Heart disease remains the leading cause of death worldwide, claiming millions of lives each year. Among its most devastating manifestations is cardiac arrest—a sudden, unexpected stoppage of heart function that, if not treated immediately, is almost always fatal. Recent research has illuminated a crucial, often overlooked fact: the warning signs of cardiac arrest can differ between men and women. Recognizing these differences is not just a matter of academic interest; it can mean the difference between life and death.

Cardiac arrest is often sudden, silent, and deadly — claiming more lives globally than most people realize. But a growing body of research shows that its early warning signs may not be the same for everyone. Specifically, men and women often experience different symptoms before cardiac arrest occurs — and recognizing these differences may mean the difference between life and death.

Sometimes called sudden cardiac arrest, occurs when the heart abruptly stops beating. This cessation halts blood flow to the brain and other vital organs, causing a person to lose consciousness within seconds. Without rapid intervention, such as cardiopulmonary resuscitation (CPR) or use of an automated external defibrillator (AED), death can occur within minutes.

Unlike a heart attack—which is caused by a blockage in the arteries supplying the heart—cardiac arrest is primarily an electrical problem. The heart’s rhythm becomes dangerously abnormal, most commonly due to ventricular fibrillation, causing it to quiver instead of pumping blood effectively.

A recent study published in The Lancet Digital Health has revealed groundbreaking findings that could reshape how we understand and respond to cardiac arrest. Researchers have now confirmed that while chest pain is the most prominent pre-symptom in men, women often experience shortness of breath in the hours leading up to a cardiac arrest episode. The data comes from community-based studies including the PRESTO study in California and the SUDS study in Oregon, which collectively examined how sex-specific symptoms could be harnessed to improve early detection and survival.

According to the study, half of all individuals who experience sudden cardiac arrest have a warning symptom within 24 hours prior to the event. However, these symptoms are not uniform across genders. For women, shortness of breath emerged as the most prominent warning sign, while men most commonly reported chest pain. Other symptoms, such as palpitations, flu-like sensations, and even seizures, were also noted in a smaller subset of patients.

Shortness of Breath vs Chest Pain

In the recent study, researchers found that over 50% of individuals who suffered cardiac arrest had at least one warning symptom within 24 hours. Men most commonly reported chest pain, while women more frequently experienced shortness of breath. A smaller percentage of both groups experienced palpitations, flu-like symptoms, or seizures.

“This is the first community-based study to evaluate sex-specific warning symptoms using real-time emergency medical service (EMS) documentation,” said Eduardo Marbán, Executive Director at the Smidt Heart Institute.

Dr. Sumeet Chugh, the study’s lead investigator, emphasized the impact: “Harnessing these symptoms could guide who needs immediate emergency response. That insight could change survival rates.”

What Exactly Is Cardiac Arrest?

Cardiac arrest, sometimes confused with a heart attack, occurs when the heart stops beating abruptly due to an electrical malfunction. This sudden stoppage halts blood flow to the brain and other vital organs, often causing loss of consciousness within seconds. If not treated immediately — typically through CPR or defibrillation — death can occur within minutes.

It’s different from a heart attack, which is caused by a blockage in the coronary arteries. However, heart attacks can trigger cardiac arrest by disrupting the heart’s electrical system.

Cardiac Arrest vs. Heart Attack

The terms “heart attack” and “cardiac arrest” are often used interchangeably, but they refer to distinct medical emergencies. A heart attack is caused by a blockage that prevents blood from reaching a part of the heart muscle, leading to tissue damage. Cardiac arrest, on the other hand, is an electrical malfunction that causes the heart to stop beating altogether.

While a heart attack can increase the risk of cardiac arrest—by disrupting the heart’s electrical system—not all cardiac arrests are preceded by a heart attack. Other causes include arrhythmias, enlarged heart (cardiomyopathy), severe blood loss, valvular heart disease, and electrolyte imbalances.

Why Younger People Are at Increasing Risk?

The rise in sudden cardiac deaths among young adults is particularly concerning. While some cases are linked to undiagnosed heart conditions such as hypertrophic cardiomyopathy or ventricular arrhythmias, others may be triggered by intense exercise, drug use, or even severe viral infections. These factors can cause the heart to beat irregularly or stop altogether, often without warning. Several factors are contributing to the alarming rise in heart disease and sudden cardiac arrests among young adults:

Genetics and lifestyle: While you can’t change your genes, factors like smoking, poor diet, lack of exercise, and unmanaged stress play significant roles in heart health.

Steroid abuse: Especially among gym-goers and bodybuilders, the use of steroids and growth hormones can damage heart muscles and disrupt rhythms.

Undiagnosed conditions: Conditions like hypertrophic cardiomyopathy or dilated cardiomyopathy (often linked to viral infections like COVID-19) may go unnoticed until it's too late.

