Ozempic Drug Now For Kidney Diseases

Updated Jan 30, 2025 | 08:52 AM IST

Weight-loss Drug Ozempic Can Benefit Patients With Kidney Diseases

SummaryIn the US, 1 in 7 adults are experiencing some type of chronic kidney disease caused by diabetes. The new approval therefore allows doctor to prescribe Ozempic to lower the risk of kidney failure, dialysis and death from heart-related problems too.

The US Food and Drug Administration (FDA) has approved Ozempic to help reduce the risk of serious kidney complications in people with type 2 diabetes and chronic kidney diseases. It is a popular drug which has been previously used to treating diabetes and obesity.

Why Is Ozempic Used For Kidney Diseases?

In the US, 1 in 7 adults are experiencing some type of chronic kidney disease caused by diabetes. The new approval therefore allows doctor to prescribe Ozempic to lower the risk of kidney failure, dialysis and death from heart-related problems too.

Doctors have already been using Ozempic to manage type 2 diabetes and reduce the risk of heart diseases in patients with diabetes. Studies have also shown that those who took Ozempic, had a 24$ lower risk of kidney-related complications and could avoid dialysis and or organ transplant. Patients also showed slower rates of kidney decline.

How Does Ozempic Help?

The active ingredient is semaglutide, which is a type of glucagon-like peptide 1 receptor against (GLP-1 RA), a drug that mimics a natural hormone which helps to regulate blood sugar. GLP-1 also protects the kidney by improving blood flow, reducing inflammation and preventing damage.

As per the study led by clinical pharmacologist Hiddo L Heerspink of the University Medical Center Geoningen, in the Netherlands, it was the first time when this diabetes drug was used to treat patients with kidney damage. The study was also published in the Nature Medicine journal and presented at the annual congress of the American Society of Nephrology.

Read all about Ozempic here.

The study was conducted in four countries, including Canada, Germany, Spain and the Netherlands and found that protein in urine that indicated kidney damage had reduced by 52% for those who received a shot of semaglutide. Kidney inflammation also decreased by 30%.

This is because the drug has direct effects on inflammation parameters in the kidney and lowers fat tissue around the kidneys.

What Is Ozempic Originally Used For?

Ozempic is originally used to treat Type 2 diabetes. This drug affects the intestinal hormone GLP-1 which is responsible for proper processing of carbohydrates from food. This stimulates insulin release in pancreas and also reduces the feeling of hunger. This also causes food to move slowly from stomach to intestines. It also gives a feeling of fullness for longer, leading to weight loss.

They are also used for various other health issues, including boosting your health. As per a study based on data from the US veterans with type 2 diabetes, these drugs have shown lower rates of heart attacks, strokes and heart failure. It has also in fact shown a significant decrease in conditions like schizophrenia, suicidal thoughts, and seizures. The study further found a 12% reduction in Alzheimer's disease, especially in participants taking the drugs for 3.5 years. The drug also reduced bacterial infections, liver cancer and chronic kidney diseases, along with fever and muscle pain.

Not Ozempic, but Eli Lilly's weight-loss drug Zepabound has been previously approved by the FDA as a treatment for moderate-to-severe sleep apnea and obesity.

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Growing miscommunication around measles

Credits: Canva

Updated Apr 26, 2025 | 07:00 AM IST

Why Is There A Growing Misinformation On Measles?

SummaryThe US is hit by the worst measles outbreak in 10 years, however, still many are not aware what to do. Why is this happening? Has there been spread of misinformation about the disease? Read on to know.

As the United States experiences the worst measles outbreak in over a decade with nearly 900 reported cases across 29 states, including deaths of two children, public understanding of the disease and its prevention strategy have been highly misunderstood due to political divide. The outbreak began in West Texas and has now spread widely. This highlights not only the persistent threat of measles but also the growing influence of vaccine misinformation, which have been fueled by political figures.

Why Is There A Resurgence of Preventable Diseases?

Measles, a highly contagious viral disease, had been largely controlled in the U.S. thanks to the widespread use of the measles, mumps, and rubella (MMR) vaccine. However, gaps in vaccination coverage have led to a resurgence. The current outbreak, centered in Texas but extending to almost 30 states, has alarmed public health officials. Two young girls who were otherwise healthy have died as a result of measles complications.

