In an accidental discovery where scientists were studying a common blood pressure drug called hydralazine, found out that it could in fact, fight cancer.

What Is Hydralazine?

Most commonly known by its brand name Apresoline, Hydralazine is a prescription medication, which is mainly used to treat high blood pressure or hypertension and heart failure. It works as a direct-acting vasodilator that relaxes the blood vessels, and allows blood to flow more easily and reduce the heart's workload.

This drug is commonly consumed orally and is prescribed by a GP to be taken two to four a day, depending on the severity of one's case. However, the drug can only control blood pressure, and not cure it. It is also used after heart valve replacement and in the treatment of heart failure.

Does Hydralazine, A Common Blood Pressure Drug Fight Cancer?

Kyosuke Shishikura, a physician-scientist at the University of Pennsylvania along with a wider research team uncovered that hydralazine directly targets a small, but a crucial enzyme called 2-aminoethanethiol dioxygenase (ADO).

In a press release, Shishikura said, "It came from a ‘pre-target’ era of drug discovery, when researchers relied on what they saw in patients first and only later tried to explain the biology behind it."

So, How does This Common Blood Pressure Drug Work To Fight Cancer?

The enzyme acts like a cellular oxygen sensor and helps the cells survive even when the oxygen levels are low. This can thus help enable the fast-growing tumors like glioblastoma, which is an aggressive form of brain cancer that resists treatment and almost always comes back.

What Happens In A Fast-growing Cancer Like Glioblastoma?

In glioblastoma, the tumor cells multiply rapidly and the blood supply therefore cannot keep up. This means parts of tumor do not get enough oxygen. While the typical cells die in low-oxygen environment, a tumor cell could switch on its survival system that could help them continue to survive even when the oxygen is scarce. This also involved the ADO enzyme.

In the same press release Megan Matthews, who is an assistant professor in Penn's Department of Chemistry and a researcher in the study said, "ADO is like an alarm bell that rings the moment oxygen starts to fall."

How Did The Research Team Approach This Study?

The team used advanced techniques, which also included X-ray crystallography, which analyzes the structure of molecules to determine how hydralazine binds to ADO. The researchers discovered that hydralazine silences that alarm by binding ADO and making it stop working, which means the tumor cells will not be able to survive even when the oxygen is low. This, as the researchers explained, in turn, shuts down the cell's oxygen response system, and forces the cancer cells to stop dividing them.

Was This Theory Of Common Blood Pressure Drug Fighting Cancer Tested?

The scientists tested this theory on human glioblastoma cells with hydralazine in the lab. After three days, they found out that the cells had stopped multiplying and became larger and flatter. The cell entered, what the scientists called a permanent "sleep mode", which is known as "senescence".

However, it is important to note that the drug did not kill the cells, but it took away the cell's ability to grow and spread.

As per Memorial Sloan Kettering Cancer Center, this is a huge step towards controlling cancers like glioblastoma, as they are extremely difficulty to treat, and they often return even after surgery and chemotherapy. The good news is that budralazine is already FDA-approved, and researchers are hoping that this drug could reshape the cancer therapy.

Trump takes more aspirin than his doctor recommend. In an interview with The Wall Street Journal, US President Trump said that he will continue doing it. He claimed that it was not old or deteriorating age, but aspirin that caused the bruising on his hand. He has repeatedly said that his health is in "excellent" condition.

In the interview, he said, "They say aspirin is good for thinning out the blood and I don't want thick blood pouring through my heart."

Trump, now, 70, was diagnosed with chronic venous insufficiency, a condition that occurs when veins have trouble moving blood back to the heart. He also showed signs of bruising on his hand, which many attributed was a result of frequent handshaking, and to the use of aspirin.

A decade ago, evidence suggested that taking aspirin routinely could lower the risk of heart attacks and strokes in people without heart disease by preventing blood clots. However, three major randomized trials published in 2018 challenged this view, showing limited benefit and a higher risk of serious bleeding and cancer-related deaths, especially gastrointestinal cancers.

