Health and Me

Tanya Dutt

World Kidney Cancer Day: ‘Overusing 'Safe’ Painkillers Are A Hidden Cause Of Kidney Cancer

‘Overusing 'Safe’ Painkillers Are A Hidden Cause Of Kidney Cancer

Headache? Take a painkiller. Joint pain? Take another. For all of us, over-the-counter (OTC) <span>painkillers</span> such as ibuprofen or acetaminophen are as much a part of daily life as a morning cup of coffee. They're fast, efficient, and appear harmless—who needs a prescription, anyway? But what if this blase dependence on painkillers is actually laying the groundwork for a much more devastating health emergency?

If that's your daily mantra, don't worry, you're in good company. In the age of instant gratification, all of us are turning to over-the-counter pain relievers as a quick fix for even mild pain. But what if this ostensibly innocuous habit is silently threatening your kidneys with a major health problem?

Painkillers, or analgesics, are usually a lifeline for individuals with chronic or severe pain. From recovery from surgery and migraines to arthritis and menstrual cramps, these drugs offer relief that ensures our quality of life is not drastically reduced. But beneath the pain relief lies a surprising question: whether the overuse of these drugs may exact too high a price-kidney damage and even <span>kidney <a href="https://www.healthandme.com/health/cancer">cancer</a></span>.

Dr. Aditya Punamiya, a GI, HPB, and Gynecologic Oncosurgery Consultant, cautions, "The long-term and uncontrolled use of over-the-counter painkillers is emerging as an under-diagnosed but serious risk factor for kidney <span>cancer</span>." Dr Punamiya observations reveal an alarming pattern, numerous patients self-medicate for chronic pains—headaches, joint pains, or back pain—unaware of the additive damage to the kidneys.

<h2>Why We Turn to Painkillers So Easily?</h2>

Pain is a biological alarm system. Helpful in warning us of injury or sickness, chronic pain can strongly interfere with our functioning on a daily basis. To counter this, painkillers provide a feeling of control and comfort. For acute on-demand pain and chronic inflammatory diseases, drugs like NSAIDs and acetaminophen are not only handy but effective as well.

Sadly, the very ease of use of these drugs has led to their misuse. Painkillers are increasingly being consumed without medical supervision, particularly in nations such as India where OTC availability is prevalent but even within well-regulated economies such as the U.S., long-term use has become an undercurrent of an epidemic.

<h2>What Are The Types of Painkillers?</h2>

<h4>Over-the-Counter (OTC) Medications</h4>

Paracetamol (Acetaminophen): Good for fever and light pain, but hepatotoxicity is a serious issue above moderate doses.

NSAIDs (Non-Steroidal Anti-Inflammatory Drugs): Contains ibuprofen, naproxen, and diclofenac. These are useful for pain that is inflammation-related but have gastrointestinal and renal toxicity with long-term use.

Opioids (Tramadol, Morphine, Oxycodone): For severe pain only but pose the risk of respiratory depression, addiction, and endocrine disruption.

<h4>Topical and Alternative Therapies</h4>

Topical creams and patches containing drugs such as menthol or capsaicin are localized treatments with fewer systemic hazards.

<h2>How Do these Drugs Harm the Kidneys?</h2>

How do such drugs damage the kidneys? Dr. Punamiya clarifies, "Drugs such as ibuprofen, diclofenac, and naproxen, if taken in excess, can harm the kidneys in two ways. One, they weaken the kidneys' function to filter blood by cutting off blood supply. Two, they cause chronic interstitial nephritis over time, scarring kidney tissues." This scarring provides a fertile ground for RCC to grow.

The kidneys, essential organs responsible for filtering waste products from the blood, are especially susceptible to chronic exposure to NSAIDs and acetaminophen. Acute kidney injury, chronic kidney disease, and, in severe cases, kidney failure can result from excessive use of these compounds. The transition to kidney cancer is not as sudden but equally alarming, since the cumulative insult changes cellular mechanisms, possibly initiating malignant growth.

A landmark meta-analysis by Toni K Choueiri, Youjin Je, and Eunyoung Cho has again highlighted the relationship between chronic painkiller use and renal cell carcinoma (RCC)—the leading form of kidney cancer.

Non-Aspirin NSAIDs: Chronic use was linked to a 25% enhancement in the risk of RCC. Heavy consumption increased that threat by 56%, long-term consumption for more than 10 years especially concerning for women.

Acetaminophen: Associated with a 21% heightened risk of kidney cancer. Heavy users who took high doses saw their risk rise by 66%.

Aspirin: While most U.S.-based research found no conclusive link, some research from other countries suggested a connection, possibly due to regional variation in formulation or consumption habits.