The disease is known for its rapid transmission. A single case can lead to significant spread if vaccination rates in a community fall below the 95% threshold needed for herd immunity. Children are particularly vulnerable; although the first dose of the MMR vaccine is typically administered at 12 months, increased parental concern has led some to seek earlier vaccination during the outbreak.

The Politics Of Vaccine

As per a new survey by KKF, a nonprofit health information group, only one-third of Republican-leaning parents were aware of the current measles outbreak. This was in comparison with the two-thirds of aware Democratic parents. The survey also found and 1 in 5 Republicans believes that measles vaccine is more dangerous than the diseases itself, this is double the rate of Democrats.

These gaps in perception are not new but are deepening. About 35% of Republicans surveyed believe the discredited theory that the MMR vaccine is linked to autism—a belief held by just 10% of Democrats. While belief in this theory has not increased significantly, public awareness of the claim has grown, reflecting the impact of persistent misinformation.

Adding to the confusion is Health and Human Services Secretary Robert F. Kennedy Jr., who has long been associated with anti-vaccine rhetoric. Since taking office, he has supported an investigation into environmental contributors to autism and has floated unproven theories, such as vitamin A being a preventative measure against measles. These statements, while not outright opposing vaccines, muddy public understanding and can discourage immunization.

At a time when clear public health messaging is critical, conflicting remarks from top officials are exacerbating distrust. Advocacy organizations like Immunize.org and The Immunization Partnership warn that such mixed messaging, especially when it originates from high-ranking leaders, undermines public confidence in vaccines.

In southern states like Texas, Louisiana, Arkansas, and Oklahoma, anti-vaccine activism has gained traction within state legislatures. Studies show that even lawmakers with medical backgrounds have not always supported public health measures, often influenced by political considerations and public pressure. Testimony from vaccine opponents at legislative hearings further amplifies misinformation, making it more difficult for facts to gain traction.

Meanwhile, healthcare providers are seeing the consequences firsthand. In California, where a 2014–15 outbreak began at Disneyland, pediatricians have treated severely ill children and taken stricter stances on accepting unvaccinated patients. These outbreaks serve as a stark reminder that the threat of measles is real and recurring.

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IBS Awareness Month: Could Gravity Be Wrecking Your Digestive Health?

Credits: Canva

Updated Apr 26, 2025 | 03:00 AM IST

IBS Awareness Month: Could Gravity Be Wrecking Your Digestive Health?

SummaryIBS affects nearly 10% of the global population, yet we still don’t fully understand its cause but a new research has suggested that gravity could be a surprising trigger.

Every year in April, IBS Awareness Month puts the spotlight on one of the world's most misunderstood and elusive gastrointestinal disorders—Irritable Bowel Syndrome (IBS). Affecting about 10% of the world's population, IBS has puzzled physicians and researchers for years. Though its chronic and interruptive symptoms—abdominal pain and bloating on one end, constipation and diarrhea on the other—there remains no agreement on what actually triggers it. A new, daring theory is disrupting conventional wisdom by posing an unusual question- Is gravity the hidden culprit behind IBS?

Dr. Brennan Spiegel, a Cedars-Sinai Medical Center physician and researcher in Los Angeles, is leading the way to a new perspective on IBS—one that looks at the constant pull of gravity on our bodies. In the American Journal of Gastroenterology, Spiegel's theory is that IBS could be the body's failure to successfully deal with gravity.

It's an interesting concept. "We spend our whole life in gravity, are formed by it, but barely appreciate its constant effect on our body," Spiegel explained in an interview. "Each strand of our body is touched by gravity every day, from the top of our head to our gastrointestinal tract."

From a scientific perspective, this hypothesis borrows from evolutionary biology and neurophysiology. The human body over millennia has evolved complex systems—musculoskeletal, gastrointestinal, neurological—to deal with the downward pull of gravity. When these systems fail, Spiegel argues, they can initiate not only gastrointestinal symptoms but also a cascade of other complaints—muscle pain, fatigue, changed mood, and more.

What is the Gut-Brain Axis and the Roller Coaster Effect?

At its core is the connection between the gut and the brain—a widely documented characteristic of IBS. Individuals with IBS tend to experience a knotted stomach upon stress or a sensation of "butterflies" in stressful situations. Such gut feeling, as Spiegel speculates, may be attributed to the nervous system's adaptation to threats from gravity, such as the free-falling experience on a roller coaster.

