Chronic hepatitis B infections among children and young adults in the United States could rise by 83% if the country moves away from routinely recommending vaccination at birth for all newborns, according to a new study titled Projected Effect of 2026 Federal Changes to the Childhood Immunization Schedule on Chronic Hepatitis B Virus Infections in the United States, published in Annals of Internal Medicine recently.Researchers from Massachusetts General Hospital and Harvard Medical School analysed outcomes for a birth cohort of 3.6 million infants over their first 20 years. The study examined the impact of changes to US hepatitis B vaccine recommendations for babies born to mothers who test negative for the virus.Under the revised approach, parents and healthcare providers decide together whether and when to begin vaccination. The findings suggest that this could leave more children vulnerable to infection, increasing the cases of chronic hepatitis B.What Did The Study Find?The model compared universal vaccination at birth with two alternatives. The first is delaying the first dose until at least two months of age, and the second is leaving the decision to parents and healthcare providers.Researchers estimated that delaying vaccination could increase chronic hepatitis B infections acquired by age 20 by 19%. Under the second option, the estimated increase was 83%.The model estimated 255 chronic infections under universal birth-dose vaccination, compared to 303 if vaccination was delayed and 467 under shared decision-making.The number of people who remained at high risk to hepatitis B at age 20 was also projected to increase. Under universal vaccination at birth, around 232,000 people in the cohort would remain at risk. This rose to 474,000 with delayed vaccination and approximately 1.8 million under shared decision-making.Study's corresponding author Amir Mohareb said, “These findings show why policy makers should re-implement recommendations for universal hepatitis B vaccination at birth.”Also read: Hepatitis C: Could 8-Week Treatment Help India Reach More Patients?Importance Of Hepatitis B Birth Dose Hepatitis B is a viral infection that affects the liver and spreads through infected blood and certain bodily fluids, including during childbirth. Infection acquired during infancy is likely to become chronic, leading to cirrhosis, liver failure or liver cancer in the future.The universal hepatitis B birth-dose recommendation was introduced in the US in 1991. The first dose provides early protection, including when maternal infection is missed or a child's exposure risk is not recognised.In December 2025, the US Advisory Committee on Immunization Practices recommended replacing universal vaccination at birth with shared decision-making for infants whose mothers test negative. The Centers for Disease Control and Prevention adopted this approach in January 2026. Babies born to mothers who test positive or whose infection status is unknown continue to be recommended to receive the birth dose promptly, along with hepatitis B immune globulin when indicated.Also read: Can Panty Liners Pose A Cancer Risk? What Science SaysIncrease In Infections, Deaths And Costs The changes in vaccine policy is also likely to lead to hundreds more infections, deaths, and millions of dollars in higher costs, according to another research published in JAMA Pediatrics.Pediatricians, public health experts, and dozens of medical groups warned that it could harm children and their families. So the JAMA studies modelled the potential impact of the policy.The first study estimated that delaying the first hepatitis B vaccine dose by two months for babies born in a single year to mothers who tested negative — about 80 percent of the 3.6 million US births annually — would increase lifetime health-care costs by at least $16 million, The Washington Post reported. If vaccination were delayed by seven months, it would cost an additional $19.8 million.The second study modeled what would happen if only 10 per cent of babies born to unscreened mothers received a birth dose; an additional 628 babies would get infected.“One of the most concerning implications is how many more infected Hep B babies will we see,” said co-author Rachel Epstein, a pediatric and adult infectious diseases clinician at Boston Medical Center.“A universal birth dose helps prevent a substantial number of infections in babies of a lifelong condition that we do not have a cure for,” she added.