DNA Test On World’s Oldest Woman Reveals Clues To Living Past 100

Updated Jan 2, 2026 | 12:42 PM IST

SummaryMaria Branyas, who lived to 117, fascinated scientists studying human longevity. DNA tests showed her cells behaved decades younger, with strong immunity, heart health, and a healthy gut microbiome. Researchers say her genetics, lifestyle, and diet offer new insights into healthy aging and potential ways to extend life span. Read on.
DNA Test On World’s Oldest Woman Reveals Clues To Living Past 100

Credits: Wikimedia Commons and Cell Reports Medicine

Who can live past 100 years? Well, to everyone's surprise, Maria Branyas Morea lived to the age of 117, with a bit of luck and a healthy diet. A study published in Cell Reports Medicine noted that her diet that included daily yogurts ensured that she could live this long. During her final year, in 2024, she was verified as the oldest living person, and drew a lot of attention of researchers from all over the world who wanted to explore the biology of aging.

The researchers also ran a DNA-test on her, and here's what they found.

Also Read: Candida Auris - The Deadly Superbug Spreads Across 27 States: Here’s Why the Fungus Is Surging

What A DNA Test On 117-year-old Revealed

Credits: Cell Reports Medicine

Health evaluation of Maria Branyas suggest that she may have an exceptionally young genome. The rare genetic variant was what linked to longevity, immune function, and a healthy heart and brain. The researchers based in Spain said that they are now using these findings to "provide a fresh look at human aging biology, suggesting biomarkers for healthy aging, and potential strategies to increase life expectancy".

The tests scientists ran were based on blood, saliva, urine, and stool samples. Branyas volunteered to have these tests run on her before she passed in August 2024. The researchers reveal that her cells "felt" or "behaved" as though they were much younger than her chronological age. She is known to have exceeded the average life expectancy of women in her home of Catalonia by more than 30 years.

While she was 117, her cardiovascular health was marked excellent, with very low levels of inflammation. Her immune system and gut microbiome both had markers that matched much younger samples. The levels of 'bad' cholesterol and triglycerides were very low, while 'good' cholesterol was very high.

"Extreme human lifespan, exemplified by supercentenarians, presents a paradox in understanding aging: despite advanced age, they maintain relatively good health," write the researchers, led by epigeneticists Eloy Santos-Pujol and Aleix Noguera-Castells.

Maria Branyas didn’t just live long, she lived fully. Mentally sharp, socially engaged, and physically active well into old age, her lifestyle clearly mattered. Genetics helped too. While her Mediterranean diet, rich in yogurt and fermented foods, may have supported her health, scientists say extreme longevity is rarely about one habit alone. It is usually a mix of biology, environment, and chance.

Also Read: Australian Cricketer Damien Martyn in Hospital With Meningitis

A Surprising Finding

One of the most surprising findings from studying Branyas was what researchers saw at the ends of her chromosomes. Her telomeres, the protective caps on DNA that typically shorten with age, showed what scientists described as “huge erosion.” Usually, shorter telomeres are associated with higher mortality risk. But in people who reach extraordinary ages, telomeres may not tell the full story.

In fact, the researchers suggest Branyas’ very short telomeres might have worked in her favour. Short-lived cells may have reduced the risk of uncontrolled cell growth, potentially protecting her from cancer. It is a counterintuitive idea, but one that challenges how scientists think about aging markers.

Longevity Does Not Equal Poor Health

What stands out most is that Branyas’ advanced age did not automatically come with prolonged illness. Her case reinforces the idea that living longer does not have to mean living sicker. As the researchers note, extreme old age and poor health are not inherently linked.

What One Life Can and Cannot Tell Us

Of course, studying one exceptional individual has limits. Researchers in Spain stress the need for larger studies to confirm these findings. Still, broader research on centenarians has already shown that some people carry unique biological traits that help them resist disease.

With centenarians now the world’s fastest-growing age group, Branyas’ life offers a rare glimpse into what might make extreme longevity possible. Her story, scientists say, opens new doors to understanding healthy aging and extending not just lifespan, but health span.

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India Bans Nimesulide Drugs Over 100mg Over Health Concerns, All That You Need To Know

Updated Jan 2, 2026 | 12:57 PM IST

SummaryIndia has banned oral nimesulide formulations above 100 mg, citing liver toxicity risks and safer alternatives. Issued under the Drugs and Cosmetics Act after DTAB and ICMR review, the move restricts high-dose use, keeps it second-line only, and reinforces wider drug safety scrutiny, alongside removing cough syrups from OTC sales.
India Bans Nimesulide Drugs Over 100mg Over Health Concerns, All That You Need To Know

Credits: iStock

Nimesulide (over 100 mg), a commonly used non-steroidal anti-inflammatory drug (NSAID) which is prescribed for pain and inflammation is now banned in India. This is to safeguard public health.

What Exactly Happened? The Centre has prohibited the manufacture, sale and distribution of oral formulations of nimesulide which contains more than 100mg, with immediate effect, across the country.

