Health and Me

Itisha Arya

Brazil Becomes The First Country To Authorise A Single-Dose Dengue Vaccine: All You Need To Know

brazil single dose dengue vaccine

Brazilian authorities on Wednesday approved the world’s first single-dose <span><a href="https://www.healthandme.com/health/dengue">dengue</a> vaccine</span>, describing it as a “historic” step amid a global surge in cases fueled by rising temperatures. <span><a href="https://www.healthandme.com/health/dengue">Dengue</a></span>, which causes severe flu-like symptoms, extreme fatigue, and body aches, hit record global levels in 2024, with scientists linking its rapid spread to climate change. Brazil’s health regulatory body <span>ANVISA</span> cleared the use of Butantan-DV, created by the Butantan Institute in São Paulo, for individuals aged 12 to 59. 

Until now, the only dengue vaccine available globally was TAK-003, which requires two doses spaced three months apart, according to the World Health Organization (WHO). Here’s everything currently known about this single-dose vaccine.

Also Read: <a href="https://www.healthandme.com/health-news/grap-3-restrictions-revoked-in-delhi-ncr-what-residents-can-use-again-and-what-stays-restricted-article-153210929" data-type="tilCustomLink" target="_blank">GRAP 3 Restrictions Revoked In Delhi-NCR: What Residents Can Use Again And What Stays Restricted</a>

<h2><span rel="noindex">Dengue Single Dose Vaccine</span> Approved In Brazil</h2>

On Wednesday, November 26, Anvisa approved the world’s first single-dose dengue vaccine. The announcement followed the signing of a term considered the final step in registering the vaccine, produced entirely at a national laboratory, during a press conference, as reported by CNN Brazil. The development of Butantan-DV is the result of collaboration between Brazil’s Ministry of Health, the Butantan Institute, and the Chinese lab Wu Xi.

<h2>Butantan-DV: All You Need To Know About The Single Dose Dengue Vaccine</h2>

Anvisa stated that the new vaccine uses live attenuated virus technology and is currently approved for people aged 12 to 59—a range that could expand if new studies support it. The Ministry of Health will determine the official vaccination start date and the target age group. The registration request for the vaccine was submitted by the Butantan Institute in January 2025. Anvisa fast-tracked its evaluation, forming a technical panel that included external experts to review the process.

<h2>What Is A Live Attenuated Virus?</h2>

A live attenuated virus is a weakened form of a virus used in vaccines to trigger a strong and lasting immune response without causing the full-blown disease. These viruses are developed in a lab, often through repeated culturing, so they can replicate in the body but only in a limited way. By closely mimicking a natural infection, they prompt the immune system to respond similarly to how it would during a real infection, according to the U.S. Department of Health and Human Services.

Also Read: <a href="https://www.healthandme.com/health-news/cdc-to-appoint-vaccine-skeptic-surgeon-ralph-abraham-as-deputy-director-article-153204942" data-type="tilCustomLink" target="_blank">CDC To Appoint Vaccine-Skeptic Surgeon Ralph Abraham As Deputy Director</a>

<h2>How Effective Is This Single Dose Dengue Vaccine?</h2>

CNN Brazil reported that the Ministry of Health found the vaccine to have an overall efficacy of 74.7% against symptomatic dengue for people aged 12 to 59. This means that nearly three out of four people were protected from the disease. Protection was similar for those who had previously had dengue and those who were never exposed to the virus.

In 2024, over 14 million dengue cases were reported globally, marking a record year, according to ScienceDirect and WHO. The death toll reached more than 9,500. While the Americas reported the highest number of cases, dengue continues to affect more than 100 countries worldwide.

Dengue, often called “breakbone fever” because of its intense symptoms, can in severe cases lead to hemorrhagic fever and even death. The disease spreads through infected Aedes mosquitoes, which are now appearing in areas beyond their traditional habitats, resulting in dengue cases in parts of Europe and the United States where it was previously uncommon.

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Brazilian authorities on Wednesday approved the world’s first single-dose dengue vaccine, describing it as a “historic” step amid a global surge in cases fueled by rising temperatures. Dengue, which causes severe flu-like symptoms, extreme fatigue, and body aches, hit record global levels in 2024, with scientists linking its rapid spread to climate change. Brazil’s health regulatory body ANVISA cleared the use of Butantan-DV, created by the Butantan Institute in São Paulo, for individuals aged 12 to 59. Until now, the only dengue vaccine available globally was TAK-003, which requires two doses spaced three months apart, according to the World Health Organization (WHO). Here’s everything currently known about this single-dose vaccine.Also Read: GRAP 3 Restrictions Revoked In Delhi-NCR: What Residents Can Use Again And What Stays RestrictedDengue Single Dose Vaccine Approved In BrazilOn Wednesday, November 26, Anvisa approved the world’s first single-dose dengue vaccine. The announcement followed the signing of a term considered the final step in registering the vaccine, produced entirely at a national laboratory, during a press conference, as reported by CNN Brazil. The development of Butantan-DV is the result of collaboration between Brazil’s Ministry of Health, the Butantan Institute, and the Chinese lab Wu Xi.Butantan-DV: All You Need To Know About The Single Dose Dengue VaccineAnvisa stated that the new vaccine uses live attenuated virus technology and is currently approved for people aged 12 to 59—a range that could expand if new studies support it. The Ministry of Health will determine the official vaccination start date and the target age group. The registration request for the vaccine was submitted by the Butantan Institute in January 2025. Anvisa fast-tracked its evaluation, forming a technical panel that included external experts to review the process.What Is A Live Attenuated Virus?A live attenuated virus is a weakened form of a virus used in vaccines to trigger a strong and lasting immune response without causing the full-blown disease. These viruses are developed in a lab, often through repeated culturing, so they can replicate in the body but only in a limited way. By closely mimicking a natural infection, they prompt the immune system to respond similarly to how it would during a real infection, according to the U.S. Department of Health and Human Services.Also Read: CDC To Appoint Vaccine-Skeptic Surgeon Ralph Abraham As Deputy DirectorHow Effective Is This Single Dose Dengue Vaccine?CNN Brazil reported that the Ministry of Health found the vaccine to have an overall efficacy of 74.7% against symptomatic dengue for people aged 12 to 59. This means that nearly three out of four people were protected from the disease. Protection was similar for those who had previously had dengue and those who were never exposed to the virus.In 2024, over 14 million dengue cases were reported globally, marking a record year, according to ScienceDirect and WHO. The death toll reached more than 9,500. While the Americas reported the highest number of cases, dengue continues to affect more than 100 countries worldwide.Dengue, often called “breakbone fever” because of its intense symptoms, can in severe cases lead to hemorrhagic fever and even death. The disease spreads through infected Aedes mosquitoes, which are now appearing in areas beyond their traditional habitats, resulting in dengue cases in parts of Europe and the United States where it was previously uncommon.