In an breakthrough scientific discovery, scientists have found that a common diabetes medication taken by millions globally—metformin, may provide unexpected protection against acute myeloid leukemia (AML), a fast-growing and frequently fatal type of blood cancer. This has been established by a new study by the University of Cambridge, which has been published in the highly-respected journal Nature. The study suggests metformin to be a low-cost, safe preventative therapy for individuals who are at high risk of developing AML.

This finding may represent a paradigm change in the approach to cancer prevention in medicine—particularly in hematological malignancies where early intervention is usually restrictive.

In contrast to solid cancers like breast or prostate cancer, which at times may be removed surgically, blood cancers are more difficult to localize and destroy. As Cambridge Stem Cell Institute Professor George Vassiliou describes it, "With blood cancers, we must first find people at risk and then apply medical treatments to halt cancer growth across the body." AML, which begins in the bone marrow and develops quickly, is an example of this difficulty.

Approximately 3,100 individuals in the UK are diagnosed with AML every year. It has a poor prognosis and few treatment options, especially in the elderly. Although the latest advances in blood testing are able to indicate individuals at risk years earlier than before, to date, there has not been a sure way to stop AML from forming.

How Diabetes Drug Interrupts Cancer Development at the Cellular Level?

Scientists targeted their research on DNMT3A, a gene commonly mutated in AML patients. This one mutation is thought to trigger as much as 15% of all AML. Metformin seems to break the energy metabolism of these pre-leukemic cells, targeting their aberrant growth pathways. By disabling the cells' capacity to produce energy, metformin stops them from developing into full-blown leukemia.

Additional analysis of health information from more than 412,000 UK Biobank participants reinforced the link. Metformin users had a significantly lower incidence of damaging mutations in the DNMT3A gene, whether or not they had diabetes. The results indicate a protective effect that is independent of the drug's initial purpose.

What is Metformi?

The origins of metformin trace back to medicinal plants used during medieval Europe. Isolated from Galega officinalis, a plant used in traditional medicine to cure urinary and metabolic problems, its active ingredient—guanidine—was discovered to lower blood sugar in the early 20th century. Although it was disfavored for a period, metformin was re-released and approved in Europe in the 1950s and subsequently by the FDA in 1995. It's now most commonly prescribed diabetes medication globally, especially in patients who have type 2 diabetes and are unable to regulate blood sugar levels by diet and exercise alone.

How Metformin Works?

Decreasing the level of glucose absorbed by the intestines through food.

Suppressing the liver's release of glucose.

Increasing insulin sensitivity, so that the body can utilize glucose more effectively.

These metabolic actions are not only helpful for controlling diabetes, but potentially for stopping or slowing other disease processes—such as cancer.

Benefits of Metformin

What's even more amazing is how metformin's benefits go beyond controlling blood sugar. According to Harvard Health and other medical centers, the medication has been linked with:

• Reduced cardiovascular mortality among diabetics
• Moderate weight loss
• Decreased risk for type 2 diabetes in persons with prediabetes
• Help with polycystic ovary syndrome (PCOS)
• Lower risk for cancers such as breast, colon, and prostate
• Possible diminishment of risk for dementia and stroke

Off-label prescriptions have also been used for some of these indications in metformin, highlighting the drug's versatile utility and solid safety profile.

One of the main advantages of metformin is its long history of safety. Taken by millions of people over many decades, it tends to have only minor side effects—e.g., nausea, bloating, or altered taste. Serious side effects, such as lactic acidosis, are infrequent and typically only occur in those with existing kidney disease.

As Blood Cancer UK's Director of Research Dr. Rubina Ahmed put it, "Repurposing existing, safe drugs such as metformin allows the possibility that new treatments might get to people earlier, without going through the extensive drug development pathways."

Being frail comes with age, your joints become weaker, your muscles lose their strength, and your skin slowly loses its elasticity. A lot of people wonder why aging people move so slowly or have difficulty doing simple tasks, but as they age, they realize that it's because there is a constant pain that accompanies moving.

There are a lot of things that can affect aging, something that many people have raised concern over. Certain foods, lifestyle activities and conditions that can age your body and organs faster than their biological age. Experts and studies have explained that to slow this rapid aging, one must incorporate many changes in their life, things like eating unprocessed food, and avoiding foods with excess saturated fats, added sugar and sodium etc., one must also live a healthy lifestyle with proper exercise and healthy choices like early mornings and appropriate sleep.

Coffee Consumption And Healthy Aging

People also suggest one should avoid things like coffee and drinks with excess caffeine. However, a new study shows that it could help you slow down aging. Published in the European Journal of Nutrition, the study suggests that regularly drinking coffee might play a role in delaying physical ageing and frailty. The research indicates that coffee drinkers could potentially experience fewer of the undesirable symptoms associated with getting older.