Post-COVID heart risks: Myocarditis and lung fibrosis can lower oxygen supply and impair heart function, increasing cardiac vulnerability.

Severe stress: Though rare, emotional trauma can induce cardiac events, especially in those with pre-existing conditions.

Recognizing the Symptoms Before It’s Too Late

For women, these symptoms may present more subtly — and are more likely to be mistaken for stress or anxiety. That’s why public health messaging must evolve to include gender-specific information. While some cardiac arrests strike without any warning, many cases are preceded by symptoms that are often misread or dismissed:

• Chest pain or tightness
• Shortness of breath
• Palpitations or irregular heartbeat
• Fainting or dizziness
• Extreme fatigue
• Nausea or stomach pain
• Sudden sweating or lightheadedness

What You Can Do Today to Prevent Cardiac Arrest?

Preventing cardiac arrest begins with understanding your risk factors and taking proactive steps to protect your heart health. Experts recommend the following:

Routine screening: Start annual checks for blood pressure, cholesterol, and blood sugar levels after age 18.

Know your numbers: Aim for total cholesterol <200 mg/dL, LDL <100 mg/dL, fasting glucose <100 mg/dL, and blood pressure <130/80 mmHg.

Get vaccinated and treated for viral infections: Viruses like COVID-19 can lead to myocarditis and long-term heart damage.

Stop smoking and avoid exposure to secondhand smoke.

Maintain physical activity but with caution. People over 40 or with a family history should consult a doctor before starting high-intensity workouts.

As cardiac events among young people rise and symptoms continue to vary across genders, researchers believe integrating biometric data, wearable tech, and AI-powered health tools can offer early detection solutions in the near future.

GLP-1 medications, including the popular brand Ozempic, have made headlines for their dramatic weight loss results. Initially created to treat type 2 diabetes, the medications were a favorite among those wanting to lose weight due to their ability to control hunger. Semaglutide, the active drug found in Ozempic, makes consumers full for extended periods, resulting in significant weight loss in the body. However, with increasing popularity comes an uptick in reports of unusual side effects—some of which are leaving women shocked and bewildered.

Among the most surprising and strange side effects making the rounds among users is what has been colloquially referred to as "Ozempic vulva." The condition involves a reduction of fat in the labia majora, a sagging appearance, pain during routine activities, and alteration of sexual anatomy aesthetics. Although sagging skin and loss of elasticity have long been linked to weight loss, particularly if it occurs rapidly, this particular side effect has only recently emerged.

A Reddit poster posted a first-hand account of experiencing the results for herself. Losing 44 pounds, she at first was jubilant about the outcome. "I've been extremely fortunate and I don't have any sagging skin in my belly or arms/legs that I can notice," she described. But the biggest shock was when she went for a gynecologist appointment. "Turns out I've lost all my fat pads in my vulva! She informed me my vulva is droopy and I will keep on having pain when cycling/sitting unless I undergo surgery or wear fillers," the user posted.

The Redditor also revealed that pelvic floor physical therapy was provided as a substitute for cosmetic intervention, although it would not fully reverse the deflation. Her case highlights the need to be aware of how sudden weight loss, especially from medications such as GLP-1s, can impact lesser-known parts of the body.

Medically, the vulva comprises external female genitalia, mostly the labia minora and labia majora, that act as cushioning protection. Fat loss in this region may cause a greater prominence of the pelvic bones, decrease in cushioning, and pain during exercises like cycling, running, or sitting for extended periods.

What is 'Ozempic Vulva'?

The vulva is the external female genitalia, especially the labia majora covering the inner structures. Redditors and users of internet forums have described decreased fat pads in this region after precipitous weight loss caused by GLP-1 medication. One Redditor summed up her experience thus: after losing 20 kg (44 pounds), she developed pain when she cycled or sat for long hours. A gynecologist described losing much of the natural padding around her vulva, leading to a sagging sensation and discomfort during exercise.

This trend, affectionately but aptly called "Ozempop vulva," highlights a singular and seldom-talked-about side effect of weight loss caused by medications. For most women, it's not just aesthetic; it impacts daily comfort, sex, and self-esteem.

Cosmetic treatments have evolved as a result of this trend. "Labia puffing" is an increasingly sought-after procedure for women who experience vulvar deflation. This treatment either involves the use of dermal fillers or fat transfer to add volume to the labia majora, evening out the texture and alleviating discomfort. Though effective, it is quite expensive, between $2,600 and $6,500 in America.

Healthcare professionals are urging caution. Novo Nordisk, the drug maker of Ozempic, reassured the public that patient safety is of utmost priority and assured that the medicines are to be used only for approved use in a medical setting. They also urge reporting side effects to healthcare professionals or regulatory bodies. "Treatment decisions should be made together with a healthcare provider who can evaluate the appropriateness of using a GLP-1 based on assessment of a patient's individual medical profile," said the company.

