1 in 1,000 to 1 in 1,100 live births worldwide are children born with down syndrome. The United Nations notes that each year, approximately 3,000 to 5,000 children are born with this chromosome disorder.

It is a genetic condition caused when an unusual cell division result in an extra full or even partial copy of chromosome 21. This extra genetic material causes the developmental changes and physical features of Down syndrome. The term "syndrome" here refers to a set of symptoms that tend to happen together. With a syndrome, there is a pattern of differences or issues in an individual's development. The condition is named after and English Physician, John Langdon Down, who was the first one to describe it.

What Is Chromosome 21?

As per the National Institute of Health's Eunice Kennedy Shriver National Institute of Child Health and Human Development, down syndrome is caused by a random error in cell division that results in the presence of an extra copy of chromosome 21.

This kind of error is called nondisjunction. This happens when one cell divides in two, pairs of chromosomes are split so that one of the pair goes to one cell and the other from the pair goes to the other cell. In nondisjunction, something goes wrong and both chromosomes from one pair go into one cell and no chromosomes from that pair go into another cell.

Humans have 46 chromosomes in each cell, which is divided into pairs of 23. Two copies of chromosome 21, one copy inherited from each parent, form one of the pairs. It is the smallest human chromosome that spans about 48 million base pairs, which are the building blocks of DNA. It represents in 1.5 to 2% of the total DNA in cells.

In 2000, researchers who worked on the Human Genome Project announced that they had determined the sequence of base pairs that make up this chromosome. Chromosome 21 was the second human chromosome to be fully sequenced.

Down syndrome happens when Trisomy 21 occurs, which means that each cell is the body has three copies of chromosome 21 instead of the usual two copies.

In rare cases, Down syndrome occurs when a portion of chromosome 21 attaches (translocates) to another chromosome during the formation of reproductive cells (eggs or sperm) or early in fetal development. As a result, individuals have two full copies of chromosome 21, along with additional genetic material from chromosome 21 attached to a different chromosome. This genetic variation is known as translocation Down syndrome.

Chromosome Changes Than Can Cause Down Syndrome

While Trisomy 21 causes down syndrome, there are three types of Trisomy chromosomal changes that occurs:

Complete Trisomy 21: This is the most common form of Down syndrome, occurring when an error during the formation of an egg or sperm results in an extra chromosome 21. When the egg and sperm unite, all resulting cells carry three copies of chromosome 21. This type, known as complete trisomy 21, accounts for nearly all cases of Down syndrome.

Mosaic Trisomy 21: In a small percentage (less than 5%) of cases, some but not all cells in the body have an extra chromosome 21. This condition, called mosaic trisomy 21 or “mosaicism,” occurs when an error in cell division happens early in development—either after a normal egg and sperm unite or when some cells lose the extra chromosome. The symptoms may vary depending on how many cells carry the extra chromosome.

Translocation Trisomy 21: In this less common form, only part of an extra chromosome 21 is present in the cells. This extra segment attaches (or “translocates”) to another chromosome and is passed along as cells divide. While translocation trisomy 21 accounts for a small number of Down syndrome cases, individuals with this type generally do not have distinct cognitive or medical differences compared to those with complete trisomy 21.

You may have heard people say that they are allergic to things, whether it is gluten, soy or peanuts. These people avoid these items, even going as far as not dining in certain places where there is a possibility of cross contamination.

While it may seem like an overreaction, allergy symptoms can range from just a few rashes to cause of death. There are many people who did not and still do not take allergies seriously. As one of the most common allergies, many people who have close ones with peanut allergy, many places have opened “nut-free” zones including schools, offices and many public spaces.

While there is no cure for allergies, a new clinical trial results show that exposure therapy with peanut allergies has proven successful.

Why Do We Need Exposure Therapy?

The research team reported in the journal Allergy, April 2025, that a significant majority of the participants, more than two out of every three (67%), were able to eat at least five peanuts without triggering an allergic reaction after undergoing the treatment. This marks a positive step forward in managing this common and often severe allergy.

Seeing as expansive as the risk associated with allergies is, researchers have continued working towards proper cures and treatments. While there are precautions like avoiding the allergens, reducing exposure, when a person with a sever, allergy is exposed to the allergens, the chances of them going into anaphylaxis is a lot, so many people care EpiPens or epinephrine shot that can counter allergic reactions for a while.

How Does Exposure Therapy Work For Peanut Allergies?

The way exposure therapy works is pretty simple but needs to be done carefully. People who are allergic to peanuts are given very, very small amounts of peanut protein every day. Over time, the amount is slowly increased. It's like gently introducing the body to the thing it's allergic to, little by little. This helps the body learn that peanuts aren't actually a threat, and it starts to react less strongly. It's a gradual process, but the goal is to build up a person's ability to handle peanuts without having a dangerous allergic reaction.

In this study, 21 adults who were allergic to peanuts took part. Every day, they ate a small amount of peanut flour mixed in with their food. The goal was for them to be able to eat a small amount of peanut flour every day for at least a month without any problems. After that, they were tested to see how much peanut they could eat. The researchers were very happy with how well the treatment worked, saying that the results were similar to what they've seen in studies with kids.

The study showed some really impressive results in how much more peanut the participants could handle after the treatment. The researchers mentioned that on average, the amount of peanut they could eat without a reaction went up by a hundred times!

Why Are Researches Like This Important?

What makes this study really important is that it's the first-time scientists have specifically looked at how well exposure therapy works for adults with peanut allergies. Usually, this kind of treatment is done with kids because their bodies are still growing and changing. However, this new research shows that even adults, whose bodies are already fully grown, can still become less allergic to peanuts with this type of treatment. This opens up a whole new possibility for adults who have lived with this allergy for many years and haven't had many treatment options before. Many said that the treatment was "life-changing" and they no longer lived in constant fear of their allergy.

