“I'm not great at the advice. Can I interest you in a sarcastic comment?”

This is what ‘Friends’ actor Matthew Perry’s character Chandler Bing was known for. He was known for being funny. However, he had his own struggles in his personal life and those struggles were acute depression. He was treating it with ketamine infusion therapy which is legal in the US and the UK.

What is Ketamine infusion therapy?

Ketamine is an anaesthetic used to treat depression, anxiety and pain under supervised and controlled medical settings. However, it does have its side effects, which can lead to distortion of sight, sound and time. It can also produce calming and relaxing effects.

Ketamine increases a person’s heart rate and blood pressure. If overdosed, it can leave users confused and agitated and can cause them to hurt themselves without even realising it. It can also lead to liver damage and bladder problems.

However, when used in moderation and under the supervision of medical doctors, it can treat depression where traditional antidepressants have failed.

Prof Rupert McShane, a University of Oxford psychiatrist who runs an NHS ketamine treatment clinic told BBC that ketamine “probably turns off the area of the brain that is involved in disappointment.”

Can Ketamine Infusion Therapy Kill Someone?

In simple terms, it cannot, be if the dosage is given in a controlled setting and as prescribed. Ketamine infusion therapy uses drugs in small doses than those used for anaesthesia. It acts faster than traditional anti-depressants, but the effects also wear off way quickly. Which is why it is important to monitor patients’ mental state for relapsing back into depression and discouraging them from overdosing on it.

There are ways of giving people ketamine. One of the ways is through “infusing”, which means to use an IV drip. However, injections, nasal sprays and capsules are also methods used to give people ketamine.

Since the dosage of ketamine used in the infusion treatment is small, it being the reason of actor Perry’s death was ruled out. The medical examiner also noted that Perry’s last ketamine infusion therapy session happened more than a week before his death, which means by the time he had died, it must have worn off.

So, What Happened To Perry?

Though Perry’s last session was more than a week before, his post-mortem showed that his blood contained a high concentration of ketamine. He had died of the “acute effects” of ketamine.

If it was not his session, then how did he get ketamine?

Prosecutors alleged that his assistant gave him at least 27 shots of ketamine in four days before his death, reported BBC.

Perry has been open about his personal struggles and this is what the doctors and dealers used against him. Martin Estrada, the US attorney for California’s Central District told the BBC that people took advantage of his condition. They charged him 165 times more than what vials of ketamine cost.

Names that have come up include Dr Salvador Plasencia, drug dealers “Ketamine Queen” aka Jasveen Sangha and Eric Fleming, and Perry’s live-in assistant Kenneth Iwamasa.

Who Are These Names And What Did They Do?

Ketamine Queen or Sangha supplied drugs that led to Perry’s death. Her home was a “drug-selling emporium,” said Estrada. More than 80 vials of ketamine, and thousands of pills including methamphetamine, cocaine and Xanax were allegedly found in her house known as the “Sangha Stash House.”

Sangha is known to deal with high-end celebs and was a “major source of supply for ketamine to others as well as Perry,” said Estrada.

Dr Plasencia called Perry a “moron” while charging him $2,000 for vials that cost only $12. He sold Perry 20 vials of ketamine between September and October 2023, costing $55,000.

He was the one who taught Iwamasa, who had no medical knowledge to inject the drug. This is after he knew that “Perry’s ketamine addiction was spiralling out of control,” as per what the investigators told the BBC.

Another dealer Fleming was told by Sangha to “delete all our messages.” While Fleming pleaded guilty to conspiring to distribute drugs unlawfully, he also allegedly messaged Sangha: “Please call...Got more info and want to bounce ideas off you. I’m 90% sure everyone is protected. I never dealt with [Perry] only his assistant. So the assistant was the enabler.”

The court documents also revealed that he asked Sangha on whether the ketamine stays in your system or “is it immediately flushed out.”

Dr Pepper, Bots, Cans

The people who allegedly exploited Perry used coded language for ketamine and called it “Dr Pepper”, “bots”, or “cans.”

Selling overpriced drugs, taking advantage of Perry’s mental condition and falsifying medical records to make the drugs given to him look legitimate by Dr Plasencia is what took Perry’s life.

Iwamasa is said to have administered more than 20 shots of ketamine and three on the day Perry died. Whereas ketamine is only administered by a physician. Authorities also found that weeks before Perry’s death, Dr Plasencia allegedly bought 10 vials of ketamine and intended to sell to Perry.

He also injected Perry with a large dose, two days later. This caused him to “freeze up” and spiked his blood pressure.

When I Die, I Want Helping Others To Be The First Thing That’s Mentioned

Perry had always been open about his drug addictions, struggles with alcohol and his depression. He said that his openness would help others who are also struggling and wanted to be remembered by his quote which also is on the homepage of the Mattew Perry Foundation that helps others struggling with the disease of addiction: “When I die, I want helping others to be the first thing that’s mentioned.”

