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Rachel V Thomas

Panxeon: New Blood Test May Detect Pancreatic Cancer Before It Begins 64% of the Time

<span>Pancreatic cancer</span> is one of the most difficult cancers to detect in its early stages. By the time it is diagnosed, the disease may have already spread, limiting treatment options and lowering survival.

Now, a novel <span>blood test</span> called <span>Panxeon</span>, developed by researchers at City of Hope, could offer a way to detect pancreatic cancer earlier. 

Panxeon is an investigational liquid biopsy designed to detect pancreatic cancer, including stage 1 and 2 disease, using a blood sample.

The test also showed potential for identifying high-grade dysplasia, a precancerous condition sometimes considered “stage 0” pancreatic cancer.

In a study of nearly 1,800 patients across the US, Europe and Asia, published in <em>Nature Medicine</em>, the blood test correctly identified stage 1 and 2 pancreatic cancer in 87% of cases. Its false-positive rate was 3% among people in low-risk groups and 16% among those in high-risk groups.

Panxeon also detected high-grade dysplasia more than 64% of the time. This could help doctors identify which pancreatic cysts may require closer monitoring or further intervention before invasive cancer develops. 

<strong>Also read: </strong><a href="https://www.healthandme.com/health-news/meet-audrey-zheng-17-yo-who-developed-blood-test-for-pancreatic-cancer-that-correctly-identified-87-of-patients-article-155885854" data-type="tilCustomLink">Meet Audrey Zheng: 17-YO Who Developed Blood Test For Pancreatic Cancer That Correctly Identified 87% Of Patients</a>

<h2>How Does Panxeon Detect Pancreatic Cancer?</h2>

Pancreatic cancer has one of the lowest survival rates among cancers. Only 14% of patients survive five years after diagnosis, according to the US National Cancer Institute.

Panxeon assesses three biological signals associated with pancreatic cancer: circulating microRNAs, exosomal microRNAs and a protein called CA19-9.

The test then uses artificial intelligence to combine these measurements into a single score estimating a person's risk of pancreatic cancer.

“Pancreatic cancer remains so deadly largely because we find it after the window for cure has begun to close,” said senior author Ajay Goel, chair of the Department of Molecular Diagnostics and Experimental Therapeutics at City of Hope.

“For patients, these findings represent progress toward finding pancreatic cancer before symptoms appear and while more treatment options remain available,” he added.

According to the researchers, Panxeon is the first investigational test to combine these three biomarkers into a single blood test.

However, Panxeon is not intended to replace imaging or other diagnostic tests. Instead, it could potentially help identify people at higher risk who need further evaluation, said Goel.

<h2>Who Could Benefit From the Test?</h2>

Read More: <a href="https://www.healthandme.com/health-wellness/former-us-senator-ben-sasse-opens-up-about-battle-with-terminal-stage-4-pancreatic-cancer-article-154042531" data-type="tilCustomLink">Former US Senator Ben Sasse Opens Up About Battle With Terminal Stage 4 Pancreatic Cancer</a>

Early detection of pancreatic cancer has been a longstanding research challenge, with previous blood-based tests failing to provide sufficient accuracy.

The researchers said Panxeon's approach differs by combining multiple biomarkers and evaluating the test in people with risk factors such as inherited or familial risk, pancreatic cysts and chronic pancreatitis, rather than relying only on healthy controls.

“Most biomarkers tell you one part of the story. Combining multiple biological signals gives us a clearer picture of what may be happening in the pancreas,” Goel said.

People who may potentially benefit from such testing include those with an inherited risk or family history of pancreatic cancer, pancreatic cysts or chronic pancreatitis.

These groups are often monitored using imaging and other tests. A reliable blood test could eventually help identify who needs further evaluation.

“A stage shift is not just a statistic,” Goel said. “The earlier we find pancreatic cancer, the greater the chance that meaningful intervention is still possible.”

