With a global estimate of 20 million cases in 2022, cancer is the leading cause of death worldwide. Cancer diagnoses can turn people’s lives upside down, as the diagnosis is followed up by treatments such as chemotherapy, immunotherapy, or even surgeries. The best way to deal with cancer is catching it early, however the chances of catching it early are very low. Many people only visit their doctors when they see concerning symptoms, but that could also mean that the cancer has progressed much further, reducing the chances of survival.

A new small pilot study suggests that a type of blood test could potentially find signs of cancer up to three years before it would typically be diagnosed. These tests, called multicancer early detection (MCED) tests, look for tiny bits of genetic material that tumors release into the bloodstream.

How the MCED Test Works

This special MCED test works by looking for what's called "tumor DNA" in your blood. Tumors, which are growths of cancer cells, shed little pieces of their genetic material into your bloodstream. The test is designed to pick up on these tiny clues. In the study, it actually found this cancer DNA in some people's blood up to three and a half years before they were officially diagnosed with cancer.

Researchers from Johns Hopkins, said that finding cancer this early could lead to much better results for patients. It's like getting a head start on fighting the disease. They also mentioned that we'd need to figure out the best way to follow up with someone if this test came back positive so early.

Early Findings from the Pilot Study

For this initial study, the researchers looked at blood samples that were already collected for a big heart disease study. They used the MCED test on two groups: 26 people who were diagnosed with cancer within six months of giving their blood, and 26 similar people who didn't get cancer.

The results were quite telling: eight of the 52 blood samples came back positive on the MCED test. And sure enough, all eight of those people were diagnosed with cancer within just four months of their blood sample being taken. The types of cancers found included colon, pancreatic, rectal, lung, breast, and liver cancer. Sadly, five of these eight patients later passed away from their cancers. This shows how serious these diseases are, even when found relatively early.

Uncovering Cancer Even Earlier

To push the boundaries even further, the researchers looked at older blood samples from six of those eight patients. These samples were taken a remarkable three to three and a half years before their cancer diagnosis.

They found tumor DNA in four of those much older samples! This strongly suggests that these cancers could have been spotted years earlier, which could have given doctors a significant head start on treatment. Researchers explained that this study really shows how promising MCED tests are for finding cancers very early. They believe it sets a new standard for how sensitive these tests need to be to truly be successful.

More Research and Enhanced Sensitivity

While these findings are very exciting, it's important to remember this was a small pilot study. We need much bigger studies to confirm these results. However, the initial findings strongly suggest that this type of blood test could be a game-changer, helping us catch cancers when they are much smaller and easier to treat, increasing the chances of survival.

The researchers also pointed out that their main goal was to show how early cancer DNA can be detected in the blood, not just to prove a new test works. They also noted that to find cancers three or more years before a diagnosis, these blood tests will need to be 50 times more sensitive than the ones currently used to detect cancers within six months.

A GP has shared an urgent alert about a clearly visible cancer symptom that many women may be brushing aside. The doctor stressed that this particular sign needs to be checked without delay. Ahead of Cervical Cancer Prevention Week, beginning January 19, as per Mirror, Dr Rupa Parmar outlined key warning signs of the disease and cautioned that one in three women are skipping their routine cervical screening appointments.

She also highlighted that some of the most common symptoms are often dismissed. One such sign is weight loss, which many women may wrongly link to cutting back after festive overindulgence or returning to a normal routine in January.

Women Urged Not To Ignore This Obvious Cancer Symptom

Dr Parmar, a GP and Medical Director at Midland Health, explained: “Cancer cells interfere with the body’s ability to properly absorb fats, proteins and carbohydrates from food. As a result, calories are burned more quickly, leading to weight loss. Unexplained weight loss is often the most obvious sign of cancer and should always be checked straight away.” She added that sudden weight loss is not exclusive to cervical cancer and is recognised as a general warning sign across several types of cancer.

Cancer Research UK also notes that weight loss is common among people with cancer and can be one of the first reasons someone seeks medical advice. The charity points out that lung cancer and cancers of the upper digestive system are among those most often linked to weight loss.

Dr Parmar also highlighted other possible signs of cervical cancer.

Pain During Sex

Pain during intercourse can be caused by issues such as vaginal dryness, infections or skin conditions, Dr Parmar said. However, if pain is new and wasn’t present before, it could be linked to cervical cancer, as a growing tumour may begin to affect nearby tissues.

Recurrent UTIs

Experiencing three or more urinary tract infections within a year could indicate an underlying problem, including cervical cancer. Dr Parmar clarified that UTIs do not cause cancer, but repeated infections may occur if a tumour has advanced and is pressing on or blocking the urinary tract.

Pelvic Pain

Ongoing and severe pain in the lower back or pelvic area with no clear explanation can be another warning sign, particularly when combined with other symptoms. As cervical cancer advances, this pain may intensify and can worsen during sex, urination or bowel movements.

Vaginal Bleeding

Bleeding that is unusual for you should never be ignored. This includes bleeding during or after sex, spotting between periods, bleeding after menopause, heavier-than-normal periods, or cycles that last longer than usual. These changes can signal that something may be wrong.

Discharge

Changes in vaginal discharge can also point to problems with the cervix. An increase in discharge, an unusual smell, changes in colour, or the presence of blood may occur once cancer has begun to affect nearby tissues.

If you notice any of these symptoms, it’s important to speak to a doctor as soon as possible.

