SummaryScientists have developed a new 4-in-1 weight loss drug combining GLP-1, GIP, glucagon, and PYY hormones, aiming to match bariatric surgery-level results while reducing obesity-related risks like diabetes, cancer, and heart disease. As the demands for weight loss drugs skyrockets, a more powerful, safer option could reshape the market and, more importantly, redefine the role of pharmacology in preventing chronic disease.