistent “food noise” that often drives overeating. They have transformed not only body shapes but also self-confidence and daily habits.

Yet questions remain: can people safely stop taking these drugs, and what happens to the body when they do? These are still largely unknown, as the drugs are relatively new. GLP-1s mimic a natural hormone that controls hunger, but the long-term effects are only beginning to be understood. Additionally, for the estimated 1.5 million people in the UK paying privately for these injections, maintaining treatment can be costly.

Two women, Tanya and Ellen, share their personal experiences with the BBC on weight-loss jabs and what life was like when they attempted to stop.

Weight Loss Jabs: Tanya Hall’s Experience

Tanya, a sales manager in the fitness industry, initially started taking Wegovy to challenge her own perceptions about weight and authority. She often felt overlooked or undervalued because of her size, and hoped that losing weight would change how others treated her, as per BBC.

Early in treatment, Tanya experienced side effects including nausea, headaches, sleep issues, and hair loss, which she describes as clumps coming out. Despite this, she steadily lost weight—six stone (38 kg) over 18 months—and the injections quieted the relentless urge to eat.

However, every time she tried to stop, her appetite surged within days, leaving her horrified at her own eating. Now, Tanya continues the medication, feeling it has become essential to maintaining her weight and the confidence it brings.

Weight Loss Jabs: What Happens To Your Body When You Stop Taking Them?

Wegovy’s manufacturer, Novo Nordisk, stresses that treatment decisions should be made with medical guidance and that side effects must be considered. Lifestyle GP Dr. Hussain Al-Zubaidi likens stopping GLP-1s abruptly to being hit by a “tsunami” of hunger.

Research shows that within one to three years of stopping these medications, people can regain 60–80% of the weight they lost. This highlights how these drugs work not just by reducing appetite temporarily but by fundamentally altering hunger cues.

Weight Loss Jabs: Ellen Ogley’s Journey

Ellen turned to Mounjaro after reaching a critical point in her life. Her weight had put her at risk during surgery, and emotional binge eating dominated her daily habits. Once on the medication, Ellen noticed her compulsive eating completely stopped.

Over 16 weeks, she lost 3 st 7 lb (22 kg) and began tapering off the injections over six weeks. She focused on developing a healthier relationship with food, creating balanced meals, and incorporating exercise into her routine. Despite some weight creep after stopping, she has since lost a total of 51 kg and now feels confident her habits are sustainable.

Weight Loss Jabs: The Importance of Support

Dr. Al-Zubaidi emphasizes that exiting GLP-1 treatment safely requires guidance and long-term support. NICE recommends at least a year of tailored advice after stopping injections to help individuals maintain their weight and prevent relapse, as per BBC.

For patients paying privately, such structured support may not always be available, increasing the risk of regaining weight. Lifestyle, mindset, and environmental factors play a significant role in long-term outcomes.

Tanya has chosen to continue with her medication, aware of the pros and cons, while Ellen has closed that chapter and built a sustainable routine for life after Mounjaro.

Weight-loss jabs can dramatically change appetite and body weight, but stopping them can be challenging. The transition off these drugs requires careful planning, support, and lifestyle adjustments. As Tanya and Ellen’s experiences show, the journey varies by individual, and long-term strategies are essential to maintaining health and weight loss results.

Eli Lilly, the manufacturer of Mounjaro, states that patient safety is its top priority and that it continually monitors and reports information on treatment outcomes to regulators and prescribers.

Flu Symptoms: Seasonal infections are spreading across the United States just as the holiday travel rush gets underway, worrying health officials about fresh spikes during family get-togethers. Flu and norovirus cases are rising in several states, while COVID-19 continues to circulate at lower but consistent levels. Together, these illnesses are adding strain on hospitals as millions of people plan to travel in the days ahead.

Flu: What Is Super Flu?

“Super flu” is not a clinical term, but it is often used to describe a flu season that feels more aggressive or spreads faster than usual. This is typically linked to a dominant strain of influenza A. The current surge is being driven by a mutated influenza A strain known as H3N2 subclade K. Health officials say this strain has become the leading flu variant in the US, accounting for roughly 89 percent of H3N2 samples analysed since late September, according to genetic sequencing data from the Centers for Disease Control and Prevention (CDC).

This variant emerged after the 2025–26 flu vaccine was formulated, meaning the vaccine may not be as closely matched as in earlier seasons. While the shot still offers protection against severe disease, experts note that the mismatch could allow the virus to spread more easily.

Flu Symptoms 2025: What Symptoms Should People Watch For?

The symptoms seen in the current flu wave are largely familiar. People may develop fever, chills, extreme tiredness, cough, and body aches. Doctors, however, caution that the wider spread could result in more serious cases, particularly among people who are at higher risk.

