In a medical first, surgeons in China have successfully transplanted a gene-edited pig liver into a living human to temporarily support his failing liver. The procedure showed that a pig liver can function inside the human body for several weeks and act as a “bridge” for patients who have no other treatment options.

The patient was a 71-year-old man with severe hepatitis B–related liver cirrhosis and a large liver cancer tumor. His condition made traditional surgery or a human liver transplant impossible. With no donor organs available and his health rapidly worsening, doctors decided to try the experimental pig liver transplant under compassionate use.

How the Pig Liver Was Engineered

The donor organ came from a specially bred Diannan miniature pig. Scientists had made 10 specific genetic changes to the animal so its liver would be more compatible with the human body.

These changes included:

• Removing pig genes that usually trigger strong immune rejection
• Adding seven human genes to help the liver work smoothly with human blood, immunity and clotting systems

Once the liver was connected to the patient’s blood supply, it began working immediately. It produced bile, supported metabolism, made important proteins like albumin and helped with blood clotting. Early tests showed stable liver and kidney function, and there were no signs of sudden or severe rejection, which is usually the biggest challenge in pig-to-human organ transplants.

A Serious Complication Emerges

But the case also revealed a major challenge for future xenotransplants. After about a month, the patient developed a condition called xenotransplantation-associated thrombotic microangiopathy (xTMA).

This complication caused:

• Breakdown of red blood cells
• A drop in platelets
• Activation of the complement system (part of the immune response)
• Small blood clots forming in blood vessels

Doctors tried multiple treatments, including blood thinners, a complement-blocking drug (eculizumab) and plasma exchange. However, the condition continued to worsen.

On day 38, the medical team decided to remove the pig liver to protect the patient. Fortunately, during this period, the patient’s remaining left portion of his own liver had grown and was able to take over enough liver function. After the pig liver was removed, the signs of xTMA gradually resolved.

The patient later developed complications unrelated to the xenotransplant — mainly repeated bleeding in his digestive tract due to his pre-existing liver condition — and he died on postoperative day 171.

What This Means for the Future

Researchers conclude that this groundbreaking case proves pig-to-human liver transplantation is technically possible and can meaningfully support patients for weeks. This offers hope for people with acute liver failure or advanced liver cancer who have no donor organs available.

However, major barriers remain. The biggest challenges highlighted include:

• xTMA
• Blood clotting incompatibilities
• Overactivation of the immune system
• The need for better gene-editing strategies

Scientists say more work is needed before such transplants can become routine. But this case sets an important foundation for future clinical trials and brings the medical world a step closer to using animal organs to save human lives.

When we think about cancer risk, it’s natural to wonder, “is it genetic?”

The truth is, sometimes it is, but in many cases, cancer develops from a mix of lifestyle, environmental factors, and DNA changes that occur over a lifetime. Understanding the difference between inherited genetic risks and those acquired along the way can help people make smarter decisions about screening, prevention, and treatment, and empower families to take proactive steps for their health.

Inherited genes or life choices?

Cancer arises from a series of changes/mutations in cells that disrupt normal growth control. Many of these changes happen over a person’s lifetime, influenced by exposures (like tobacco, UV rays, infections), aging, and random DNA errors. These are called “somatic mutations” and occur in our tissues—they are not inherited, and are not passed to children.

By contrast, a smaller fraction of cancers are influenced by inherited mutations called “germline mutations”; these are changes in the DNA that you are born with, and are present in every cell of your body. These mutations can predispose someone to cancer by impairing DNA repair, controlling cell division, or through other mechanisms. Approximately 5–10% of all cancers are thought to have a strong hereditary component.

So, while your DNA can influence your cancer risk, most cancers don’t occur because of an inherited gene defect. And even when a germline mutation is present, environment, lifestyle, and chance usually play significant roles in whether cancer actually develops.

Recognizing hereditary cancer syndromes

When should we suspect hereditary cancers? Here are red flags:

A strong family history of cancer, especially the same type (e.g. multiple members with breast cancer, or several relatives with colon cancer).

• Early-onset cancer, e.g. diagnosis before the age of 50 or 40 years.
• Multiple primary cancers in the same person (e.g., ovarian + breast).

Rare cancers or specific tumor types tied to known syndromes (e.g. medullary thyroid cancer, male breast cancer, pancreatic cancer in some families).

