Respiratory virus season is upon the United States as colder months arrive, bringing an expected rise in cases of COVID-19, influenza, and RSV. In its annual outlook, the Centers for Disease Control and Prevention (CDC) predicts that peak hospitalizations from these viruses during the 2025–26 season will be similar to last year. Public health experts speaking to ABC News have emphasised that vaccination remains the most effective way to protect against severe illness. Below, we answer common questions about the RSV vaccine for anyone seeking guidance.What Is The RSV Vaccine?The RSV vaccine is a shot designed to protect against respiratory syncytial virus (RSV), which can cause serious lung infections in infants and older adults. Vaccines work by prompting the body to create antibodies that help fight off the virus. There are several types of RSV vaccines, including mRNA and protein-based versions, each working in slightly different ways to stimulate the immune system.Who Can Get An RSV Immunization?According to the CDC, RSV vaccines are recommended for adults aged 75 and older, as well as those between 50 and 74 who have a higher risk of severe illness. Studies suggest that a single dose provides protection for at least two years in older adults. For infants, protection can be achieved either by vaccinating mothers during pregnancy or by giving babies an antibody shot after birth to help prevent severe RSV infection.When Is The RSV Vaccine Available?Eligible adults can receive the RSV vaccine at any time, though late summer and early fall are generally considered the best period, according to the CDC. For expectant mothers, the vaccine is usually available between September and January, while the antibody shot for infants is typically recommended from October through March.How Much Does The RSV Vaccine Cost?For those with insurance, the RSV vaccine may be fully covered. Without insurance, the shot can cost around $350, according to Dupont. “Patient assistance programs are available that can significantly reduce out-of-pocket costs,” Dupont added.Does RSV Vaccine Have Any Side Effect?Like all vaccines, the RSV shot can have side effects. Common ones include pain, redness, or swelling at the injection site, as well as fever, headache, fatigue, and muscle or joint aches. Serious side effects are rare but can occur. Fainting may also happen after the shot, and observation may be advised to prevent injury.Common side effectsPain, redness, or swelling at the injection siteFeverFatigueHeadacheMuscle or joint painNausea or vomitingDiarrheaSwelling or tenderness under the armRare but serious risksSevere allergic reaction (anaphylaxis): Symptoms may include hives, facial or throat swelling, difficulty breathing, rapid heartbeat, or dizziness. This is a medical emergency; call emergency services immediately.Guillain-Barré Syndrome (GBS): A very rare condition where the immune system attacks the nerves. Seek medical attention if you experience sudden weakness, tingling in the hands or feet, or pain.Fainting: This can occur after vaccination, and you may be asked to stay for a short observation period to prevent injury.