Women should make sure their diets include enough omega fatty acids, researchers say, after finding unusually low levels of these compounds in female Alzheimer’s patients.This comes from an analysis of blood samples from both Alzheimer’s patients and healthy individuals, which showed that unsaturated fats, including those rich in omega fatty acids, were up to 20% lower in women living with the disease. So, could an omega-rich diet actually help reduce Alzheimer’s risk?Can Omega-3 Rich Diet Protect Women From Alzheimer’s?A major study has shown that women with Alzheimer’s have markedly lower levels of unsaturated lipids, including omega fatty acids, in their blood compared to cognitively healthy women. This points to a potential protective role for these fats in maintaining brain health.Alzheimer’s tends to affect women more, particularly after 80, though the biological reasons are still not fully understood. To explore differences between men and women, researchers analyzed plasma samples from 841 participants in the AddNeuroMed cohort: 306 with Alzheimer’s, 165 with mild cognitive impairment, and 370 cognitively healthy controls. Using lipidomics, they studied 268 individual lipids per participant and examined how lipid composition varied by sex, while also exploring possible causal links through mediation analysis.The findings revealed clear sex differences. Three lipid groups were linked to Alzheimer’s in women, but only one in men (pThese results highlight that lipid biology in Alzheimer’s is sex-specific, with women showing a clear loss of protective omega-rich fats. While this does not prove a cause-and-effect relationship, it suggests that omega-rich foods like oily fish or supplements could help reduce risk, though clinical trials are needed to confirm this.How Does Omega Rich Diet Help With Alzheimer's?A diet high in omega-3 fatty acids may support brain health and lower Alzheimer’s risk through anti-inflammatory, antioxidant, and neuroprotective effects. The most important omega-3s are docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), which are essential for proper brain structure and function, according to Healthline.Women And AlzheimersAbout two-thirds of people with Alzheimer’s in the US are women, notes Harvard neuropsychologist Rachel Buckley, PhD. “Women actually tend to live with dementia longer than men.”Women are more likely to develop Alzheimer’s due to a mix of biological, social, and cultural factors, including longer life expectancy, hormonal changes after menopause, and differences in education and work experience. The disease can also show up differently in women; some studies suggest tau protein spreads faster in their brains, which may delay diagnosis until later stages, according to Harvard Health.Recent research has highlighted that the reasons for the sex gap in Alzheimer’s are complex, involving both biology and social factors. Potential contributors include women’s exposure to sex hormones, genes on the X chromosome, the presence of risk factors like hearing loss, the APOE4 genetic variant, and lower cognitive reserve related to education levels.
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