Heart attacks and strokes are among the leading causes of death globally, with millions suffering from cardiovascular diseases (CVD) every year. There are more than seven million people in the UK alone, with about 100,000 patients experiencing heart attacks annually. However, a group of researchers at University College London (UCL) estimate that one 'polypill' taken daily day could eliminate a majority of these cases dramatically lowering death tolls.

The proposed polypill, a combination of a statin and three blood pressure-lowering drugs, has been under study for over two decades. Experts argue that introducing this pill universally for individuals aged 50 and above could be more effective than the current NHS Health Check, which assesses risk factors every five years for those aged between 40 and 74.

Studies have repeatedly proven the effectiveness of the polypill in preventing CVD. A groundbreaking 2019 study in The Lancet found that five years' use of the polypill cut the risk of heart attack and stroke by a third. In addition, previous modelling analyses have estimated that if given universally to people over 55, the polypill might be able to prevent 80% of heart attacks and strokes.

Today, the NHS Health Check follows a risk-based model in which patients are tested for CVD risk factors and treated with drugs accordingly. Yet, as per UCL's study, this system has serious flaws:

Low Uptake: Just 40% of those eligible for the NHS Health Check choose to have it, leaving a considerable number of at-risk patients undiagnosed and untreated.

Ineffective Prediction of Risk: The majority of heart attacks and strokes happen to people at average risk levels, thus making it challenging to identify the need for intervention effectively.

Limited Effectiveness: Even at maximum take-up, the NHS Health Check programme is predicted to have fewer health impacts compared to a polypill initiative applied to the whole population.

Simplicity and Affordability of the Polypill Strategy

One of the big benefits of the polypill is that it is so easy. In contrast to the existing screening-based model, the polypill scheme would not involve complicated medical tests or lengthy risk assessments. Instead, people reaching 50 would just have to fill out a few questions to determine possible side effects before they were prescribed.

Professor Aroon Hingorani of the UCL Institute of Cardiovascular Science, one of the strongest proponents of this scheme, says:

"Finally, the time is now to do much better on prevention. A population approach would prevent a lot more heart attacks and strokes than is done today with a strategy of trying to target a smaller group only."

Aside from the possible health implications, the polypill is also an economic solution. The drugs used are off-patent, thus cheap to produce and distribute. With the vast economic cost of managing CVD-related illnesses, a preventive model could result in substantial cost-saving for the NHS in the future.

The polypill has been proven to be effective by numerous international trials. In 2019, a randomised trial in rural Iran discovered that participants who took the polypill for five years had a 34% reduced risk of having a heart attack or stroke compared to non-participants.

Likewise, modelling research has indicated that even if only 8% of people aged over 50 took up the polypill regimen, it would still be more beneficial to their health than the NHS Health Check programme.

Is This a Case of Over-Medicalisation?

One of the main objections to the polypill strategy is the suggestion that it might result in the unnecessary medicalisation of a significant proportion of the population. But, it is argued, it should be considered as a preventative measure, not as mass medication.

Professor Sir Nicholas Wald of UCL's Institute of Health Informatics explains:

"Instead of being a 'medicalisation' of a significant proportion of the population, a polypill programme is a prevention measure to prevent an individual from becoming a patient."

He compares it with public health measures like water fluoridation or compulsory seatbelts—interventions that have been shown to have a significant impact in reducing public health danger at low individual cost.

With the evidence in favour of the polypill's effectiveness and viability overwhelming, experts are calling on the NHS to act now. It is their belief that substituting the NHS Health Check with a polypill-based prevention program could be the UK government's flagship policy under its pledge to put disease prevention ahead of cure.

As Professor Hingorani points out, "The status quo is not a justifiable option." With CVD still a major cause of death globally, taking a population-wide polypill approach could be a turning point for preventative medicine, potentially saving thousands of lives annually. The question now is whether the NHS will take up this call and establish a policy with the potential to transform the prevention of cardiovascular disease on a national level.

Eli Lilly’s weight-loss and diabetes injection, Mounjaro, has overtaken GSK’s antibiotic Augmentin (GSK.L) to become India’s highest-selling drug by value in October, as demand for weight-loss treatments continues to surge in the world’s most populated country. According to new data from research firm Pharmarack, the U.S.-based drugmaker’s popular injectable earned ₹1 billion ($11.38 million) in sales last month, compared to Augmentin’s ₹800 million.

