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Rachel V Thomas

GLP-1 Drugs Like Mounjaro, Ozempic Linked To 82 Deaths In UK, 162 In US

From weight loss and diabetes to cancers and much more, GLP-1 drugs have delivered blockbuster results and transformed treatment for millions of people worldwide.

Clinical data have consistently shown that GLP-1 receptor agonists containing semaglutide and tirzepatide—including Ozempic, Wegovy and Mounjaro—reduce overall mortality as well as the risk of heart-related deaths.

However, reports from the UK and US have linked these medicines to more than 200 deaths. While a direct causal relationship has not been established and millions of people use these medications safely, high-profile inquests and adverse event databases have highlighted reports of deaths in which these drugs were listed as a suspected contributing factor, including cases associated with severe complications, dosing errors, and the use of counterfeit or compounded products.

<h2>UK Reports 82 Deaths Linked to GLP-1 Drugs</h2>

Data submitted to the UK's Medicines and Healthcare Products Regulatory Agency (MHRA) show a total of 82 deaths associated with glucagon-like peptide-1 (GLP-1) receptor agonists, the class of drugs used to treat obesity and type 2 diabetes, up to January 31, 2025.

The data includes 22 deaths associated with GLP-1 agonists used for weight loss, while 60 deaths were linked to their use in treating type 2 diabetes. As per the MHRA data:

<ul><li>18 deaths were linked to tirzepatide (Mounjaro), including 10 associated with weight loss and eight with type 2 diabetes treatment.</li><li>29 deaths werelinked to semaglutide products, including Ozempic, Rybelsus and Wegovy. Of these, four were associated with weight loss and 25 with diabetes treatment.</li><li>35 deaths werelinked to liraglutide products, including Saxenda and Victoza.</li></ul>

"The decision to start, continue, or stop treatments should be made jointly by patients and their doctor, based on full consideration of benefits and risks," said Alison Cave, MHRA Chief Safety Officer.

<h2>Northern Ireland Reported Two Deaths in 2026</h2>

In 2026, the deaths of two people in Northern Ireland potentially linked to Wegovy and Mounjaro injections were also reported to the MHRA.

The two cases are among more than 500 suspected adverse drug reaction reports submitted from Northern Ireland over the past two years related to GLP-1 medications.

In the US, <span>Ozempic and Wegovy</span> have been linked to 162 deaths since 2018, according to reports in the FDA's FAERS (FDA Adverse Event Reporting System) database.

While none of the deaths have been proven to be directly caused by semaglutide injections, the reports indicate the drugs were listed as a factor in the fatalities.

Driven by the rising prevalence of obesity and type 2 diabetes, the use of GLP-1 medications such as Ozempic, Wegovy, Mounjaro and Zepbound has increased dramatically in recent years. The global GLP-1 drug market is estimated to reach $200 billion by 2030.

Although each medication has distinct FDA-approved uses, they share four common mechanisms of action:<ul><li>Stimulate insulin release.</li><li>Reduce blood sugar.</li><li>Slow digestion.</li><li>Reduce hunger.</li></ul>

<h2>FDA Warning on Unapproved GLP-1 Drugs</h2>

In June 2026, the FDA raised concerns about patients and healthcare professionals seeking unapproved versions of GLP-1 receptor agonists, including semaglutide and tirzepatide, for weight loss.

The agency warned that unapproved products do not undergo FDA review for safety, effectiveness or quality before being marketed.

<ul><li>Compounded drugs should only be used when a patient's medical needs cannot be met by an FDA-approved drug.</li><li>Patients should obtain a prescription from their doctor and fill it at a state-licensed pharmacy.</li><li>Patients should use the FDA's BeSafeRx campaign resources to safely purchase prescription medicines online.</li><li>Patients should consult their doctor if they have questions about their medications.</li><li>Patients should contact the compounder or telehealth platform where they purchased the drug if they have questions about instructions for use or label information.</li></ul>

The FDA advises consumers to watch for warning signs, including companies that:

<ul><li>Claim a compounded drug is the same as an FDA-approved product.</li><li>Offer medicines at deep discounts or prices that seem too good to be true.</li><li>Send medicines that look different from previous prescriptions, arrive in damaged packaging or lack instructions for use.</li><li>Do not require screening and a prescription from a licensed doctor.</li><li>Do not have a licensed doctor available to answer questions after the medication is received.</li><li>Have spelling errors on labels or provide incorrect pharmacy addresses.</li><li>List a pharmacy name on the label that appears to be fraudulent.</li></ul>

