Immunization has been one of the most remarkable public health achievements of modern times, it has not only slowed down child mortality, eradicating certain diseases to be wiped off, and reduced outbreaks of conditions that could potentially kill, but also raised awareness of the seriousness of the emerging threat to these immunization campaigns during World Immunization Week from April 24–30. The rise in vaccine-preventable diseases is a cause for concern, as misinformation, population growth, funding cuts, and humanitarian crises jeopardize years of progress. This article explores the ongoing challenges in immunization and the global consequences of failing to maintain vaccination rates.

In the past decade, vaccines have saved more than 150 million lives, making immunization one of the most effective tools in preventing infectious diseases. However, even with these gains, the global health community is experiencing setbacks. Increased outbreaks of vaccine-preventable illnesses like measles, meningitis, and yellow fever have risen alarmingly. Illnesses that were previously almost eradicated, such as diphtheria, are coming back in some areas. WHO, UNICEF, and Gavi have all issued urgent calls for governments to invest in immunization programs to prevent further health crises.

While the United States has come far in vaccination efforts, the effects of no longer continuing immunization programs would be disastrous. If vaccination programs were to be discontinued in the country, diseases such as measles would instantly become much larger outbreaks than they are at present and spread to infect tens of thousands or more. Even those who never travel outside the nation might encounter sick carriers within their own communities and thus be subject to rapid spread of diseases that are otherwise preventable.

Consider measles. Although the U.S. has experienced a decline in measles cases due to strong vaccination efforts, outbreaks elsewhere in the world—particularly in nations with low vaccination rates—could do serious damage if the U.S. were to discontinue vaccinating. Complacency about vaccine-preventable diseases can be fatal. The dangers of being infected with these diseases may appear to be low, yet each person is at risk and nobody can tell if they will be the "one in 10,000" to die from an illness that could be prevented by a basic vaccine.

Why Health Systems Are Struggling to Keep Up?

Measles is coming back particularly perilously globally. Since 2021, incidence has been increasing, following declines in immunization coverage that happened during and following the COVID-19 pandemic. Measles cases increased to an estimated 10.3 million in 2023—a 20% rise from the previous year—according to WHO estimates. The trend is predicted to continue into 2024 and 2025, with outbreaks worsening across the globe.

Last year, 138 nations recorded cases of measles, and 61 of these had large or disruptive outbreaks. This is the highest number of outbreaks since 2019, and the trend is expected to increase in the next few months. Measles, which is a very infectious viral infection, is not only a public health threat but also overburdens health systems, taking away resources that can be used to address other critical health issues.

Meningitis and yellow fever have also increased substantially in recent years. In Africa, meningitis cases jumped in early 2024 with over 5,500 suspected cases and close to 300 fatalities in only three months. That is a major upsurge from other years, highlighting the necessity for proper immunization coverage. The same is true of yellow fever, whose cases are on the rise in Africa as confirmed cases appear in nations where the disease was on the decline in the last decade.

Role of Funding and Humanitarian Crises

One of the largest dangers to immunization campaigns is the decline in international funding for health programs. A recent WHO rapid stock take in 108 countries found that nearly half of these countries experience moderate to severe interruption in vaccination campaigns and routine immunization programs because of reductions in donor support. Least developed countries are being compelled to make difficult choices between important services, which tend to come at the cost of lifesaving vaccination programs.

Humanitarian emergencies, including armed conflicts and natural disasters, add complexity to the delivery of immunizations. Children in conflict or fragile areas are most at risk. In 2023, an estimated 14.5 million children did not receive all routine vaccine doses, a decline from 13.9 million in the previous year. Those children reside in areas where access to healthcare services is drastically reduced, which increases their likelihood of acquiring preventable illness.

The growing global health crisis underscores the urgent need for continued investment in immunization. Dr. Tedros Adhanom Ghebreyesus, Director-General of WHO, emphasized that vaccines have saved millions of lives over the past five decades. However, without proper funding and political will, these hard-won gains are at risk. The WHO is urging governments, especially in lower-income countries, to invest in vaccines, as they are one of the most cost-effective interventions for public health.