<h2>Why Kidney Cancer Is a Silent Threat?</h2>

Kidney cancer is especially stealthy since it usually presents late without any symptoms. "Flank pain, hematuria and weight loss are typically late presentations," states Dr. Punamiya. For patients such as Sarah, who might have been taking painkillers for years, these signs may only manifest by the time cancer has metastasized, and so treatment is less effective.

Risk factors such as smoking, hypertension, diabetes, and obesity increase the risk, particularly in individuals with previous long-term analgesic use. Women also have an increased risk with non-aspirin NSAIDs, possibly because of hormonal or metabolic variation, although further work is required to explain this difference. He describes two principal mechanisms:

Decreased Renal Blood Flow: NSAIDs inhibit prostaglandins, decreasing kidney blood flow and compromising kidney filtration capability.

Chronic Interstitial Nephritis: Long-term NSAID use leads to fibrosis and inflammation of kidney tissue, setting the stage for RCC.

"Most patients self-treat for headaches or joint pain without knowing they're gradually driving their kidneys towards failure," he adds.

<h2>Why Early Detection Of Kidney Cancer Symptoms is Difficult?</h2>

Kidney cancer is infamous for its asymptomatic nature in the early stages. By the time symptoms such as pain in the flank, hematuria (urine containing blood), or unexplained weight loss appear, the disease is usually advanced. Patients with pre-existing risk factors—such as smoking, hypertension, and diabetes—and with a history of analgesic abuse are particularly susceptible.

Dr. Punamiya advises individuals to consult a doctor for ongoing pain rather than resorting to self-medication. "Routine screening and preventive caution are necessary, especially for vulnerable groups," he points out.

<h2>What Are Ways You Can Manage Pain Management Smartly?</h2>

Not every use of painkillers is risky. "Short-term, doctor-monitored use is generally safe," says Dr. Punamiya. The trick is not entering into uncontrolled, long-term use. Here's how to handle pain more safely:

<strong>Consult a Healthcare Provider</strong>

For long-term pain, consult a professional to treat the underlying condition, whether arthritis, neuropathy, or migraines. A customized treatment plan can minimize painkiller dependency.

Physical therapy, acupuncture, yoga, and cognitive-behavioral therapy can treat chronic pain without medication risks. For sudden pain, ice, heat, or rest may be enough.

Follow instructions on dosing and avoid prolonged use outside of medical guidance. For NSAIDs, eat food when taking to reduce stomach discomfort, and drink enough fluids to aid kidney function.

Encourage regular health screening for early detection of kidney problems, particularly among high-risk groups. Dr. Punamiya urges "preventive vigilance" with follow-up visits and attention to early signs such as blood in the urine or recurrent flank pain.

A balanced diet, exercise, and weight control can cut pain from conditions such as arthritis while reducing kidney cancer risk factors such as obesity and high blood pressure.

There may be the temptation to cover up pain instead of comprehending its cause but swallowing a pill with a glass of water can be an instant solution that might come at a price of long-term health. The growing body of evidence linking commonly used painkillers to kidney cancer is a call for informed, cautious use. As more people take their health into their own hands, the importance of education, medical guidance, and moderation cannot be overstated.

<em>Dr. Aditya Punamiya is a Consultant GI, HPB &amp; Gynec Onsosurgery at HCG Cancer Centre, Borivali in India</em>

