Sleeping is an important part of staying healthy that many people do not take seriously. According to Centre of Disease Control and Prevention about one in three people in the United States report not getting enough sleep or rest every day. The National Heart, Lung and Blood Institute tells us that lack of sleep causes mental as well as physical issues including injuries and greater likelihood of death. Other symptoms include heart disease, kidney disease, high blood pressure, diabetes, stroke, obesity, and depression. Another thing that gets affected by sleep is your hormones.

According to International Journal of Endocrinology in 2015 hormones, like growth hormone, melatonin, cortisol, leptin, and ghrelin, are closely tied to our sleep and body clock. This means they change based on when we sleep and when it's light or dark. Our bodies also have built-in systems that control things like how we use sugar and fat, and these are also linked to our internal clock.

Sometimes, we might think we're just stressed or have a small bug, but it could be a hormone imbalance. It's important to pay attention to these signs because they can tell us if something is not quite right inside our bodies. Ignoring them might lead to bigger problems later. Knowing what to look for can help us take better care of ourselves and know when to ask for help from a doctor.

What Hormones Affect Our Sleep?

When we sleep, our bodies should be resting, but hormone problems can make this difficult. Two things that happen at night can be signs of trouble. First, having very vivid and scary nightmares can be linked to high levels of progesterone. This hormone can mess with our sleep and cause us to have intense dreams. Second, if you can't stop your mind from racing before bed, it might be because of high cortisol, the stress hormone. This hormone should be low at night, but if it stays high, it keeps your brain awake. Also, thyroid problems can cause similar racing thoughts. These nighttime problems can really disrupt our sleep and make us feel tired during the day.

Other Signs of Hormone Imbalance

Besides nighttime problems, there are other ways your body might tell you about a hormone imbalance. Sometimes, you might just feel "off" or like you're not yourself. You might feel tired, unmotivated, or just generally unwell. This can happen when your hormones are changing, even in small ways. Hormones like estrogen, progesterone, testosterone, and cortisol can all affect how you feel. Also, you might feel dizzy, unsteady, or confused, like you're drunk or hungover, even if you haven't had any alcohol. This can happen when your blood sugar is not being controlled properly by insulin, or if your adrenal glands are overworked. These symptoms can be confusing, but they're important signs that something might be wrong.

If you keep having these symptoms, it's a good idea to talk to a doctor. They can help figure out if your hormones are out of balance. Doctors have tests that can check your hormone levels and help them understand what's happening. They can also help you find ways to feel better, like changing your diet, taking medicine, or making lifestyle changes.

Scrolling through social media, many women encounter stories of celebrities describing years of unexplained symptoms before receiving a diagnosis of polycystic ovary syndrome (PCOS). Model and actress Lori Harvey recently shared her experience with weight fluctuations, acne, facial hair growth, and painful irregular periods, highlighting a common struggle among women of reproductive age. Stories like hers resonate with women like Alexis King, who found validation in hearing someone else’s journey, as reported in Washington Post.

PCOS is a hormone disorder affecting roughly one in ten women worldwide, including about six million Americans. It is linked to both reproductive and metabolic dysfunction, increasing the risk of fertility problems as well as chronic conditions such as high blood pressure, diabetes, obesity, and cardiovascular disease. Despite its prevalence, PCOS remains underfunded and under-recognized, leaving many women to navigate the condition largely on their own.

A “Silent” Diagnosis

For many, PCOS is identified only after years of unexplained symptoms. Patients often encounter healthcare providers who focus on cosmetic solutions rather than addressing the underlying hormonal imbalance. Researchers note that PCOS is considered an “orphan disorder” in women’s health, receiving significantly less funding than conditions with comparable prevalence and severity. From 2016 to 2022, average annual funding for PCOS was around $32 million, compared with $262 million for rheumatoid arthritis and $66 million for tuberculosis, according to recent studies reported in Washington Post.

