With 28 percent of adults in the UK now classified as obese and another 36 percent considered overweight, it is unsurprising that weight-loss injections have surged in popularity. Estimates suggest around 1.5 million people are currently using these jabs each month.While the injections can lead to significant weight loss, experts warn that they come with notable risks and often fail to address the root causes of weight gain. Mike Wakeman, a researcher, pharmacist, and founder of Evera Nutrition, explained how these medications work and why they may fall short in the long term.“These medicines mainly act by increasing two gut hormones, GLP-1 and GIP. These hormones reduce appetite, increase feelings of fullness, and slow stomach emptying,” he said. “The problem is that many people rely on medication alone.”Why Weight-Loss Jabs May Not Solve the ProblemWakeman pointed out that several underlying contributors to weight gain are frequently overlooked. “Stress, poor sleep, alcohol misuse, binge eating, and even certain medications or hormonal and medical conditions, such as an underactive thyroid, are often ignored when discussing weight issues,” he said. “If these factors are not addressed, they will still be present at the end of treatment and are likely to trigger weight regain.”Recent research supports this concern. Studies have found that participants regained almost all of the weight they lost within a year of stopping weight-loss injections.Weight Loss Jabs Side Effects and Long-Term RisksSide effects linked to weight-loss jabs are common and include nausea, vomiting, constipation, and acid reflux. More serious health issues have also been reported in some individuals. These include pancreatitis, gallbladder problems, and depression. Rapid weight loss can result in muscle loss, while hair thinning and vision problems have also been associated with the use of these injections.Natural Ingredients That Work Like Weight Loss Jabs Without Side EffectsAccording to specialists, growing scientific evidence suggests that certain natural ingredients may help support healthy weight loss when combined with proper diet and lifestyle changes, without the same side-effect profile seen with injections.“The good news is that some natural ingredients can mimic the effects of GLP-1,” Mike said. “These include glucomannan, which is a type of fibre, along with resveratrol, hibiscus, green tea, berberine, curcumin, cinnamon, and mulberry.”Ingredients That Act Like ‘Natural Weight-Loss Jabs’Explaining the science behind these ingredients, Wakeman broke down how each one may support weight management.“Glucomannan is a natural fibre derived from the konjac root. It expands in the gut, helping you feel full, and may also increase GLP-1 levels,” he said, as per Mirror. “Resveratrol, found in foods such as grapes, has been shown to significantly reduce body weight, waist circumference, and BMI.”“Hibiscus has been shown to reduce obesity, abdominal fat, and blood lipid levels,” he added. “Catechins like EGCG, found in green tea, have been linked to meaningful reductions in body weight, BMI, and waist circumference, particularly at higher doses and over longer periods, when combined with a healthy diet and exercise. They also help boost metabolism and fat burning.”“Berberine is a plant compound that, according to a meta-analysis of 12 studies, reduces body weight, BMI, and waist circumference,” he said. “Curcumin, the active compound in turmeric, has also shown strong evidence. An umbrella meta-analysis covering 14 systematic reviews and 39 randomised controlled trials found that curcumin supplementation reduces body weight, BMI, and waist size, while also improving blood sugar and blood fat levels.”“Cinnamon may help reduce weight by improving blood sugar control,” Wakeman continued. “A meta-analysis of 12 trials involving 734 people found that cinnamon intake lowered body weight, BMI, and waist circumference. Mulberry has also shown anti-obesity effects, including activating brown fat.”How Some Ingredients May Boost GLP-1 FurtherWakeman also noted that certain ingredients may work by slowing the breakdown of GLP-1 and GIP. “Some compounds may help inhibit Dipeptidyl Peptidase-4, or DPP-4,” he said. “DPP-4 is an enzyme that breaks down GLP-1 and GIP. When this enzyme is blocked, these hormones remain active for longer.”Ingredients that may play a role in DPP-4 inhibition include curcumin, resveratrol, cinnamon, maritime pine bark extract, blackcurrant, mulberry, quercetin, and rosemary.