"Our nervous system has mechanisms for perceiving and reacting to changes in gravity," he added. "When it flakes out or overcompensates, it may show up as IBS symptoms." This is related to another fascinating twist: the difference between individuals' reactions to gravitational stress. There are those who love roller coasters; others get nauseated or frantic—implying a continuum of what Spiegel refers to as G-force vigilance.

This might explain why IBS tends to overlap with disorders such as anxiety, depression, fibromyalgia, and chronic fatigue syndrome—all of which could potentially have an underlying sensitivity to gravitational stress.

Link Between IBS and Gravity

Spiegel's theory also explores deeper into anatomy. The abdominal cavity houses heavy organs that need to be "suspended" effectively. Genetic predispositions—lax connective tissues, a weak diaphragm, or spinal misalignments in some—may lead to sagging or movement of organs, including the intestines. The downward movement could affect motility, lead to cramping, and result in bacterial overgrowth—all prevalent in IBS.

In addition, the hypothesis delves into serotonin's role. This mood-regulating neurotransmitter also facilitates balance, blood circulation, and the movement of intestinal contents. "Dysregulated serotonin," Spiegel explains, "could actually be a type of gravity failure," which may connect depression, IBS, and even dizziness in a common physiological cycle.

What It Means for Treatment and Prevention

If confirmed, the gravity hypothesis has the potential to transform how we conceptualize—and treat—IBS. "The beauty of it is that it's testable," said Dr. Shelly Lu, director of the Division of Digestive and Liver Diseases at Cedars-Sinai. Unlike so many vague IBS theories, this one invites us to the possibility of targeted interventions.

This hypothesis can also assist us in better comprehending the reason why exercise, posture correction, core strengthening, and physical therapy work for most IBS sufferers. By fortifying the structural support system of the body, these strategies might decrease gravity's effect on the gut.

Symptoms, Triggers, and the IBS Daily Struggle

IBS is an individualized disease. Symptoms range widely and may include:

  • Abdominal bloating, pain, and cramping related to bowel movements
  • Alterations in stool appearance or frequency
  • A feeling of not fully emptying the bowels, gas, and mucus in stool

Its triggers are also multifactorial. Stress and some foods—dairy, citrus, beans, wheat, and carbonated beverages—may exacerbate symptoms. Although food intolerances are not the cause in every case, many individuals find significant symptom relief through diet, such as a low FODMAP diet.

IBS isn't only an intestinal affliction—it can also blow a person's life off track. Chronic patients usually suffer from complications such as hemorrhoids due to constant diarrhea or constipation, and generally decreased quality of life. Research indicates that individuals with moderate to severe IBS experience three times more work absences compared to others. The psychological price is high too—aún and depression often accompany one another in IBS, one worsening the other.

Could this be the long-lost piece to a hundred-year-old puzzle? Maybe. Although further research is necessary to establish the gravity connection, the theory is already creating new avenues for comprehension and healing.

If you have ongoing digestive problems, see a healthcare provider. IBS is a treatable condition, and treatment options can involve medication, counseling, physical therapy, or dietary changes depending on your individual symptoms.

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A 10% Drop In Vaccination Rates Could Lead To Millions Of Measles Cases In US Over 25 Years

Updated Apr 25, 2025 | 08:45 PM IST

10% Drop In Vaccination Rates Could Lead To Millions Of Measles Cases In US Over 25 Years

SummaryVaccination has significantly reduced the spread of deadly diseases. Measles, once causing millions of cases annually, has been almost wiped out in the U.S. due to widespread immunization programs.

US childhood vaccination rates have taken a disturbing decline, exacerbated by the disruption caused by the COVID-19 pandemic. It is not simply a statistic—but a warning sign of future health threats. The effects are already being seen, with measles rebounding and potentially the return of other diseases once brought under control, such as rubella and polio. A recent Stanford Medicine study, published in the Journal of the American Medical Association, paints a dire picture: a 10% decline in vaccination rates could result in millions of measles cases over the next 25 years.

The rising danger of preventable illness, and the reason why vaccination is key to protecting public health. From the emergence of vaccine hesitancy to the surging spread of measles.

The drop in childhood vaccinations in the U.S. has been a rising concern among health professionals. Although the disruptions brought about by the COVID-19 pandemic were a major factor, the trend of declining immunization rates is not new. For years, growing vaccine hesitancy, driven by misinformation, political controversy, and skepticism about health systems, has fueled a change in public perception, particularly among parents. Consequently, fewer kids are getting the necessary vaccines and diseases that previously were under control are now being a threat again.

