As worldwide use of GLP-1 drug such as Ozempic and Mounjaro increase, medical experts are ringing the alarm over a bizarre new cosmetic side effect- loose skin on the feet. Ozempic, generic name semaglutide, was originally created to treat type 2 diabetes. Now it's a name on every lip for its unbelievable impact on weight loss. By mimicking the hormone GLP-1, it reduces hunger, decelerates digestion, and regulates blood sugar. But with the touted advantages comes a new and less sexy concern: Ozempic feet.

This is a slang term for visible signs of skin aging and sagging on the feet — a side effect now making its public debut thanks to social media gossip and sharp-eyed observers at celebrity makeovers. It's been added to a growing list of cosmetic issues like Ozempic face and Ozempic butt—terms used to describe the gaunt facial appearance and buttock deflation in some on these injectable medications.

What Is 'Ozempic Feet'?

'Ozempic feet' is a description of the creased, sloping skin and empty appearance of the feet — particularly at the top, where the skin is naturally thinner. This is due to a rapid and extreme reduction in fat reserves as patients lose weight. Unlike intentional body sculpting or fat reduction from exercise, weight loss with Ozempic is fast and even, subjecting areas that typically have small fat reserves, such as the feet.

Experts explain that the sudden and severe loss of fat leaves skin looking deflated, aged, or disproportionate to the rest of your body. Your feet don't have much cushioning to begin with. After the fat loss, you're left with wrinkled skin and a higher likelihood of experiencing pain when walking.

Essentially, the same drug that is helping drug users lose weight is giving them feet that look prematurely old without intending to.

The celebrity side effect was the subject of viral rumination following reports of speculation between followers that TV personality Sharon Osbourne and chat show host Oprah Winfrey may have 'Ozempic feet.' Sharon, 72, posted a snap with her grandson in April 2025 that prompted fans to comment upon an inconsistency between ageless looking face and sharply creased ankles. The reaction varied from worry to wonder, "Your ankles are giving your age away," a follower suggested.

Oprah Winfrey, 71, faced similar criticism when she showed up at the 55th NAACP Image Awards. Spectators commented on how loose her foot skin looked — a striking difference for someone who had seemingly shed almost 50 pounds on GLP-1 drugs.

Neither Osbourne nor Winfrey has indicated whether they attribute these differences to their weight-loss regimens, but the internet chatter has pushed the topic into the mainstream.

Is 'Ozempic Feet' a Cause for Concern?

While the term is likely to be ringing somewhat flippant or superficial in tone, it opens up into a wider, more serious discussion of the long-term impact of rapid medical weight loss.

Doctors note that any sudden change in weight — especially one achieved through drug methods — can affect soft tissue, elasticity of the skin, and distribution of fat. In a couple of cases, GLP-1 medication like Ozempic has been determined to cause treatment-induced neuropathy in patients with diabetes, producing symptoms of numbness, tingling, or burning sensations in the feet.

Healthcare professionals suggest the users to take care of their foot health very carefully. "If you notice changes in your feeling, persistent pain, or swelling, seek medical attention," says Dr. Weintraub. "Your feet also develop symptoms of nutrient deficiency or rapid muscle and fat loss which can affect your balance and stance."

Other Side Effects of Taking Weight Loss Drugs

As the fame of Ozempic shoots through the roof with nearly 1 in every 8 Americans having seemingly used GLP-1 medications by 2024, so has its psych effect.

A study indicated that the patients taking semaglutide were 195% more likely to suffer from severe depression and over 100% more likely to be suicidal. Even though both the U.S. FDA and the European Medicines Agency (EMA) have stated that no conclusive link has been made between Ozempic and suicidal thoughts, the increased number of reports is raising alarms.

These findings have prompted most health experts to emphasize the requirement for sustained assistance as well as frequent surveillance of individuals who take these drugs- physically as well as mentally.

Add to the complexity is the "rebound" phenomenon. Northwestern University studies indicate that patients who had stopped GLP-1 therapy regained nearly two-thirds of the lost weight. The reversal also logged increases in blood pressure, cholesterol, and risk for cardiovascular disease thus, lifestyle alteration and upkeep a priority, even after the drug.

Winfrey herself echoed those words in a recent interview, "These drugs are not a magic bullet. They're a tool, not a replacement for lifestyle change."

'Ozempic feet' is a superficial aesthetic issue, but it reflects on a larger narrative: the evolving landscape of weight loss pharmaceuticals. As ever more people pursue drugs to manage weight and comorbid risk, the focus must remain with overall well-being far and above the reading on the scale.

Ananda Lewis, celebrated TV host known for her authenticity and warmth, passed away at 52 after a long and brave battle with breast cancer. Once a beloved face on BET’s Teen Summit and MTV’s Total Request Live, she used her platform to engage young audiences with pressing social issues and celebrity interviews that left a mark.