Health Conditions A-Z

health

cancer

painkillers

kidney cancer

nsaids kidney damage

overuse of painkillers

renal cell carcinoma risk

painkiller side effects

acetaminophen cancer risk

ibuprofen kidney failure

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Headache? Take a painkiller. Joint pain? Take another. For all of us, over-the-counter (OTC) painkillers such as ibuprofen or acetaminophen are as much a part of daily life as a morning cup of coffee. They're fast, efficient, and appear harmless—who needs a prescription, anyway? But what if this blase dependence on painkillers is actually laying the groundwork for a much more devastating health emergency?If that's your daily mantra, don't worry, you're in good company. In the age of instant gratification, all of us are turning to over-the-counter pain relievers as a quick fix for even mild pain. But what if this ostensibly innocuous habit is silently threatening your kidneys with a major health problem?Painkillers, or analgesics, are usually a lifeline for individuals with chronic or severe pain. From recovery from surgery and migraines to arthritis and menstrual cramps, these drugs offer relief that ensures our quality of life is not drastically reduced. But beneath the pain relief lies a surprising question: whether the overuse of these drugs may exact too high a price-kidney damage and even kidney cancer.Dr. Aditya Punamiya, a GI, HPB, and Gynecologic Oncosurgery Consultant, cautions, "The long-term and uncontrolled use of over-the-counter painkillers is emerging as an under-diagnosed but serious risk factor for kidney cancer." Dr Punamiya observations reveal an alarming pattern, numerous patients self-medicate for chronic pains—headaches, joint pains, or back pain—unaware of the additive damage to the kidneys.Why We Turn to Painkillers So Easily?Pain is a biological alarm system. Helpful in warning us of injury or sickness, chronic pain can strongly interfere with our functioning on a daily basis. To counter this, painkillers provide a feeling of control and comfort. For acute on-demand pain and chronic inflammatory diseases, drugs like NSAIDs and acetaminophen are not only handy but effective as well.Sadly, the very ease of use of these drugs has led to their misuse. Painkillers are increasingly being consumed without medical supervision, particularly in nations such as India where OTC availability is prevalent but even within well-regulated economies such as the U.S., long-term use has become an undercurrent of an epidemic.What Are The Types of Painkillers?Over-the-Counter (OTC) MedicationsParacetamol (Acetaminophen): Good for fever and light pain, but hepatotoxicity is a serious issue above moderate doses.NSAIDs (Non-Steroidal Anti-Inflammatory Drugs): Contains ibuprofen, naproxen, and diclofenac. These are useful for pain that is inflammation-related but have gastrointestinal and renal toxicity with long-term use.Prescription PainkillersOpioids (Tramadol, Morphine, Oxycodone): For severe pain only but pose the risk of respiratory depression, addiction, and endocrine disruption.Topical and Alternative TherapiesTopical creams and patches containing drugs such as menthol or capsaicin are localized treatments with fewer systemic hazards.How Do these Drugs Harm the Kidneys?How do such drugs damage the kidneys? Dr. Punamiya clarifies, "Drugs such as ibuprofen, diclofenac, and naproxen, if taken in excess, can harm the kidneys in two ways. One, they weaken the kidneys' function to filter blood by cutting off blood supply. Two, they cause chronic interstitial nephritis over time, scarring kidney tissues." This scarring provides a fertile ground for RCC to grow.The kidneys, essential organs responsible for filtering waste products from the blood, are especially susceptible to chronic exposure to NSAIDs and acetaminophen. Acute kidney injury, chronic kidney disease, and, in severe cases, kidney failure can result from excessive use of these compounds. The transition to kidney cancer is not as sudden but equally alarming, since the cumulative insult changes cellular mechanisms, possibly initiating malignant growth.A landmark meta-analysis by Toni K Choueiri, Youjin Je, and Eunyoung Cho has again highlighted the relationship between chronic painkiller use and renal cell carcinoma (RCC)—the leading form of kidney cancer.Non-Aspirin NSAIDs: Chronic use was linked to a 25% enhancement in the risk of RCC. Heavy consumption increased that threat by 56%, long-term consumption for more than 10 years especially concerning for women.Acetaminophen: Associated with a 21% heightened risk of kidney cancer. Heavy users who took high doses saw their risk rise by 66%.Aspirin: While most U.S.-based research found no conclusive link, some research from other countries suggested a connection, possibly due to regional variation in formulation or consumption habits.Why Kidney Cancer Is a Silent Threat?Kidney cancer is especially stealthy since it usually presents late without any symptoms. "Flank pain, hematuria and weight loss are typically late presentations," states Dr. Punamiya. For patients such as Sarah, who might have been taking painkillers for years, these signs may only manifest by the time cancer has metastasized, and so treatment is less effective.Risk factors such as smoking, hypertension, diabetes, and obesity increase the risk, particularly in individuals with previous long-term analgesic use. Women also have an increased risk with non-aspirin NSAIDs, possibly because of hormonal or metabolic variation, although further work is required to explain this difference. He describes two principal mechanisms:Decreased Renal Blood Flow: NSAIDs inhibit prostaglandins, decreasing kidney blood flow and compromising kidney filtration capability.Chronic Interstitial Nephritis: Long-term NSAID use leads to fibrosis and inflammation of kidney tissue, setting the stage for RCC."Most patients self-treat for headaches or joint pain without knowing they're gradually driving their kidneys towards failure," he adds.Why Early Detection Of Kidney Cancer Symptoms is Difficult?Kidney cancer is infamous for its asymptomatic nature in the early stages. By the time symptoms such as pain in the flank, hematuria (urine containing blood), or unexplained weight loss appear, the disease is usually advanced. Patients with pre-existing risk factors—such as smoking, hypertension, and diabetes—and with a history of analgesic abuse are particularly susceptible.Dr. Punamiya advises individuals to consult a doctor for ongoing pain rather than resorting to self-medication. "Routine screening and preventive caution are necessary, especially for vulnerable groups," he points out.What Are Ways You Can Manage Pain Management Smartly?Not every use of painkillers is risky. "Short-term, doctor-monitored use is generally safe," says Dr. Punamiya. The trick is not entering into uncontrolled, long-term use. Here's how to handle pain more safely:Consult a Healthcare ProviderFor long-term pain, consult a professional to treat the underlying condition, whether arthritis, neuropathy, or migraines. A customized treatment plan can minimize painkiller dependency.Try Non-Drug OptionsPhysical therapy, acupuncture, yoga, and cognitive-behavioral therapy can treat chronic pain without medication risks. For sudden pain, ice, heat, or rest may be enough.Use Painkillers WiselyFollow instructions on dosing and avoid prolonged use outside of medical guidance. For NSAIDs, eat food when taking to reduce stomach discomfort, and drink enough fluids to aid kidney function.Take PrecautionsEncourage regular health screening for early detection of kidney problems, particularly among high-risk groups. Dr. Punamiya urges "preventive vigilance" with follow-up visits and attention to early signs such as blood in the urine or recurrent flank pain.Lifestyle MattersA balanced diet, exercise, and weight control can cut pain from conditions such as arthritis while reducing kidney cancer risk factors such as obesity and high blood pressure.There may be the temptation to cover up pain instead of comprehending its cause but swallowing a pill with a glass of water can be an instant solution that might come at a price of long-term health. The growing body of evidence linking commonly used painkillers to kidney cancer is a call for informed, cautious use. As more people take their health into their own hands, the importance of education, medical guidance, and moderation cannot be overstated.Dr. Aditya Punamiya is a Consultant GI, HPB & Gynec Onsosurgery at HCG Cancer Centre, Borivali in India