Experts stress the need for comprehensive management rather than relying on individual supplements, though some, such as inositol, have shown promise in improving metabolic and reproductive outcomes. There is no cure or FDA-approved treatment specifically for PCOS, though existing interventions can alleviate symptoms and reduce long-term health risks, according to Richard Legro, chair of obstetrics and gynecology at Penn State Health Milton S. Hershey Medical Center, as reported in Washington Post.

Challenges in Diagnosis

A full PCOS diagnosis requires meeting at least two of three criteria: irregular periods, elevated male hormones, or ovaries with fluid-filled sacs visible on ultrasound. Yet many patients never undergo complete hormone testing or imaging, leaving the disorder undiagnosed for years. Clinicians often lack training to treat PCOS effectively, as it spans multiple specialties, from reproductive endocrinology to general gynecology. Multidisciplinary clinics exist but are limited in number, forcing patients to seek care from providers unfamiliar with the full scope of the disorder, as reported in Washington Post.

Delayed diagnosis can have serious consequences. Women with PCOS face increased risks of infertility, pregnancy complications, and chronic conditions. Endometrial cancer risk is higher due to irregular shedding of the uterine lining, and Black women experience disproportionately higher rates of adverse outcomes due to later diagnosis and barriers to care.

Research and Emerging Treatments

In the absence of robust funding, clinicians have relied on medications such as metformin, which improves insulin sensitivity, to manage PCOS symptoms. Research is also exploring the use of weight-loss drugs, such as semaglutide, to regulate hormone levels, restore periods, and reduce metabolic risks. Early trials show promise, with participants reporting restored menstrual cycles, improved hormone balance, and weight loss, as reported in Washington Post.

Despite these advances, insurance coverage remains a challenge. Patients often must pay out of pocket for medications that are not yet FDA-approved specifically for PCOS. Researchers like Melanie Cree, a pediatric endocrinologist, are pushing for standardized testing and more clinical trials, but funding delays and reduced philanthropic support continue to slow progress.

As awareness grows, advocates and researchers aim to prioritize PCOS as a significant public health concern, emphasizing early detection, comprehensive treatment, and equitable access to care. For millions of women, improved understanding and treatment of PCOS could transform lives, reducing both immediate discomfort and long-term health risks, as reported in Washington Post.

For the first time, patients in England and Wales will be able to access a long-acting injection to prevent HIV through the NHS, bringing the policy in line with Scotland. The new jab, administered every two months, provides an alternative to daily oral pills, offering convenience and discretion for those who find tablets challenging to take.

Experts hope the introduction of cabotegravir (CAB-LA) injections will help the UK meet its goal of eliminating new HIV cases by 2030. Meanwhile, early results from another injection, lenacapavir, suggest that annual HIV prevention injections could become a possibility in the future.

A “Game-Changing” Option

Wes Streeting, the Secretary of State for Health and Social Care, described the new injection as “game-changing” and told the BBC: “For vulnerable people who are unable to take other methods of HIV prevention, this represents hope”.

HIV prevention therapy, known as PrEP (pre-exposure prophylaxis), is used by HIV-negative individuals to reduce the risk of infection. While daily oral PrEP has been effective for years, some people find it difficult to adhere to. Challenges include lack of privacy, homelessness, domestic violence, or the fear of others discovering their medication.

A long-acting injection that lasts for months addresses these issues, offering both practicality and discretion. Cabotegravir, produced by ViiV Healthcare, is intended to be used alongside safer sex practices, such as condom use. NHS England has secured a confidential discount from the manufacturer, whose list price is around £7,000 per patient per year, as reported by the BBC.

Who Will Be Eligible?

The injection will be offered to adults and adolescents at high risk of sexually acquired HIV who are eligible for PrEP but may struggle with daily tablets. Around 1,000 people are expected to be offered the injection initially, with others continuing or starting oral PrEP. Patients can access it through NHS-operated sexual health clinics “in the coming months,” according to the National Institute for Health and Care Excellence (NICE).