The research done by a group of researchers from Stanford, together with other universities' experts, shows the risk of measles becoming endemic again in the U.S. It might occur in as little as two decades if the vaccination rate is sustained at current levels. Nevertheless, a 10 percent decline in the rate of vaccinations could make things even worse, and millions of individuals could become susceptible to infection, hospitalizations, and death.

Measles is the most infectious disease on Earth, with the potential to spread quickly through populations. Prior to the introduction of the measles vaccine in 1963, the illness was rampant throughout the U.S., affecting millions of individuals annually. Indeed, before the vaccine, an estimated 3 million to 4 million individuals were infected with the disease every year, with 400 to 500 deaths, 48,000 hospitalizations, and 1,000 instances of brain swelling (encephalitis).

As per the CDC, measles remains a lethal disease, primarily for children. It spreads via respiratory droplets when an infected person coughs or sneezes and symptoms may range from fever, cough, runny nose, and a characteristic red, blotchy rash. As the disease is vaccine-preventable with the MMR (measles, mumps, rubella) vaccine, unvaccinated individuals are at the greatest risk of being infected and infecting others.

The recent study by Stanford researchers utilized large-scale epidemiological modeling to simulate how infectious diseases like measles would spread across the United States based on different levels of childhood vaccination coverage. The results are concerning. Even at current vaccination rates, the study suggests that measles could re-emerge as an endemic disease in the U.S. within the next two decades. A mere 10 percentage point reduction in vaccination coverage would accelerate this process significantly, potentially resulting in millions of measles cases in the next 25 years.

Dr. Nathan Lo, a Stanford physician and the study's senior author, underscored the seriousness of the situation. "Our nation is at a tipping point for measles to become a routine household disease again," he said. "The declining routine childhood vaccinations, coupled with increasing vaccine hesitancy, may send us to a place we were working to avoid for decades."

Vaccine Hesitancy and Its Contribution to the Measles Outbreak

The problem of vaccine hesitancy has been a major contributor to the fall in immunization rates. The disinformation regarding the safety and effectiveness of vaccines has instilled fear and confusion, particularly among parents. A KFF survey published in 2025 found that more than half of adults were unsure about whether to believe assertions about the risks of the measles vaccine—assertions that have been magnified by anti-vaccine personalities, such as Robert F. Kennedy Jr.

This widespread misinformation has caused many to doubt the necessity of vaccines for diseases no longer perceived as a threat, like measles. But as recent outbreaks have shown, measles is hardly eradicated and still poses a lethal threat, especially to vulnerable groups like infants, immunocompromised individuals, and the unvaccinated.

Recent measles outbreaks in the U.S. are stark reminders of the risks of low vaccination levels. In 2025 alone, the nation has already seen some 800 cases of measles, the most in a single year since 2019. The largest outbreak took place in West Texas, which had over 620 cases, 64 hospitalizations, and two deaths. These outbreaks are a wake-up call that the U.S. is not immune to outbreaks of this extremely contagious disease.

According to Mathew Kiang, a study co-author, "The impact of waning vaccinations won't be sudden, but the aggregate effect could be devastating. If we do not take action now, we can expect millions of measles cases in the coming years."

What Can Be Done to Prevent a Measles Crisis?

Although the situation is grim, there is hope. Specialists such as Dr. Lo and Kiang propose that even slight increases in vaccination rates could make a significant difference in preventing the spread of measles and other preventable illnesses. A 5 percent boost in vaccination coverage could avert a sharp spike in cases, safeguard vulnerable populations, and ultimately save lives.

Health professionals remind parents to discuss with pediatricians the value of vaccinations and have faith in healthcare professionals' recommendations. Public health officials and policymakers also need to act to address vaccine misinformation and make sure vaccination mandates for school entry are intact.

This study's findings highlight the crucial role that vaccination plays in protecting public health. By potentially preventing millions of cases and countless fatalities, high vaccination coverage needs to be sustained. With the U.S. still struggling to deal with the consequences of declining vaccine coverage, it is vital that both the public and policymakers take proactive measures to ensure that such diseases as measles do not experience a resurgence.

The decision to vaccinate is such a simple choice, but the difference it makes can be gargantuan. It is incumbent on all of us—parents, medical practitioners, and members of society—to take our turn in safeguarding the next generation against the ruining effects of vaccine-preventable diseases. As Dr. Lo highlighted, "Increasing vaccination levels by just 5% can make a world of difference in keeping these diseases at bay."

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