As the number of people reporting pancreatic issues after taking the weight loss and diabetic jabs increases, UK health officials have launched an investigative study to figure out the unexpected side-effects of the drug.

In the UK, the Medicines and Healthcare products Regulatory Agency (MHRA) and Genomics England are asking anyone who was using these shots and ended up in the hospital with a sudden pancreas problem called acute pancreatitis to get in touch. Hundreds of people have reported pancreas issues after taking drugs like Mounjaro, Ozempic, and Wegovy, but doctors haven't yet proven that the shots caused these problems.

The study is part of the MHRA's Yellow Card scheme, this system lets anyone report a problem with a medicine, vaccine, or medical device, which helps doctors find safety issues early. People aged 18 and older who had a serious reaction to these weight loss shots (which are also used for type 2 diabetes) should report it on the Yellow Card website.

They'll then be asked if they want to join the study. This study will check if some people's genes make them more likely to get acute pancreatitis when taking these medicines. Patients will give more information and a saliva sample, hoping to reduce these side effects in the future.

As of May 13 this year, 10 deaths from pancreatitis in people using weight loss drugs were reported to the Yellow Card website, though other health factors might have been involved. It's tough to track exact user numbers since many buy these drugs online without a prescription. While health officials suggest these shots can aid obesity efforts, they caution that they're not a "magic solution" and often cause side effects like nausea, constipation, or diarrhea. The MHRA also warned that Mounjaro could reduce the effectiveness of birth control pills for some users.

Does Weight-Loss Injection Affect Pancreas?

A January 2025 study published in the Nature Medicine had looked into this question before. The study observed how the weight loss drug GLP-1, affected 175 different diseases. The study found that while GLP-1 users saw some benefits, they also had a higher risk of 19 side effects or diseases compared to those on traditional medications.

The most significant finding was that people on GLP-1 agonists were nearly 2.5 times more likely to develop drug-induced acute pancreatitis, a serious condition where the pancreas becomes inflamed.

Other common side effects included a 30% higher risk of nausea or vomiting, an 11% higher risk of arthritis, and a 6% higher risk of low blood pressure. These findings highlight that while beneficial for some conditions, these drugs come with a range of potential risks.

In 2024 a case study published in the journal Cureus, also looked into this, however at the time, they did not have enough evidence to back it. The study explained that some reports had connected Semaglutide to a sudden swelling of the pancreas, called acute pancreatitis. This report talked about a 36-year-old woman who came to the emergency room with sudden, severe stomach pain. She was diagnosed with acute pancreatitis. She had just started using Semaglutide shots for weight loss, which she got from a friend without talking to a doctor first.

After she stopped taking Semaglutide, her pancreas levels (lipase) went back to normal, and her symptoms got much better. This suggests that Semaglutide was likely what caused her acute pancreatitis.

What Is Pancreatitis?

Pancreatitis is inflammation of the pancreas, and this can either be acute or chronic. Finding out whether one has pancreatitis as well as getting it under control is very important as if left unchecked, it can lead to long-term damage and other complications.

As you may know, our pancreas makes important digestive enzymes as well as insulin, which helps us break down glucose components and transform it into energy. Pancreatitis happens when the pancreas enzymes damage the pancreatic tissue itself.

The key difference between acute and chronic pancreatitis is that they are actually different conditions. According to a 2021 study published in the Cureus journal, acute pancreatitis is a sudden, short-term inflammation of the pancreas. When someone has acute pancreatitis, they usually feel severe pain in the upper part of their belly, either in the middle or on the right side. This type of pancreatitis often comes on quickly and, with proper treatment, can resolve. Here are the symptoms, causes and treatment options, according to National Health Services UK.

Chronic pancreatitis is a long-lasting inflammation of the pancreas that often gets worse over time. Unlike acute pancreatitis, the symptoms of chronic pancreatitis can be much broader. People might have ongoing belly pain, but they can also show signs that their pancreas isn't working properly. This can lead to problems with digestion and even diabetes.

Symptoms of Pancreatitis

Acute pancreatitis is a sudden, short-term swelling of your pancreas. The most common signs are severe, sudden pain in the middle of your stomach. You might also feel or be sick, and have diarrhea.

Whereas, the main symptom of chronic pancreatitis is repeated, severe stomach pain, usually in the middle or left side, that can spread to your back. This pain is often described as burning or shooting and can last for hours or days, sometimes without a clear trigger.

As the condition worsens, these painful episodes might happen more often and be more severe. Eventually, you might feel a constant, dull pain in your belly even between bad episodes, especially if you keep drinking alcohol.