‘overusing 'safe’ painkillers are a hidden cause of kidney cancer

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New advice from the NHS suggests that people who stop taking weight-loss drugs like Wegovy and <span>Mounjaro</span> should have check-ups for at least a year. The main reason for this is that it's very common for people to gain most of the weight once they stop the medication. 

The guidance from NICE (National Institute for Health and Care Excellence) emphasizes that managing weight is a long-term effort, not a quick fix. Patients need extra help and a clear plan to maintain their new weight, which includes habits like eating healthy food and being physically active. 

Clinical trials show that people on these drugs often regain a lot of the weight they lost. For example, a trial for Wegovy found that patients put back on about two-thirds of their lost weight after they stopped the injections. It was a similar story for those who took Mounjaro. 

Professor Jonathan Benger from NICE explained that the time right after stopping treatment is very important. He said people need "structured support" to keep up the healthy changes they've made. The new advice encourages patients to create healthy habits, use tools to monitor their own weight, and get support from family, friends, and online groups. 

<h2>Why Are <span rel="noindex">Weight Loss Drugs</span> Popular in UK? </h2>

Obesity affects about one in four adults in England. While an estimated 1.5 million people in the UK are using these weight-loss jabs, most are paying for them privately and won't get this NHS support. 

Wegovy is available on the NHS for a period of two years for those who have health problems because of their weight and have a high BMI. The drug Mounjaro is expected to be offered to about 240,000 people over the next three years, and there's no set time limit for how long they can take it. 

Both drugs work by reducing a person's appetite. They are given along with programs that help people make healthy changes to their diet and exercise habits. 

The UC Health explains that currently Mounjaro is approved for people with diabetes, not for those who are overweight or obese without diabetes. There is still a lot we have to learn about Mounjaro and researchers are working on the same. A big question that everyone who wishes to start on the weight loss drug are thinking about is whether you will have to keep using the drug forever or can you stop. 

To maintain the weight loss achieved with Mounjaro, you will likely need to keep taking the medication indefinitely. 

If you lose a significant amount of weight with Mounjaro, Wegovy, or Ozempic, you will likely need to continue taking the medication to keep the weight off. People who have stopped taking <span>Ozempic and Wegovy</span> have typically regained the weight they lost. 

As one UC Health expert noted that if you stop taking these medications, and don’t change your behaviors, then the weight can pile back on. Since Mounjaro is newer, there is less information about long-term use, but the trend is expected to be similar. 