Five arrests have been made in the case so far.

In a surprising video, a woman who ordered a tub of Kwality Wall's Frozen Dessert - Fruit & Nut in Rajasthan found the bottom of the container filled mostly with oil, raising questions about the quality of the product.

In the clip, the distressed customer was heard saying: "It is not even melting and has a weird flavor. I am never eating this ice cream again. I have asked my husband not to purchase this again. It was my favourite ice cream, but now I feel very disappointed."

However, after the post went viral, many X users pointed out that the brand sells frozen dessert, instead of ice cream and that frozen dessert contains palm oil which could explain why she found oil floating inside the container.

What Did Kwality Wall's Say?

As the video continued to go viral across the country, an official spokesperson of Kwality Walls India Limited confirmed that an investigation had been launched into the product's quality.

Speaking about what could have gone wrong, they told NDTV: "Given that ice cream/frozen dessert requires a continuous cold chain from factory to outlet and then to the freezer at consumers' homes, and as it is a sensitive product, temperature variations-especially during peak summer-can impact it.

"We are closely examining all stages of the supply chain for any deviations in storage or handling at the front end. We continue to work with our partners to ensure strict adherence to temperature-controlled protocols until the product reaches consumers' homes."

READ MORE: Zepto Customer Claims To Find 'Plastic' Inside Eggs, FSSAI Says Impossible

Frozen Desserts vs Ice Cream

Ice cream is essentially defined a frozen food dessert made from dairy products, such as milk and cream. For a product to qualify as ice cream, it has to contain atleast 10 percent milk fat and have a rich, creamy texture.

Often, natural color is used in ice cream to enhance its visual appeal, maintaining a healthier alternative to artificial dyes. The process involves churning a sweetened mixture of cream, milk, and flavors while freezing, incorporating air to create a light and airy consistency.

On the other hand, frozen desserts are typically made of a mixture of fats (vegetable oil or milk fat), sweeteners (sugar, glucose), milk solids and stabilizers/emulsifiers to create a smooth, creamy texture. They include diverse range of options, from fruit-based sorbets to creamy non-dairy alternatives.

Unlike ice creams, frozen desserts often use vegetable fats like palm oil, along with additives to manage texture and hold their shape longer when melting, and often have higher stabilizer content.

Due to being made from hydrogenated vegetable oils as well as are high in added sugars, saturated fats and processed ingredients, most frozen desserts are not considered healthy.

While some options have lower calories or fat than traditional ice cream, they are considered ultra-processed treats.

Experts recommend looking for fewer ingredients, less sugar, and dairy-based rather than palm-oil-based options as well as opting for single-serve items like small bars or cups to avoid overeating to stay healthy.

From higher costs on syringes, catheters, and MRIs, to medical supply shortages and longer wait times, the increasing geopolitical tensions around the Strait of Hormuz, which is likely to prolong, can spell trouble for the healthcare industry.

Amid a 48-hour "ultimatum" from US President Donald Trump to "fully open" the crucial waterway, Iran on Sunday said the Strait of Hormuz remains open to all shipping except that of its “enemies”.

Also Read: Shigella Cases Rise To 12 In Kerala: Doctor Explains Why The Bacterial Infection Is Fatal For Young Kids

The ongoing conflict has already spiked prices for medical devices—specifically plastics for syringes and catheters – due to the rising cost of raw materials. If disruptions persist, it can also warn of potential shortages, experts told HealthandMe.

In a statement, the Association of Indian Medical Device Industry (AiMeD) noted that the medical device input costs have already risen by nearly 50 percent for critical plastics, over 20 percent for packaging, and self-generated power running on diesel. It noted that PNG gas prices used for power generation and process heating have nearly doubled due to reduced availability.

This is eroding razor-thin margins on essentials like syringes, nitrile gloves, catheters, and plastic disposable medical devices in a highly competitive, volume-driven market.

“A shortage of liquid helium could impact the installation of new MRI scanners, each of which requires around 1,500 liters for the initial magnet fill. Supply disruptions linked to the war may delay new installations and push up costs, as helium prices are likely to rise amid tighter availability,” Dr. Harsh Mahajan, Mentor FICCI & Founder Mahajan Imaging & Labs, told HealthandMe.

Also read: Middle East Crisis Disrupting Health Services, Fueling Diseases & Environmental Hazards: WHO

Hormuz Blockade: No Shortage Now

The expert noted that there is no immediate concern for existing MRI machines.

It is because most currently installed scanners use K4 technology with zero boil-off systems, allowing them to operate efficiently without frequent helium refills.

“Typically, a top-up is needed only once every three years, when the magnet’s cold head is replaced. As a result, the existing installed base is expected to continue functioning without disruption in the near term,” Dr. Mahajan said.

