While orange juice is a simple part of breakfast for most people, new research shows that this everyday drink may influence the body far more than we once thought. A recent study reports that drinking orange juice regularly can alter how thousands of genes in our immune cells behave. Many of these genes play roles in controlling blood pressure, easing inflammation and managing the way our bodies handle sugar. These are key functions that support long term heart health.Orange Juice Immune Cell: Orange Juice Found To Affect Genes In Immune CellsFor anyone thinking about staying healthy as they grow older, new findings suggest that one daily glass of a particular drink may lower the risk of several problems. A recent study indicates that a daily serving of orange juice can even reprogramme certain genes. David C. Gaze, Senior Lecturer in Chemical Pathology at the University of Westminster, wrote in The Conversation about the changes that take place inside the body after regular orange juice consumption, drawing on evidence from earlier studies.Orange Juice Immune Cell: Decline In Genes Associated With Inflammation And Blood PressureIn the study, adults drank 500 ml of pure pasteurised orange juice each day for two months. After sixty days, genes linked to inflammation such as NAMPT, IL6, IL1B and NLRP3, which tend to switch on during stress, were found to be less active. The SGK1 gene, involved in how the kidneys hold on to sodium, also showed reduced activity. These results fit with older research showing that regular orange juice intake can bring down blood pressure in young adults.The researchers believe these findings show that orange juice creates small yet meaningful adjustments in the body’s control systems, encouraging blood vessels to relax, lowering inflammation and supporting heart health.The flavonoid hesperidin in oranges is known for its antioxidant and anti inflammatory effects. The new research adds to this by showing that processes related to blood pressure, cholesterol balance and sugar handling are also influenced by this natural compound.Body composition appears to shape the response too. Genes connected to fat metabolism changed more in people who were overweight, while inflammation related genes shifted more in leaner volunteers.Orange Juice Immune Cell: May Reduce Insulin Resistance And CholesterolA review of fifteen controlled studies involving 639 people found that regular orange juice intake may lower insulin resistance and LDL cholesterol. Insulin resistance is a major warning sign for pre diabetes, while raised cholesterol increases the chance of heart disease.In another study with overweight participants, several weeks of daily orange juice slightly lowered systolic blood pressure and raised HDL, the type of cholesterol considered beneficial. These shifts may appear small, yet their effect on cardiovascular health can build over time.In people with metabolic syndrome, orange juice was shown to improve endothelial function, which refers to the ability of blood vessels to widen and relax. Better endothelial function is tied to a lower chance of heart attack.Although not every study reported major changes in HDL or triglycerides, the overall pattern suggests that orange juice helps reduce inflammation, supports smoother blood flow and improves key markers linked to heart disease.