Health and Me

Itisha Arya

Are Diet Sodas Really Safe? New Research Points To Liver Risk

diet soda healthy or not

Most people assume that low- or no-sugar drinks are a healthier alternative to regular sodas, but new research suggests that might not be the full picture. A large-scale study presented at UEG Week 2025 found that both sugar-sweetened beverages (SSBs) and low- or non-sugar-sweetened beverages (LNSSBs) are linked to an increased risk of developing metabolic dysfunction-associated steatotic liver disease (MASLD), a condition previously known as non-alcoholic fatty liver disease.

According to the Cleveland Clinic, MASLD—short for metabolic dysfunction-associated steatotic liver disease, is a condition in which extra fat accumulates in the liver. It was previously called nonalcoholic fatty liver disease (NAFLD). Unlike liver damage caused by heavy drinking, MASLD is linked to metabolic risk factors such as obesity, type 2 diabetes, high blood pressure, and high cholesterol. If left untreated, it can progress to more serious liver problems.

Researchers analyzed data from 123,788 participants in the UK Biobank who did not have liver disease at the start of the study. Participants reported their beverage consumption through multiple 24-hour dietary questionnaires, giving researchers insight into how both sugary and “diet” drinks might affect liver health.

The results were striking: individuals consuming more than 250 grams per day of either SSBs or LNSSBs faced significantly higher risks of MASLD, about 60% higher for LNSSBs and 50% higher for SSBs. Over a median follow-up of 10.3 years, 1,178 participants were diagnosed with MASLD, and 108 died from liver-related causes. Interestingly, LNSSBs, but not SSBs, showed a notable link to liver-related mortality. Both drink types were also tied to increased liver fat.

<h2>Understanding MASLD and Its Growing Impact</h2>

MASLD occurs when excess fat builds up in the liver, which can eventually lead to inflammation, fatigue, abdominal pain, and loss of appetite. Once considered less common, MASLD has now become the most widespread chronic liver disease globally, affecting more than 30% of the population. It is also emerging as a leading cause of liver-related deaths worldwide.

Lead author Lihe Liu emphasized, “SSBs have long been scrutinized, while their ‘diet’ counterparts are often seen as a healthier choice. Our study shows that both types of beverages are widely consumed, yet their effects on liver health have not been fully understood.”

Liu added, “Even modest consumption of LNSSBs, like a single can per day, was linked to a higher risk of MASLD. These findings challenge the perception that ‘diet’ drinks are harmless and highlight the need to reconsider their role in our diets, especially as MASLD continues to grow as a public health concern.”

<h2>Why Both Sugary and Diet Drinks May Harm the Liver</h2>

The researchers explained potential mechanisms behind the risks. SSBs, with their high sugar content, can spike blood glucose and insulin, promote weight gain, and increase uric acid levels, all contributing to liver fat accumulation. LNSSBs may affect liver health differently: by altering the gut microbiome, disrupting feelings of fullness, triggering sugar cravings, or even stimulating insulin secretion.

Experts recommend limiting both sugar-sweetened and artificially sweetened beverages. Replacing either type with water showed a significant reduction in MASLD risk, about 13% for SSBs and 15% for LNSSBs. Simply switching between SSBs and LNSSBs did not reduce risk.

The researchers plan to investigate causal mechanisms more deeply with long-term studies, including randomized and genetic trials. They aim to better understand how sugar and its substitutes interact with the gut microbiome and influence liver disease.

Health Conditions A-Z

health

diet-soda-healthy-or-not

diet soda

diet soda health

diet soda health risks

diet soda health effects

diet soda health studies

regular vs diet soda health

shift-to-plant-based-proteins-low-fat-dairy-to-boost-heart-health-american-heart-association

Shift to Plant-Based Proteins, Low-Fat Dairy To Boost Heart Health: American Heart Association

ozempic-and-wegovy-prices-slashed-again-in-india-to-counter-cheaper-generics

Ozempic And Wegovy Prices Slashed Again In India To Counter Cheaper Generics

breast-conservation-surgery-vs-mastectomy-what-surgeons-recommend-today

Breast Conservation Surgery vs Mastectomy: What Surgeons Recommend Today

Nutrition

8 Sit-Up Variations to Strengthen Your Core and Build Stability

Benefits Of Ayurvedic Health Supplement Ashwagandha

9 Anti-Inflammatory Breakfast Options You Should Try

5 Foods You Should Avoid For PCOS, Says Gynecologist

Love Sitting With Your Legs Crossed? Here’s You Should Avoid It

6 Daily Foods That Are Secretly Increasing Your Calories

9 Brain Boosters You Should Do Everyday

Hip Exercises That Will Keep You Flexible As You Age

9 Leg Exercises Office Workers’ Should Do At Home

Benefits of Having Herbal Tea Every Morning

9 Daily Habits That Boost Your Brain Power

Lower-Body Exercises That Are Game-Changers

How Drinking Apple Cider Vinegar Helps You

Aging Myths You Should Never Believe

Superfoods That Support Your Gut Health

What Happens To Your Body When You Eat Instant Noodles Every Day?

