Roughly one out of six people globally suffer with infertility according to the World Health Organization. A common issue that affects many, infertility, is a condition where a person is unable to reproduce offsprings. While the condition may be common, it can cause a lot of health problems as well as stress for people who wish to have children. To tackle this, people often opt for fertility treatment including reproductive technology called in vitro fertilization (IVF). However, could your infertility be a sign of impending health issues?

A new evidence review suggests a link between infertility in women and a heightened risk of heart problems, particularly among younger women and those undergoing fertility treatments.

Is Infertility An Early Warning for Heart Health?

Infertility may serve as an early sign for future heart health issues, according to researchers at the National and Kapodistrian University of Athens in Greece. This finding was recently presented in Copenhagen, Denmark, at a joint meeting of the European Society of Pediatric Endocrinology and the European Society of Endocrinology.

Researchers looked at data from many different studies – almost 21 of them! They compared nearly 179,000 women who couldn't get pregnant with about 3.4 million women who didn't have fertility issues. What they discovered was that women who were infertile had a higher chance of facing heart issues:

• They were 17% more likely to get heart disease, which is a general term for problems with the heart itself.
• They had a 16% higher chance of having a stroke, which happens when blood flow to the brain is blocked.
• They were 14% more likely to have problems with their heart or blood vessels in general.

Elevated Risk for Younger Women and Those Undergoing Treatment

The research highlights two groups of women who face an even bigger risk. First, it's younger women. The study found that women under 40 who were infertile had a 20% higher chance of heart disease. That's a significant increase for younger individuals. Second, it also showed that women who went through fertility treatments (like IVF) had an 18% greater risk of heart problems. This suggests that either the treatments themselves or the underlying reasons for needing them could be connected to heart health.

Implications for Clinical Care

Researchers believe that because infertility might be an early sign of heart problems, doctors can use this information. They can identify women who might need extra check-ups or special strategies to prevent heart disease earlier in life. It's like giving doctors a heads-up to be more careful with these patients. She also brought up an important question: what are the long-term effects of fertility treatments on a woman's heart? This is something doctors need to consider.

Researchers want to follow women’s health over time to really understand why infertility might be linked to heart health. They hope to figure out the exact biological reasons behind this connection and identify which specific groups of women are most at risk. The ultimate goal is to use all this information to create better guidelines for preventing heart disease early on and to improve heart care for women who have had infertility.

As our economy and connectivity evolved, many companies and professionals have moved onto working 24/7. To make this happen, people have come up with shift schedules that will allow some people to work during the day, while others work night shifts. However, an issue people face is that night shifts are unconventional and can impact your health. It changes the way your body functions and can have a severe impact on your body.

A study published on June 16 in ERJ Open Research found that women who consistently work night shifts have a 50% increased risk of moderate to severe asthma compared to women who workday shifts. Interestingly, this connection wasn't observed in men.

Researchers from the University of Manchester in the U.K., explained that while the study doesn't pinpoint why this link exists, it might be due to disruptions in the body's natural clock, which can affect hormone levels.

Hormonal Connections and Increased Risk

The idea that hormones play a role is supported by a key finding: postmenopausal women on the night shift who were not using hormone replacement therapy (HRT) saw their risk of moderate to severe asthma nearly double.

Researchers noted that asthma already affects women more severely than men, leading to higher hospitalization and death rates for women. Previous studies have also linked night shift work to more severe asthma in general. This led the team to investigate if night shifts would further increase asthma risk specifically for women.

Study Details and Findings

The study tracked the health of nearly 275,000 working individuals in the U.K. Biobank, a large health research project. Over 5% of these workers had asthma, with 2% suffering from severe asthma requiring a rescue inhaler.

The results clearly showed that women working only night shifts had 50% higher odds of moderate to severe asthma. This risk jumped to 89% higher for postmenopausal women on the night shift who were not taking HRT.

Researchers suggested that HRT might offer some protection against asthma for night shift workers, but he stressed that more research is needed to confirm this. He also speculated that higher testosterone levels in men might protect them from asthma, as testosterone has previously been linked to asthma protection.