Causes of Pancreatitis

Acute pancreatitis happens when digestive chemicals inside your pancreas start to attack the organ itself. It's most often linked to two main things: gallstones, which cause about half of all cases, and drinking alcohol, which is behind about a quarter of cases. You can lower your risk by drinking less alcohol and making diet changes to prevent gallstones.

The most common reason for chronic pancreatitis is drinking too much alcohol for many years. This can cause repeated attacks of sudden pancreatitis, leading to more and more damage. In children, cystic fibrosis is the most common cause. Other less common causes include smoking, your immune system attacking the pancreas, genetic problems, injury, gallstones blocking ducts, or radiation. Sometimes, no cause is found.

Treatment Options for Pancreatitis

Treatment for acute pancreatitis focuses on supporting your body while the swelling goes down. You'll usually need to stay in the hospital for fluids through a vein, pain relief, food support, and oxygen. Most people get better within a week and can leave the hospital in 5 to 10 days, though severe cases might take longer due to complications.

The damage to your pancreas from chronic pancreatitis is permanent, but treatment can help manage the condition and symptoms. Doctors usually advise stopping alcohol and smoking. You'll also get medicine to relieve pain. In some cases of severe pain, surgery might be an option to help control the condition and improve your quality of life.

Researchers have explained that like many other medicines, weight loss jabs also have side-effects, some of which are very serious. The next steps they are taking is to make the medicine safer by gathering more information and helping more personalized prescriptions to prevent any such situation from arising in future.

You cannot see it, feel it, or hear it increasing, but cholesterol might be quietly present in your bloodstream, creating trouble for your heart. Your everyday habits, like late-night scrolling, snack-bingeing, or skipping workouts, could be some of the reasons.

Experts warn that ignoring cholesterol is not a wise idea. “High cholesterol is not always easy to spot, and your everyday habits could be quietly leading to it. Making small, steady changes can really help your heart stay healthy,” explains Dr Vikas Vashisth, MD, Internal Medicine, SilverStreak Multispeciality Hospital.

We turn to experts to know what causes bad cholesterol and, more importantly, how you can lower it.

Rethink Your Fats

Fried food might taste divine, but they are not doing your heart any favours. Foods high in saturated fats, like red meat and full-fat dairy, increase LDL (the “bad” cholesterol). Trans fats, lurking in packaged snacks and baked goodies, are equally problematic.

“Go for healthier fats instead,” advises Dr Vashisth. Like olive oil for your cooking, a handful of nuts for your 4 pm cravings, or avocado on toast.

Increase Fibre Intake

If there is one thing that helps fight cholesterol, it is soluble fibre. Found in foods like oatmeal, apples, pears, kidney beans, and even Brussels sprouts, fibre acts like a sponge, soaking up cholesterol and flushing it out.

“Try to get 5 to 10 grams of soluble fibre every day to lower LDL cholesterol,” says Dr Vashisth. And no, that does not mean buying ‘fibre-rich’ biscuits; stick to whole, natural foods.

Sweat It Out

HDL is the “good” cholesterol that protects your heart. Exercise boosts HDL while lowering LDL, making it a double win. “Aim for at least 30 minutes of moderate activity most days,” suggests Dr Vashisth. Brisk walks, cycling, swimming, or even a dance session in your living room can do the trick.

Pick Heart-Healthy Foods

Food can be medicine if chosen wisely. Omega-3 fatty acids found in salmon, mackerel, walnuts, and flaxseeds help lower triglycerides and blood pressure. You can also try plant sterols or stanols (often in fortified foods) that block cholesterol absorption. Consider them little bodyguards in your kitchen.

Keep an Eye on the Scales

Carrying extra weight does not just sit on your waistline; it affects your cholesterol, too. “Even small changes in weight can have a positive impact,” says Dr Vashisth. Balance your meals, cut back on sugar-loaded snacks, and stick to consistent movement. Think of it as housekeeping for your health.

Why Indians Need to Pay Extra Attention

Most people imagine cholesterol to be a “Western problem”. But Indians are at higher risk of heart disease at younger ages. “We develop heart disease earlier due to a distinctive pattern of dyslipidaemia—high triglycerides and small, dense LDL particles,” warns Dr Honey Sharma, Consultant, Interventional Cardiology, Shalby Hospital.

On top of that, some people have genetically high cholesterol, making monitoring all the more vital. Dr Sharma stresses that guidelines by the Cardiological Society of India recommend stricter cholesterol targets than Western populations.