Dietary supplements are already part of many people’s daily habits, especially at the start of the year when health goals are front of mind. What many may not realise is that there is one supplement the Government says everyone should be taking through the colder months. Health guidance recommends a small daily dose of vitamin D for everyone in the UK from around October to late March, as sunlight levels are too low for the body to produce enough on its own. Vitamin D supplements are easy to find and come in several forms, including tablets, capsules, gummies and liquid drops. Here is a simple breakdown of what vitamin D is and why it matters.

What Is Vitamin D?

Vitamin D is an essential nutrient that helps control calcium and phosphate levels in the body. These minerals work together to support healthy bones, teeth and muscles.

When vitamin D levels are too low, children can develop rickets, a condition that causes bones to become soft and weak. In adults, deficiency may lead to osteomalacia, which can result in bone pain, muscle weakness and a higher risk of fractures.

What Does The Government Recommend?

UK health advice states that everyone should take a daily supplement containing 10 micrograms, or 400 international units, of vitamin D during autumn and winter.

This amount is considered sufficient to maintain general wellbeing, particularly bone and muscle health, at a time of year when sunlight alone is not enough for vitamin D production.

Official guidance explains: “This advice is particularly important for people who have little exposure to sunlight during spring and summer, including those living in residential or nursing care homes, people in prisons, and individuals who regularly wear clothing that covers most of their skin when outdoors.

“These groups are at greater risk of vitamin D deficiency. People with darker skin tones, such as those from African, African-Caribbean or South Asian backgrounds, may also struggle to get enough vitamin D from sunlight alone.

“All of these groups are advised to take a vitamin D supplement throughout the year, in line with standard government dietary guidance.”

A scheme that once allowed eligible people to apply for free vitamin D supplements was available previously, but this programme ended in 2021.

Where Can You Get Vitamin D?

Between late March or early April and the end of September, most people can produce enough vitamin D naturally through sun exposure. The body creates vitamin D when UV-B rays from sunlight reach the skin.

Vitamin D is also present in certain foods, including oily fish, red meat, egg yolks, and fortified products such as some spreads and breakfast cereals.

Supplements can be bought easily from pharmacies and supermarkets, with some costing as little as 2p per day. Vitamin D3 is generally the preferred form.

Can You Get Too Much Vitamin D?

Yes. While sunlight does not cause vitamin D overdose, taking excessive supplements over a long period can lead to a build-up of calcium in the body. This can weaken bones and cause damage to the kidneys and heart.

For most people, a daily intake of 10 micrograms is sufficient. NHS advice states that adults should not take more than 100 micrograms, or 4,000IU, per day, as higher amounts may be harmful.

If a doctor has advised a different dosage based on your individual health needs, it is important to follow their guidance.

Concerns around fertility and vaccines often surface when people plan a family, and the HPV vaccine is no exception. Many women and men worry that getting vaccinated today could affect their ability to conceive later in life. Medical experts, however, say this fear is misplaced. According to fertility specialists, there is no evidence linking the HPV vaccine to reduced fertility. In fact, the vaccine may play a quiet but important role in protecting reproductive health over the long term.

Does The HPV Vaccine Affect Fertility?

The short and clear answer is no. The HPV vaccine does not negatively affect fertility in women or men. Dr. Madhu Patil, Consultant and Fertility Specialist at Motherhood Fertility and IVF, Sarjapur, Bangalore, explains that there is no scientific proof showing the vaccine causes fertility problems of any kind.

She notes that concerns often arise from misinformation rather than medical data. Extensive research and global vaccination programmes have consistently shown that people who receive the HPV vaccine do not experience reduced chances of conceiving in the future.

How HPV Infection Can Threaten Future Fertility

While the vaccine itself does not harm fertility, an untreated HPV infection can. HPV is the leading cause of nearly all cervical cancer cases. As per Dr Patil, “treatment for cervical cancer often involves procedures such as cone biopsy or LEEP, which can weaken the cervix. In more advanced cases, radiation or chemotherapy may be required.”

These treatments can reduce a woman’s ability to conceive and, in some cases, make it difficult to carry a pregnancy to full term. By preventing HPV-related cancers in the first place, the vaccine helps preserve the reproductive system and lowers the risk of fertility-compromising treatments later in life.

Why The HPV Vaccine Supports Reproductive Health

Dr. Patil points out that the HPV vaccine should be viewed as a protective measure rather than a risk. By stopping high-risk HPV strains from causing cancer or precancerous changes, the vaccine helps maintain cervical health. A healthy cervix and reproductive system are key factors in natural conception and safe pregnancies.

In this way, the vaccine indirectly supports fertility by reducing the likelihood of medical interventions that could interfere with reproductive function.

When Should the HPV Vaccine Be Taken?

Health experts recommend starting HPV vaccination at ages 11 or 12. At this stage, the immune response is strongest, and the vaccine offers protection well before any potential exposure to the virus. Dr. Patil strongly encourages parents to consult a gynaecologist and consider timely vaccination for their children.

That said, adults who missed vaccination earlier can still benefit. Many women and men receive the vaccine later in life after discussing it with their doctor.

Why Men Should Also Get The HPV Vaccine

The HPV vaccine is not only for women. Dr. Patil stresses that men should also be vaccinated, as HPV can cause cancers and genital warts that affect sexual health. Vaccination in men also reduces transmission to partners, adding another layer of protection for couples planning a family.

By limiting the spread of HPV, vaccination helps safeguard the reproductive and sexual health of both partners.

There is no evidence that the HPV vaccine reduces fertility. On the contrary, it helps prevent cancers and medical treatments that can threaten the ability to conceive or carry a pregnancy. Experts advise speaking with a gynaecologist, understanding the benefits, and making an informed decision based on medical facts rather than fear.