The international health community also urges continued efforts to build more resilient immunization systems and to ensure vaccines reach the most at-risk communities. WHO and its agencies have initiated efforts like the "Big Catch-Up," to vaccinate children who lost doses due to the COVID-19 pandemic. The effort, supplemented with ongoing investment in mass vaccination campaigns, is critical to stopping subsequent outbreaks and saving lives.

Importance of Herd Immunity

Vaccination not only protects the individual—it also safeguards communities. This phenomenon, referred to as "community immunity" or "herd immunity," is when a high percentage of the population has been vaccinated, thus limiting the transmission of disease. This is especially important for those who are unable to be vaccinated because of medical conditions or age, such as infants, older adults, or those with weakened immune systems.

By vaccinating ourselves and our kids, we not only protect our loved ones but also protect the others in our communities who cannot get vaccinated. Keeping vaccination rates high is what makes sure diseases that used to cause widespread sickness and death stay under control and never come back.

Vaccine-Preventable Disease Outbreaks Across The World

• Pertussis (Whooping Cough)
• COVID-19
• Measles
• Mumps
• Meningitis
• Influenza (flu)
• Human Papillomavirus (HPV)
• Hepatitis A

What Can You Do to Keep Your Family Safe from Vaccine-Preventable Diseases?

Keeping your family safe from vaccine-preventable diseases is important to make them healthy and safe. By keeping pace with recommended vaccinations, not only are you keeping your loved ones safe but also your community. Here's how you can do it:

1. Adhere to Immunization Schedules

The initial and most critical step is to adhere to the recommended immunization schedules for your family and yourself. These schedules are formulated to give protection in a timely manner against a variety of preventable illnesses. Sticking to these schedules ensures that people, particularly children, get vaccinated when they are most effective. This can avert outbreaks of diseases such as measles, whooping cough, and mumps.

2. Support Herd Immunity

Vaccines do not only immunize individuals, but they also immunize populations, a process referred to as "community immunity" or "herd immunity." If large numbers of people are vaccinated, it becomes more difficult for infection to spread. This is particularly important for groups that cannot themselves be vaccinated, like babies that are too young for some vaccines or people who have weakened immune systems from such diseases as cancer or HIV. By getting vaccinated and your family, you're helping protect the most vulnerable members of your community.

3. Stay Current on Vaccines for All Household Members

It's not just kids who require vaccines. Adults need to stay up to date on their immunizations as well. Many illnesses, such as the flu or shingles, can strike adults as well. Keeping all members of your household current on their vaccinations helps keep herd immunity intact and stops outbreaks.

4. Know the Consequences of Not Vaccinating

If vaccination levels fell, diseases that have been almost eliminated or contained could return. Diseases such as measles, whooping cough, and even polio have returned in regions with low vaccination levels. These diseases were once all but eliminated in much of the world but remain a threat, especially if vaccination levels fall.

5. Guard Future Generations

Vaccinating now doesn't only keep your family safe today—it helps to keep future generations healthy. By maintaining high levels of immunization, we ensure our children's children—and their children—are safeguarded against illnesses that were once widespread. If we discontinue vaccination, we might be fighting infections that we previously believed to be a relic of the past, and which create serious public health issues.

6. Stay Informed About Disease Outbreaks

Recent disease outbreaks like pertussis (whooping cough), measles, mumps, and COVID-19 have proven that vaccination efforts are always a concern. Keeping yourself updated regarding current outbreaks and vaccination schedules changes ensures that you can protect your family more effectively. Being aware of the when and where of outbreaks will also enable you to take preventive actions against exposure.

Our communities' well-being, and that of their most vulnerable, rely on common effort. If we stop vaccinating, the consequences could be dire, resulting in preventable deaths and overwhelming health systems.

“This is a warning specifically for parents” — Influencer Michael Brown recently released a video warning parents as well as others, about a potentially addictive drink that is easily available at gas stations in the US. He detailed how, during a casual visit to the gas station store for a beverage, he was approached by a young boy who asked him to buy ‘Feel Free’ for him. Despite being refused, the kid persisted and even tried lunging for Michael’s wallet, leaving him shaken up.

