When blockbuster diabetes drugs double as miracle weight-loss injections, it seems like everyone wants in. But now, the same medications are making headlines for possible vision loss.

The Double Life of GLP-1 Drugs

Originally designed to regulate blood sugar in type 2 diabetes, GLP-1 receptor agonists, which cover Ozempic, Mounjaro, Wegovy, Trulicity, Rybelsus and others, quickly became famous in the weight-loss world. Social media crowned them the “skinny jab”, while pharmaceutical companies rushed out new versions to keep up with demand.

But as prescriptions soared, so did reports of odd side effects. Stomach paralysis (gastroparesis), intestinal blockages and now a rare vision condition are creeping into the conversation. It turns out shedding pounds might come with strings attached, ones that affect more than your waistline.

A Shadow on the Horizon: NAION

The latest condition in this story is nonarteritic anterior ischaemic optic neuropathy, or NAION for short. It is a mouthful, but the condition itself is no joke. NAION can blur vision permanently or even lead to blindness by damaging the optic nerve.

Whispers of this link first appeared in mid-2024, when Harvard researchers published a study claiming Ozempic users faced a seven-fold higher risk of NAION compared to non-users. Just weeks later, another paper in JAMA Ophthalmology suggested the concern was not limited to Ozempic; it was likely an issue across the entire GLP-1 family.

What the Experts Are Saying

Researchers point out that while there is a measurable increase in eye complications, the story isn’t as clear-cut as it sounds.

A recent retrospective study found a slight but significant uptick, about 7 per cent, in new cases of diabetic retinopathy (DR) among GLP-1 users. DR is a common complication of diabetes itself, where blood vessels in the retina become damaged. Interestingly, though, these same patients did not show a higher risk of progressing to severe complications like proliferative retinopathy or diabetic macular oedema.

Reports suggest that patients on GLP-1 drugs should be screened regularly for eye problems, no matter their baseline status. In other words, keep your ophthalmologist on speed dial.

From Courtrooms to Clinics

While doctors debate the data, lawyers are already busy. Eli Lilly, maker of Mounjaro and Zepbound, has asked federal judges to consolidate the growing pile of lawsuits into one massive multidistrict litigation (MDL). This would lump together claims of optic nerve damage with the thousands of cases already filed over gastroparesis.

The lawsuits accuse manufacturers of pushing profits over patient safety, alleging that the risks of vision loss were downplayed or overlooked. With more patients joining the legal fray, the story is no longer confined to medical journals; it is unfolding in courtrooms across the US.

The Balancing Act for Patients

For people with type 2 diabetes, GLP-1 drugs remain highly effective. They lower blood sugar, help with weight loss, and even offer some protection against heart disease. For many, the benefits still outweigh the risks.

But the newfound spotlight on NAION is a reminder that no drug is without trade-offs. Those weekly injections may slim waistlines, but they also highlight the need for vigilance. Patients should discuss eye health with their doctors, schedule regular check-ups, and report any sudden changes in vision immediately.

When most people think of COVID today, they imagine a mild illness, like a cold, a few days of fever, a sore throat, or a cough, before recovery. But for many, the story does not end there. Long COVID, which the World Health Organization defines as symptoms lasting at least three months after infection, has become a lasting reality of the pandemic.

Most studies have focused on describing symptoms such as fatigue, brain fog, and shortness of breath. However, a recent study has shown that long COVID, especially in women, can trigger a chronic condition known as Postural Orthostatic Tachycardia Syndrome (POTS).

What Is Long Covid?

Long COVID affects roughly 6% of people who had COVID, with over 200 symptoms recorded. For some, it lasts just a few months, while for “long haulers,” it can continue for years. Measuring the scale of the problem is difficult because symptoms differ widely from person to person. This has sparked debates over what long COVID truly is, what causes it, and even whether it is real.

However, as per Johns Hopkins Medicine, common symptoms include fatigue, brain fog, shortness of breath, headaches, and changes in smell or taste, and multiple organ systems can be affected.