CDC estimates indicate that the US has already seen about 4.6 million flu cases this season, along with nearly 49,000 hospital admissions and around 1,900 deaths. Flu activity increased sharply in mid-December, with test positivity jumping from 8.1 percent to 14.3 percent within a single week.

Flu Symptoms 2025: How To Reduce The Risk

Doctors recommend staying home when feeling unwell, washing hands often, especially to limit norovirus spread, and considering vaccination against flu and COVID-19. Even when the strain match is not ideal, experts stress that vaccines remain crucial in reducing the risk of severe illness, hospitalisation, and death.

Flu Cases In The US: How Contagious Is Superflu?

In terms of how easily it spreads, it behaves much like regular flu, which is known to be highly contagious.

Someone with flu can pass on the virus from around one day before symptoms appear and continue to be contagious for five to seven days after becoming sick. Children, older adults, and those with weakened immune systems may remain infectious for a longer period.

The virus mainly spreads through respiratory droplets released when an infected person coughs, sneezes, speaks, or breathes near others. It can also spread through contact with contaminated surfaces, followed by touching the mouth, nose, or eyes. Crowded indoor settings, poor airflow, and close contact make transmission far more likely, which explains why flu spreads quickly during peak season.

What makes a so-called “super flu” seem more contagious is not a new way of spreading, but higher case numbers, quicker community transmission, and stronger symptoms, all of which increase coughing, fever, and the amount of virus released.

Raised cholesterol levels do more than strain the heart. They can sharply limit blood circulation to the arms and legs, increasing the risk of serious health problems. High cholesterol is already known to raise the chances of heart attacks and strokes, which makes recognising early warning signs especially important.

Low-density lipoprotein, commonly known as LDL or “bad” cholesterol, builds up along artery walls. Over time, this build-up narrows the blood vessels and increases the likelihood of blockages that can lead to cardiac arrest. According to the NHS, diets high in fatty foods, frequent alcohol intake, and a lack of physical activity are among the main reasons cholesterol levels rise.

Why Symptoms May Appear in the Feet

Although cholesterol is often detected through medical tests, warning signs can sometimes surface in unexpected parts of the body, including the feet. Paying attention to these changes can help doctors identify peripheral artery disease, or PAD, which develops when fatty deposits restrict blood flow. This has been reported by Surrey Live.

The British Heart Foundation explains that as circulation worsens, the body struggles to supply enough oxygen, nutrients, and blood to the skin and surrounding tissues. This problem is most noticeable in the feet, as they are the farthest point from the heart.

Three Serious Foot Symptoms Linked to High Cholesterol

There are three major signs of high cholesterol that may show up in the feet:

• Pain
• Ulcers
• Gangrene

Other PAD Symptoms to Look Out For

People with peripheral artery disease may also notice additional changes, such as:

* Loss of hair on the legs or feet

* Weakness or numbness in the legs

* Toenails that grow slowly or become brittle

* Open sores on the feet or legs that take a long time to heal

* Changes in skin colour, including pale or bluish tones

* Skin that looks shiny

* Erectile dysfunction in men

* Loss of muscle mass in the legs

Lowering cholesterol levels is essential to reduce the risk of PAD and other complications associated with high cholesterol.

It is important to confirm high cholesterol with a healthcare professional, as many people experience few or no symptoms.

A blood test remains the most reliable way to detect high cholesterol, which often goes unnoticed without screening.

When Symptoms Become an Emergency

Symptoms such as foot pain, ulcers, and gangrene may signal a severe form of PAD known as critical limb ischaemia. The British Heart Foundation warns that this condition needs urgent medical treatment to help prevent limb loss.

If a doctor suspects high cholesterol, the NHS advises that a blood test will usually be recommended.

How Cholesterol Is Tested

There are two main ways cholesterol levels can be checked:

* A blood sample taken from the arm

* A finger-prick test

If results confirm high cholesterol, a GP will talk through ways to bring levels down, which may include changes to diet or prescribed medication.

Diet Changes That Can Help

Adjusting what you eat is often one of the most effective ways to reduce cholesterol, as diet is a common cause of high levels. One practical step is to cut back on saturated fats and replace them with unsaturated fats.

Saturated fats are commonly found in foods such as fatty cuts of meat, butter, cheese, and lard. Unsaturated fats, on the other hand, are present in vegetables, nuts, seeds, and plant-based oils.

Apart from that, increasing physical activity can also help manage cholesterol and support overall heart health.

UK health guidelines recommend that adults aim for at least 150 minutes of moderate-intensity activity each week, or 75 minutes of vigorous exercise. Doing more activity, or increasing intensity, can reduce the total time needed. Moderate exercise means your heart rate rises and breathing becomes heavier, but you should still be able to talk without struggling for breath.

One practical way to reach the 150-minute target is to stay active for 30 minutes a day, on at least five days each week.