Habits That Raise Cholesterol

Not all cholesterol triggers are obvious. According to Dr Sharma, your everyday choices might be the stealthy culprits:

• Poor Sleep: Burning the midnight oil raises cortisol, which spikes cholesterol. Target at least 7 hours of shut-eye.
• Inactivity: Long hours at the desk lower HDL. Stand, stretch, or walk every hour.
• Chronic Stress: Stress pushes your liver to churn out cholesterol. Counter it with yoga, journaling, or short breaks.
• Sugar Overload: Beware of “low-fat” snacks that hide sugar. They raise triglycerides. Instead, choose fruit, nuts, or homemade curd.

Simple Fixes That Actually Work

You do not need a total lifestyle makeover. Start with tiny swaps:

• Eat more greens, legumes, and fruits.
• Walk, cycle, or dance daily.
• Replace stress scrolling with music, meditation, or journaling.
• Snack smart: pick seeds, roasted chickpeas, or fresh fruit.

Donald Trump’s health has once again become a hot talking point, but this time it is not about his diet or late-night Twitter habits. Instead, two psychologists are raising red flags about something far more serious: dementia. According to them, the US president has been showing what they describe as a “dead ringer telltale sign” of frontotemporal dementia (FTD) and they warn that the symptoms appear to be getting “worse and worse”.

The psychologists’ concern

Clinical psychologists Dr. Harry Segal and Dr. John Gartner, hosts of the podcast Shrinking Trump, claim that Trump’s psychomotor functioning has visibly deteriorated. Speaking to The Guardian, Dr. Gartner said, “Some of the more evidence that we've been talking about recently has been his psychomotor performance, that we're seeing a deterioration in his motor performance, which also goes with dementia because with dementia there's a deterioration of all faculties, all functions.”

Adding to the intrigue, the Mirror reported that Trump has been spotted “frantically” trying to hide the back of his hand, fuelling speculation about his health. According to Dr. Gartner, Trump’s verbal slips, struggles with language, and now motor difficulties fit the pattern of a neurodegenerative disorder. He even suggested Trump may have more than one form of dementia, but he believes one stands out: frontotemporal dementia.

“One of the things that one of the neuropsychologists that we were working with last year pointed out that is almost a dead ringer telltale sign of frontotemporal dementia is something they call a wide-based gait, where you have a sort of one of your limbs, one of your legs, and you kind of swing it in a semicircle,” Dr. Gartner explained.

What exactly is frontotemporal dementia?

Frontotemporal dementia (FTD) is not a single disease but a group of disorders that attack the brain’s frontal and temporal lobes. These regions control personality, social behaviour, and language, the very things that often change first in people with the condition.

Unlike Alzheimer’s disease, which is better known, FTD often shows up earlier, typically between the ages of 40 and 65. However, it can appear later in life, making it tricky to diagnose. Many patients are first misdiagnosed with psychiatric conditions or even Alzheimer’s because the symptoms overlap.

Symptoms that raise eyebrows

The Mayo Clinic states that the symptoms of FTD vary depending on the most affected part of the brain. The progression is gradual but relentless.

Behavioural symptoms include:

• Socially inappropriate behaviour.
• Loss of empathy and sensitivity to others.
• Poor judgement and impulsivity.
• Apathy that can be mistaken for depression.
• Compulsive habits such as tapping, clapping, or repetitive lip-smacking.
• Decline in hygiene.
• Odd eating habits – from sudden sugar cravings to chewing on non-food items.

Language-related symptoms include:

• Trouble understanding and producing speech.
• Difficulty finding the right words.
• Using vague terms like “it” instead of specific words.
• Simplified, telegraphic speech.
• Errors in building sentences.

Movement-related symptoms (less common but significant) include:

• Tremors, stiffness, or muscle spasms.
• Difficulty swallowing or weakness.
• Poor balance leading to falls.
• Inappropriate emotional outbursts like laughing or crying.

The “wide-based gait” noted by Dr. Gartner falls into this movement-related cluster, aligning with the suspicion of FTD.

What causes it?

FTD literally shrinks the brain; the frontal and temporal lobes undergo atrophy while abnormal proteins accumulate. The precise cause is not always clear, but genetics plays a role in some cases. Mutations in certain genes overlap with conditions like ALS (amyotrophic lateral sclerosis), hinting at a deeper biological link that scientists are still trying to untangle.

Interestingly, over half of people diagnosed with FTD have no family history of dementia, meaning the condition can strike seemingly out of the blue.

Who is at risk?

The only established risk factor is family history. Unlike heart disease or type 2 diabetes, lifestyle choices have not been clearly tied to developing FTD. Still, because it often appears earlier than Alzheimer’s, it can be devastating for families, robbing individuals of their personality, judgement, and communication skills during what should be the prime of life.