As per the government notification, oral formulations of nimesulide that contains more than 100 mg have been banned as such high-dose could be risky for human health. The order states that safer alternatives to this drug is available in market, and thus in public interest, the continued availability of this drug at such high dosage is not justified.

The ban is issued under the Section 26A of the Drugs and Cosmetics Act, 1940. This section empowers the Centre to restrict or prohibit drugs that pose a risk to patients. The government also consulted the Drugs Technical Advisory Board (DTAB), which is also country's apex advisory body on technical matters related to drugs and cosmetics.

Why Did Government Ban Nimesulide?

The drug had long been under regulatory and medical scrutiny. The major concern is the liver toxicity, which is one of the side effects of this high-dose drug. In fact the World Health Organization (WHO) has no included nimesulide in its Model List of Essential Medicines, all due to the global caution around it. Several other countries too have either restricted or completely withdrew the drug.

The Ministry of Health and Family Welfare in a notification said that the Central government is "satisfied that the use of all oral formulations containing Nimesulide above 100 mg in immediate release dosage form is likely to involve risk to human beings and that safer alternatives to the said drug are available".

The restriction on certain nimesulide formulations follows recommendations made by the Indian Council of Medical Research (ICMR) after reviewing the drug’s effects in adults. These recommendations were accepted by an expert committee under the apex drug regulator. Nimesulide is known to cause liver toxicity in some cases.

ICMR had also advised that nimesulide be used only as a second-line treatment when other medicines fail or cannot be prescribed. It recommended against its use in pregnant or lactating women, those planning pregnancy, and patients with liver or kidney impairment. The drug should also not be used alongside other medicines that are toxic to the liver or kidneys. Nimesulide is already banned for children under 12 years of age.

The committee has further asked ICMR to review the impact of the drug across different age groups, including adolescents and older adults.

Read: Cough Syrup Row: Death Toll Rise To 22 As 2 More Children Succumb

What Are The New Development On Drug Ban In India?

The Ministry also removed cough syrups from the list of over-the-counter medicines. While lozenges, pills or tablets for cough continue to remain on the list. This has come in the backdrop of 22 children who died in Madhya Pradesh after they consumed contaminated cough syrups.

Disclaimer: Health and Me's report is based on the notice issued in public knowledge and is not a substitute for prescribed drugs. Always consult your doctor before making changes in your medicines.

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Explained: Indore Water Contamination Linked to E. coli and Klebsiella Bacteria — What Are They?

Updated Jan 2, 2026 | 12:39 PM IST

SummaryIndore’s water contamination, caused by E. coli and Klebsiella bacteria, has killed 10 people and sickened many. Officials traced the outbreak to sewage mixing with drinking water due to civic lapses. Engineers have been suspended, surveys expanded, hospitals alerted, and health workers are distributing ORS to prevent further casualties. Read on.
Explained: Indore Water Contamination Linked to E. coli and Klebsiella Bacteria — What Are They?

Credits: PTI and CDC

Indore water contamination is linked to fecal bacteria like E coli and Klebsiella, confirmed officials. These bacteria are known to cause severe vomiting and diarrhea. The death toll too have risen to 10, confirmed the local officials. Indore councillor Kamal Waghela said that two more persons died on Thursday night. The laboratory tests of the water supplied through the Narmada pipeline in Bhagirathpura, which is the epicentre of the outbreak confirmed E coli and Klebsiella bacteria to be the culprits.

Also Read: Australian Cricketer Damien Martyn in Hospital With Meningitis

What Happened In Indore That Led To Water Contamination?

The outbreak occurred due to lapses in civic infrastructure. Investigation revealed that a toilet constructed directly above a main drinking pipeline near a police outpost, without a mandatory safety tank resulted in the sewage mixing with drinking water.

Indore Municipal Corporation Commissioner Dilip Kumar said, “We have found that in case of the construction of the toilet, no safety tank was constructed beneath it. We are also probing the other lapses.”

What Is E. Coli - The Bacteria Found In Indore Contaminated Water?

Escherichia coli, or E.coli is a bacterium that lives in the human intestine and is one of the most common causes of foodborne illness.

The Centers for Disease Control and Prevention (CDC), these bacteria are commonly found in environment, food, water, and the intestines of people and animals. While most E.coli are harmless, some can make people sick with diarrhea, urinary tract infection, pneumonia, sepsis, and other illnesses.

E. Coli from Contaminated Water

WebMD writes that one can swallow E.coli from contaminated water, as in the case of Indore, a toilet was constructed directly above the main drinking water pipeline, without a mandatory safety tank, which may have led to the contamination. Studies have also shown that some E.coli could regrow even after chlorine treatment.

What Is Klebsiella - The Bacteria Found In Indore Contaminated Water?

CDC notes that Klebsiella is a type of gram-negative bacteria which is also found in human stool and can cause healthcare-associated infections or HAIs. They are also highly resistant to antibiotics and can also resist carbapenems, which is the last line of defense against multi-drug resistant bacterial infections.