Health Issues Premature Babies Often Face

Exercises Office Workers Should Do For Their Heart Health

Reasons Why You Should Add Raw Turmeric To Your Diet

Benefits Of Drinking Milk At Night: Why You Should Do It

Food That Provides Vitamin B12 Naturally In Your Diet

Surprising Health Benefits Of Fenugreek Seeds

9 Superfoods You Should Eat For Your Brain Health

What Does Mental Health Support Look Like At Work?

Long Stretches You Should Do To Unwind From Your Day

Colon Cancer In Young Adults: Early Symptoms You Should Know

Health Benefits Of Eating Dry Fruits Everyday

Are You At Risk For Fried Rice Syndrome?

These Tests Reveal How Well You Are Aging

Lower-Back Exercises You Should Do After A Long-Day's Work

Children’s Diet – What Kids Need To Eat For Immunity Building

Common Diabetes Myths That Could Hurt Your Health

Love Spicy Food? Here’s How It Affects Your Health

Superfood List: Veggies And Fruits You Must Have For Immunity

Foods People With IBS Should Avoid

Exercises To Improve Digestion

Easy Work Lunches You Can Make In The Morning

Hunger Vs Craving: Difference Explained In 60 seconds

These Things Can Cause Your Heart To Age Faster

High Carb Foods That Are Actually Healthy

Most people assume that low- or no-sugar drinks are a healthier alternative to regular sodas, but new research suggests that might not be the full picture. A large-scale study presented at UEG Week 2025 found that both sugar-sweetened beverages (SSBs) and low- or non-sugar-sweetened beverages (LNSSBs) are linked to an increased risk of developing metabolic dysfunction-associated steatotic liver disease (MASLD), a condition previously known as non-alcoholic fatty liver disease.What Is MASLD?According to the Cleveland Clinic, MASLD—short for metabolic dysfunction-associated steatotic liver disease, is a condition in which extra fat accumulates in the liver. It was previously called nonalcoholic fatty liver disease (NAFLD). Unlike liver damage caused by heavy drinking, MASLD is linked to metabolic risk factors such as obesity, type 2 diabetes, high blood pressure, and high cholesterol. If left untreated, it can progress to more serious liver problems.What The Study FoundResearchers analyzed data from 123,788 participants in the UK Biobank who did not have liver disease at the start of the study. Participants reported their beverage consumption through multiple 24-hour dietary questionnaires, giving researchers insight into how both sugary and “diet” drinks might affect liver health.The results were striking: individuals consuming more than 250 grams per day of either SSBs or LNSSBs faced significantly higher risks of MASLD, about 60% higher for LNSSBs and 50% higher for SSBs. Over a median follow-up of 10.3 years, 1,178 participants were diagnosed with MASLD, and 108 died from liver-related causes. Interestingly, LNSSBs, but not SSBs, showed a notable link to liver-related mortality. Both drink types were also tied to increased liver fat.Understanding MASLD and Its Growing ImpactMASLD occurs when excess fat builds up in the liver, which can eventually lead to inflammation, fatigue, abdominal pain, and loss of appetite. Once considered less common, MASLD has now become the most widespread chronic liver disease globally, affecting more than 30% of the population. It is also emerging as a leading cause of liver-related deaths worldwide.Lead author Lihe Liu emphasized, “SSBs have long been scrutinized, while their ‘diet’ counterparts are often seen as a healthier choice. Our study shows that both types of beverages are widely consumed, yet their effects on liver health have not been fully understood.”Liu added, “Even modest consumption of LNSSBs, like a single can per day, was linked to a higher risk of MASLD. These findings challenge the perception that ‘diet’ drinks are harmless and highlight the need to reconsider their role in our diets, especially as MASLD continues to grow as a public health concern.”Why Both Sugary and Diet Drinks May Harm the LiverThe researchers explained potential mechanisms behind the risks. SSBs, with their high sugar content, can spike blood glucose and insulin, promote weight gain, and increase uric acid levels, all contributing to liver fat accumulation. LNSSBs may affect liver health differently: by altering the gut microbiome, disrupting feelings of fullness, triggering sugar cravings, or even stimulating insulin secretion.Water Remains the Safest ChoiceExperts recommend limiting both sugar-sweetened and artificially sweetened beverages. Replacing either type with water showed a significant reduction in MASLD risk, about 13% for SSBs and 15% for LNSSBs. Simply switching between SSBs and LNSSBs did not reduce risk.The researchers plan to investigate causal mechanisms more deeply with long-term studies, including randomized and genetic trials. They aim to better understand how sugar and its substitutes interact with the gut microbiome and influence liver disease.