According to experts, while one to three week shipment delays are manageable via buffers, prolonged disruptions risk production halts, hospital shortages, and costs due to inflated prices from market abuse by dominant large raw materials players.

Rajiv Nath, Forum Coordinator, AiMeD, has assured that “as of now, there are no shortages of syringes or other medical disposables, contrary to circulating rumors—there is no need to panic”.

While many manufacturers have adjusted product pricing by 10-20 percent to sustain operations, there is no acute shortage in key polymer grades like Polypropylene, HDPE, or LDPE, he added.

Also read: Black Rain Over Iran's Capital Tehran Sparks Health Fears

Long-term Hormuz Blockade Can Affect Critical Medical Supplies

However, the rapidly deteriorating situations and a longer blockade of Hormuz can lead to “substantial price increases, longer lead times, and highly elevated freight costs, which are pressuring cost structures and planning cycles”.

Nath said evolving global supply chain dynamics require close monitoring to prevent impacts on production timelines and industry stability.

The Medical Technology Association of India (MTaI) also warned that the ongoing US/Israel-Iran conflict and disruption in the Strait of Hormuz directly threaten India’s access to critical and life-saving medical technologies.

"Modern healthcare systems operate on just-in-time inventory models with minimal buffer stock. When large consignments - like those shipped by sea - are delayed or stranded, there is simply not enough inventory in the system to compensate, even through costlier alternatives like air freight," Pavan Choudary, Chairman, MTaI, told HealthandMe.

He also noted that shipment delays beyond March 31 can lead to "budget lapse, forcing a fresh approval cycle - thereby compounding delays that often stretch to months".

It is because many public institutions in India front-load procurement toward the financial year-end.

The industry experts urged the government to take urgent action to safeguard over 5 lakh jobs, ensure affordable healthcare access under Atmanirbhar Bharat, and protect exports to the US and EU.

The AiMeD also urged the Indian government not to reduce import duties on medical devices based on rumors of shortages.

Kerala is yet again in the grip of a deadly and highly contagious disease. This time, a fresh outbreak of Shigella (caused by the bacteria shigellosis) has been reported in the southern state’s Kozhikode district.

Shigella is a fast-spreading bacterium that causes diarrhea, which in some cases can lead to complications including arthritis, kidney damage , and death.

In the Kozhikode, Kerala outbreak, at this time, 51 people are under observation, 12 have developed the illness, and one child of three and a half years has died.

The child, who had been undergoing treatment at Kozhikode Medical College Hospital, passed away on Sunday after suffering from high fever and seizures.

Health officials in the state have identified at least 11 more children who had come into contact with the girl and were subsequently infected.

Around five more children are currently under close observation in various hospitals, with doctors monitoring symptoms and preventing further complications, Onmanorama reported. The health authorities are also investigating whether adults in the area may have contracted the infection, raising concerns about a broader community spread.

As a precautionary measure, the Anganwadi center has been temporarily shut down to prevent further spread of the fatal infection.

Shigella: Why Are Young Children At High Risk?

Speaking to HealthandMe, Dr. Rajeev Jayadevan, Ex-President of IMA Cochin and Convener of the Research Cell, Kerala, explained that even a small number of bacteria—as few as 10 —is enough to cause infection.

It is because the Shigellosis bacteria “is able to withstand the hostile acidic environment of the human stomach. Outside the human body, it can stay alive in water for weeks together,” he said.

Shigella is most severe in children below the age of five, as their immune systems are less efficient at clearing the infection early.

“Adults also become ill, but acquired immunity from childhood keeps the infection mild in many instances,” the expert said.

Shigella Outbreak: How Does It Spread? What Are The Symptoms?

Shigella spreads through:

• touching contaminated surfaces or objects
• physical contact with an infected individual
• drinking contaminated water or ice made from unclean water

The expert noted that houseflies can also spread the bacteria.

Flies transmit the bacteria from human feces to food, water, and surfaces, contributing to up to 37 percent of cases in some regions, according to a study published in the PLoS Neglected Tropical Diseases.

The disease onset occurs typically within 1 to 3 days of ingestion of the bacteria, with fever, diarrhea, body aches, and headache.

Once it involves the large intestine, bloody diarrhea occurs, with severe abdominal cramps.

Shigella: How To Prevent

Dr. Jayadevan said. stressed the need for early recognition and treatment with appropriate antibiotics.

ORS can help prevent dehydration, while Zinc tablets can enhance recovery.

Other measures to prevent the risk of spread include:

• Washing hands with soap and water, especially before touching food and also after toilet use
• Food handlers must maintain hygiene
• Control flies

“A multipronged approach is required, involving sustained sanitation measures and strict attention to clean drinking water supplies, to prevent such outbreaks,” the expert said.