Specifically, the study revealed that consistently consuming four to six or more cups of coffee (each 125ml) daily is linked to a lower risk of developing frailty in older adults.

What Is Considered Frail and How Does Coffee Affect It?

This study was funded by the Institute for Scientific Information on Coffee (ISIC) and they wanted to find the relationship between coffee consumption and how it is linked to frailty. Using Fried’s five component of frailty, which has been determined as a useful criteria for inpatient assessment by Clinical Interventions in Aging, which are,

• Unintentional weight loss
• Feelings of weakness
• Exhaustion
• Slow walking speed
• Low levels of physical activity.

What Did The Study Find?

Building on previous studies that associated coffee with benefits like improved brain function and protection against inflammation-related diseases, they looked into long term benefits of coffee.

Researchers conducted a thorough seven-year analysis of 1,161 adults aged 55 and over, using data from the Longitudinal Ageing Study Amsterdam (LASA). The study focused on the relationship between how much coffee participants drank and the presence and development of frailty.

The researchers suggested that the antioxidants present in coffee may be a key reason for its potential to reduce frailty. These antioxidants could help lessen inflammation, combat muscle loss (sarcopenia), and protect against muscle damage. Furthermore, coffee might improve how the body uses insulin and absorbs glucose in older individuals. Their findings showed that daily coffee consumption can reduce frailty in older population.

Food Safety Regulations To Keep In Mind

These findings should be considered alongside the European Food Safety Authority's (EFSA) guidelines on caffeine consumption. EFSA considers up to 400mg of caffeine daily (equivalent to three to five cups of coffee) to be a moderate and safe amount for most adults. However, individuals with high sensitivity to caffeine or high blood pressure should limit their coffee intake. The NHS also advises pregnant women to limit their caffeine consumption to no more than 200mg per day, roughly equivalent to two cups of coffee.

Beds are usually considered a safe place for people; it is a place that you can always count on to help you rest and recuperate no matter how tough things get. However, sometimes this safe place can become home to some unwanted guests. While our parents would often urge us to make sure our beds remained clean and no food articles remained on it, sometimes leaving things here and there does not seem like a big concern for us. However, this could also be an invitation for bed bugs to enter the equation.

According to the U.S. Environmental Protection Agency (EPA) bed bugs are public health pests. While they do not transmit any diseases, they can cause our physical, mental as well as economical health to suffer. Severe health consequences to them can include allergic reactions which could be on the spectrum of small rashes to anaphylaxis, which is a full body reaction. It can also cause anxiety, insomnia and impact people’s mental health. However, how does one distinguish bed bug bites to normal insect bites?

NHS Guidance on Bed Bugs and Their Bites

The National Health Service (NHS) highlights that bed bugs can hide in various locations, including bed frames, mattresses, clothing, furniture, behind pictures, and under loose wallpaper. They identify three key signs of a bed bug infestation:

Bites: Often appearing on exposed skin areas during sleep, such as the face, neck, and arms.

Blood Spots: Small spots of blood on bedding, resulting from bites or crushed bed bugs.

Brown Spots: Tiny brown spots (bed bug excrement) found on bedding or furniture.

On fair skin, bed bug bites typically appear red, while on darker skin, they may look purplish and can be less noticeable. Reactions to bites vary; some people experience intense itching and painful swelling. Generally, bed bug bites resolve on their own within a week or two.

How Can You Treat Bed Bug Bites?

To manage bed bug bites, the NHS recommends several self-care measures. Applying a cool, damp cloth to the affected area can help alleviate itching and swelling. It's also important to keep the bite area clean to prevent any potential infections. Finally, resisting the urge to scratch the bites is crucial in minimizing the risk of further irritation or infection. Some over the counter products that you may get for relief may include mild steroid creams like Hydrocortisone cream can help ease the itching associated with bed bug bites. NHS notes that children under 10 and pregnant women should consult a doctor before using hydrocortisone cream. You may also be given Antihistamines, which provide relief if the bites are severely itchy and interfere with sleep.

How Can You Get Rid Of Them?

The NHS suggests that if you have bed bugs, it's best to get in touch with your local council or a pest control company. Getting rid of bed bugs on your own can be really tough because they can hide well and some bug sprays don't work on them. While there are a few things you can try yourself, they probably won't completely solve the problem.