While Augmentin still led in overall units sold—5.8 million doses versus 85,000 of Mounjaro—the latter’s premium pricing pushed it ahead in total value, as per Reuters. Analysts say India is rapidly emerging as a major market for obesity treatments, with the global weight-loss drug sector expected to cross $150 billion annually by the end of this decade.

Eli Lilly’s Mounjaro Becomes India’s Top-Selling Medicine in October

Launched in India in March 2025, Mounjaro which helps regulate blood sugar levels and reduces appetite—has seen its sales double within months, surpassing its rival Wegovy by Novo Nordisk, which entered the Indian market in June. Data from Pharmarack shows that Mounjaro has so far generated ₹3.33 billion in total revenue.

“Mounjaro’s consumption in India by volume was nearly ten times higher than Wegovy in October,” said Sheetal Sapale, Vice President (Commercial) at Pharmarack. Eli Lilly sold around 262,000 doses of Mounjaro last month, compared to 26,000 doses of Wegovy. Both drugs belong to the GLP-1 receptor agonist class, designed to treat obesity and type 2 diabetes.

How Does Mounjaro Work?

Mounjaro is a once-weekly injectable medication developed primarily for managing type 2 diabetes. Its key ingredient, tirzepatide, is the first of its kind to act on two gut hormones—GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide). This dual mechanism makes Mounjaro more advanced than older drugs such as Ozempic (semaglutide) or Victoza (liraglutide), which target only GLP-1, which is thus driving a surge in its sale in india.

Although it was originally approved for diabetes management, Mounjaro has attracted global attention for its strong weight-loss effects. Ongoing studies are evaluating its use for non-diabetic individuals struggling with obesity. The drug mimics the action of GIP and GLP-1, which are hormones released naturally after meals to regulate insulin release, lower blood sugar, and suppress appetite.

Mounjaro for Type 2 Diabetes

For people living with type 2 diabetes, keeping blood sugar in check often requires a combination of medicines, diet adjustments, and regular monitoring. Mounjaro offers a more integrated solution by targeting multiple factors that influence glucose levels. Findings from clinical trials, including the SURPASS-1 to SURPASS-5 studies, show that Mounjaro delivers better outcomes than many existing diabetes treatments, particularly in lowering HbA1c levels—a key marker of long-term glucose control.

Patients using Mounjaro have shown:

• Lower fasting and post-meal blood sugar levels
• Reductions in HbA1c by up to 2.5%
• Improved insulin sensitivity

Mounjaro and Weight Loss

Beyond its use for diabetes, Mounjaro has gained global popularity for its significant role in weight reduction. Clinical studies reveal that people taking the drug often lose between 15% and 20% of their body weight over several months of consistent use. This level of weight loss surpasses that seen with many earlier treatments and even some surgical interventions, making Mounjaro one of the most effective options currently available for managing obesity.

Disclaimer: This article is intended for general information and should not replace professional medical guidance. Always consult your doctor for advice or concerns regarding any health condition.

Following the sharp hike in the H-1B visa fee to $100,000, the Trump administration may soon begin rejecting visa applications from foreigners with certain health conditions, including diabetes and obesity.

While there has been no formal confirmation from U.S. authorities, a report by KFF Health News said a cable from the State Department to embassies and consulates listed new health-related grounds for visa denials.

Trump May Now Deny Entry to Diabetic and Obese Immigrants

According to the report, the guidance instructs visa officers to consider applicants ineligible for entry based on factors such as age and medical conditions, including cardiovascular and respiratory diseases, cancer, diabetes, metabolic and neurological disorders, and certain mental health conditions.

Officers have also been told to evaluate other issues such as obesity — which can contribute to high blood pressure, asthma, and sleep apnea, when assessing whether an applicant might become a “public charge,” or a potential financial burden on the U.S. government.

The guidance further directs officials to determine whether the applicant has sufficient financial resources to pay for their care. “Does the applicant have adequate financial resources to cover the costs of such care over his entire expected lifespan without seeking public cash assistance or long-term institutionalization at government expense?” the cable states.

It adds that individuals who could become a “public charge” — due to age or chronic health problems, may be denied entry for potentially relying on U.S. public resources.

Although the directive applies broadly to most visa categories, it is expected to primarily impact those applying for permanent residency, senior attorney Charles Wheeler told KFF Health News.

Can US Officers Reject Visas Over Health Or Financial Ability?

Visa officers have also been instructed to evaluate whether applicants can afford medical treatment independently, without relying on U.S. public funds.