“We’ve really changed how we think about and recommend aspirin,” said Dr Alex Krist, a family physician at Virginia Commonwealth University and Inova Health System, who helped update the U.S. Preventive Services Task Force’s aspirin guidelines in 2022, reported The New York Times.

How Safe Is This Habit Of Taking Aspirin Daily?

Aspirins work by inhibiting the action of platelets, which are the cell fragments that stick together to form clot and prevent bleeding. Clots are in fact the reason of heart attacks. However, at the same time, it is the same anti-clotting effect that causes aspirin to increase the risk of bleeding, a risk that increases with age.

Doctors are most concerned about rapid internal bleeding that can be fatal, such as gastrointestinal bleeding or sudden brain hemorrhages. While the overall risk remains low, recent preventive health recommendations note that it rises with age, especially in adults over 60.

Some studies suggest aspirin may help lower the risk of colorectal cancer, but current evidence is not strong enough to support its use for cancer prevention alone.

Read: Trump Denies Health Concerns, Says Hand Bruise Was Caused By Aspirin

Should You Be Taking Aspirin Daily?

Medical guidelines have shifted on aspirin use, especially for older adults. Groups like the preventive services task force and major heart associations now advise against starting or routinely taking aspirin to prevent heart disease in people over 60 or 70 who have never had a heart attack or stroke. For this group, the bleeding risks often outweigh the benefits.

Daily aspirin is still clearly recommended for people who already have cardiovascular disease, such as those who’ve had a heart attack, an ischemic stroke, or peripheral artery disease. In these cases, aspirin helps prevent another serious event, making the risk–benefit balance more favorable.

Recent health disclosures have shown no history of heart attack or stroke in some high-profile cases, though the presence of arterial plaque alone is fairly common with age and does not automatically justify aspirin use.

For those who do need aspirin to prevent a second heart attack or stroke, the usual dose is a low-dose or “baby” aspirin of 81 milligrams. Higher doses are generally not recommended unless specifically advised.

Aspirin may still be considered for some people under 60 or 70 who have a higher risk of heart disease, but this decision should be made carefully. Factors like high blood pressure, high cholesterol, diabetes, smoking history, or a strong family history can influence whether aspirin makes sense for an individual.

Flu cases are surging in the US, and New York has reported the highest number of cases, including hospitalizations recorded in a single week. The state's health department said on Friday. During the week ending December 27, 4,546 people were hospitalized with flu, a 24% increase from the 3,666 who were hospitalized the previous week, as per the data from the New York State Department of Health (NYSDOH). This report has come after the State reported a record-breaking number of flu cases in a single week with 72,133 infections during the week ending December 20.

"We are having a more severe flu season than prior years, almost 1,000 more people were admitted to a hospital during this most recent seven-day period compared to the prior week," Dr. James McDonald, the state's health commissioner, said in a statement on Friday.

NYSDOG also issued a declaration last month and stated the influenza is prevalent in New York. This requires health care facilities and agencies to ensure any staff who has not yet received this year's flu vaccine, must wear masks whenever they are in the area with patients.

Will The Old Vaccine Work Against This New Strain?

"The vaccine remains the most effective means to prevent disease. We still want to encourage people to get the vaccine," said Professor Antonia Ho, Professor and Honorary Consultant in Infectious Diseases at the University of Glasgow. Experts have stressed enough on the immunity that one can receive from the vaccine that that these flu jab remain the best defense against the flu, even though the current strain circulated may have drifted away from the strain included in this year's jab.

The flu vaccine is currently also available to New Yorkers who are aged 2 years and older at a health care provider's office or participating pharmacies while children aged 6 months and older can receive the flu vaccine at a health care provider's office, according to the state health department.

Can You Die From Flu?

As per the infectious physician at the Johns Hopkins University Center for Health Security, as reported in Scientific American, "Dying from the flu is not like dying from a bullet or a black widow spider bite. The presence of the virus itself isn't going to be what kills you. An infectious disease always has a complex interaction with its host.”