The larger context of extreme weight loss makes visible the far-reaching consequences GLP-1 drugs can have. Patients experience a range of side effects, from gastrointestinal distress to loose skin, facial fat redistribution, and effects on sexual anatomy and desire. While the physical changes are something to be admired, these effects are a reminder that extreme weight loss is not risk-free.

Incidentally, online discussions of "Ozempic vulva" have become widespread in private online forums and social media sites. Users freely exchange experiences, coping mechanisms, and aesthetic issues. Many recommend practical measures like padded bike shorts or briefer periods of exercise to alleviate discomfort. Others discuss surgical or nonsurgical treatments, although opinions are highly diverse on whether such a procedure would be desirable or required.

Medical professionals emphasize the need for integrated treatment. Sudden loss of weight must be watched over by medical professionals who can advise on likely risks to both general health and particular aspects such as the vulva. Preservation of muscle tone, padding, and elasticity of skin is essential to avoid long-term complications. For women suffering from discomfort, focused physical therapy, proper protective equipment during exercise, and well-informed consideration of cosmetic interventions may all be part of a successful management plan.

Finally, "Ozempic vulva" highlights an increasing trend on the intersection of weight-loss medication and women's health. While the drug has transformed weight control for millions of people, its unintended side effects serve as a reminder that there are risks associated with every medical intervention and that they need to be closely monitored. Education, research, and transparency with healthcare professionals are critical towards preventing such unintended outcomes.

As GLP-1 drugs become more mainstream, patients and providers alike need to be watchful. New side effects such as "Ozempic vulva" demonstrate the importance of full education on the entire range of possible changes wrought by sudden weight loss. Meanwhile, women dealing with these effects are complying with both medical advice and home remedies, being resilient in the face of an odd but increasingly prevalent health issue.

Anxiety in your twenties is practically a rite of passage. Between job hunts, rent hikes, and figuring out how to cook good food, it is no wonder many young adults feel on edge. But according to a recent study published in Psychological Medicine, your worry levels might not just be about deadlines and landlords; they may also be written in your genes.

The Big Twin Reveal

The research comes from the Twins Early Development Study (TEDS), which has been tracking thousands of twins born in England and Wales since the mid-1990s. For this analysis, scientists zoomed in on over 6,400 twin pairs aged 23 to 26. By comparing identical twins (who share all their DNA) with fraternal twins (who share only half), researchers teased apart how much of persistent anxiety is genetic and how much comes from life’s curveballs.

About 60 per cent of the stability in anxiety across those years can be explained by genetics. That means if your anxiety keeps tagging along like a clingy flatmate, there is a good chance your DNA is to blame. But before you start cursing your ancestors, remember: genes set the stage, but your environment decides which play gets performed.

Anxiety’s Double Act

• Somatic distress—the jittery, tense, cannot-sit-still kind of anxiety.
• Worry-avoidance—the mental wheel of endless “what ifs” plus ducking situations that trigger them.

Even though these types look different, they share many of the same genetic roots. Interestingly, life experiences seemed to have more influence on whether someone leans toward restless fidgeting or relentless worrying.

Heritability Does Not Mean Destiny

A heritability estimate of 60 per cent does not mean you are doomed to be 60 per cent anxious. Instead, it means that across a population, 60 per cent of the differences in anxiety can be chalked up to genetic differences. The rest is life, including jobs, relationships, pandemics, or even just too much caffeine.

Speaking of pandemics, the study captured data during COVID-19, when average anxiety levels spiked. The researchers even spotted new genetic effects surfacing during the first wave, suggesting global stressors can pull fresh strings on our biological vulnerabilities. Apparently, your DNA and world events like to team up for surprise collabs.

Why This Matters

Rates of anxiety among young adults have shot up in recent years, making it a pressing public health concern. Yet most past research has focused on kids and teens, leaving the twenty-something years—arguably some of the most chaotic of all—less understood. This study fills in that gap by showing that while anxiety symptoms fluctuate in the short term, there’s a genetically shaped core that stays put.

That has big implications. For one, studies that only measure anxiety at a single point may underestimate the role of genetics, missing the stable undercurrent that persists over time. It also highlights why treatments should consider both the “nature” and “nurture” sides of the equation: biological predispositions and real-world stressors both matter.

In a nutshell, genetics play a role, but they are not the whole story. You might have been dealt some anxious genes, but lifestyle choices, coping strategies, and supportive environments can still change the plot.

Flu season has meant rolling up your sleeve for a shot at the doctor’s office or pharmacy. Now, that’s changing. AstraZeneca has launched FluMist Home, the first FDA-approved flu vaccine that can be delivered to your doorstep and self-administered—no needles required.

