Health and Me

Itisha Arya

Gabapentin May Carry Serious Side Effects Beyond Pain Relief, Experts Warn

gabapentin warning

<span>Gabapentin</span> was first approved decades ago for epilepsy and nerve pain linked to shingles. Over time, it has turned into one of the most frequently prescribed medicines in the United States. In 2024 alone, around 15.5 million people were given prescriptions for it, placing it seventh among the country’s most prescribed drugs. Its popularity grew around a reassuring belief that it could ease pain without carrying the addiction risks long associated with opioids.

For a growing number of patients, that expectation has fallen short, according to reporting by The Wall Street Journal

Gabapentin is a prescription drug that belongs to a group of medicines known as anticonvulsants, also called anti-epileptic drugs. It is mainly prescribed to manage specific seizure disorders and to treat nerve-related pain. The medication is sold under brand names such as Neurontin, Gralise, and Horizant and comes in several forms, including capsules, tablets, extended-release tablets, and a liquid taken by mouth.

<h2>Gabapentin: When Stopping Becomes The Crisis</h2>

John Avery, a former high school physical education teacher from Illinois, was given gabapentin after a slipped disc triggered nerve pain. He recalls being told the drug was not addictive, as per Wall Street Journal. After a little over three weeks on it, he stopped taking it and says he was hit with severe and long-lasting withdrawal symptoms. These now include tremors, intense burning sensations across his body, muscle spasms, sleeplessness, and drastic weight loss. Several doctors later told him gabapentin was the likely cause. Avery says if he had known the drug required a slow taper, he would have refused it altogether.

Today, most gabapentin prescriptions are written for conditions it was never formally approved to treat by the US Food and Drug Administration. Doctors commonly prescribe it for long-term pain, anxiety, migraines, sleep problems, menopausal hot flashes, and more. While prescribing drugs off-label is legal and widespread, it also means the FDA has not formally evaluated the drug’s safety or benefits for many of these uses. Among people on Medicare, more than 90 percent of gabapentin prescriptions linked to doctor visits were for off-label reasons.

<h2>Gabapentin Linked To Dementia And Other Serious Problems</h2>

An expanding body of research suggests gabapentin may not be as harmless or as helpful as once believed. Studies have associated it with a higher risk of dementia, suicidal thoughts or behaviour, dangerous breathing problems in people with lung disease, swelling, and problems with thinking and memory. One recent study found that giving gabapentin to patients after surgery did not lower complications or shorten hospital stays. Instead, more patients reported ongoing pain months later.

Although medical guidance has long described gabapentin as non-habit-forming, many patients report serious symptoms when they try to reduce or stop the drug. These experiences point to physical dependence, even when gabapentin is taken exactly as prescribed.

<h2>Gabapentin: A Dangerous Combination</h2>

Gabapentin is frequently taken alongside opioids, either by design or because prescriptions overlap. The US Centers for Disease Control and Prevention has warned that this combination can be fatal. Federal and state records show that at least 5,000 deaths each year over the past five years have involved gabapentin overdoses.

One of those deaths was Nancy Hammer, a 77-year-old woman from South Carolina. She was prescribed gabapentin along with an opioid and other drugs that slow the nervous system. A later toxicology report found that the mix suppressed her breathing until it stopped. Her family says they were never clearly told how risky the combination could be.

<h2>Gabapentin: Why Doctors Keep Prescribing It</h2>

Gabapentin prescriptions have more than doubled in the past 15 years. This rise coincided with doctors pulling back from opioids and benzodiazepines as regulations tightened and scrutiny increased. For many clinicians, gabapentin became what one pain specialist described as a moral and regulatory “safe harbour” when they needed to treat pain quickly but had limited options.

Many doctors maintain that the drug does help certain patients and is often well tolerated. Others now argue that it has been prescribed too casually, used for too many complaints, and renewed too easily without enough follow-up.