Unanswered Questions and Future Steps

While the study highlights a strong association, it can't definitively prove that night shifts cause asthma in women. Other factors, like the different types of jobs men and women hold on night shifts, could also contribute to the risk.

Experts pointed out that it's often not easy for workers to simply change their shifts. She emphasized the need for further research to fully understand this link and to find ways to reduce the risk for women who work night shifts.

What Are Some Other Long-Term Effects Of Night Shifts?

Shift work, especially at night, seriously disrupts your body's natural 24-hour cycle, called the circadian rhythm, leading to various health challenges. Here are some long-term health issues that may arise from it, according to UCLA health.

Cancer

Disrupted circadian rhythm impacts cell function, DNA repair, and cell death, potentially leading to cancer, as reported by the National Toxicology Program. Reduced melatonin from irregular light/dark exposure hinders cell repair, making cancer progression easier.

Cardiovascular Disease

Working unusual hours increases heart disease and stroke risk. A European Society of Cardiology-linked study found women with five-plus years of rotating night shifts faced higher death risk, tied to stress, high blood pressure, and metabolic factors.

Gastrointestinal Disorders

Shift workers often experience digestive issues like abdominal discomfort, constipation, diarrhea, and IBS. These gut problems stem from sleep deprivation and unhealthy, processed food diets common in shift work, altering gut bacteria.

Mental Health Disorders

Nonstandard hours make maintaining relationships difficult, leading to isolation, stress, depression, and anxiety. A large study in The Lancet Psychiatry found shift work directly linked to higher risks of depression and anxiety, increasing with shift frequency.

Metabolic Disorders

Shift work disrupts circadian rhythm and hormones, raising risks for obesity, metabolic syndrome, and Type 2 diabetes. It's linked to higher BMI, hormonal imbalances affecting appetite/weight, and unhealthy lifestyle choices like smoking and poor diet.

Taking care of a sick person is a taxing job not many people can fullfill. Patients with mental health issues like dementia require specialized care and not everyone is equipped to handle these situations. Many times, people with dementia have emotional outbursts, difficulty communicating as well as doing normal lifestyle activities. Caring for people with dementia requires a team of people, sometimes 24/7 care with rotations for staff, so that the patient is not left unattended for an extended period of time. However, does this extensive routine affect the caregiver’s health? A new study has found concerning future implications for dementia caregivers.

Caring for someone with dementia might put caregivers at higher risk for their own brain aging and future dementia, a new study suggests. This is largely due to certain lifestyle factors.

Caregivers' Hidden Risk

A recent report from the Public Health Center of Excellence on Dementia Caregiving, released on June 12, found that nearly 3 out of 5 dementia caregivers (59%) have at least one risk factor that increases their chances of developing dementia over time. Even more concerning, about 1 in 4 (24%) have two or more of these risk factors.

Matthew Baumgart, senior vice president of health policy for the Alzheimer's Association, called this analysis a "wake-up call." He noted that caregivers are often so focused on their loved ones that they neglect their own health. This highlights a critical need for public health strategies to support these vulnerable individuals.

Key Risk Factors Identified

Researchers analyzed health data from caregivers across 47 states in 2021 and 2022. They found that caregivers were more likely than the average person to have five things that aren't good for brain health:

Smoking

Caregivers were 30% more likely to smoke. Smoking is bad for your overall health, including your brain.

High Blood Pressure

They were 27% more likely to have high blood pressure. High blood pressure can damage blood vessels, including those in the brain.

Poor Sleep

21% more likely to say they didn't sleep well. Not getting enough good sleep can affect how your brain works and ages.

Diabetes

They had a 12% higher chance of having diabetes. Diabetes can lead to problems with blood flow and brain function.

Obesity

Caregivers were 8% more likely to be overweight or obese. Being overweight is linked to many health problems, including some that affect the brain.

Interestingly, there was one good piece of news: caregivers were actually less likely to be inactive (meaning they moved around more) compared to others. This might be because looking after someone with dementia often involves a lot of moving around.