<h2>Pancreatic Cancer: Know The Warning Signs</h2>

<strong>READ: </strong><a href="https://www.healthandme.com/health-news/daraxonrasib-us-fda-approves-once-daily-pill-for-metastatic-pancreatic-cancer-article-155991835" data-type="tilCustomLink">Daraxonrasib: US FDA Approves Once-Daily Pill for Metastatic Pancreatic Cancer</a>

Pancreatic cancer can begin with few or nonspecific symptoms, making early diagnosis difficult. Symptoms may become more apparent as the disease progresses.

Symptoms that should not be ignored include:

<ul><li>Abdominal or back pain</li><li>Unexplained weight loss</li><li>Jaundice</li><li>Changes in urine or stool.</li></ul>

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Pancreatic cancer is one of the most difficult cancers to detect in its early stages. By the time it is diagnosed, the disease may have already spread, limiting treatment options and lowering survival.Now, a novel blood test called Panxeon, developed by researchers at City of Hope, could offer a way to detect pancreatic cancer earlier. Panxeon is an investigational liquid biopsy designed to detect pancreatic cancer, including stage 1 and 2 disease, using a blood sample.The test also showed potential for identifying high-grade dysplasia, a precancerous condition sometimes considered “stage 0” pancreatic cancer.In a study of nearly 1,800 patients across the US, Europe and Asia, published in Nature Medicine, the blood test correctly identified stage 1 and 2 pancreatic cancer in 87% of cases. Its false-positive rate was 3% among people in low-risk groups and 16% among those in high-risk groups.Panxeon also detected high-grade dysplasia more than 64% of the time. This could help doctors identify which pancreatic cysts may require closer monitoring or further intervention before invasive cancer develops. Also read: Meet Audrey Zheng: 17-YO Who Developed Blood Test For Pancreatic Cancer That Correctly Identified 87% Of PatientsHow Does Panxeon Detect Pancreatic Cancer?Pancreatic cancer has one of the lowest survival rates among cancers. Only 14% of patients survive five years after diagnosis, according to the US National Cancer Institute.Panxeon assesses three biological signals associated with pancreatic cancer: circulating microRNAs, exosomal microRNAs and a protein called CA19-9.The test then uses artificial intelligence to combine these measurements into a single score estimating a person's risk of pancreatic cancer.“Pancreatic cancer remains so deadly largely because we find it after the window for cure has begun to close,” said senior author Ajay Goel, chair of the Department of Molecular Diagnostics and Experimental Therapeutics at City of Hope.“For patients, these findings represent progress toward finding pancreatic cancer before symptoms appear and while more treatment options remain available,” he added.According to the researchers, Panxeon is the first investigational test to combine these three biomarkers into a single blood test.However, Panxeon is not intended to replace imaging or other diagnostic tests. Instead, it could potentially help identify people at higher risk who need further evaluation, said Goel.Who Could Benefit From the Test?Read More: Former US Senator Ben Sasse Opens Up About Battle With Terminal Stage 4 Pancreatic CancerEarly detection of pancreatic cancer has been a longstanding research challenge, with previous blood-based tests failing to provide sufficient accuracy.The researchers said Panxeon's approach differs by combining multiple biomarkers and evaluating the test in people with risk factors such as inherited or familial risk, pancreatic cysts and chronic pancreatitis, rather than relying only on healthy controls.“Most biomarkers tell you one part of the story. Combining multiple biological signals gives us a clearer picture of what may be happening in the pancreas,” Goel said.People who may potentially benefit from such testing include those with an inherited risk or family history of pancreatic cancer, pancreatic cysts or chronic pancreatitis.These groups are often monitored using imaging and other tests. A reliable blood test could eventually help identify who needs further evaluation.“A stage shift is not just a statistic,” Goel said. “The earlier we find pancreatic cancer, the greater the chance that meaningful intervention is still possible.”Pancreatic Cancer: Know The Warning SignsREAD: Daraxonrasib: US FDA Approves Once-Daily Pill for Metastatic Pancreatic CancerPancreatic cancer can begin with few or nonspecific symptoms, making early diagnosis difficult. Symptoms may become more apparent as the disease progresses.Symptoms that should not be ignored include:Abdominal or back painUnexplained weight lossJaundiceChanges in urine or stool.

panxeon: new blood test offers hope for earlier pancreatic cancer detection

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