New Study Says Long Covid Can Trigger This One Chronic Illness

A study from Sweden found that young women with symptomatic long COVID were at a higher risk of developing POTS, adding an extra burden, according to research from the University of Nebraska Medical Center. Among a cohort of predominantly younger women with highly symptomatic post-COVID-19 sequelae (PCS), also called long COVID, there was a notable incidence of POTS. The research noted significantly lower physical activity and capacity in long COVID patients with POTS compared to those without it.

The study examined 467 non-hospitalized, highly symptomatic long COVID patients, 91% of whom were healthy, physically active women before their COVID infection. About 12 months after their initial COVID illness, patients underwent cardiologist evaluations including a 48-hour electrocardiogram, head-up tilt test, and Active Stand Test for those suspected of having POTS.

What Is Postural Orthostatic Tachycardia Syndrome (POTS)?

POTS is a disorder of the autonomic nervous system in which the heart rate rises excessively when standing. This can lead to symptoms like lightheadedness, fatigue, and fainting. In POTS, blood vessels don’t constrict as they should, causing blood to pool in the lower body and reducing blood flow to the brain. The nervous system compensates by releasing hormones that sharply increase heart rate, producing various symptoms, according to Johns Hopkins Medicine.

COVID-19 and POTS: Is There A Link?

POTS can be triggered by various factors, including viral or bacterial infections. Researchers believe the coronavirus that causes COVID-19 may act as a trigger, as more people recovering from COVID are showing POTS-like symptoms such as brain fog, rapid heartbeat (tachycardia), and severe chronic fatigue. The overlap in symptoms has prompted doctors to start testing patients for POTS.

Johns Hopkins explains that the autonomic nervous system controls functions we don’t consciously think about, like heart rate, blood pressure, sweating, and body temperature. Problems in these areas can cause symptoms that overlap with other conditions. Patients may have their POTS symptoms dismissed as lingering COVID effects or even psychological issues. Accurate diagnosis is critical, as POTS can be debilitating and requires targeted treatment.

How Can Volume Expansion Therapy Help With POTS?

The main goal of initial POTS treatment is to improve blood flow back to the heart, a strategy known as volume expansion therapy. This can include medication-based and non-medication approaches. Physical therapy also plays a key role in increasing blood volume over time. However, it often takes months before patients are able to respond enough to participate fully in physical therapy.

If you are experiencing COVID-like POTS symptoms, consult your healthcare professional for evaluation and guidance.

Diwali season is here, which brings with it the joy of celebrations, endless sweets, and festive food, all of which make this time of year so special. But to enjoy it fully without health worries, it is important to keep a check on your wellbeing with a few basic tests.

As the festivities begin, it is natural to get carried away with indulgent meals, late nights, and social gatherings. However, a few simple blood tests before Diwali can help you stay active, balanced, and ready to celebrate without any setbacks.

Why You Should Get Tested Before Diwali

Surrounded by all the happiness and excitement, many people tend to overlook their health during the festive season. This often leads to avoidable health issues that can interrupt the joy of celebrations and take away from the festive mood.

These problems usually stem from a few common habits that creep in during festivals, overeating, irregular sleep schedules, eating too many fried or sugary foods, skipping workouts, or changing usual meal times. They can also worsen any chronic health condition you already have.

You might now be wondering what these health problems are and whether they should be taken seriously. Mostly, they begin with stomach-related troubles that interfere with digestion, causing discomforts like acidity, gas, tiredness, constipation, diarrhoea, or irregular bowel movements. We got in touch with Dr Ranjeet Singh, Professor and HOD General Medicine- NIIMS Medical College And Hospital.

Do These Health Tests Before Diwali For A Festive Free Season

HbA1c and Blood Sugar Test

People living with diabetes should check their sugar levels before the festive season. An HbA1c test shows your average blood sugar over the last three months and helps your doctor adjust your diet or medicines accordingly. Even if you don’t have diabetes, a simple fasting or random blood sugar test can help you track early signs of imbalance, especially if you plan to indulge in sweets and rich foods.

Blood Pressure Check

Irregular blood pressure is common during festivals due to stress, erratic sleep, and heavy food intake. Both high and low BP can cause headaches, dizziness, or even heart complications. Checking your blood pressure and basic heart health markers before Diwali ensures you celebrate safely without fatigue or uneasiness.