More Updates On Flu Cases

Meanwhile, flu cases are surging across the country. The US Centers for Disease Control and Prevention estimates at least 7.5 million illnesses, 81,000 hospitalizations and 3,100 flu-related deaths so far this season.

New York is among 20 states reporting “very high” respiratory illness activity, the latest CDC data shows.

Public health experts say a significant share of infections is being driven by a new flu strain known as subclade K, a variant of the H3N2 virus under influenza A. The strain has been circulating internationally since summer and previously fuelled spikes in Canada, Japan and the UK.

CDC testing found that around 92% of flu samples were H3N2, with nearly 90% classified as subclade K.

Robert Carlos, who is known to be the Brazil and Real Madrid legend is finally "recovering well" after he underwent a "preventative medical procedure" as he wrote on his Instagram page. The 52-year-old was seen smiling on the hospital bed, as he cleared rumors around heart attack. "I would like to clarify recent information that has been circling. I recently underwent a preventative medical procedure, planned in advance with my medical team. The procedure was successful, and I am well. I did not suffer a heart attack."

He further wrote: "I am recovering well, and looking forward to returning to full fitness and resuming my professional and personal commitments soon. I sincerely thank everyone of the messages of support, care, and concern. I would like to reassure everyone that there is no cause for concern. My heartfelt thanks go to the entire medical team who took care of me."

ESPN reported that he underwent a preventative heart surgery. While no reports confirmed the exact surgery he underwent, there are different preventative heart surgeries that one can get to restore blood flow, or prevent heart attacks in people with severe blockages.

What Are the Preventative Heart Surgeries?

Coronary Artery Bypass Grafting (CABG)

Coronary Artery Bypass Grafting (CABG) is a surgical procedure used to treat severe coronary artery disease, where blood flow to the heart is reduced due to blocked arteries. In this surgery, a healthy blood vessel is taken from the chest, leg, or arm and grafted to bypass the blocked artery, allowing blood to flow freely to the heart muscle again. CABG is often recommended for patients with multiple blockages, diabetes, or reduced heart function. While it is a major surgery, advances in surgical techniques and post-operative care have significantly improved outcomes and recovery. The procedure not only helps relieve symptoms such as chest pain and breathlessness but also reduces the risk of heart attacks and improves overall quality of life.

Minimally Invasive/ Robotic Surgery

Minimally invasive and robotic surgeries involve performing procedures through small incisions using advanced instruments and robotic arms controlled by a surgeon. These techniques offer greater precision, flexibility, and control compared to traditional open surgery. Robotic systems provide a magnified, high-definition view of the surgical area, allowing surgeons to operate with enhanced accuracy. Patients benefit from smaller scars, reduced blood loss, less pain, and quicker recovery times. Minimally invasive and robotic approaches are commonly used in cardiac, orthopedic, urological, and gynecological surgeries. While not suitable for every patient or condition, these procedures have transformed modern surgical care by making complex operations safer and less physically taxing for patients.

Pacemakers Defibrillators

Pacemakers and defibrillators are implantable devices designed to regulate abnormal heart rhythms. A pacemaker helps maintain a steady heartbeat by sending electrical signals when the heart beats too slowly. Defibrillators, also known as ICDs, can detect life-threatening rhythm disturbances and deliver a shock to restore normal rhythm. These devices are recommended for patients with arrhythmias, heart failure, or those at high risk of sudden cardiac arrest. Implantation is usually a minimally invasive procedure, and most patients can return to normal activities within a few weeks. Pacemakers and defibrillators play a crucial role in preventing complications, improving symptoms, and significantly enhancing survival and quality of life for heart patients.

Are There Non-Surgical Alternatives Too?

There are certain non surgical alternatives, which include preventive cardiology, ECEP (Enhanced External Counter pulsation) , and certain medications like statins to lower cholesterol, or beta-blockers for angina, or aspirin to prevent clots, notes Cleveland Clinic.