As a significant breakthrough in rare disease therapy, the U.S. Food and Drug Administration (FDA) has just approved Andembry (garadacimab‑gxii), the first-ever prophylactic treatment that aims for factor XIIa to prevent attacks of hereditary angioedema (HAE). This once-monthly injectable has provided patients 12 years and older with a new, convenient way to manage symptoms effectively—but its significance extends far beyond convenience, as it is a sea change in the way we treat this incapacitating illness.

Hereditary angioedema is an inherited, rare illness that results in sudden, aching swelling of the body's different regions, such as the face, limbs, or inner tissues like the airway or intestines. Blockages caused by it can result in life-threatening respiratory problems or severe abdominal pain. These occur because leakage from small blood vessels lets fluid seep into nearby tissues. HAE typically presents in childhood or adolescence, worsens after puberty, and strikes almost everyone diagnosed through age 20.

While the swelling may be painful and disfiguring, the most significant danger is airway involvement, which can be fatal. Conventional treatments are primarily concerned with treating these sudden attacks or maintaining regular infusions to prevent them. But until now, real long-term prevention was out of reach.

How Andembry Works?

Andembry is a monoclonal antibody that directly blocks factor XIIa, a central protein in the cascade of processes that leads to HAE attacks. By blocking factor XIIa's action, Andembry stops the process before swelling occurs—making the first line of defense against unpredictable flare-ups.

Administered through a straightforward autoinjector that delivers the dose in 15 seconds or less, Andembry is designed to become an integral part of patients' lives. Users simply have to self-administer the injection on a monthly basis, making it a convenient option for teenagers as well as adults who are treating this condition.

The FDA's approval is based on powerful Phase III clinical trial data. During six months, 62% of Andembry patients were wholly attack-free—a remarkable benchmark for a disease characterized by constant flare-ups.

Are There Any Possible Side Effects?

Like any drug, Andembry has potential side effects, although most were mild. The most frequent problems encountered involved nasal and upper throat inflammation and abdominal pain, each of which were observed in approximately 7% of patients. Most importantly, no severe adverse events or drop-outs from treatment were seen—testifying to the drug's overall safety and tolerability.

Such a positive profile represents an important victory for a long-term treatment—particularly one that will be repeatedly self-administered by families and patients.

Dr. Bill Mezzanotte, R&D Head at CSL (who created Andembry), refers to the drug as a "game-changer". He mentions it's the first monoclonal antibody to be created wholly by CSL and the only injectable treatment for factor XIIa. The fact that it's designed to give treatment in seconds speaks to a patient-centric focus—particularly necessary for a disease that is notoriously unpredictable and can hit at any time.

What This Means for HAE Treatment and Care

Apart from clinical efficacy, Andembry vows to greatly improve the daily lives of HAE patients. The benefits in everyday life are:

• Relief from emotional distress of never knowing when the swelling will occur
• Fewer visits to emergency rooms and reliance on on-demand drugs
• More independence to travel, socialize, and enjoy activities
• Better school or work productivity because of more consistent health

Preventing attacks before they occur can cut down school or workplace absences, decrease hospital visits, and reduce emergency care expenses—all substantial quality-of-life differences.

Andembry's approval represents a tipping point in the direction of personalized, preventive treatment for HAE. It changes the emphasis from responding to swelling attacks to actively preventing them, a shift with broad implications for patients and the health care system as a whole.

Providers now have a powerful, easy-to-use option to present to patients and families. Investigators are looking at whether Andembry can supplant or minimize the use of current prophylactics, like C1 inhibitor treatments or bradykinin receptor antagonists.

Economically, although monoclonal antibody therapies are generally very expensive, Andembry's ability to decrease emergency room visits and hospital stays could potentially yield dramatic cost savings for both patients and payers over time.

With Andembry's approval, individuals with hereditary angioedema can now receive a once-per-month injection that provides near-total attack prevention, outstanding safety, and improved quality of life. For the increasingly large population of diagnosed and undiagnosed patients, Andembry provides a new level of confidence and control in managing a condition long known to be capricious and highly restrictive.

The XFG “Stratus” COVID-19 variant is officially strutting into the pandemic spotlight. It is new, it is bold, and according to the latest data from the Centres for Disease Control and Prevention (CDC), it is now the third most common variant in the US. But it is popping up in certain states more than others, and the way it announces its arrival could be by making your throat feel like you have swallowed a box of sandpaper.

While the national Covid-19 test positivity rate sits in the 5–9.9 per cent range, a dozen states are seeing significantly higher numbers.

According to CDC data, the states with the highest positivity rates are:

• New Mexico (12%)
• Texas (12%)
• Oklahoma (12%)
• Arkansas (12%)
• Louisiana (12%)
• Nevada (11.3%)
• Arizona (11.3%)
• California (11.3%)
• Alaska (11.1%)
• Washington (11.1%)
• Oregon (11.1%)
• Idaho (11.1%)

These states are not just reporting higher numbers but are also providing ideal conditions for Stratus to spread. With case trends officially “growing” according to the CDC, it is a situation that demands close attention.

