SummaryMpox, formerly known as monkeypox, is a viral infection caused by the monkeypox virus, part of the Orthopoxvirus family. The World Health Organization (WHO) classifies the virus into two major clades, Clade I (which includes Ia and Ib) and Clade II (IIa and IIb), with the 2022–2023 global outbreak traced mainly to Clade IIb.