Ever wondered why some people live well past 100 with their minds sharp and bodies still moving? While external factors like your lifestyle choices, diet, and exercise are important for a long life, science also shows that your genetic makeup may also play an important role for how long you live.

Thomas Perls, who is a professor of geriatrics at the Boston University School of Medicine and direct of the New England Centenarian Study (NECS) explains that longevity can, in fact, be inherited. This is especially the case when we talk about living past 100 years old.

What Makes One A Centenarian?

In the United States, around 1 in every 5,000 people is a centenarian. This means anyone who lives at least 100 years of age. Among them, a striking number are women, making them to be 85% of the total centenarian population. What sets these people apart is not their lifestyle but something beyond the external factors.

As per Perls, centenarians tend to age more slowly and push back age-related diseases like heart conditions, diabetes, or diseases like heart conditions, diabetes, or dementia until their 90s or beyond. This slow aging process is a key to their biological trait among those who reach extremely old age.

Is There A Genetic Link?

Getting to your 90s, Perls says, is roughly 30 percent due to genetics and 70 percent due to lifestyle. But if you’re aiming for 110—the elite club of supercentenarians—that flips: genetics likely accounts for up to 70 percent of your chances.

So, yes, picking the right parents (or grandparents) does matter. NECS has shown that centenarians often come from families where siblings and even parents lived exceptionally long lives. These families seem to carry genetic variations that protect them from aging-related diseases, allowing their bodies to function well even in old age.

One example is Celia, a 102-year-old NECS participant who still played complex Chopin pieces on the piano at public events. She wasn't an exception—many centenarians in the study live independently well into their late 90s or early 100s.

But, Are Genes All?

While you cannot change your DNA, but you can adopt habits that can increase your odds or living a healthier and a longer life. Perls recommends adding these to your routine:

Manage stress: Chronic stress accelerates aging. Finding healthy ways to cope—whether through meditation, community, or hobbies—can slow that process.

Eat smart: A plant-heavy diet with limited meat (ideally only once a week) helps maintain a healthy weight and reduces the risk of chronic illnesses.

Don’t smoke: Smoking is still one of the leading preventable causes of early death.

Exercise regularly: A mix of aerobic and strength training exercises helps maintain muscle, which is essential as you age.

The Older The Better Or The Older The Sicker?

While the common belief is that the older you get, the sicker you become, however, many centenarians reach old age mostly have lived a healthy lives. This is in contrast to people who develop chronic illness in their 60s or 70s. While centenarians often reach their 90s without a major health condition and experience only a short period of illness before their deaths.

This is why the concept of NECS is so valuable. This was funded by the National Institute on Aging, the William M. Wood Foundation, and the Martin and Paulette Samowitz Family Foundation. The study has tracked more than 2,000 centenarians, identifying not only genetic patterns but lifestyle commonalities.

Laughing gas or nitrous oxide is making headlines not for its role in dental clinics or surgical procedures, but as a potential treatment for depression. Once only considered a part of short-term anaesthetics used to relieve pain or anxiety during surgical procedures, like childbirth, nitrous oxide is now gaining attention in the world of mental health research for its potential to alleviate symptoms of depression, especially in people who have not responded to traditional treatments.

Even A Low Dose Of Laughing Gas Provides Rapid Relief From Depression

Several studies in recent years have shown that even a low dose of laughing gas can provide rapid relief from depressive symptoms. Unlike conventional antidepressants, which can take weeks to show results, nitrous oxide has demonstrated an almost immediate impact in some patients. Scientists believe this fast-acting effect could be a game-changer in managing treatment-resistant depression.

How Was The Research Conducted?

Researchers at Washington University School of Medicine and the University of Chicago conducted clinical trials on people with severe depression who had not responded well to typical medications. Participants were given a single one-hour inhalation session of nitrous oxide. Remarkably, many reported relief from symptoms within just a few hours, and in some cases, the effects lasted for several days.

Laughing gas is thought to work differently from traditional antidepressants, which usually act on serotonin and other neurotransmitters. Nitrous oxide instead affects the NMDA receptors in the brain, which are involved in mood regulation and cognitive functions. This is similar to how ketamine—another fast-acting antidepressant—works. However, nitrous oxide has the added advantage of being less intense and more manageable in terms of side effects.

Patients who received nitrous oxide in the study experienced a noticeable reduction in their depression scores, even when given low concentrations of the gas. Researchers found that a 25% concentration of nitrous oxide was nearly as effective as the 50% dose but caused fewer side effects, such as nausea or dissociation.

Nitrous Oxide Has Advantage Over Others-Its Long Term Medical Use

One of the reasons nitrous oxide is being seriously explored as a depression treatment is its accessibility and long-standing safety profile. It has been used in medical settings for over 150 years, primarily for pain relief. Its safety, low cost, and ease of administration make it an appealing option for rapid intervention in psychiatric emergencies, particularly for those at risk of suicide.