Iron is more than a figure on a blood work report—it's the foundation of a woman's energy. From the moment menstruation begins to the final stages of menopause, a woman's need for iron isn't fixed; it varies, develops, and becomes even more essential. Underestimated and underappreciated, iron is not only vital for maintaining healthy blood but also for making energy, keeping the mind functioning, supporting the immune system, regulating hormones, and maintaining good moods. As women progress through the different hormonal stages of life, fluctuating iron levels can deeply impact their quality of life, making this mineral a non-negotiable part of lifelong health planning.

Iron deficiency is the most common nutritional deficiency on earth, and it disproportionately affects women. An estimated 38% of pregnant women and 29% of non-pregnant women around the world suffer from anaemia—most frequently resulting from iron deficiency. The World Health Organization (WHO) indicates that iron deficiency anaemia (IDA) peaks in reproductive ages, pregnancy, and early motherhood.

This is due primarily to menstruation, in which repeated monthly blood loss drains iron stores, and augmented further in instances of heavy menstrual bleeding (HMB), present in as many as one-third of menstruating women. Iron is still important even after menopause, although for other purposes—maintaining immunity, intellect, and metabolism in the absence of monthly loss.

Menstrual Years

Menstruation makes women aware of their life-long connection with iron. Every menstrual cycle, women lose approximately 30–40 millilitres of blood, which amounts to about 15–20 milligrams of iron. In individuals suffering from HMB, frequently due to fibroids, PCOS, or endometriosis—or for whom no cause is identified—the loss of iron is even greater. Unless replenished by a diet rich in iron or by supplements, the loss can cause fatigue, impaired concentration, pallor, and compromised immunity—typical manifestations of IDA.

Actually, iron lost during menstruation is in the form of haem iron, which is more bioavailable than non-haem iron from plant foods. Nevertheless, regular dietary intake is necessary.

Pregnancy and Postpartum Recovery

While pregnant, a woman's blood supply is increased by almost 50% to supply the developing fetus, placenta, and maternal tissues. This increase drastically elevates the requirement for iron. A deficiency here not only poses a risk to the mother but can influence fetal brain development, birth weight, and preterm delivery risk.

Postpartum, iron is still important. Between delivery blood loss and the iron requirements of lactation, most new mothers are struggling with fatigue and low immunity—not only from sleepless nights but because their iron stores haven't been replenished.

Menopause

Most think that postmenopause, iron is obsolete. Although the monthly blood loss ends, the body continues to need iron for metabolic processes, production of red blood cells, and immune system protection. Further, iron serves to fight off age-related muscle loss and for brain health—two of postmenopausal women's top concerns.

As per Shimpli Patil, Head Nutritionist & Lifestyle Expert, "Even without periods, iron is still essential for vitality, immunity, and brain health. Low iron levels are common in many women not only because of diet but also because of poor gut health and ongoing stress."

It's a myth that simply consuming more iron does the trick. The fact is that iron uptake is a multifaceted process, which depends on gut health, stress, and the availability of inhibitors like calcium, tea, and coffee.

"Many women nowadays are suffering from low iron not just because of nutritional deficiencies but also compromised absorption," Patil says. "So, it's not merely about consuming more iron but making sure the body is indeed absorbing it."

Foods That Naturally Boost Iron Levels

Patil advises a combination of traditional and contemporary nutrition to sustain iron levels:

Garden cress seeds (Halim/Aliv): Small but mighty, particularly when soaked overnight and eaten with lemon juice for maximum uptake.

Moringa leaves: Packed with plant iron and antioxidants.

Dark leafy greens: Spinach, amaranth, dill, and colocasia.

Broccoli: Both high in iron and Vitamin C.

Pumpkin and sesame seeds: Convenient snack ingredients with a mighty iron kick.

Wheatgrass: Rich in "green hemoglobin."

Dried fruits: Dates, raisins, and figs make excellent instant iron boosters.

Organ meats: Especially liver, when obtained responsibly.

Tips to Maximize Iron Intake

To make the most of your iron-rich foods:

• Always combine iron sources with Vitamin C (consider: lemon juice, oranges, amla) to maximize absorption.
• Avoid tea, coffee, and milk an hour before or after an iron-rich meal to avoid interference with absorption.
• Consider supplements if you are at high risk or have a diagnosed deficiency, under medical guidance.

Why Iron Count Is About More Than Numbers?

"Iron isn't only about lab tests. It's about energy, clarity, healthy hair, radiant skin, and bouncing back," states Patil. "Healing occurs when we feed with simple, seasonal foods, and care for the gut."

Women need to be in charge of their iron requirements at all stages—by tuning into their bodies, seeing experts, and making informed food choices. And for goodness' sake, iron isn't all about blood—it's the building block of life and health for every woman.

Ms Shimpli Patil is the Head Nutritionist & Lifestyle Expert at Luke Coutinho Holistic Healing Systems (LCHHS) in India