Weight loss jabs

mounjaro

ozempic and wegovy

weight loss drugs

Weight loss drugs guidelines

Weight loss drugs need healthy habits

New advice from the NHS suggests that people who stop taking weight-loss drugs like Wegovy and Mounjaro should have check-ups for at least a year. The main reason for this is that it's very common for people to gain most of the weight once they stop the medication. The guidance from NICE (National Institute for Health and Care Excellence) emphasizes that managing weight is a long-term effort, not a quick fix. Patients need extra help and a clear plan to maintain their new weight, which includes habits like eating healthy food and being physically active. Clinical trials show that people on these drugs often regain a lot of the weight they lost. For example, a trial for Wegovy found that patients put back on about two-thirds of their lost weight after they stopped the injections. It was a similar story for those who took Mounjaro. Professor Jonathan Benger from NICE explained that the time right after stopping treatment is very important. He said people need "structured support" to keep up the healthy changes they've made. The new advice encourages patients to create healthy habits, use tools to monitor their own weight, and get support from family, friends, and online groups. Why Are Weight Loss Drugs Popular in UK? Obesity affects about one in four adults in England. While an estimated 1.5 million people in the UK are using these weight-loss jabs, most are paying for them privately and won't get this NHS support. Wegovy is available on the NHS for a period of two years for those who have health problems because of their weight and have a high BMI. The drug Mounjaro is expected to be offered to about 240,000 people over the next three years, and there's no set time limit for how long they can take it.  Both drugs work by reducing a person's appetite. They are given along with programs that help people make healthy changes to their diet and exercise habits.  Does Mounjaro Work For Everyone? The UC Health explains that currently Mounjaro is approved for people with diabetes, not for those who are overweight or obese without diabetes. There is still a lot we have to learn about Mounjaro and researchers are working on the same. A big question that everyone who wishes to start on the weight loss drug are thinking about is whether you will have to keep using the drug forever or can you stop. To maintain the weight loss achieved with Mounjaro, you will likely need to keep taking the medication indefinitely. If you lose a significant amount of weight with Mounjaro, Wegovy, or Ozempic, you will likely need to continue taking the medication to keep the weight off. People who have stopped taking Ozempic and Wegovy have typically regained the weight they lost. As one UC Health expert noted that if you stop taking these medications, and don’t change your behaviors, then the weight can pile back on. Since Mounjaro is newer, there is less information about long-term use, but the trend is expected to be similar. 

weight loss jabs are not enough to lose weight, help is needed even after

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“This is a warning specifically for parents” — Influencer Michael Brown recently released a video warning parents as well as others, about a potentially addictive drink that is easily available at gas stations in the US. He detailed how, during a casual visit to the gas station store for a beverage, he was approached by a young boy who asked him to buy ‘<span>Feel Free</span>’ for him. Despite being refused, the kid persisted and even tried lunging for Michael’s wallet, leaving him shaken up.

While paying at the counter, Michael recalled asking the shop cashier what ‘Feel Free’ was, to which she pointed at little blue bottles on the counter. She said people are so addicted to it that sometimes they visit 5–6 times a day to buy it — “It’s addictive and people lose their minds.” A quick look at the comments section of the post, which now has more than 9 million views on Instagram, had many people shocked at the severity of the drink and its consequences. Different healthcare professionals also detailed their experience with patients. “It’s Kratom! Have had patients with seizures because of this and also babies experiencing withdrawal from maternal use during pregnancy. It’s no joke,” commented Dr. Shilpa, MD, Child Neurologist and Development Specialist.

To know how many people are affected or it continues to affect, you do not have to look too far — a subreddit known as QuittingFeelFree, which has 5k members, and QuittingKratom with 52k members, are prime spots to get first-person accounts of people who struggled for years or months with their addictions.

In one of the stories, Jasmine Adeoye from Austin posted on TikTok that just a few months before June 2024, she drank several bottles of Feel Free a day and found that quitting it was not easy.

Last year, the production company of Feel Free also faced lawsuits, however, many people are not aware of the same. CBS News had reported that Botanic Tonics had also faced a class-action lawsuit filed in 2023. The lawsuit alleged that the company's marketing was misleading and targeted individuals with a history of addiction. In a statement, the company said it had "fallen short of the high standards of transparency" and implemented changes like enhanced labeling and age restrictions.

<h2>Feel Free and List of Ingredients</h2>

One of the main ingredients listed in the ‘Feel Free’ drinks is ground kratom leaves. Now a regular person would think — how bad can leaves be? — and consume the drink, but it’s these same leaves that are risky and can lead to severe addiction.

Native to Southeast Asia, the US Food and Drug Administration explains that it also carries the risk of addiction, seizures, and, in rare cases, death. Since kratom is unregulated in the U.S., some products are sold in highly concentrated forms and may contain contaminants like heavy metals and harmful bacteria.

<h2>What Happens with Unregulated Use of Kratom?</h2>

The American Addiction Centers detailed how lower doses of kratom could help people increase energy and alertness, while higher doses could produce effects similar to that of opioid drug abuse. They detailed a 7-year study done from 2011–2017. The study pointed out how there were 1,800 calls to poison control centers about kratom, with most of those calls happening in the last two years of that period. Here are some things that can happen with unregulated use of kratom:

While it's not common, long-term and heavy kratom use can lead to addiction. People who stop using it suddenly might experience withdrawal symptoms that feel similar to the flu, such as nausea, vomiting, body aches, and chills.

