Autism has increased significantly since 2000, particularly in the US, triggering public concern about what might contribute ot its prevalence. In November, Robert F Kennedy Jr, who was selected to lead the US Department of Health and Human Services (HHS), linked autism to childhood vaccinations. Soon, medical experts jumped on it to discredit his claim. But then many raised this question: if autism is not caused by vaccines, then what causes this neurological disorder? Research tells us that autism tends to run in families, and a meta-analysis of 7 twin studies claims that 60 to 90% of the risk of autism comes from your genome. If you have a child with autism, you are more likely to have another autistic child. Your other family members are also more likely to have a child with ASD.Changes in certain genes or your genome increase the risk that a child will develop autism. If a parent carries one or more of these gene changes, they may get passed to a child (even if the parent does not have autism). For some people, a high risk for ASD can be associated with a genetic disorder, such as Rett syndrome or fragile X syndrome. For the majority of autism cases, multiple changes in other regions of your DNA increase the risk of autism spectrum disorder. The majority of these DNA changes do not cause autism by themselves but work in conjunction with many other genes and environmental factors to cause autism.If you or your child has ASD, we recommend that you explore genetic testing. Genetic testing could show you the genetic cause of you or your child’s autism and reveal any genetic mutations that might be linked to serious co-occurring conditions like epilepsy. Genetic testing can give doctors useful information so they can provide better, more personalized interventions. Read two families' stories on how genomics helped their understanding of autism and receiving personalized healthcare.What environmental factors are associated with autism?According to the National Institute of Environmental Health Sciences, certain environmental influences may increase autism risk:Advanced parental agePrenatal exposure to air pollution or certain pesticidesMaternal obesity, diabetes or immune system disordersExtreme prematurity or very low birth weightBirth complications leading to periods of oxygen deprivation to the baby’s brain