Vax-Before-Travel, an international publisher of vaccine information noted that in 2025 Lyme disease ticks have progressed westward into many midwestern states. It has also reported a significant increase. However, while the Tick Season is back, there is a new Lyme treatment on the horizon. But, with it, there are also unique symptoms that one has to be aware of. Unique Symptoms Of Lyme Disease In 2025The ongoing threat of ticks is usual when one is enjoying their time as the weather warms up. They can be found in your backyard and can transmit Lyme disease, a tickborne infection caused by the bacteria Borrelia burgdorferi. While Lyme disease is usually resolved with a short course of antibiotics, it is not always a simple illness. Sometimes, it can lead to prolonged symptoms, if untreated. As per American Medical Association (AMA), Lyme disease is the most common vector-borne disease in the US, with an estimated 476,000 people diagnosed and treated each year. The numbers are also corroborated with the Centers for Disease Control and Prevention (CDC). The Maryland Government Health website also notes that for about 75% of those diagnosed with Lyme disease, the first sign is always a skin lesion. This appears within one to four weeks after being bitten by an infected deer tick. However, only about 20% of these lesions take on the classic bull's eye appearance, which is most commonly associated with Lyme disease. This means, 55% of those with lesions may not even be diagnosed with the condition, and may not get the treatment.ALSO READ: Lyme Disease In US: How Worried Should You Be Of Ticks? Here Are 7 Unique Symptoms Of Lyme DiseaseHeart ProblemsThe Time reports that if Lyme is not treated early on, it can impact the cardiac, neurologic, and rheumatologic systems. The CDC notes that 1 out of 100 patients have Lyme bacteria in their heart tissues. The condition is also called Lyme carditis. This leads to heart inflammation, light headedness, fainting, shortness of breath, heart palpitations, or chest pain. Brain FogJohn Hopkins Medicine Lyme Disease Research Center notes that advanced brain imaging shows that Lyme disease brain fog is real. It can lead to various brain effects, including difficulty in focusing, thinking, reading, and absorbing information. Bell's PalsyThere are 12 essential nerves, also known as the cranial nerves that originate in the brain and play an important role in sensory functions and movements in the different parts of the head, face, neck, and torso. Lyme disease can also affect those nerves, leading to Bell's Palsy, causing sudden weakness or even paralysis. Eye ProblemsSome people may experience eye irritation and conjunctivitis. The American Journal of Medicine's 1995 study also suggests that Lyme can cause sudden vision loss, damage to optic nerve, and neurotrophic keratitis (decreased corneal sensation). Other symptoms include blurry vision, eye floaters, tearing and extreme sensitivity to light. Hearing Problems A 2018 study published in Otolaryngologia Polska, reported of the 216 people with tickborne disease, 162 experienced otolaryngological symptoms—making them a “frequent manifestation,” according to the study authors. The most common hearing issues are tinnitus, vertigo and dizziness, headache, and unilateral sensorineural hearing or hearing loss in one ear. ArthritisIt is one of the common symptoms of Lyme disease, especially in young people. It can be seen in form of a swollen knee, a low grade fever, or a kid limping. It usually starts at a fourth week of being bitten. On a hopeful note, researchers at Northwestern University in Illinois recently screened over 500 antibiotics and FDA-approved compounds to identify treatments that specifically target the unique cellular makeup of Borrelia burgdorferi, the bacteria behind Lyme disease.Their findings, published in Science Translational Medicine, revealed that piperacillin, an antibiotic from the penicillin family, successfully cured mice of Lyme disease at doses 100 times lower than doxycycline, the standard treatment currently in use.FatigueThis is not just any fatigue, but a weakness that is debilitating. A 2022 study published in the International Journal of Infectious Diseases noted that people with a history of Lyme were 8 to 15 times more likely to report severe or moderate fatigue than those who have never had the disease.READ: Family Shares How A Lyme Disease Misdiagnosis Cost Their Son's Childhood How Long Do These Symptoms Last?As per the National Health Service, (NHS), UK, in case of a rash, it can appear up to 3 months after being bitten by an infected tick. However, in most common cases, it appears within 1 to 4 weeks, and stays for several weeks. In cases of untreated Lyme disease, the symptoms may appear later, and may become chronic, like debilitating fatigue.