Wheeler said the new rule gives officers the power to form their own opinions on what might lead to future medical emergencies or financial strain. “That’s concerning because these officers are not medically trained, have no expertise in this area, and should not be making projections based on personal judgment or bias,” Wheeler said.

US Visa Officers To Consider Health Of Applicants’ Family Members

The cable also instructs visa officers to assess the health of applicants’ family members — including children or elderly parents, when determining visa eligibility.

“Do any of the dependents have disabilities, chronic medical conditions, or other special needs and require care such that the applicant cannot maintain employment?” the State Department communication asks.

Currently, immigrant applicants must undergo a medical examination conducted by a doctor approved by the U.S. embassy. The screening includes tests for infectious diseases, an evaluation of mental health history, substance use, and proof of vaccination against illnesses such as measles, polio, and hepatitis B.

However, immigration lawyer Sophia Genovese from Georgetown University noted that the new guidance expands these requirements by directing officials to weigh long-term health conditions, not just communicable diseases, when reviewing visa applications.

While TrumpRx is making headlines for lowering the prices of popular weight loss drugs, something else has also grabbed attention of many. A video from the Oval Office from the Thursday Press Conference when President Donald Trump was announcing the deal with the drugmakers, a man had collapsed. Many claimed that the person who collapsed was Gordon Findlay, who is Novo Nordisk's executive. Dr Mehmet Oz, an American present and a physician was swift to check on the man who had collapsed. Independent journalist Eric Daugherty shared the video and wrote: "A man just passed out during President Trump's Oval Office announcement. Dr Oz Sprung into action and assisted him. Pray for him."

Also Read: TrumpRx: Will Trump’s New Website Make Prescription Drugs More Affordable?

Is The Man Gordon Findlay?

The reason why many have identified the man as Gordon Findlay because in the video, David Ricks, CEO of Eli Lily could be heard asking, "You okay? Gordon, you okay?" Upon this, the White House Press Secretary Karoline Leavitt said in the statement that "a representative with one of the companies fainted". However, no names were given.

Also Read: TrumpRx Lowered Prices Of Popular Weight Loss Drugs; What More Does Trump's New Medical Website Offer?

Novo Nordisk later clarified the claims, and in a statement to Newsweek, the company said, "Please be aware that CEO Mike Doustdar and EVP, US operations, Dave More were the only two Novo Nordisk representatives in the Oval Office."

Dr Oz had previously also helped out at the Oval office in April, when a child fainted while he was being sworn in. A woman, who many media outlets claimed, appeared to be Oz's daughter, Daphne, escorted the girl who had fainted. Later, the White House official confirmed to Fox News Digital that the girl was family member of Oz and had recovered.

What To Do When Someone Collapses?

If someone collapses in front of you, the first need is for someone to try simple CPR or cardiopulmonary resuscitation, while medical help is on its way. What must one keep in mind if someone collapses?

Check for any danger around the person, and give the shoulders of the person who collapsed a shake. Ask them if they can hear you, notes BBC.

If there is no response, tilt their head back to ensure that the airway is clear. This may be enough for the person to again start breathing.

If they are not breathing, this is when CPR becomes important.

Also Read: Trump Strikes Agreement To Cut Costs of Popular Weight Loss Drugs: All You Need to Know

How To Do CPR The Right Way?

As per NHS, UK, there are two correct ways to practice CPR on adults:

Hands-only CPR

This is to be carry out as a chest compression

• Start with kneeling next to the person and place the heel of your hand on the breastbone at the centre of their chest. Place the palm of your other hand on top of the hand that is on their chest and interlock your fingers.
• Position yourself so your shoulders are directly above your hands.
• Using your body weight (not just your arms), press straight down by 5 to 6cm (2 to 2.5 inches) on their chest.
• Keeping your hands on their chest, release the compression and allow their chest to return to its original position.
• Repeat these compressions at a rate of 100 to 120 times a minute until an ambulance arrives or for as long as you can.

CPR with rescue breaths

• Place the heel of your hand on the center of the person's chest, then place the palm of your other hand on top and press down by 5 to 6cm (2 to 2.5 inches) at a steady rate of 100 to 120 compressions a minute.
• After every 30 chest compressions, give 2 rescue breaths.
• Tilt the person's head gently and lift the chin up with 2 fingers. Pinch the person's nose. Seal your mouth over their mouth and blow steadily and firmly into their mouth for about 1 second. Check that their chest rises. Give 2 rescue breaths.
• Continue with cycles of 30 chest compressions and 2 rescue breaths until they begin to recover or emergency help arrives.