Still, experts caution that laughing gas is not a magic bullet. While it shows promise, more research is needed to understand its long-term effects and how often it can be safely administered without causing dependency or neurological issues. It also needs to be administered under medical supervision. Mental health professionals are optimistic, though. With increasing cases of depression worldwide and many patients not responding to current treatments, the medical community is on the lookout for new and effective therapies. Laughing gas may not be the ultimate cure, but it represents a promising step forward.

Scientists at the University of Pittsburgh School of Medicine are making significant progress toward developing a brain-computer interface (BCI) that could help people with tetraplegia (paralysis) restore their lost sense of touch. In the new study published in Nature Communications, participants explored digitally represented objects using an artificially created sense of touch. Through the interface, they described sensations as vivid as the warm fur of a purring cat, the smooth, rigid surface of a door key, and the cool roundness of an apple. This collaborative effort between the University of Pittsburgh and the University of Chicago represents a major step forward in neuroprosthetics.

Unlike earlier experiments—where artificial touch often felt like undifferentiated buzzing or tingling—this study introduced a novel feature: BCI users had control over the details of the electrical stimulation that generated their tactile sensations. By enabling participants to personalise their sensory input, scientists were able to help them recreate intuitive and meaningful experiences.

"Touch is an important part of nonverbal social communication; it is a sensation that is personal and that carries a lot of meaning," said lead author Ceci Verbaarschot, Ph.D., assistant professor of neurological surgery and biomedical engineering at the University of Texas-Southwestern and a former postdoctoral fellow at Pitt’s Rehab Neural Engineering Labs. "Designing their own sensations allows BCI users to make interactions with objects feel more realistic and meaningful, which gets us closer to creating a neuroprosthetic that feels pleasant and intuitive to use."

BCI converts Brain Activity Into Signals

A brain-computer interface converts brain activity into signals that can replace, restore, or enhance bodily functions normally controlled by the brain, such as movement. BCIs can also be used to restore lost sensations by directly stimulating the brain, essentially bypassing damaged neural pathways. Over the last decade, Pitt researchers have shown that a paralysed individual can feel sensation using a mind-controlled robotic arm. However, those sensations lacked nuance—touching a person’s hand felt no different than grasping a hard rock.

In this new study, researchers moved closer to creating a realistic, intuitive sense of touch. BCI users were able to "design" different tactile experiences for objects displayed on a screen and could identify objects based on sensation alone—though not perfectly. Participants, all of whom had lost hand sensation due to spinal cord injuries, were challenged to match stimulation settings with sensations like petting a cat or touching an apple, key, towel, or toast.

Sensations Were Subjective

Describing their sensations in rich and subjective detail, one participant noted a cat felt "warm and tappy," while another described it as "smooth and silky." Even when images were removed and participants had to rely solely on touch, they correctly identified the objects 35% of the time—better than chance. "We designed this study to shoot for the moon and made it into orbit," said senior author Robert Gaunt, Ph.D., associate professor of physical medicine and rehabilitation at Pitt. "Participants had a really hard task... and they were quite successful.

Vanellope Hope Wilkins made medical history in 2017 when she was born with her heart outside her body—a condition so rare it's described by experts as "one of a kind." Recently, she underwent a procedure wherein doctors split open her ribs to insert her heart back into her chest cavity. After the successful operation, they shared how they performed the seemingly impossible surgeries.

Born in the UK with a condition known as ectopia cordis, Vanellope underwent three major operations at Glenfield Hospital in Leicester to place her heart back inside her chest. The hospital says it knows of no other case in the UK where a baby with this condition has survived. Now seven years old, Vanellope has undergone groundbreaking surgery to reconstruct a protective cage around her heart—using her own ribs. Since then, she has worn a brace around her chest for protection.

She lives with complex medical needs and requires one-to-one care 24 hours a day. Vanellope is autistic and non-verbal, but according to her mother, Naomi Findlay, 39, from Clifton, Nottingham, she is "a happy little thing" who "brings a lot of joy and happiness." Speaking to the BBC, Naomi said she is extremely proud of the fact that her daughter has not only survived her rare medical condition but also achieved. "It makes me extremely proud to see how far she's come, what she's overcome, and what she's achieving. It's a real journey of strength and bravery... she's so brave," Naomi said, adding that saying goodbye at the theatre door before surgery is always emotional.

How Was It Done?

The surgical team carefully decided that the timing was right for this next step. Vanellope was placed on a bypass machine, which temporarily took over the function of her heart and lungs. This allowed her heart to deflate, making it easier to perform the “very tricky” procedure.

Surgeons first detached part of her heart—the right ventricular outflow tract—and the pulmonary artery from where it had fused to her skin. Then came the bilateral rib osteotomy, a procedure involving breaking her ribs on both sides. The ribs were then repositioned to create a protective cage around her heart.

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