Health and Me

Itisha Arya

Can Diabetes Increase Your Risk Of Dementia? Doctors Explain The Link

diabetes and dementia

Due to rising obesity levels, sedentary lifestyles, and a rapidly aging population, type 2 <span><a href="https://www.healthandme.com/health/diabetes">diabetes</a></span> has become far more common than it was a few decades ago. While high-income countries saw a decline in diabetes-related deaths between 2000 and 2010, this trend reversed from 2010 to 2016. As a result, there has been an overall 5 percent rise in premature deaths linked to diabetes since 2000. 

What is especially concerning is that type 2 diabetes is now increasingly diagnosed in children, largely driven by poor diet, excess weight, and lack of physical activity. Beyond its well-known effects on the heart, kidneys, eyes, and nerves, diabetes is also associated with long-term conditions affecting the brain, including <span><a href="https://www.healthandme.com/health/dementia">dementia</a></span>. 

This raises an important question: how exactly are <span>diabetes and dementia</span> connected? To understand this better, we spoke to Dr Prabhojit Mohanty, Psychiatrist, Sexologist, and De-addiction Specialist, who shared insights on the link.

Diabetes is a long-term metabolic disorder in which blood sugar levels remain consistently high. This happens either because the pancreas does not produce enough insulin or because the body is unable to use insulin properly. Insulin plays a crucial role in helping glucose enter cells to be used as energy. When this process is disrupted, sugar builds up in the bloodstream, gradually causing damage to vital organs such as the heart, eyes, kidneys, and nerves. 

The two main forms are Type 1 diabetes, an autoimmune condition that requires lifelong insulin therapy, and Type 2 diabetes, which is linked to insulin resistance and influenced by lifestyle and genetic factors, according to the Cleveland Clinic.

Dementia refers to a group of symptoms marked by a significant decline in cognitive abilities that interferes with everyday functioning. It affects memory, thinking, reasoning, and decision-making. Dementia is not a single disease but an umbrella term for conditions caused by different underlying disorders, the most common being Alzheimer’s disease. 

As dementia progresses, symptoms become more severe, affecting mood, behavior, and the ability to carry out routine activities, often leading to increased dependence on others. Early diagnosis can help slow progression and improve quality of life, as noted by the Alzheimer’s Association.

<h2>Diabetes And Dementia: What Is The Link?</h2>

An expanding body of research points to a clear association between diabetes and dementia. Large-scale studies and meta-analyses indicate that individuals with diabetes face nearly a 59 percent higher risk of developing dementia compared to those without the condition. This increased risk applies to both Alzheimer’s disease and vascular dementia and tends to rise the longer a person lives with diabetes. From a clinical perspective, several mechanisms are involved. Persistently high blood sugar levels and insulin resistance cause damage to both small and large blood vessels. Over time, this harms the brain’s microvasculature, reducing blood supply and raising the likelihood of strokes and vascular dementia.

Dr Prabhojit Mohanty explained, “When diabetes occurs alongside hypertension, the danger becomes even greater. Both conditions speed up damage to blood vessels in the brain. High blood pressure weakens vessel walls and contributes to plaque formation, which further limits blood flow to the brain. From a biological standpoint, insulin has roles beyond regulating sugar. When the brain becomes resistant to insulin, it affects neuron health, communication between brain cells, and how the brain uses glucose, increasing vulnerability to neurodegenerative conditions such as Alzheimer’s disease.”

Scientists have also introduced the idea of “type 3 diabetes” to describe Alzheimer’s disease as a condition driven by insulin resistance within the brain itself. According to this theory, impaired insulin signalling in neural tissue plays a role in the buildup of amyloid plaques and tau tangles, which are defining features of Alzheimer’s disease. People with diabetes often also struggle with high blood pressure and abnormal cholesterol levels. Together, these factors further raise the risk of dementia and significantly affect the quality of life of both patients and their caregivers. Detecting diabetes early, maintaining good control of blood sugar and blood pressure, and adopting healthier lifestyle habits can go a long way in protecting cognitive function with age.

