A suspected case of pneumonic plague in Siberia has triggered quarantine measures after a laboratory worker at Russia’s Irkutsk Anti-Plague Research Institute died following severe pneumonia. Russian health authorities have not yet confirmed that the 28-year-old died due to plague. Rospotrebnadzor has described the illness as pneumonia of unknown origin and said tests have found no evidence linking her death to pathogens at the institute. Reportedly, around 200 people who may have had contact with her have been placed under medical observation. As of October 5, Russian health authorities said about 60% of contacts had completed observation successfully and no one reported symptoms of plague infection. The incident has attracted international attention as unconfirmed reports claimed that the woman may have developed pneumonic plague after she accidentally broke a test tube at the research facility. Russian authorities have denied that there was a laboratory accident. The hospital where she died has also been placed under quarantine. Pneumonic vs Bubonic vs Septicemic Plague: Which Is Deadlier? Also read: Russia Plague Outbreak: Lab Worker Dies Of 'Unknown Infection' After Suspected Exposure; CDC Monitors The SituationBubonic plague is the most common form. It accounts for most number of naturally occurring human plague infections. It usually develops after an infected flea bite. The bacteria this case travels to nearby lymph nodes and causing the characteristic painful swelling known as a bubo. If diagnosed early, it can be successfully treated with antibiotics. Septicemic plague occurs when the bacteria enter the bloodstream. It can develop as a complication of bubonic plague, but it can also occur as a primary infection. Because the bacteria are circulating throughout the body, patients can rapidly develop shock, bleeding and tissue death. Pneumonic plague is the most dangerous from a transmission standpoint. It infects the lungs and can develop after inhaling Y. pestis or when infection spreads to the lungs from another form of plague. Unlike bubonic and septicemic plague, pneumonic plague can spread directly from one person to another through respiratory droplets. The CDC describes pneumonic plague as the most serious form of plague and says untreated pneumonic plague is almost always fatal. It can also progress rapidly, making early diagnosis and antibiotic treatment critical. There isn’t a definitive answer to which one is deadlier as we have no simple ranking based purely on fatality percentage because outcomes depend heavily on how quickly treatment begins. But pneumonic plague is generally regarded as the most dangerous form because it can be rapidly fatal and can spread directly between people. The World Health Organization says untreated bubonic plague has a case-fatality rate of around 30% to 60%, while pneumonic and septicemic plague can be 100% fatal without treatment. Its incubation period is sometimes as short as one day. Bubonic plague is less transmissible between humans and is usually more treatable when identified early. Septicemic plague can also become rapidly life-threatening because the infection has entered the bloodstream.Also read: Pneumonic Plague: COVID-19, Rhinovirus Detected in Russian Lab Worker’s Contacts; Trump Offers US Help Russia Plague: Updates Regarding Russia’s plague scare, the concern around pneumonic plague is not only its severity, but the possibility of respiratory transmission if a case were ever confirmed. No plague infection has been confirmed in the reported Russian case so far. Russian authorities have repeatedly said there is no confirmed plague outbreak and urged people to rely on official information rather than rumours. The Kremlin has also said the situation is under control. The WHO has said, based on unofficial information, that the risk to the general public appears to be low. Meanwhile, the US State Department says it is monitoring the situation. Secretary of State Marco Rubio said the possibility of an infectious disease spreading from a laboratory was being watched closely, while stressing that it was not currently a cause for alarm. There are also reports that preventive measures have been introduced in the region, including isolation of hospital contacts and mask use at a nearby aluminum plant.