Known syndrome features, such as colon polyps and colon cancer in Lynch syndrome.

In such cases, genetic testing can identify mutations in genes like BRCA1/2, Lynch syndrome genes (MLH1, MSH2, MSH6, PMS2, EPCAM), TP53, PALB2, and others. Identifying carriers has implications for targeted screening (e.g. colonoscopic surveillance or mammography at regular intervals), preventive surgery like mastectomy, and sometimes therapy in case cancer does develop.

How do hereditary mutations lead to cancer?

Imagine your cells are factories, following a strict set of instructions (your DNA). Inherited mutations can mean that a “safety check” is broken from the start. For example:

A mutation in the BRCA1 or BRCA2 genes weakens the cell’s ability to repair DNA. Over time, unrepaired damage accumulates, raising the risk of developing breast, ovarian, prostate, and pancreatic cancer.

Mutations in DNA mismatch repair genes (as in Lynch syndrome) allow errors during DNA copying to persist, boosting mutation load and increasing the risk of developing colon, endometrium, stomach, and other cancers.

But even when a high-risk mutation is present, cancer doesn’t appear overnight. Additional “hits”, or more mutations, microenvironment changes, hormonal exposures, or lifestyle factors need to typically accumulate before cells turn cancerous.

Why does hereditary information matter?

You might ask: if it’s a small percentage of cancers, does knowing about hereditary risk make a difference?

The answer is, yes, absolutely. Knowing your hereditary risk of cancer has some important benefits:

Prevention & early detection: If you carry a pathogenic mutation, you can undergo more frequent surveillance, chemoprevention (e.g. tamoxifen for breast cancer), or risk-reducing surgeries (e.g. prophylactic mastectomy or oophorectomy).

Therapeutic choices: Certain inherited mutations also influence how cancers respond to therapy. For example, PARP inhibitors are effective in tumors with BRCA-related homologous recombination deficiency (HRD). Thus, knowing that a patient has a germline BRCA mutation may alter drug selection.

Family risk & cascade testing: Identifying a hereditary mutation allows cascade testing, where close relatives can also get genetic testing done. This helps them understand risks and take prevention measures before cancer develops.

Clinical trial access: Many modern trials require knowledge of inherited DNA defects. Patients with known germline mutations may qualify for therapies designed precisely for those DNA repair vulnerabilities.

However, it is also important to understand that absence of a germline mutation does not mean absence of risk. Many cancers are driven purely by somatic mutations, and many hereditary variants remain undiscovered or classified as Variants of Uncertain Significance (VUS). Testing negative for known genes does not guarantee immunity.

Also, hereditary risk is not absolute: a person may carry a mutation but never develop cancer, due to protective factors like healthy lifestyle, background genetics, or luck. Interpretation must be done thoughtfully, ideally with genetic counselling.

Conclusion

While hereditary mutations play a role in a minority of cases, their impact on prevention, therapy, and family planning can be profound. Knowing whether cancer “came from your DNA” is often less important than using that knowledge wisely—both for patients and their relatives.

As we move deeper into the era of precision medicine, clinicians and patients alike should appreciate that hereditary and somatic worlds coexist, and that DNA insight is a tool—not a verdict.

Screening for all men is "likely to cause more harm than good", says the UK National Committee. This recommendation is based on a clinical trial called Transform, which is now filling gaps in the evidence on how screening could be safely rolled out to other groups.

As of now, as per the recommendation, men who are between the ages of 45 and 61 should be screened every two years, if they have specific genetic mutations called BRCA variants.

The UK National Screening Committee recommends:

• No screening for black men due to "uncertainties" around the impact due to a lack of clinical trials in black men
• No screening based on family history

Why Is The New Recommendation Asking People To Not Get Screened For Prostrate Cancer?

As per the clinical study and the Cancer Research UK, of the 1000 men who get screened between the age of 50 to 60 for PSA test or the prostate-specific antigen test, around 100 have a positive PSA test. Of them, 34 have a positive MRI and receive a biopsy. Then only 28 are diagnosed with prostrate cancer. Of those 28, 10 are offered active surveillance, 13 are offered surgery or radiotherapy, and 4 need surgery or radiotherapy, while 1 need any other treatment.