While paying at the counter, Michael recalled asking the shop cashier what ‘Feel Free’ was, to which she pointed at little blue bottles on the counter. She said people are so addicted to it that sometimes they visit 5–6 times a day to buy it — “It’s addictive and people lose their minds.” A quick look at the comments section of the post, which now has more than 9 million views on Instagram, had many people shocked at the severity of the drink and its consequences. Different healthcare professionals also detailed their experience with patients. “It’s Kratom! Have had patients with seizures because of this and also babies experiencing withdrawal from maternal use during pregnancy. It’s no joke,” commented Dr. Shilpa, MD, Child Neurologist and Development Specialist.

To know how many people are affected or it continues to affect, you do not have to look too far — a subreddit known as QuittingFeelFree, which has 5k members, and QuittingKratom with 52k members, are prime spots to get first-person accounts of people who struggled for years or months with their addictions.

In one of the stories, Jasmine Adeoye from Austin posted on TikTok that just a few months before June 2024, she drank several bottles of Feel Free a day and found that quitting it was not easy.

Last year, the production company of Feel Free also faced lawsuits, however, many people are not aware of the same. CBS News had reported that Botanic Tonics had also faced a class-action lawsuit filed in 2023. The lawsuit alleged that the company's marketing was misleading and targeted individuals with a history of addiction. In a statement, the company said it had "fallen short of the high standards of transparency" and implemented changes like enhanced labeling and age restrictions.

Feel Free and List of Ingredients

One of the main ingredients listed in the ‘Feel Free’ drinks is ground kratom leaves. Now a regular person would think — how bad can leaves be? — and consume the drink, but it’s these same leaves that are risky and can lead to severe addiction.

Native to Southeast Asia, the US Food and Drug Administration explains that it also carries the risk of addiction, seizures, and, in rare cases, death. Since kratom is unregulated in the U.S., some products are sold in highly concentrated forms and may contain contaminants like heavy metals and harmful bacteria.

What Happens with Unregulated Use of Kratom?

The American Addiction Centers detailed how lower doses of kratom could help people increase energy and alertness, while higher doses could produce effects similar to that of opioid drug abuse. They detailed a 7-year study done from 2011–2017. The study pointed out how there were 1,800 calls to poison control centers about kratom, with most of those calls happening in the last two years of that period. Here are some things that can happen with unregulated use of kratom:

Addiction and Withdrawal

While it's not common, long-term and heavy kratom use can lead to addiction. People who stop using it suddenly might experience withdrawal symptoms that feel similar to the flu, such as nausea, vomiting, body aches, and chills.

Lack of Regulation

The FDA has not approved kratom for any use. This means that kratom products are not regulated and can sometimes be contaminated with dangerous substances like heavy metals and harmful bacteria. The FDA has warned consumers not to use kratom and has seized shipments of kratom-containing products.

Mixing with Other Substances

Taking kratom with other drugs or alcohol can be very dangerous. In rare but serious cases, this combination has led to severe side effects like liver damage and even death.

Overdose

Overdosing on kratom alone is very rare. However, when it is combined with other substances, the risk increases. For example, a CDC report linked kratom to 152 deaths in 2016 and 2017, but other substances were involved in 87% of those cases.

Over the past few years, doctors and researchers have noticed a clear pattern: more young adults are being diagnosed with colorectal cancer—those under 50. On the surface, some of this surge can be credited to increased screening, especially following guideline updates that lowered the recommended starting age from 50 to 45. But deeper beneath those screening numbers lies a troubling reality: diagnoses among truly younger adults aren’t solely due to being screened earlier. That means we’re facing a bigger shift, one that demands fresh solutions.

In 2018, the American Cancer Society recommended colorectal cancer screening begin at age 45—five years earlier than before. In 2021, the US Preventive Services Task Force followed suit. Unsurprisingly, this led to a jump in early-stage diagnoses among 45-to-49-year-olds.