Stratus is a variant under monitoring by the World Health Organisation (WHO). First detected in January, XFG Stratus now accounts for about 14 per cent of Covid cases in the US.

While theW says the health risk from Stratus remains low at a global level, this variant is still on a growth spurt, outpacing other circulating forms of the virus, including its sibling, the “Nimbus” NB.1.8.1 variant. The concerning bit is that the WHO says Stratus could be more adept at sidestepping immune defences. The reassuring bit is that the current vaccines are expected to continue protecting against symptomatic and severe disease caused by Stratus.

Spotting Unique Stratus Symptoms

The tricky thing about Stratus is that it is not trying to reinvent the Covid symptom wheel. According to experts, its symptoms look suspiciously similar to other recent Omicron descendants. But there is one possible stand-out, a sensation some patients are calling “razor blade throat”.

Here’s the full checklist:

• Sore throat (sometimes severe)
• Cough
• Congestion or runny nose
• Fever or chills
• Shortness of breath
• Loss of taste or smell
• Fatigue
• Headache
• Muscle aches
• Nausea, vomiting or diarrhoea

The “razor blade throat” description might sound too much, but anyone who has had that burning, scratchy pain knows it is no joke. Hoarseness has also been reported more often lately. Still, a sore throat has been a hallmark Covid symptom since the early days of the pandemic; Stratus just seems to be leaning into it.

Why the Positivity Spike Matters

Higher positivity rates do not just mean more people are testing positive; they can also signal under-testing. If more than 10 per cent of people tested are infected, it suggests many cases are flying under the radar, which means more opportunities for the virus to spread unchecked. That is especially risky when you have a variant with a knack for growing its share of cases quickly, like Stratus.

The fact that 12 states are sitting above the 11 per cent mark means public health teams will be watching these regions closely in the coming weeks. In the meantime, everyday precautions like masking in crowded places, testing if symptomatic, and staying up to date with vaccines remain the best tools in the toolbox.

Stratus vs. Nimbus

While Stratus is currently the one hogging headlines, it is not alone. The “Nimbus” NB.1.8.1 variant is still in the mix, though it is being outpaced by Stratus globally.

For now, Stratus is the one to watch and not because it is the most dangerous, but because it is the fastest climber.

Final Forecast

The XFG Stratus variant is not changing anything, but it is a reminder that the virus is still evolving and still finding ways to make itself known. Got a sudden sore throat that feels like sandpaper? Do not brush it off. Stratus may not be a storm you can see on a weather map, but it is definitely in the air.

Health authorities in the UK have reported a significant rise in chikungunya cases, a mosquito-borne disease known for causing severe joint pain that can leave sufferers hunched over. Between January and June 2025, there were 73 confirmed cases in England, Wales, and Northern Ireland, more than double the 27 recorded during the same period in 2024. The UK Health Security Agency (UKHSA) says this is the highest number ever recorded, with nearly all linked to overseas travel.

What is Chikungunya?

Spread by the bite of infected Aedes mosquitoes, particularly the Aedes aegypti and Aedes albopictus species, chikungunya is not usually deadly but can be devastating for the very young, the elderly, or those with underlying health conditions.

Typical symptoms include:

• Excruciating joint pain that can leave sufferers bent over in agony
• High fever and headaches
• Muscle aches and swelling in the joints (especially hands and feet)
• Nausea, fatigue, and a rash that’s red, bumpy, and decidedly not Instagrammable

In severe cases, the arthritis-like pain can linger for months or even years, turning every movement into a reminder that mosquitoes are not just a mild holiday nuisance.

The majority of UK cases this year were linked to travel to Sri Lanka, India, and Mauritius. All were reported in England, with London taking the dubious honour of having the most cases. However, the two mosquito species that spread the virus are not established in the UK, so there is no risk of it transmitting locally.

UK logs first cases of oropouche virus

As if one virus was not enough, the UK has also logged its first cases of the oropouche virus, also dubbed ‘sloth fever’. This one circulates in the wild between primates, sloths, and birds before occasionally hopping over to humans via midges or mosquitoes.

Found primarily in the Amazon basin, oropouche has recently started wandering further across the Americas. All the UK cases were linked to travel from Brazil, so unless your staycation involves tree-dwelling mammals and tropical insects, you are safe for now.

The Global Bug Crawl

Chikungunya is typically found in Africa and southern Asia, but 2025 has seen it pop up in unexpected places. Outbreaks have been reported in China, the Indian Ocean islands of Reunion, Mayotte and Mauritius, and across the Americas. In southern China, more than 7,000 people have been infected since June, prompting COVID-style lockdowns in Foshan and at least a dozen other cities in Guangdong province. Hong Kong and Taiwan have also reported cases.