While Trump’s team has not confirmed or denied any health concerns, the observations of Dr. Segal and Dr. Gartner point to a broader issue: recognising the early signs of dementia in public figures and ordinary people alike. If the psychologists are correct, the president may be experiencing symptoms that fit squarely within the profile of frontotemporal dementia.

What is Bruce Willis's health update? He was also diagnosed with FTD over three years ago

Bruce Willis Health Update: Besides Trump's news, there is an update on Bruce Willis's health. At the preview of ABC's special Emma & Bruce Willis: The Unexpected Journey, Willis' wife Emma opened up about her husband's battle with frontotemporal dementia, saying his “brain is failing him” and his “language is going.” Despite the heartbreaking progression of the disease, she says their family has found new ways of communicating and cherishes the rare moments when his true personality shines through.

The 70-year-old “Die Hard” and “Sixth Sense” star was diagnosed with frontotemporal dementia more than three years ago. In 2023, his family revealed the condition.

When couples struggle to conceive, they usually think of hormone imbalances, advancing age, or lifestyle problems. But did you ever imagine that the real hindrance could be something as silent as chronic inflammation? It does not make headlines like PCOS or low sperm count, yet it silently disrupts the reproductive system in both men and women. And yes, it could be standing between you and your dream of parenthood.

Inflammation is More Than Just Swelling

Dr. Rupali Tambe, Fertility Specialist at Nova IVF Fertility, Lullanagar, explains that chronic inflammation is increasingly being linked to infertility. “Some conditions, such as infections, endometriosis, and polycystic ovary syndrome (PCOS), are marked by inflammation. This can impact the uterus and cervix, ultimately reducing the chances of conception,” she says.

Inflammation is like the body’s fire alarm. It is helpful when you have hurt yourself or caught an infection. But when the alarm does not switch off, the body is stuck in a low-level state of stress, which can interfere with ovulation, sperm production, and even implantation.

The Science of Why It Affects Fertility

According to Dr. Mandavi Rai, Senior Fertility and IVF Specialist at Motherhood Fertility & IVF, Noida, the trouble goes deeper than you think. “Chronic inflammation due to conditions like PCOS, autoimmune diseases, poor diet, or stress can impact the ovaries, fallopian tubes, and uterus in women. In men, it damages sperm production, count, and motility,” she points out.

For women, this could mean poor egg quality, scarring of the fallopian tubes due to pelvic inflammatory disease or endometriosis, or hormonal imbalances that block ovulation. For men, issues like orchitis (testicular inflammation) or varicocele (enlarged veins in the scrotum) can heat things up. Higher testicular temperature disrupts sperm formation, leaving fewer healthy swimmers.

Can Diet Calm the Fire?

You do not have to live with inflammation forever. Dr. Tambe says that studies suggest an anti-inflammatory diet may boost pregnancy rates in women and even improve sperm quality in men.

An anti-inflammatory diet would include foods like salmon, walnuts, flaxseeds, berries, mushrooms, leafy greens, tomatoes, yoghurt, and even kimchi. Avocados, turmeric, ginger, kale, and green tea also make the cut. These foods are packed with antioxidants and healthy fats that cool inflammation naturally.

And Dr. Tambe advises skipping processed, fried, and sugary foods. That means saying no to French fries, pizzas, pastries, namkeens (salty mixtures), and fizzy drinks. Basically, if it comes in a packet or is dripping with oil, it is not doing your fertility any favours.

Beyond Food Choices

Food is not the only reason here. Dr. Rai stresses that daily exercise, quitting smoking and alcohol, and maintaining a healthy weight are essential. “Regular activities like swimming, cycling, or yoga reduce inflammation markers in the body and improve reproductive health,” she says.

Do not forget stress. Chronic stress itself is a proven inflammation trigger. Meditation, deep breathing, or just unplugging from your phone for an hour a day can help quiet your nervous system. And yes, quality sleep, at least 7 to 8 hours, acts as nature’s best anti-inflammatory pill.

When Lifestyle Changes Aren’t Enough

Sometimes, lifestyle fixes and diets cannot tackle severe inflammation. That is when medical interventions step in. Non-steroidal anti-inflammatory drugs (NSAIDs), antibiotics (for infections), or hormonal treatments may be prescribed by specialists.

For couples facing stubborn infertility, assisted reproductive technologies (ART) like IVF or ICSI can provide hope. “Women with infertility who followed an anti-inflammatory diet during IVF had better pregnancy outcomes compared to those who didn’t,” Dr. Tambe says.

Infertility is rarely caused by a single factor, but chronic inflammation is an under-recognised condition. The right mix of an anti-inflammatory diet, lifestyle changes, and expert care can make all the difference.