ACS data published in JAMA shows a steady increase in screening rates: from 20.8% in 2019 and 19.7% in 2021, rising to 33.7% in 2023 among that age group. A second ACS-led study tracked early-stage diagnosis rates—from 9.4 cases per 100,000 in 2019, to 11.7 in 2021, then 17.5 in 2022. That’s a 50% relative increase between 2021 and 2022. Experts note this trend largely reflects held-back cases being detected earlier thanks to broader testing.

But that doesn’t chalk up the entire story. Colon and rectal cancers have been increasing steadily in younger adults—those under 45—for decades. This early-onset rise began in the mid-1990s and includes late-stage diagnoses—not just early detection.

Who Is Getting Diagnosed?

Doctors stress that while the decline in age recommendations helped some, it doesn’t explain the persistent rise in younger adults. In fact, research suggests annual case increases of 2–2.6% have occurred since 2012 among those under 50. In the 20–39 age group, incidence has been rising by around 1.6% per year since 2004.

More than 20% of colorectal cancer cases now occur in adults under 55—double the rate from the mid-1990s. Alarmingly, this early-onset trend is contributing to colorectal cancer becoming the leading cause of cancer death among younger men and the second-leading cause among younger women.

These are not always lifestyle-driven cases. Many patients are young, active, and with no known family history. As clinicians, many have expressed how unsettling it is to see so many seemingly healthy people presenting with aggressive tumors—and often at advanced stages.

What Might Be Driving This Worrisome Surge?

Researchers are testing multiple theories—but none yet fully explain the rise:

Gut microbe toxins such as colibactin, produced by certain E. coli, are drawing attention. These toxins leave a specific DNA mutation fingerprint in early-onset tumors—over three times more common compared to cancers in older patients. Some studies suggest 15% of early-onset cases involve colibactin-driven mutations.

Diet- and lifestyle-related risks remain central: obesity, processed meats, low-fiber diets, sedentary behavior, refined sugar, insufficient sleep, and environmental pollutants. One prominent study links higher birth and adolescent BMI with increased colon cancer risk later in life. Even every additional kilogram at birth above normal is tied to 9% higher colorectal cancer risk.

Other suspected contributors include microplastics, antibiotic use, and artificial light exposure, although more conclusive evidence is pending.

Symptoms You Should Never Ignore

Crucial to stopping this trend early is awareness. Here’s what to watch for—and not dismiss, even if you’re under 45:

• Rectal bleeding
• Persistent abdominal pain or cramping
• Changes in bowel habits or stool shape
• Unexplained weight loss or appetite changes

Jessica Star of ACS—lead author on both new JAMA papers—warns, more than half of cases in younger adults occurred in those not yet eligible for screening. So symptoms matter, regardless of age. If you're dismissed with a benign diagnosis like hemorrhoids, consider a second opinion.

How to Lower Your Risk?

Screening matters. Most colorectal cancers begin as precancerous polyps, and removing these early saves lives. Current recommended options include:

• Annual or triennial stool-based fecal tests
• Colonoscopy every 10 years
• Virtual colonoscopy every five years
• Sigmoidoscopy every five years

Promising new research shows that mailing stool test kits directly to eligible adults dramatically increases completed screenings—even more than simply offering choice. Yet, screening is still underused: more than 1 in 3 adults aged 45 and older report not getting screened as recommended. To reduce personal risk:

• Maintain healthy body weight and regular physical activity
• Cut back on red and processed meats, refined sugars, and ultraprocessed foods
• Boost fiber intake through plant-based nutrition
• Avoid tobacco and limit alcohol
• Stay alert to symptoms and seek screening or evaluation promptly when indicated

If you’re under 50—or even nearing that threshold—understand this: colorectal cancer is no longer just a disease of older adults. While earlier screening through age-lowering guidelines has helped catch many early-stage cancers in 45–49-year-olds, it doesn’t address the underlying, persistent rise in true early-onset cancer.

The surge among younger adults signals something deeper—and possibly preventable—but only if we tackle it strategically. That means screening more women and men at the right age, investing in research, and making early testing easier and more equitable.