The FDA has not approved kratom for any use. This means that kratom products are not regulated and can sometimes be contaminated with dangerous substances like heavy metals and harmful bacteria. The FDA has warned consumers not to use kratom and has seized shipments of kratom-containing products.

Taking kratom with other drugs or alcohol can be very dangerous. In rare but serious cases, this combination has led to severe side effects like liver damage and even death.

Overdosing on kratom alone is very rare. However, when it is combined with other substances, the risk increases. For example, a CDC report linked kratom to 152 deaths in 2016 and 2017, but other substances were involved in 87% of those cases.

wellness drink addiction

feel free

energy drink addiction

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feel free addiction

7 oh

“This is a warning specifically for parents” — Influencer Michael Brown recently released a video warning parents as well as others, about a potentially addictive drink that is easily available at gas stations in the US. He detailed how, during a casual visit to the gas station store for a beverage, he was approached by a young boy who asked him to buy ‘Feel Free’ for him. Despite being refused, the kid persisted and even tried lunging for Michael’s wallet, leaving him shaken up.While paying at the counter, Michael recalled asking the shop cashier what ‘Feel Free’ was, to which she pointed at little blue bottles on the counter. She said people are so addicted to it that sometimes they visit 5–6 times a day to buy it — “It’s addictive and people lose their minds.” A quick look at the comments section of the post, which now has more than 9 million views on Instagram, had many people shocked at the severity of the drink and its consequences. Different healthcare professionals also detailed their experience with patients. “It’s Kratom! Have had patients with seizures because of this and also babies experiencing withdrawal from maternal use during pregnancy. It’s no joke,” commented Dr. Shilpa, MD, Child Neurologist and Development Specialist.To know how many people are affected or it continues to affect, you do not have to look too far — a subreddit known as QuittingFeelFree, which has 5k members, and QuittingKratom with 52k members, are prime spots to get first-person accounts of people who struggled for years or months with their addictions.In one of the stories, Jasmine Adeoye from Austin posted on TikTok that just a few months before June 2024, she drank several bottles of Feel Free a day and found that quitting it was not easy.Last year, the production company of Feel Free also faced lawsuits, however, many people are not aware of the same. CBS News had reported that Botanic Tonics had also faced a class-action lawsuit filed in 2023. The lawsuit alleged that the company's marketing was misleading and targeted individuals with a history of addiction. In a statement, the company said it had "fallen short of the high standards of transparency" and implemented changes like enhanced labeling and age restrictions.Feel Free and List of IngredientsOne of the main ingredients listed in the ‘Feel Free’ drinks is ground kratom leaves. Now a regular person would think — how bad can leaves be? — and consume the drink, but it’s these same leaves that are risky and can lead to severe addiction.Native to Southeast Asia, the US Food and Drug Administration explains that it also carries the risk of addiction, seizures, and, in rare cases, death. Since kratom is unregulated in the U.S., some products are sold in highly concentrated forms and may contain contaminants like heavy metals and harmful bacteria.What Happens with Unregulated Use of Kratom?The American Addiction Centers detailed how lower doses of kratom could help people increase energy and alertness, while higher doses could produce effects similar to that of opioid drug abuse. They detailed a 7-year study done from 2011–2017. The study pointed out how there were 1,800 calls to poison control centers about kratom, with most of those calls happening in the last two years of that period. Here are some things that can happen with unregulated use of kratom:Addiction and WithdrawalWhile it's not common, long-term and heavy kratom use can lead to addiction. People who stop using it suddenly might experience withdrawal symptoms that feel similar to the flu, such as nausea, vomiting, body aches, and chills.Lack of RegulationThe FDA has not approved kratom for any use. This means that kratom products are not regulated and can sometimes be contaminated with dangerous substances like heavy metals and harmful bacteria. The FDA has warned consumers not to use kratom and has seized shipments of kratom-containing products.Mixing with Other SubstancesTaking kratom with other drugs or alcohol can be very dangerous. In rare but serious cases, this combination has led to severe side effects like liver damage and even death.OverdoseOverdosing on kratom alone is very rare. However, when it is combined with other substances, the risk increases. For example, a CDC report linked kratom to 152 deaths in 2016 and 2017, but other substances were involved in 87% of those cases.

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Over the past few years, doctors and researchers have noticed a clear pattern: more young adults are being diagnosed with colorectal cancer—those under 50. On the surface, some of this surge can be credited to increased screening, especially following guideline updates that lowered the recommended starting age from 50 to 45. But deeper beneath those screening numbers lies a troubling reality: diagnoses among truly younger adults aren’t solely due to being screened earlier. That means we’re facing a bigger shift, one that demands fresh solutions.

In 2018, the American <span>Cancer</span> Society recommended colorectal cancer screening begin at age 45—five years earlier than before. In 2021, the US Preventive Services Task Force followed suit. Unsurprisingly, this led to a jump in early-stage diagnoses among 45-to-49-year-olds.