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From weight loss and diabetes to cancers and much more, GLP-1 drugs have delivered blockbuster results and transformed treatment for millions of people worldwide.Clinical data have consistently shown that GLP-1 receptor agonists containing semaglutide and tirzepatide—including Ozempic, Wegovy and Mounjaro—reduce overall mortality as well as the risk of heart-related deaths.However, reports from the UK and US have linked these medicines to more than 200 deaths. While a direct causal relationship has not been established and millions of people use these medications safely, high-profile inquests and adverse event databases have highlighted reports of deaths in which these drugs were listed as a suspected contributing factor, including cases associated with severe complications, dosing errors, and the use of counterfeit or compounded products.UK Reports 82 Deaths Linked to GLP-1 DrugsData submitted to the UK's Medicines and Healthcare Products Regulatory Agency (MHRA) show a total of 82 deaths associated with glucagon-like peptide-1 (GLP-1) receptor agonists, the class of drugs used to treat obesity and type 2 diabetes, up to January 31, 2025.The data includes 22 deaths associated with GLP-1 agonists used for weight loss, while 60 deaths were linked to their use in treating type 2 diabetes. As per the MHRA data:18 deaths were linked to tirzepatide (Mounjaro), including 10 associated with weight loss and eight with type 2 diabetes treatment.29 deaths werelinked to semaglutide products, including Ozempic, Rybelsus and Wegovy. Of these, four were associated with weight loss and 25 with diabetes treatment.35 deaths werelinked to liraglutide products, including Saxenda and Victoza."The decision to start, continue, or stop treatments should be made jointly by patients and their doctor, based on full consideration of benefits and risks," said Alison Cave, MHRA Chief Safety Officer.Northern Ireland Reported Two Deaths in 2026In 2026, the deaths of two people in Northern Ireland potentially linked to Wegovy and Mounjaro injections were also reported to the MHRA.The two cases are among more than 500 suspected adverse drug reaction reports submitted from Northern Ireland over the past two years related to GLP-1 medications.US Reported 162 DeathsIn the US, Ozempic and Wegovy have been linked to 162 deaths since 2018, according to reports in the FDA's FAERS (FDA Adverse Event Reporting System) database.While none of the deaths have been proven to be directly caused by semaglutide injections, the reports indicate the drugs were listed as a factor in the fatalities.Growing Use of GLP-1 DrugsDriven by the rising prevalence of obesity and type 2 diabetes, the use of GLP-1 medications such as Ozempic, Wegovy, Mounjaro and Zepbound has increased dramatically in recent years. The global GLP-1 drug market is estimated to reach $200 billion by 2030.Although each medication has distinct FDA-approved uses, they share four common mechanisms of action:Stimulate insulin release.Reduce blood sugar.Slow digestion.Reduce hunger.FDA Warning on Unapproved GLP-1 DrugsIn June 2026, the FDA raised concerns about patients and healthcare professionals seeking unapproved versions of GLP-1 receptor agonists, including semaglutide and tirzepatide, for weight loss.The agency warned that unapproved products do not undergo FDA review for safety, effectiveness or quality before being marketed.The FDA recommends that:Compounded drugs should only be used when a patient's medical needs cannot be met by an FDA-approved drug.Patients should obtain a prescription from their doctor and fill it at a state-licensed pharmacy.Patients should use the FDA's BeSafeRx campaign resources to safely purchase prescription medicines online.Patients should consult their doctor if they have questions about their medications.Patients should contact the compounder or telehealth platform where they purchased the drug if they have questions about instructions for use or label information.What Are The Red FlagsThe FDA advises consumers to watch for warning signs, including companies that:Claim a compounded drug is the same as an FDA-approved product.Offer medicines at deep discounts or prices that seem too good to be true.Send medicines that look different from previous prescriptions, arrive in damaged packaging or lack instructions for use.Do not require screening and a prescription from a licensed doctor.Do not have a licensed doctor available to answer questions after the medication is received.Have spelling errors on labels or provide incorrect pharmacy addresses.List a pharmacy name on the label that appears to be fraudulent.

glp-1 drugs like mounjaro, ozempic linked to 82 deaths in uk, 162 in us

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