As prescribing continues to rise, more researchers and doctors are questioning whether gabapentin represents another chapter in America’s long history of overprescribing. For some patients, a drug once promoted as a safer answer to pain has instead brought lasting harm.

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Gabapentin was first approved decades ago for epilepsy and nerve pain linked to shingles. Over time, it has turned into one of the most frequently prescribed medicines in the United States. In 2024 alone, around 15.5 million people were given prescriptions for it, placing it seventh among the country’s most prescribed drugs. Its popularity grew around a reassuring belief that it could ease pain without carrying the addiction risks long associated with opioids.For a growing number of patients, that expectation has fallen short, according to reporting by The Wall Street JournalWhat Is Gabapentin?Gabapentin is a prescription drug that belongs to a group of medicines known as anticonvulsants, also called anti-epileptic drugs. It is mainly prescribed to manage specific seizure disorders and to treat nerve-related pain. The medication is sold under brand names such as Neurontin, Gralise, and Horizant and comes in several forms, including capsules, tablets, extended-release tablets, and a liquid taken by mouth.Gabapentin: When Stopping Becomes The CrisisJohn Avery, a former high school physical education teacher from Illinois, was given gabapentin after a slipped disc triggered nerve pain. He recalls being told the drug was not addictive, as per Wall Street Journal. After a little over three weeks on it, he stopped taking it and says he was hit with severe and long-lasting withdrawal symptoms. These now include tremors, intense burning sensations across his body, muscle spasms, sleeplessness, and drastic weight loss. Several doctors later told him gabapentin was the likely cause. Avery says if he had known the drug required a slow taper, he would have refused it altogether.Today, most gabapentin prescriptions are written for conditions it was never formally approved to treat by the US Food and Drug Administration. Doctors commonly prescribe it for long-term pain, anxiety, migraines, sleep problems, menopausal hot flashes, and more. While prescribing drugs off-label is legal and widespread, it also means the FDA has not formally evaluated the drug’s safety or benefits for many of these uses. Among people on Medicare, more than 90 percent of gabapentin prescriptions linked to doctor visits were for off-label reasons.Gabapentin Linked To Dementia And Other Serious ProblemsAn expanding body of research suggests gabapentin may not be as harmless or as helpful as once believed. Studies have associated it with a higher risk of dementia, suicidal thoughts or behaviour, dangerous breathing problems in people with lung disease, swelling, and problems with thinking and memory. One recent study found that giving gabapentin to patients after surgery did not lower complications or shorten hospital stays. Instead, more patients reported ongoing pain months later.Although medical guidance has long described gabapentin as non-habit-forming, many patients report serious symptoms when they try to reduce or stop the drug. These experiences point to physical dependence, even when gabapentin is taken exactly as prescribed.Gabapentin: A Dangerous CombinationGabapentin is frequently taken alongside opioids, either by design or because prescriptions overlap. The US Centers for Disease Control and Prevention has warned that this combination can be fatal. Federal and state records show that at least 5,000 deaths each year over the past five years have involved gabapentin overdoses.One of those deaths was Nancy Hammer, a 77-year-old woman from South Carolina. She was prescribed gabapentin along with an opioid and other drugs that slow the nervous system. A later toxicology report found that the mix suppressed her breathing until it stopped. Her family says they were never clearly told how risky the combination could be.Gabapentin: Why Doctors Keep Prescribing ItGabapentin prescriptions have more than doubled in the past 15 years. This rise coincided with doctors pulling back from opioids and benzodiazepines as regulations tightened and scrutiny increased. For many clinicians, gabapentin became what one pain specialist described as a moral and regulatory “safe harbour” when they needed to treat pain quickly but had limited options.Many doctors maintain that the drug does help certain patients and is often well tolerated. Others now argue that it has been prescribed too casually, used for too many complaints, and renewed too easily without enough follow-up.As prescribing continues to rise, more researchers and doctors are questioning whether gabapentin represents another chapter in America’s long history of overprescribing. For some patients, a drug once promoted as a safer answer to pain has instead brought lasting harm.