Every three seconds someone in the world develop dementia. Forgetting things every now and then is normal, it happens to everyone. However, nobody expects to lose their sense of being, all the memories and life experiences that make you who you are. Dementia is the condition that makes all of these fears come true. It is a collective name for different brain syndromes which affect one's memory, thinking, behavior as well as emotions.

Many symptoms of dementia are vague, especially early ones, and they can easily mislead people. However, a new technological advancement may help people get diagnosed early, through shoes.

How Can Shoes Help Us Diagnose Dementia?

This new technology, published in Science Advances in April 2025, works by using special insoles you put inside your shoes. These insoles have tiny sensors that can feel the pressure when you walk or stand. What's really clever is that these sensors don't just feel pressure; they turn that pressure into tiny electrical signals. These signals carry hidden information about how you move and how your body is working, kind of like secret messages from your feet that can tell a story about your health without you even realizing.

How Do These Shoes Work?

The electrical signals created by the smart insoles are then sent wirelessly to a special application on your smartphone, just like getting a text message. This app takes all that data and turns it into easy-to-understand pictures and information about how you walk and stand. It can show exactly where you put the most pressure on your feet and how your movement changes over time. Even more impressively, the app uses smart computer programs to learn and recognize different ways you move, like sitting, standing, or running, giving a detailed look at your daily activities.

For patients who might be developing health issues, the smart insoles could provide early clues that doctors can use to make diagnoses sooner. For athletes, this technology can help them understand their posture better, which can prevent injuries and improve their performance. If someone is recovering from an injury, the insoles can track their progress and make sure they are healing correctly.

Researchers have already discovered that the way people walk can change when they have certain health problems, especially conditions that affect the brain and nerves, like Parkinson's disease. People with Parkinson's might start to shuffle their feet or lean to one side when they walk. The team behind these smart insoles believes that by having much better sensors in shoes, doctors could get a more accurate and earlier warning sign of these kinds of conditions just by analyzing someone's walk. This could lead to earlier treatments and better management of these challenging illnesses.

Why Is Early Diagnosis Important?

According to Alzheimer’s Disease International there are 55 million people living with dementia in 2020.

Their research shows that most of the people who have dementia have not received proper treatment for the same. About three quatre of the people who have been diagnosed with dementia lack treatment or have access to healthcare. Even in high-income countries only about 20-50% of people receive the proper care they need.

This treatment gap can only be fixed when people start getting a diagnosis. Not just receiving care, but receiving early diagnosis and treatment is crucial for proper dementia care, as explained by World Alzheimer Report 2011.

Whooping cough or pertussis, has been making headlines for its comeback across the United States. As per the recent data, there have been 8,485 reported cases for far this year. This is double the number recorded at the same time last year. The resurgence had already led to the deaths of two infants in Louisiana and a 5-year old child in Washington state over the past six months.

Pertussis is a highly contagious respiratory disease caused by the Bordetella pertussis bacterium. It is most dangerous for infants and young children, particularly before they are old enough to receive their first dose of vaccine at two months of age.

Why Are Cases Increasing?

During the COVID-19 pandemic, whooping cough cases dropped due to the increase in the use of masks, social distancing, and other preventive measures. However, it has made a comeback after 2 to 5 years as these preventive measures have decreased.

There is another factor in the increase of cases, it is the decline in vaccine rotes. As per an AP report, kindergarten vaccination coverage dropped last year, and vaccines exemptions reached an all-time high in the United States.

Public health officials worry that growing vaccine hesitancy could further fuel outbreaks of vaccine-preventable diseases like whooping cough.

Pregnant women are also recommended to receive the Tdap (tetanus, diphtheria, and pertussis) vaccine to protect their newborns. Unfortunately, vaccination rates during pregnancy remain suboptimal, leaving many babies vulnerable in their first months of life.

Which States Reported The Highest Cases?

There are certain states that have reported more numbers than others. As of the recent data, Pennsylvania reported 207 cases so far, whereas Michigan has seen an even sharper rise in cases. In 2025, Michigan has reported 516 cases, mostly among children, between ages 5 to 17. Michigan, in the last year, reported 2,081 pertussis cases.

The Centers for Disease Control and Prevention (CDC) recommends that all infants, children, adolescents, and pregnant women get vaccinated against pertussis. Adults who missed vaccinations earlier in life should also receive a dose to ensure protection.

How Does It Affect Your Body?

According to the CDC, Bordetella pertussis bacteria attach to the cilia (small hair-like structures) lining parts of the upper respiratory tract. The bacteria release toxins that damage the cilia and cause swelling, leading to severe coughing fits.

Symptoms of whooping cough can vary depending on a person’s age and vaccination status. Initial symptoms often resemble a common cold: runny nose, mild cough, and low-grade fever. However, as the disease progresses, patients may experience uncontrollable, violent coughing fits that can make it hard to breathe. The characteristic "whoop" sound often occurs when the patient gasps for air after a coughing fit.

Who Is More At Risk?

Babies under 1 year old are most at risk for severe complications, including pneumonia, seizures, and even death. Individuals with underlying health conditions like asthma or those who are immunocompromised also face a higher risk of serious illness.

How It Spreads And How Can It Be Prevented?

Whooping cough spreads easily through respiratory droplets when an infected person coughs or sneezes. People can remain contagious for at least two weeks after symptoms begin. Some individuals may only have mild symptoms yet can still unknowingly transmit the bacteria to vulnerable groups like infants.

The best way to prevent whooping cough is vaccination. Practicing good hygiene, such as frequent handwashing and covering coughs and sneezes, can also help limit the spread. In some cases, preventive antibiotics (post-exposure prophylaxis) may be recommended for those who have been in close contact with an infected person.