Dom Baldwin, who currently takes PrEP pills, told the BBC he is “over the moon” about the injections: “When you look at where we are now compared to the epidemic in the 80s… HIV is no longer a death sentence”.

Calls for Rapid and Equitable Rollout

Charities have emphasized the need for a fast rollout, as some patients face long waits for appointments. Richard Angell, of the Terrence Higgins Trust, said to the BBC that the therapy should be offered in more settings, not just sexual health clinics: “It’s highly effective and acceptable for patients, and a vital tool for tackling inequalities, with the potential to reach those who are not currently accessing other HIV prevention”.

Official figures show that PrEP access in England is increasing, but gaps remain. In 2024, 146,098 HIV-negative people attending sexual health services were at substantial risk of HIV, with about 76% starting or continuing PrEP, a 7.7% rise from 2023. However, uptake varies by group, with lower rates among black African heterosexual men and women compared to men who have sex with men.

Dr Michael Brady, NHS England’s National Advisor for LGBT+ Health, said to the BBC: “This long-acting injection is a significant addition to our HIV prevention strategies, giving us a powerful new option for people at risk of HIV who cannot have oral PrEP tablets”.

In a recent study published in The Lancet, by the Global Burden of Disease Study, 2023 reveals that non-communicable diseases (NCDs) like heart disease, stroke, and diabetes now account for nearly two-thirds of global deaths, surpassing infectious diseases, according to an analysis of over 33 years.

The study covered 375 diseases and injuries, including 88 risk factors and healthy life expectancy across 204 countries and territories. It included 660 subnational locations, from 1990 to 2023.

The report also highlighted the sharp rise in mental health disorders with anxiety disorders, which were increased by 63%. The report also noted an increase in depressive disorders by 26%.

Environmental Factors That Impact Health

Furthermore, it added that environmental risks such as extreme heats and air pollution also bears an impact on health. There have been deaths due to climate-sensitive exposures rising by 6% annually between 2013 and 2023.

In fact, recently, a health conference of the Indian Rheumatology Association revealed that pollution also triggers rheumatoid arthritis. Heat waves also pose serious health risks, from heat cramps and exhaustion to the life-threatening heatstroke, by overwhelming the body's ability to cool itself.

An Increase In Life Expectancy Rate

As per the study, the global life expectancy rates have rebounded post COVID-19 pandemic. It has now reached 76.3 for women and 71.5 years for men in 2023. Earlier, in the pandemic, the age for women went down to 74.7 years, while for men, it was at 69.3 years, in 2021. Since 1950, the global life expectancy has increased by roughly 20 years.

In 2023, the total deaths globally reached 60.1 million, which included 4.67 million deaths of children under five. The population growth and aging however has driven a 35.2 per cent increase in global deaths since 1950, under-five mortality has steadily declined in this period.

The report also highlighted the difference in the health outcomes. The global life expectancy has improved, however, the geographic inequities still persisted. The mean age at death rose from 46.4 years in 1990 to 62.9 years in 2023.

Who Lived Longer, Where?

High-income countries reported the longest lifespans, women lived up to 80.5 years on average, while men reached 74.4 years. In stark contrast, sub-Saharan Africa recorded the lowest life expectancy, with women living an average of 37.1 years and men 34.8 years.

The report highlights that nearly half of all global deaths and disabilities could be prevented by tackling key risk factors such as high blood sugar, obesity, and social determinants like sexual abuse and intimate partner violence.

India recorded 9.85 million deaths in 2023, ranking second after China’s 10.7 million. The average life expectancy in India stood at 73 years for women and 70.2 years for men.

Encouragingly, India has made notable strides in reducing child mortality. The under-five mortality rate has dropped to 32.1 deaths per 1,000 live births. However, due to the country’s large population, the total number of deaths among children under five remained high, at around 6,92,000.