This new option, a nasal spray version of the vaccine, builds on FluMist’s two-decade track record. First approved by the Food and Drug Administration (FDA) in 2003, FluMist has long been available at clinics and pharmacies. But in September 2024, the FDA gave the green light for at-home self-administration. Less than a year later, the program is rolling out across 34 states in time for the 2025–2026 flu season.

The stakes couldn’t be higher, last flu season was one of the most severe in recent memory. The CDC estimates up to 82 million illnesses, 1.3 million hospitalizations, and 130,000 deaths from flu between October 2024 and May 2025. Yet vaccination rates remained low, with fewer than half of Americans getting their annual shot.

Experts say that convenience is a major barrier. Between busy schedules, limited access to clinics, and vaccine hesitancy, too many people skip protection. FluMist Home could remove at least one of those hurdles by making the process as simple as ordering online.

“People are increasingly comfortable with managing their health at home—whether through Covid-19 tests or self-injections for chronic conditions,” explains AstraZeneca. “This option takes advantage of that shift and expands access to flu vaccination.”

Do's and Don'ts Of Using Flu Nasal Spray

FluMist Home is FDA-approved for people ages 2 through 49. Adults can use it themselves, while children as young as 2 can receive it with help from a parent or caregiver.

However, it’s not for everyone. Because FluMist is a live, weakened-virus vaccine, pregnant women and people with weakened immune systems should consult their doctors before considering it. Those outside the approved age range must still rely on traditional flu shots.

How FluMist Works?

The ordering process mirrors a telehealth experience. Patients complete a brief medical questionnaire online, which is reviewed by a licensed healthcare provider before the prescription is approved. Insurance covers the cost for most users, with a flat $8.99 shipping and handling fee.

When FluMist arrives, it’s shipped in insulated, temperature-controlled packaging with ice packs to preserve stability. Each vial contains two pre-measured doses one for each nostril—separated by a clip. To administer, simply breathe normally while spraying; there’s no need to inhale deeply. A slight tickle, sneeze, or drip afterward is normal.

Patients can download a vaccination record from the online portal, and—if permission is given—the record is automatically shared with their doctor and uploaded to state vaccine registries.

Effectiveness and Safety

AstraZeneca emphasizes that FluMist Home uses the same formulation and vial as the version given in clinics. Its efficacy is on par with injectable flu vaccines, but the delivery method is needle-free.

The most common side effects are mild: runny nose, nasal congestion, and sore throat in adults. Children may experience low-grade fever. These symptoms generally resolve quickly.

Importantly, the FDA required AstraZeneca to conduct a usability study before approval. Results showed that 100% of participants were able to correctly self-administer the full dose without healthcare supervision.

How This Helps Tackle The Vaccination Gaps?

Needle-free, self-administered vaccines aren’t just about convenience—they may be critical in improving uptake. FluMist Home joins a growing trend of decentralizing preventive healthcare, putting tools directly into patients’ hands.

Historically, nasal spray flu vaccines were popular among children and adults who disliked shots. Now, offering a home option could further broaden access. As public health experts warn about the dangers of simultaneous flu, RSV, and Covid-19 waves, innovations like FluMist Home might play a pivotal role in reducing strain on hospitals.

The CDC notes that every additional percentage point increase in vaccination coverage can save thousands of lives during peak flu seasons. By lowering logistical barriers, FluMist Home could help close that gap.

Nasal Spray vs Shot: What Works Better?

The differences between FluMist and injectable vaccines come down to technology. Traditional flu shots use either killed viruses or specific proteins to teach the immune system how to respond. FluMist, by contrast, uses a live but weakened influenza virus. Both methods are proven to work, but some patients respond better to one than the other.

For people who avoid shots due to fear or discomfort, FluMist offers a gentler alternative. For children, especially, a quick nasal spray can mean less stress and higher compliance.

Could Nasal Sprays Be the Future of Vaccination?

The rollout of FluMist Home may be a harbinger of bigger changes. The pandemic normalized home-based care and accelerated acceptance of mail-order biologics, self-testing kits, and virtual consultations. Vaccines, once the exclusive domain of clinics, could follow suit.

Some researchers are already working on shelf-stable, oral, or patch-based vaccines that could one day make prevention even more accessible. For now, FluMist Home represents a significant step forward in modernizing how people protect themselves during flu season.

Useful Tips for Patients

Storage: Keep FluMist refrigerated (35°F to 46°F) until use.

Timing: Administer early in flu season for maximum protection.

Recordkeeping: Save your vaccination confirmation for medical records and travel purposes.

Disposal: Packaging materials are largely recyclable; chill packs can be reused.

FluMist Home gives people a practical, needle-free, at-home option to stay protected against the flu. While it’s not suitable for everyone, its convenience could boost vaccination rates at a time when respiratory viruses remain a major public health threat.