A Powerful Presence on Screen

Lewis first came into the spotlight through BET’s Teen Summit, where she led candid conversations on challenges facing Black youth. Her interviews with figures like Kobe Bryant, Tupac Shakur, and Hillary Clinton earned her critical acclaim, including an NAACP Image Award.

In 1997, she joined MTV, becoming a key voice on MTV Live, Hot Zone, and TRL. Though her move sparked criticism, she remained unapologetic. “Growth is necessary,” she told the Associated Press. “You’ve got to get out there and live your life.”

She later launched The Ananda Lewis Show in 2001, a daytime talk show aimed at real conversations, even if it followed a familiar format. The show lasted one season, but Lewis remained a powerful presence, later joining The Insider as a correspondent.

Breast Cancer Journey That She Shared With The World

In 2020, Lewis revealed that she had been living with stage 3 breast cancer since 2018—later advancing to stage 4. Her diagnosis came after years of ignoring persistent inflammation linked to mastitis from breastfeeding. A lump discovered in her right breast led to a biopsy, confirming it was invasive carcinoma.

Instead of following a conventional medical path, Lewis chose alternative treatments. “I wanted to understand why my body created cancer and how to change the terrain,” she explained. She focused on diet changes, stress management, detoxing, and holistic therapies like high-dose vitamin C, acupuncture, and cryoablation.

A Different Kind of Battle

Lewis moved to Arizona in 2020 for 16 weeks of intensive integrative treatment. Her cancer reduced from stage 3 to 2 and was no longer in her lymph nodes. But the journey wasn’t without hardship—financial struggles and insurance lapses made consistent treatment difficult.

In early 2023, a scan showed the tumor had grown slightly, but it had not spread. She underwent electrical ablation in Mexico, which unfortunately didn’t succeed. By October 2023, a PET scan confirmed the cancer had advanced to stage 4. Still, Lewis continued treatment and saw significant improvement by January 2024.

Lewis was candid about her journey, using her story to raise awareness about early detection and holistic health. “Stage 4 doesn’t mean the end,” she said. “It means I have to do more.”

Her message to women was clear: be proactive. Prioritize mammograms, manage stress, sleep well, and adopt a clean lifestyle. “If I had known what I know now ten years ago, perhaps I wouldn’t have ended up here,” she said.

“I want to look back and say—I did that exactly how I wanted to,” Lewis reflected. Her legacy is one of resilience, wisdom, and an enduring belief in the right to choose one’s own path—even through cancer.

In a revolutionary medical breakthrough, scientists have identified that a five-minute phone test will soon be able to detect early onset of Huntington's disease—a rare, genetic brain disorder—long before symptoms become visibly apparent. With digital health technologies revolutionizing the future of diagnosis, the new app test offers promise of quicker, more convenient, and highly accurate tracking, all from the comfort of the patient's own home. Wondering how your phone could be part of the future of neurology? Here's what a new study says.

Scientists have created a smartphone application that can identify early signs of motor symptoms of Huntington's disease within five minutes. The research, published in the journal Brain, is presented here with the explanation of how simple devices used on a daily basis can become big medical devices to analyze a subject's neurological well-being in real time from the comfort of his or her home. This innovation is especially valuable considering the scarcity and intricacy of Huntington's disease (HD), a genetically inherited disease in which there is, as of yet, no cure.

How the Smartphone Test Works?

The test developed is composed of five smartphone tasks assessing factors like finger tapping, balance, and involuntary movements. These activities together create a Huntington's Disease Digital Motor Score (HDDMS), a sensitive measure that can identify minimal changes in motor function that could occur before more evident clinical signs. As Ed Wild, Professor of Neurology at University College London's Huntington's Disease Center, points out, the fact that motor impairment can be measured in only five minutes at home has the potential to change the way clinical trials are carried out and disease progression followed.

Huntington's disease is a genetically inherited condition that leads to progressive degeneration of nerve cells within the brain, particularly in areas responsible for movement, cognition, and emotion. The symptoms usually occur between ages 30 and 50 and gradually worsen. In the early stages, there can be involuntary jerking or contorting movements (chorea), clumsiness, imbalance, and mood swings. When the disease progresses, patients become severely disabled from a motor standpoint, develop loss of cognitive abilities, and have psychiatric disturbances.

Conventional diagnostic approaches such as neurological assessment and imaging studies can be costly, time-consuming, and not as sensitive when identifying early-stage symptoms. The HDDMS tool is a cost-friendly, easily accessible alternative that could result in improved disease management through earlier intervention.

What Sets the HDDMS Test Unique and Accurate?

In contrast to traditional clinical evaluations that entail patients visiting specialized clinics, the HDDMS may be taken on a smartphone in under five minutes. The measure was created using information from more than 1,000 participants in four independent studies and is among the most widely validated digital tests for HD to date.