Younger Caregivers Face Greater Vulnerability

This part focuses on younger caregivers, and the news isn't great for them. The study found that younger people who care for someone with dementia are at an even higher risk.

• 40% more likely to have many of these risk factors at once, compared to other people their age.
• 86% more likely to smoke. That's a huge difference!
• 46% more likely to have high blood pressure.
• 29% more likely to get less than six hours of sleep each night compared to their friends who aren't caregivers.

The researchers explained that knowing which groups of caregivers are most at risk, public health officials can better plan and offer help. Instead of a one-size-fits-all approach, they can create specific programs and resources for the groups that need it most.

A parasite that causes malaria is halted by sickle cells and makes people who carry the sickle cell trait more resistant to the disease. This is why sickle cell trait also occurs more in people who live in tropical and sub-tropical regions where cases of malaria were or still is common.

It comes from the copy of an abnormal sickle or the HBB gene and one copy of the normal HBB gene. The gene is an evolutionary response to malaria, where humans begin to develop an abnormal HBB gene and pass it onto to the next generation.

The "Black Disease"

The earliest documentation of sickle cell symptoms in medical texts could be found from the 1870s. However, it had not been formally identified until in 1910. when the first case was detected in the United States. The first case of sickle cell disease or SCD in the US was in 1904, when Walter Clement Noel, a 20-year-old dental student from Grenada, sought care for anemia at Chicago Presbyterian Hospital, where he met Dr James B Herrick. Dr Herrick was a cardiologist and professor of medicine and he was assigned noel who had experienced recurrent episodes of "muscular rheumatism" and "bilious attacks" over a period of 3 years.

This case was assigned to an intern Dr Ernest E Irons by Dr Herrick. Dr Ernest performed initial blood work on Noel and observed the unusual sickle-shaped red blood cells in the sample under the microscope. This is when Dr Herrick was told about it, leading to him publishing the first documented case study of SCD, titled, "Peculiar Elongated and Sickle-Shaped Red Blood Corpuscles in a Case of Severe Anemia."

However, the name, sickle cell anemia, was not coined until in 1922, by Vernon Mason. It was also the first diagnosed genetic disease and the first to be linked to the hemoglobin protein.

But, how did it gain the name "Black Disease"? This is because the disease often disproportionately affected Black Americans in the US, which caused racial bias and prevented people with sickle cell from receiving quality care.

In response to this, in the 1960s, the Black Panther Party worked to expand community-based care for education and treatment of this disease. This was part of their initiative to tackle the sickle cell, which received little to no attention because it mostly affected a large part of Black community.

While Herrick may have described the first known case in the US, SCD did exist for generations in African and Mediterranean descent, due to the regions being prone to diseases like malaria. In African medical literature, it was known as "ogbanjes", which loosely translated into "children who come and go" as the infants born with this disease had a high mortality rates. One of the first records, as is also noted by the Sickle Cell Association from Africa is from a Ghanian family in 1670.

A Groundbreaking Discovery

In 1927, scientists Hahn and Gillespie made a discovery that reshaped our understanding of blood disorders. While studying red blood cells in a low-oxygen environment saturated with carbon dioxide, they observed a curious phenomenon: the cells twisted into sickle shapes—not just in patients with sickle cell disease (SCD), but sometimes in people without any symptoms at all.

This puzzling observation hinted at an invisible carrier state and eventually led to the identification of what we now call the sickle cell trait.

Fast-forward to the late 1940s and early 1950s, and the pieces of the puzzle began falling into place. In 1949, two scientists working continents apart independently uncovered the genetic blueprint of SCD.

Col. E. A. Beet, a military physician stationed in what is now Mozambique, published his findings in an African medical journal. Around the same time, Dr. James V. Neel at the University of Michigan released a parallel study in the journal Science. Both revealed that SCD follows an autosomal recessive inheritance pattern—meaning the disease only occurs when a person inherits two copies of the mutated gene. Those with just one copy? They carried the trait, but not the illness.

Together, their work laid the foundation for our modern understanding of genetic inheritance and reshaped how we screen for and manage sickle cell disorders today.