In simple terms, there is strong clinical and biological evidence showing a clear and well-established connection between diabetes and dementia.

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Due to rising obesity levels, sedentary lifestyles, and a rapidly aging population, type 2 diabetes has become far more common than it was a few decades ago. While high-income countries saw a decline in diabetes-related deaths between 2000 and 2010, this trend reversed from 2010 to 2016. As a result, there has been an overall 5 percent rise in premature deaths linked to diabetes since 2000. What is especially concerning is that type 2 diabetes is now increasingly diagnosed in children, largely driven by poor diet, excess weight, and lack of physical activity. Beyond its well-known effects on the heart, kidneys, eyes, and nerves, diabetes is also associated with long-term conditions affecting the brain, including dementia. This raises an important question: how exactly are diabetes and dementia connected? To understand this better, we spoke to Dr Prabhojit Mohanty, Psychiatrist, Sexologist, and De-addiction Specialist, who shared insights on the link.What Is Diabetes?Diabetes is a long-term metabolic disorder in which blood sugar levels remain consistently high. This happens either because the pancreas does not produce enough insulin or because the body is unable to use insulin properly. Insulin plays a crucial role in helping glucose enter cells to be used as energy. When this process is disrupted, sugar builds up in the bloodstream, gradually causing damage to vital organs such as the heart, eyes, kidneys, and nerves. The two main forms are Type 1 diabetes, an autoimmune condition that requires lifelong insulin therapy, and Type 2 diabetes, which is linked to insulin resistance and influenced by lifestyle and genetic factors, according to the Cleveland Clinic.What Is Dementia?Dementia refers to a group of symptoms marked by a significant decline in cognitive abilities that interferes with everyday functioning. It affects memory, thinking, reasoning, and decision-making. Dementia is not a single disease but an umbrella term for conditions caused by different underlying disorders, the most common being Alzheimer’s disease. As dementia progresses, symptoms become more severe, affecting mood, behavior, and the ability to carry out routine activities, often leading to increased dependence on others. Early diagnosis can help slow progression and improve quality of life, as noted by the Alzheimer’s Association.Diabetes And Dementia: What Is The Link?An expanding body of research points to a clear association between diabetes and dementia. Large-scale studies and meta-analyses indicate that individuals with diabetes face nearly a 59 percent higher risk of developing dementia compared to those without the condition. This increased risk applies to both Alzheimer’s disease and vascular dementia and tends to rise the longer a person lives with diabetes. From a clinical perspective, several mechanisms are involved. Persistently high blood sugar levels and insulin resistance cause damage to both small and large blood vessels. Over time, this harms the brain’s microvasculature, reducing blood supply and raising the likelihood of strokes and vascular dementia.Dr Prabhojit Mohanty explained, “When diabetes occurs alongside hypertension, the danger becomes even greater. Both conditions speed up damage to blood vessels in the brain. High blood pressure weakens vessel walls and contributes to plaque formation, which further limits blood flow to the brain. From a biological standpoint, insulin has roles beyond regulating sugar. When the brain becomes resistant to insulin, it affects neuron health, communication between brain cells, and how the brain uses glucose, increasing vulnerability to neurodegenerative conditions such as Alzheimer’s disease.”Scientists have also introduced the idea of “type 3 diabetes” to describe Alzheimer’s disease as a condition driven by insulin resistance within the brain itself. According to this theory, impaired insulin signalling in neural tissue plays a role in the buildup of amyloid plaques and tau tangles, which are defining features of Alzheimer’s disease. People with diabetes often also struggle with high blood pressure and abnormal cholesterol levels. Together, these factors further raise the risk of dementia and significantly affect the quality of life of both patients and their caregivers. Detecting diabetes early, maintaining good control of blood sugar and blood pressure, and adopting healthier lifestyle habits can go a long way in protecting cognitive function with age.In simple terms, there is strong clinical and biological evidence showing a clear and well-established connection between diabetes and dementia.