ACS data published in JAMA shows a steady increase in screening rates: from 20.8% in 2019 and 19.7% in 2021, rising to 33.7% in 2023 among that age group. A second ACS-led study tracked early-stage diagnosis rates—from 9.4 cases per 100,000 in 2019, to 11.7 in 2021, then 17.5 in 2022. That’s a 50% relative increase between 2021 and 2022. Experts note this trend largely reflects held-back cases being detected earlier thanks to broader testing.

But that doesn’t chalk up the entire story. Colon and rectal cancers have been increasing steadily in younger adults—those under 45—for decades. This early-onset rise began in the mid-1990s and includes late-stage diagnoses—not just early detection.

Doctors stress that while the decline in age recommendations helped some, it doesn’t explain the persistent rise in younger adults. In fact, research suggests annual case increases of 2–2.6% have occurred since 2012 among those under 50. In the 20–39 age group, incidence has been rising by around 1.6% per year since 2004.

More than 20% of colorectal cancer cases now occur in adults under 55—double the rate from the mid-1990s. Alarmingly, this early-onset trend is contributing to colorectal cancer becoming the leading cause of cancer death among younger men and the second-leading cause among younger women. 

These are not always lifestyle-driven cases. Many patients are young, active, and with no known family history. As clinicians, many have expressed how unsettling it is to see so many seemingly healthy people presenting with aggressive tumors—and often at advanced stages. 

<h2>What Might Be Driving This Worrisome Surge?</h2>

Researchers are testing multiple theories—but none yet fully explain the rise:

Gut microbe toxins such as colibactin, produced by certain E. coli, are drawing attention. These toxins leave a specific DNA mutation fingerprint in early-onset tumors—over three times more common compared to cancers in older patients. Some studies suggest 15% of early-onset cases involve colibactin-driven mutations.

Diet- and lifestyle-related risks remain central: obesity, processed meats, low-fiber diets, sedentary behavior, refined sugar, insufficient sleep, and environmental pollutants. One prominent study links higher birth and adolescent BMI with increased colon cancer risk later in life. Even every additional kilogram at birth above normal is tied to 9% higher colorectal cancer risk. 

Other suspected contributors include microplastics, antibiotic use, and artificial light exposure, although more conclusive evidence is pending. 

<h2>Symptoms You Should Never Ignore</h2>

Crucial to stopping this trend early is awareness. Here’s what to watch for—and not dismiss, even if you’re under 45:

<ul><li>Rectal bleeding</li><li>Persistent abdominal pain or cramping</li><li>Changes in bowel habits or stool shape</li><li>Unexplained weight loss or appetite changes</li></ul>

Jessica Star of ACS—lead author on both new JAMA papers—warns, more than half of cases in younger adults occurred in those not yet eligible for screening. So symptoms matter, regardless of age. If you're dismissed with a benign diagnosis like hemorrhoids, consider a second opinion. 

Screening matters. Most colorectal cancers begin as precancerous polyps, and removing these early saves lives. Current recommended options include:

<ul><li>Annual or triennial stool-based fecal tests</li><li>Colonoscopy every 10 years</li><li>Virtual colonoscopy every five years</li><li>Sigmoidoscopy every five years</li></ul>

Promising new research shows that mailing stool test kits directly to eligible adults dramatically increases completed screenings—even more than simply offering choice. Yet, screening is still underused: more than 1 in 3 adults aged 45 and older report not getting screened as recommended. To reduce personal risk:

<ul><li>Maintain healthy body weight and regular physical activity</li><li>Cut back on red and processed meats, refined sugars, and ultraprocessed foods</li><li>Boost fiber intake through plant-based nutrition</li><li>Avoid tobacco and limit alcohol</li><li>Stay alert to symptoms and seek screening or evaluation promptly when indicated</li></ul>

If you’re under 50—or even nearing that threshold—understand this: colorectal cancer is no longer just a disease of older adults. While earlier screening through age-lowering guidelines has helped catch many early-stage cancers in 45–49-year-olds, it doesn’t address the underlying, persistent rise in true early-onset cancer.

The surge among younger adults signals something deeper—and possibly preventable—but only if we tackle it strategically. That means screening more women and men at the right age, investing in research, and making early testing easier and more equitable.