Liver Function Test (LFT)

Festive feasts are often loaded with fried, oily, and sugary items that can strain your liver. The Liver Function Test helps assess how well your liver is processing toxins and nutrients. If you already have liver concerns or a history of fatty liver, this test becomes even more essential before you begin your festive indulgence.

Kidney Function Test (KFT)

The Kidney Function Test checks how efficiently your kidneys are filtering waste and maintaining fluid balance. Overeating, dehydration, or excess salt and sweets can put pressure on your kidneys. Getting this test done before the festivities helps detect any early signs of kidney stress or damage.

Thyroid Function Test

Thyroid hormones control your metabolism, mood, and energy levels but when they get imbalanced, they can lead to fatigue, mood swings, or sudden weight changes, issues that tend to worsen during the festive rush. A Thyroid Function Test ensures your hormone levels are stable, helping you feel active and positive throughout the season.

Lipid Profile (Cholesterol Test)

During Diwali, fried snacks and sweets can cause a spike in cholesterol levels. A Lipid Profile Test helps measure good and bad cholesterol and triglycerides in your blood. If you get your Lipid profile done before Diwali, it can make you make better decisions when you are gorging on all the diwali sweets and make smarter food choices through the festive week.

To enjoy Diwali while reducing the risk of health problems, it’s a good idea to get these essential tests done in advance. Keeping your health in check will help you make the most of the celebrations without worry.

You can also encourage your family and friends to do the same. Remind them to take simple preventive steps and schedule their checkups so that everyone can enjoy a safe Diwali.

It was 1846, when a young man lay on an operating table as doctors were ready to perform a surgery to remove a tumor from his neck. Then came a strange-smelling vapor. It was mix of ether and oil, and it filled the room. The man lying on the operation table did not flinch or cry out, there was no pain. When he woke up, it was as if nothing had happened.

This was the day that marked the dawn of general anesthesia. It was on this day today in 1846, that surgical anesthetic WTG Morton conducted the first successful demonstration of ether. Thus, this day is observed as the World Anesthesia Day.

Nearly two centuries later, scientists are still trying to figure out what actually happens to the brain when we under go anesthesia?

The Mind Under Anesthesia

Anesthesia doesn’t simply make a person “fall asleep.” It creates a state where the brain disconnects from conscious awareness while vital body functions remain stable.

When the drug enters your bloodstream, it alters how the nerve cells in the brain communicate. Usually, a billion of neurons send and receive signals rapidly, and forms networks responsible for thinking, feeling, and awareness. However, when anesthesia enters the body, these signals slow down or stop and it disrupts the communication between key regions, such as the cortex, which is responsible for handling thought and sensory perception, and the thalamus, which is responsible for processing information from the body.

Furthermore, the brainwave pattern, which usually looks fast and varied on an EEG, shift into slower and larger waves. The mind actually "tunes out" losing its ability to form memories, sense time, or even to process pain.

While anesthesia is designed to create total unconsciousness, it’s a delicate balance. Too little, and traces of awareness can slip through, a phenomenon known as accidental awareness, where patients recall sounds, sensations, or pressure during surgery. It’s rare but can be distressing.

However, too much can make the brain enter a state of extreme suppression. In such cases, EEG readings show almost flat patterns, indicating that neurons have gone quiet. This can also raise the risk of confusion or cognitive issues after surgery, especially among older adults.

In most people, the fog clears within hours, but some experience short-term problems with memory or focus, known as post-operative cognitive dysfunction. In older patients, this sometimes extends into delirium — temporary disorientation or hallucinations caused by lingering changes in brain activity.

How Does The Mind Wake Up?

You do not immediately wake up, but the mind reboots in layers. High-order functions like reasoning and self-awareness are the first to recover, then attention, coordination, and reaction time.

Studies show that as the anesthetic wears off, brain activity gradually reconnects across different regions. Certain rhythms that dominate during unconsciousness fade, replaced by faster, more complex patterns as the brain resumes its normal communication. It’s as though the mind is reassembling itself, piece by piece.

Anesthesia does not just turn the brain off, but reshapes consciousness, suspending awareness, while also preserving life.