However, the Cancer Research UK notes that while 1000 men are screening, and 28 diagnosed, only 2 lives could be saved, with 20 being over diagnosed, this means they have a slow-growing tumor that does not need treating, and of them 12 men will receive treatments that do not benefit them, rather harms them. These harms come in forms like being unable to control your bladder, or maintain an erection.

Is Prostrate Cancer Screening Recommendation Fit For All?

While experts say it is, patients are disappointed. Sir Chris Hoy, a terminal prostrate cancer patient says he was "disappointed and saddened" by the new recommendations as BBC reports.

However, Prof Freddie Hamdy, who is a urological surgeon in Oxford tells BBC: "The diagnosis of prostrate cancer in a healthy man is hugely disruptive event, with potential to affect quality of life, very significantly, for many years."

"It cannot be done lightly, men need to be really well counselled and informed before the 'snowball' starts. Before you know it, you are on the operating table having your prostate removed – and we see examples of that all the time," he said.

The screening committee’s decision is not final. It marks the beginning of a three-month public consultation period, after which the committee will reconvene and present its final recommendations to ministers in England, Wales, Scotland, and Northern Ireland. Each nation will then make its own decision on prostate screening.

England’s Health Secretary Wes Streeting said he supports screening “if backed by evidence” and promised to review the data “thoroughly” ahead of the final guidance expected in March.

Reactions to the draft recommendations have been sharply divided. Cancer Research UK welcomed the consideration of screening for men with faulty BRCA genes and agreed that, for most men, screening could currently do more harm than good.

But others strongly disagreed. Sir Chris Hoy said he was “extremely disappointed and saddened,” calling the BRCA-specific recommendation “a very small step forward” that falls short. Sharing his own experience, he emphasised that “early screening and diagnosis saves lives.”

Prostate Cancer UK CEO Laura Kerby also expressed being “deeply disappointed,” saying the decision will “come as a blow” to tens of thousands of men.

Prostate Cancer Research criticized the move as “a serious error that ignores modern evidence,” calling it a missed opportunity for Black men and those with a family history.

Many people struggle to fall asleep because their minds race with worries about the next day or even old memories. To stop this mental chatter, some try complicated breathing exercises or relaxation hacks. However, a simple neuroscience trick involving temperature might help you drift off instantly.

Neuroscientist Kyle Cox suggests that you can fall asleep in seconds simply by placing something cold on your forehead when you go to bed. He explains that this method has been backed by sleep clinics and can be highly effective.

Sleep Hack That Could Help You Sleep Quicker

Researchers have learned that the temperature right on your forehead controls whether your brain stays active or decides to rest.

When the front part of your brain, called the frontal lobe, gets cooled down by even a little bit, just one degree, it automatically tells your body to start producing the chemicals needed for sleep.

The cold also quickly slows down all that busy mental chatter because the part of your brain that handles thinking (the prefrontal cortex) literally cannot work as hard when it is being cooled down.

A 2018 study published in the Sleep Journal also found similar results through a device that that cooled the forehead temperature as a treatment for insomnia. The device improved things like the time it took to fall asleep compared to the patient's own baseline sleep and the time it took to enter different stages of light and deep sleep (NREM Stages 1 and 2).

The two-night treatment helped patients fall asleep faster according to most PSG measurements and was safe. The researchers recommend more studies to see if this treatment works for the longer-term management of insomnia.

General Tips for Treating Insomnia

If you struggle with sleep, the NHS (National Health Service) says that often the best cure is to change your daily sleep habits. If you stick to a healthier routine, your insomnia usually gets much better over time.

Keep a Schedule

Go to bed and set your alarm to wake up at the exact same time every day, even on weekends. This helps set your body's internal clock.

Wind Down

Start relaxing at least one hour before you plan to sleep. This could mean taking a warm bath, listening to calm music, or reading a physical book.

Optimize Your Room

Make your bedroom a perfect place for sleeping. It should be as dark and quiet as possible. Use heavy curtains, blinds, or even an eye mask and earplugs if needed.

Get Moving

Exercise is great for sleep, but do it regularly during the day, not right before bed.

Be Comfortable

Check that your mattress, pillows, and blankets are supportive and cozy so you can easily relax once you lie down.

Things You Should Avoid For Better Sleep

To sleep better, avoid things that keep you awake. Stop smoking, drinking caffeine or alcohol six hours before bed. Do not eat a large meal or exercise intensely late at night. Avoid screens right before bed, limit daytime naps, and always stick to your regular morning wake-up time.