The investigators discovered that the HDDMS was almost twice as effective as conventional techniques in detecting significant changes in motor function. Such accuracy is important in rare conditions such as HD, where clinical trials have often been hindered by limited sample sizes and heavy participant burden.

With a number of hopeful treatments for Huntington's disease being developed, the need to measure disease progression accurately has never been greater. Integrating the HDDMS into clinical trials could make the research process more efficient by cutting the number of participants needed and the time needed to determine the effectiveness of a drug.

Professor Wild highlighted that more sensitive equipment is essential in rare disease investigation, where the limited patient base means it is challenging to set large-scale trials. He added the HDDMS provides a "more meaningful and convenient" means of assessing motor function than standard in-clinic tests.

What is Huntington's Disease?

Huntington's disease is a hereditary, always fatal disease due to a mutation in the gene encoding a protein named huntingtin. The mutation results in an abnormal repetition of the DNA sequence CAG (cytosine, adenine, guanine), causing brain cells to degenerate over time. Every child of a parent with HD has a 50% possibility of inheriting the defective gene.

Symptoms are:

• Chorea (involuntary jerking motions)
• Cognitive impairment
• Personality and mood changes
• Trouble with walking, talking, and swallowing
• Insomnia and weight loss

With time, people with HD become unable to take care of themselves. The disease is eventually fatal, and no cure is available. Medications can be used to control chorea, depression, and anxiety, however.

Diagnosis is usually made through neurological examination, genetic testing, and imaging tests like MRIs or CT scans. Although these work well in establishing the disease, they are frequently unable to identify early signs, especially minor motor dysfunctions.

Treatment is mainly supportive. Medications like tetrabenazine and deuterabenazine are employed to manage movement disorders, and antipsychotic medications can be given for psychiatric abnormalities. Genetic counseling is highly advised for HD-affected families.

Although the HDDMS has been impressive in its accuracy in initial trials, scientists recognize that additional studies are necessary to assess its ability to forecast long-term functional decline. Additional research will also investigate how the tool can be introduced into standard clinical practice and patient follow-up.

If successful, smartphone-based HDDMS will be the cornerstone of the global battle against Huntington's disease, providing an affordable and scalable means of monitoring one of the most complicated neurological diseases in the arsenal of medicine.

We have all heard people say that they are old souls trapped in a young body, however, this is a figure of speech people use. While this phrase may mean you like old school things, it can also happen literally. Sometimes your body ages faster than you do, but this is the biological age we are talking about. While chronological aging is counted as the years we have lived, biological age can be faster or slower.

Think of it as perishable food. If you leave them in unfavorable environments, they can spoil fast, becoming edible. However, when you keep them in the correct environment with even temperature, the food will stay edible for longer than it should. Our bodies are similar in that sense. If you take care of it, limiting processed food, exercising and taking care of your health, you will find that your biological age is much slower or healthier than a person who does the opposite. However, what is the connection between biological aging and our lifestyle. How do we age slower/faster depending on our choices.

A new study suggests that signs of faster aging in your body are connected to a higher chance of developing dementia and stroke. Specifically, researchers found that people with shorter telomeres in their white blood cells tend to have an increased risk of these two brain conditions. These findings were published recently in the journal Neurology.

What Are Telomeres and Why Do They Matter?

Think of telomeres as the protective caps on the ends of your chromosomes, much like the plastic tips on shoelaces. They prevent your chromosomes from unraveling and getting damaged. Every time your cells divide, these telomeres get a little shorter. This makes them a useful way to estimate a person's biological age, which is how much wear and tear your body has accumulated from stress over time, rather than just your age in years. Your biological age can be quite different from your actual age.

Lifestyle Habits Can Counter the Risk

However, there's good news: the study found that this link between shorter telomeres and brain diseases wasn't present in people who maintained healthy lifestyle habits. This suggests that even if your body shows signs of faster aging, you can still reduce your risk of age-related brain diseases. This includes things like keeping a healthy weight, limiting alcohol, getting enough sleep, and exercising regularly. These healthy choices can help delay the aging of your cells and lower your chances of developing these conditions, especially if you're already at a higher risk.

Shorter Telomeres, Higher Risk

For this study, researchers looked at genetic data from over 356,000 people. They categorized participants into three groups based on the length of their telomeres: short, medium, or long. They then compared telomere length to people's lifestyle habits and whether they had developed dementia, stroke, or depression.

Over an average of seven years, nearly 26,000 people developed at least one of these three age-related brain diseases. People with the shortest telomeres had significantly more cases of these brain diseases compared to those with the longest telomeres. Overall, after considering other risk factors, individuals with short telomeres were 11% more likely to develop one of these brain diseases. More specifically, they faced an 8% increased risk of stroke, a 19% increased risk of dementia, and a 14% increased risk of late-life dementia.

It's important to remember that this study shows a connection, not a direct cause-and-effect relationship between telomere length and brain health.