As expert researchers remind us, we’re not merely diagnosing more cancers—we’re getting better at catching them earlier. But to save more lives, identify root causes, and reverse these trends, we must remain proactive. Not just for our generation—but for all who follow.

colon cancer in young adults

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rising colon cancer cases

Over the past few years, doctors and researchers have noticed a clear pattern: more young adults are being diagnosed with colorectal cancer—those under 50. On the surface, some of this surge can be credited to increased screening, especially following guideline updates that lowered the recommended starting age from 50 to 45. But deeper beneath those screening numbers lies a troubling reality: diagnoses among truly younger adults aren’t solely due to being screened earlier. That means we’re facing a bigger shift, one that demands fresh solutions.In 2018, the American Cancer Society recommended colorectal cancer screening begin at age 45—five years earlier than before. In 2021, the US Preventive Services Task Force followed suit. Unsurprisingly, this led to a jump in early-stage diagnoses among 45-to-49-year-olds.ACS data published in JAMA shows a steady increase in screening rates: from 20.8% in 2019 and 19.7% in 2021, rising to 33.7% in 2023 among that age group. A second ACS-led study tracked early-stage diagnosis rates—from 9.4 cases per 100,000 in 2019, to 11.7 in 2021, then 17.5 in 2022. That’s a 50% relative increase between 2021 and 2022. Experts note this trend largely reflects held-back cases being detected earlier thanks to broader testing.But that doesn’t chalk up the entire story. Colon and rectal cancers have been increasing steadily in younger adults—those under 45—for decades. This early-onset rise began in the mid-1990s and includes late-stage diagnoses—not just early detection.Who Is Getting Diagnosed?Doctors stress that while the decline in age recommendations helped some, it doesn’t explain the persistent rise in younger adults. In fact, research suggests annual case increases of 2–2.6% have occurred since 2012 among those under 50. In the 20–39 age group, incidence has been rising by around 1.6% per year since 2004.More than 20% of colorectal cancer cases now occur in adults under 55—double the rate from the mid-1990s. Alarmingly, this early-onset trend is contributing to colorectal cancer becoming the leading cause of cancer death among younger men and the second-leading cause among younger women. These are not always lifestyle-driven cases. Many patients are young, active, and with no known family history. As clinicians, many have expressed how unsettling it is to see so many seemingly healthy people presenting with aggressive tumors—and often at advanced stages. What Might Be Driving This Worrisome Surge?Researchers are testing multiple theories—but none yet fully explain the rise:Gut microbe toxins such as colibactin, produced by certain E. coli, are drawing attention. These toxins leave a specific DNA mutation fingerprint in early-onset tumors—over three times more common compared to cancers in older patients. Some studies suggest 15% of early-onset cases involve colibactin-driven mutations.Diet- and lifestyle-related risks remain central: obesity, processed meats, low-fiber diets, sedentary behavior, refined sugar, insufficient sleep, and environmental pollutants. One prominent study links higher birth and adolescent BMI with increased colon cancer risk later in life. Even every additional kilogram at birth above normal is tied to 9% higher colorectal cancer risk. Other suspected contributors include microplastics, antibiotic use, and artificial light exposure, although more conclusive evidence is pending. Symptoms You Should Never IgnoreCrucial to stopping this trend early is awareness. Here’s what to watch for—and not dismiss, even if you’re under 45:Rectal bleedingPersistent abdominal pain or crampingChanges in bowel habits or stool shapeUnexplained weight loss or appetite changesJessica Star of ACS—lead author on both new JAMA papers—warns, more than half of cases in younger adults occurred in those not yet eligible for screening. So symptoms matter, regardless of age. If you're dismissed with a benign diagnosis like hemorrhoids, consider a second opinion. How to Lower Your Risk?Screening matters. Most colorectal cancers begin as precancerous polyps, and removing these early saves lives. Current recommended options include:Annual or triennial stool-based fecal testsColonoscopy every 10 yearsVirtual colonoscopy every five yearsSigmoidoscopy every five yearsPromising new research shows that mailing stool test kits directly to eligible adults dramatically increases completed screenings—even more than simply offering choice. Yet, screening is still underused: more than 1 in 3 adults aged 45 and older report not getting screened as recommended. To reduce personal risk:Maintain healthy body weight and regular physical activityCut back on red and processed meats, refined sugars, and ultraprocessed foodsBoost fiber intake through plant-based nutritionAvoid tobacco and limit alcoholStay alert to symptoms and seek screening or evaluation promptly when indicatedIf you’re under 50—or even nearing that threshold—understand this: colorectal cancer is no longer just a disease of older adults. While earlier screening through age-lowering guidelines has helped catch many early-stage cancers in 45–49-year-olds, it doesn’t address the underlying, persistent rise in true early-onset cancer.The surge among younger adults signals something deeper—and possibly preventable—but only if we tackle it strategically. That means screening more women and men at the right age, investing in research, and making early testing easier and more equitable.As expert researchers remind us, we’re not merely diagnosing more cancers—we’re getting better at catching them earlier. But to save more lives, identify root causes, and reverse these trends, we must remain proactive. Not just for our generation—but for all who follow.

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