Is the sex of your child really just a coin toss? For generations, we’ve accepted the idea that every pregnancy comes with an even 50-50 shot of producing a boy or a girl. But new research suggests that might not be the full story.A study published in Science Advances challenges this long-held belief and adds a fascinating new layer to our understanding of human reproduction. Drawing from data spanning nearly 60 years and over 58,000 pregnancies, researchers found compelling evidence that the biological sex of children may sometimes run in families — and that age, genetics, and possibly other overlooked factors could nudge the odds away from that supposedly fair coin flip.The 50-50 Myth?At first glance, the logic behind the 50-50 assumption seems solid. Sex in humans is determined primarily by whether the sperm that fertilizes the egg carries an X chromosome (resulting in a girl) or a Y chromosome (resulting in a boy). Since roughly half of a man’s sperm carry each chromosome, it stands to reason that the odds of having a boy or a girl should be equal — right? Not exactly.Dr. Jorge Chavarro, a reproductive epidemiologist at Harvard T.H. Chan School of Public Health and senior author of the study, wasn’t so sure. Along with PhD student Siwen Wang and a team of collaborators, Chavarro analyzed pregnancy and birth data from the long-running Nurses' Health Study — a landmark series of investigations into women’s health dating back to 1976. They focused on a group of more than 58,000 women who had at least two children.The team noticed something striking: far more families than expected had multiple children of the same sex — all girls or all boys — especially among women who had their first child later in life. These clusters couldn’t be explained by chance alone.In other words, some families seemed “tipped” toward having one sex over the other — and the tilt wasn’t always subtle.Why Age Matters But Not In the Way You Think?One of the clearest signals in the study was maternal age. Women who had their first child after the age of 28 were about 10% more likely to have all girls or all boys than women who started their families before age 23. It’s a modest but statistically significant increase that held up even after adjusting for various other factors.It comes down to the biology of reproduction and how it changes over time. As women age, they undergo shifts in the vaginal environment and reproductive hormones that could influence which sperm — X or Y — are more likely to reach and fertilize the egg. For instance:The vaginal environment may become more acidic with age, and X-carrying sperm (which are slightly larger and more chemically robust) may survive better in such conditions.The first phase of the menstrual cycle, called the follicular phase, tends to shorten with age. Some researchers believe this could create changes in cervical mucus and oviduct fluid that favor Y sperm instead.These competing factors mean the impact of aging on sex outcome may not be uniform — it could vary depending on individual biology. But the net result is that older maternal age seems to increase the odds of having children all of the same sex.Another eye-opening part of the study was its genetic analysis. Researchers examined genetic data from a subset of over 7,500 women and found two specific gene variants that were significantly associated with single-sex offspring.One gene variant (located near NSUN6) was linked to having all daughters.Another (near TSHZ1) was associated with having all sons.These genes aren’t currently known to affect fertility or reproduction directly, and their exact roles remain unclear. But their presence suggests a biological basis for sex-skewed births in some families — an area ripe for future research.In short, while we’ve long believed sex determination is a random roll of the dice, some people might have a “weighted coin” — without ever realizing it.Could Behavior Be Driving the Pattern?Some might wonder: what if this pattern is just driven by behavior? For instance, parents who have two boys might keep trying until they have a girl, leading to more same-sex siblings by default. The researchers considered this too.To rule out this explanation, they ran an analysis excluding the last birth in each family — the one most likely to be affected by the decision to stop having more children after getting “one of each.” Even then, the same-sex clustering held strong.That suggests something deeper is going on, rooted in biology rather than just human choice.What This Means for Expecting Parents?So, what should couples take away from this? First, there’s no need to overthink your chances if you’re planning to start a family. Across the entire population, the average likelihood of having a boy or a girl still hovers close to 50%. But for some individual families, those odds may be subtly skewed by age, genetics, and biological quirks we’re only beginning to understand.Importantly, the study also highlights just how much we still don’t know about sex determination and human reproduction. It opens new avenues for exploring how maternal and paternal factors interact — and how genetic and environmental forces shape outcomes in subtle but meaningful ways.Wang and her team hope to replicate the findings in more diverse populations and include paternal data in future analyses. Since most participants in this study were white and from the U.S., it’s not yet clear how these patterns hold across other racial, ethnic, and geographic groups.This research doesn’t rewrite the biology of reproduction — but it does suggest that some old assumptions might be oversimplified. Sex may still be determined by the X or Y chromosome in sperm, but the journey to conception is influenced by a dynamic, personal landscape of biological factors.What the study captures is a new lens: a shift away from the purely statistical view of childbirth toward a more personalized understanding of how life begins.And perhaps, for families that have always wondered why they have “just boys” or “just girls,” the answer might be: it’s not just chance. It might be part of your biological story written long before the baby arrives.