Health officials are urging travellers to take bite prevention seriously.

How to safeguard against mosquito bites

According to the US Centres for Disease Control and Prevention (CDC), your best defence is to stop mosquitoes from making contact in the first place.

Top tips include:

• Use Environmental Protection Agency (EPA)-registered insect repellent
• Wear long-sleeved shirts and trousers (mosquitoes can’t bite what they can’t reach)
• Treat clothing and gear with 0.5% permethrin for extra armour
• Choose accommodation with air conditioning or window screens
• If sleeping outdoors, use a mosquito net unless you enjoy sharing your bed with the local insect population

Vaccination

In addition to covering up and dousing yourself in repellent, some travellers may be advised to get the chikungunya vaccine before heading to certain destinations. Your healthcare provider can help you decide if this applies to your travel plans.

Why the Surge Now?

Several factors could be behind the sharp rise in cases. Increased international travel post-pandemic, changing weather patterns favouring mosquito breeding, and outbreaks in popular holiday destinations have created a perfect storm. Mosquitoes thrive in warm, wet conditions, and with climate change extending those conditions into more regions, these viruses are no longer staying politely within their old borders.

Chikungunya virus can turn a dream getaway into a painful endurance test, and once contracted, it is all about managing symptoms; there is no cure. The same goes for oropouche: prevention is your best friend. In the world of tropical diseases, an ounce of repellent really is worth a pound of cure.

Scott Swift, 73, pop singer Taylor Swift's dad just underwent a quintuple bypass surgery, revealed Taylor during one of the episodes of Travis Kelce and Jason Kelce's New Heights podcast.

She also shared that she had moved in with her dad earlier this year to take care of him for a speedy recovery. She noted that her father has been full of gratitude after the surgery. "He was the loveliest patient ever. He just kept saying thank you over and over again."

Why Did Scott Swift Need A Surgery?

Taylor called the surgery "really intense" and said that her dad's heart always had a healthy ECG or electrocardiogram. He also ensures to get it every year to remain a step ahead of any physical ailments. However, five hard blockages were found in his heart during a resting stress test.

"He's been telling all his friends, 'You need to get the stress test,' because that's what's actually preventative. If you can find that earlier, you don't have to have a bypass surgery," she said.

Also Read: Daughter Of Kate Shemirani Passes Away From Cancer At 23, Son Says She Fell For Anti-vaxxer 'Mum's Conspiracy Theories'

Taylor confirmed that her father is doing "incredibly well" and that his humor has helped him go through during the hard times. It still is very much intact in him.

She shares that he did not know how many blockages he's had, on being told that he underwent a quintuple bypass, which means five blockages, he also joked about it. "Well, you see, I come from a very competitive family," he told Taylor.

What Is A Stress Test?

As per the National Institute of Health (NIH), US, it is a form of physical test that typically utilizes electrocardiography along with blood pressure monitoring and exercise, which involves a treadmill or bicycle.

However, in a resting stress test, the assessment happens when the heart muscle is at rest after stress. This stress helps in identifying areas of reduced blood flow like ischemia or damage to the heart muscle, which can indicate conditions like coronary artery disease.

The test involves injecting a radioactive tracer into the bloodstream, then using a special camera to take images of the heart at rest and after stress.

What Is A Bypass Surgery?

As per Johns Hopkins Medicine, bypass surgery or coronary artery bypass graft surgery (CABG) is a procedure used to treat coronary artery disease. Coronary artery disease (CAD) is the narrowing of the coronary arteries. These are the blood vessels that supply oxygen and nutrients to the heart muscle. CAD is caused by a build-up of fatty material within the walls of the arteries. This buildup narrows the inside of the arteries, limiting the supply of oxygen-rich blood to the heart muscle.

How Does It Work?

One way to treat the blocked or narrowed arteries is to bypass the blocked portion of the coronary artery with a piece of a healthy blood vessel from elsewhere in your body. Blood vessels, or grafts, used for the bypass procedure may be pieces of a vein from your leg or an artery in your chest. An artery from your wrist may also be used.

ALSO READ: 4 Rare Heart Diseases That Are Becoming Common By Each Passing Day

This surgery is done to treat a blockage or narrowing of one or more of the coronary arteries. It can restore the blood supply to your heart muscle when nonsurgical procedures are not a choice.

More Updates From The Swift Family

In addition to Scott, Taylor shared that her mom Andrea Swift, too, under a procedure. “My mom just got a new knee,” Taylor shared. “She’s doing great. She’s scampering around. We’re not quite at scampering yet, but she’s doing great.”

She noted that her parents are her best friends.

"It was actually one of the most special things that's ever happened to me, spending all that time with them this summer. You have those long talks that you don't have when it's a small, concentrated period of time.”