As expert researchers remind us, we’re not merely diagnosing more cancers—we’re getting better at catching them earlier. But to save more lives, identify root causes, and reverse these trends, we must remain proactive. Not just for our generation—but for all who follow.

One of the most common cancers in the world, it is the leading cause of cancer related deaths in the world. It accounts for the highest mortality rates among men and women. However, this has become a rising issue among women. A 2014 study published in the Seminars in Thoracic and Cardiovascular Surgery journal explained that historically lung cancer was mainly studied in men because it was very rare in women. However, as social habits changed and more women started smoking, the number of lung cancer cases in women increased. They mentioned that lung cancer often behaves differently in women than it does in men, especially in non-smokers. This review looks at these differences, including risk factors, how the disease develops, and treatment options.

Lung Cancer in Women

In the United States, lung cancer is the second most common cancer in women and the top cause of cancer-related death. Here are some important statistics from 2012:

• There were an estimated 109,690 new diagnoses in women.
• Lung cancer caused an estimated 72,590 deaths in women, which was more than the number of deaths from breast and colon cancer combined.
• The 5-year survival rate for women is about 18%, which is slightly better than the 14% rate for men, but it is still very low.
• Globally, lung cancer cases and deaths in women are still on the rise, especially in countries where more women are starting to smoke.

What Are Some Risk Factors Other Than Smoking?

Smoking is still the biggest cause of lung cancer in women, responsible for 80-90% of cases. However, a significant number of women who get lung cancer have never smoked.

• Women married to men who smoke have a 25-29% higher risk of getting lung cancer.
• Burning cooking oil or other fuels indoors in areas with poor airflow, especially in developing countries, is a major risk factor.
• A family history of lung cancer increases a woman's risk more than a man's.
• Hormones like estrogen may play a role in the development of lung cancer.
• Studies in some women, particularly in East Asia, have linked the human papillomavirus (HPV) to lung cancer.

What Are Some Challenges Women Face With Lung Cancer Diagnosis?

According to Lungevity, women often face delays and hurdles in getting a lung cancer diagnosis, which can worsen their chances of survival.

Diagnosis Delays

Women are less likely to seek help for early symptoms and can experience longer waiting times between initial doctor visits and a final diagnosis. This can allow the disease to progress before treatment even begins.

Lack of Screening

Many women are not offered lung cancer screening. A study found that women of color who are eligible for screening are six times less likely to be offered it than their male counterparts.

Outdated Rules

Even with recent updates to screening guidelines in the Center of Disease Control and Prevention, which now include people aged 50 and older and with a smoking history of at least 20 pack-years, many women still don't qualify. This is a major issue because a large number of women with lung cancer have a limited smoking history, which means they are often overlooked.

What Other Ways Does Lung Cancer Affect Women

The impact of lung cancer on a woman's well-being is often ignored, yet research shows it's a significant burden.

Psychological Distress

Women with lung cancer have higher rates of depression and anxiety than men. This stress is often made worse by the stigma of the disease, with many women reporting judgmental comments about smoking, regardless of whether they have a smoking history.

Sexual Health

Sexual health is often an overlooked part of cancer care for women. A study of 249 women with lung cancer found that 77% experienced moderate to severe sexual dysfunction. The women reported issues like fatigue and shortness of breath during intimacy, as well as vaginal dryness and pain.

Lack of Women in Clinical Trials

A long-standing problem in healthcare is the low number of women in clinical trials. This makes it difficult to know how effective a treatment is for women specifically.

Low Participation

Women make up only 40% of participants in clinical trials for diseases that affect them, like cancer. For non-small cell lung cancer, this number has not changed much over the past two decades.

Unique Barriers

Women face extra challenges in participating in trials, such as being primary caregivers, which limits their time. There are also gender biases from doctors who may assume women are less interested in research.

Safety Concerns

The lack of female representation is a safety issue. One study found that women were 25% more likely to have severe side effects from cancer treatments, but another study found that they were less likely to report these issues.