Klebsiella can cause pneumonia, bloodstream infections, wound or surgical site infections and meningitis.

It can spread from person-to-person contact, which is one of the most common way of spreading. Other ways could also be from contact with contaminated water or soil, contact with contaminated equipment, for example, ventilators, breathing machines, or intravenous catheters. Klebsiella cannot spread through the air.

Also Read: Sewage Mixing With Drinking Water Kills 7 in Madhya Pradesh’s Indore, Over 100 Remain Hospitalized

What Actions Have Been Taken So Far In Indore?

As of now, the water supply Assistant Engineer (AE) has been suspended, and the sub-engineer relieved of duty. The Zonal Officer has also been suspended for failing to ensure proper coordination. “The zonal officer has been suspended because he should have seen overall coordination,” Commissioner Kumar said.

“We have found a few chambers that intersect the distribution line. We are getting them diverted,” Kumar also noted.

Authorities have stepped up efforts to contain the crisis and avert further casualties. District Magistrate Shivam Verma said the response has been extensive, with around 149 people currently hospitalised and survey teams conducting door-to-door checks. By 31 December, 2025, nearly 2,700 houses had already been covered.

The survey has been extended to other surrounding areas in Indore to check the water quality and to know whether the contamination has spread beyond Bhagirathpura, which was the initial epicentre. for precaution, ASHA workers and Auxiliary Nurse Midwives are also distributing oral rehydration solution (ORS) to residents.

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Candida Auris - The Deadly Superbug Spreads Across 27 States: Here’s Why the Fungus Is Surging

Updated Jan 2, 2026 | 12:31 PM IST

SummaryCandida auris, a drug-resistant fungal superbug, has spread across 27 US states, infecting at least 7,000 people in 2025. First detected in 2016, it thrives in healthcare settings, resists disinfectants, spreads via equipment and surfaces, and poses serious risks to vulnerable patients. Read on to know more about this deadly fungus.
Deadly Superbug Spreads Across 27 States: Here’s Why the Fungus Is Surging

Credits: iStock

Deadly fungus, the superbug has now hit 27 states. Hospitals, nursing homes and other medical facilities are struggling to treat this, as it is a drug-resistant fungus. In 2025 alone, the Centers for Disease Control and Prevention (CDC) reveals that it has infected at least 7,000 people.

This fungus is known as Candida auris, which was first reported in the US in 2016. In the past several years, it has spread rapidly. This fungus can also survive on surfaces for a long period and thus could easily spread to people, especially in medical environment, through catheters, breathing tubes, or IVs.

Why Is this Superbug So Difficult To Control?

Unlike many other infections, Candida auris can spread easily through shared medical equipment and direct contact between people. Its ability to withstand commonly used disinfectants makes it difficult to eliminate once it enters a healthcare facility.

State health officials say cases have increased every year, pointing to a steady and worrying trend. “Each year, we have seen increases in our case counts which underscores the need for sustained vigilance,” the Alabama Department of Public Health told AL.com.

Also Read: What Is Candida Auris Infection? The Deadly Superbug Spreading In US

Origin of Superbug Candida Auris

This was first discovered in 2009 in Japan from the ear canal of a patient. Since then, it has spread to many countries, including India, where it was identified as a major public health threat in 2014.

Who Can Or Cannot Fight Off This Superbug

Healthy people could possibly fight off this infection on their own. However, the population vulnerable could find it more difficult to fight off this deadly fungus. Melissa Nolan, an assistant professor of epidemiology and biostatistics at the University of South Carolina told Nexstar, "If you get infected with this pathogen that’s resistant to any treatment, there’s no treatment we can give you to help combat it. You’re all on your own."

Like the mystery disease, adenovirus, this fungus too can survive on surfaces, said Nolan. “It’s really good at just being, generally speaking, in the environment. So if you have it on a patient’s bed for example, on the railing, and you go to wipe everything down, if in whatever way maybe a couple of pathogens didn’t get cleared, then they’re becoming resistant. And so over time, they can kind of grow and populate in that hospital environment," said Nolan.

The health department confirmed via email that it is following the CDC’s recommended containment strategy to limit further spread. Healthcare providers and laboratories in Alabama are voluntarily reporting cases, although the state’s figures are not currently listed on the CDC’s national tracking dashboard, as per USA Today.

Alabama is not alone in dealing with the superbug. Nearby states are also seeing significant numbers. CDC data shows Tennessee has reported 189 cases, Mississippi 108, and Georgia 377. Florida, like Alabama, does not yet have figures publicly listed on the CDC website.

Studies show that this superbug is not just limited to the US, but is spreading globally. It has already been found in at least 61 countries and on 6 continents. The study also found that the fungus is becoming more and more drug resistant, all due to its ability to switch from a yeast-like growth to a filament-driven spread. It also contains a cell wall that has proteins and makes it easier to stick on human skin "like glue". This is what enables it to colonize the human cells.

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